Early Renal Hyperfunction and Hypertrophy in Insulin-Dependent Patients: Changes Found at Diagnosis and Early in the Course of Diabetes

  • Jens Sandahl Christiansen
Part of the Topics in Renal Medicine book series (TIRM, volume 6)

Abstract

This chapter reviews studies on glomerular filtration rate (GFR), renal plasma flow (RPF), and kidney volume in insulin-dependent diabetes mellitus (IDDM) patients and the impact upon GFR of glucose, ketone bodies, and vasoactive hormones.

Keywords

Glomerular Filtration Rate Continuous Subcutaneous Insulin Infusion Renal Plasma Flow Kidney Volume IDDM Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gambier P: Application de la théorie de Rehberg à l’étude clinique des affections rénales et du diabète. Ann Med 35: 273–299, 1934.Google Scholar
  2. 2.
    Mogensen CE: Kidney function and glomerular permeability to macromolecules in juvenile diabetes. Dan Med Bull 19 [Suppl 3]: 1–36, 1972.PubMedGoogle Scholar
  3. 3.
    Christiansen JS, Gammelgaard J, Tronier B, Svendsen PA, Parving H-H: Kidney function and size in diabetics before and during initial insulin treatment. Kidney Int 21: 683–688, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Ditzel J, Schwartz M: Abnormally increased glomerular filtration rate in short-term insulin-treated diabetic subjects. Diabetes 16: 264–267, 1967.PubMedGoogle Scholar
  5. 5.
    Mogensen CE, Andersen MJF: Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22: 706–713, 1973.PubMedGoogle Scholar
  6. 6.
    Parving H-H, Noer I, Deckert T, Evrin P-E, Nielsen SL, Lyngsoe J, Mogensen CE, Borth M, Svendsen PAA, Trap Jensen J, Lassen NA: The effect of metabolic regulation on micro-vascular permeability to small and large molecules in short-term juvenile diabetics. Diabetologia 12: 161–166, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Mad£csy L, Kiss S, Borsodi A: The size of the kidneys of diabetic children in the early stage of the disease. Orvosi Hetilab 119: 317–320, 1978.Google Scholar
  8. 8.
    Brochner-Mortensen J, Ditzel J, Mogensen CE, Rodbro P: Microvascular permeability to albumin and glomerular filtration rate in diabetic and normal children. Diabetologia 16: 307311, 1979.Google Scholar
  9. 9.
    Christiansen JS, Gammelgaard J, Frandsen M, Parving H-H: Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin-dependent diabetics. Diabetologia 20: 451–456, 1981.PubMedGoogle Scholar
  10. 10.
    Nyberg G, Granerus G, Aurell M: Renal extraction ratios for 51 Cr-EDTA, PAH, and glucose in early insulin-dependent diabetic patients. Kidney Int 21: 706–708, 1982.PubMedCrossRefGoogle Scholar
  11. 11.
    Christiansen JS, Christensen CK, Hermansen K, Pedersen EB, Mogensen CE: Enhancement of glomerular filtration rate and renal plasma flow by oral glucose load in well controlled insulin-dependent diabetics. Scand J Clin Lab Invest 46: 265–272, 1986.CrossRefGoogle Scholar
  12. 12.
    Brenner BM, Humes HD: Mechanisms of glomerular ultrafiltration. N Engl J Med 297: 148–154, 1977.PubMedCrossRefGoogle Scholar
  13. 13.
    Tucker BJ, Blantz RC: An analysis of the determinants of nephron filtration rate. Am J Physiol 232: F477 - F483, 1977.PubMedGoogle Scholar
  14. 14.
    Hostetter TH, Troy TL, Brenner BM: Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19: 410–415, 1981.PubMedCrossRefGoogle Scholar
  15. 15.
    Jensen PK, Christiansen JS, Steven K, Parving H-H: Renal function in streptozotocin-diabetic rats. Diabetologia 21: 409–414, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Brochner-Mortensen J: Glomerular filtration rate and extracellular fluid volumes during normoglycaemia and moderate hyperglycaemia in diabetics. Scand J Clin Lab Invest 32:311_316, 1973.Google Scholar
  17. 17.
    Parving H-H, Rutili F, Granath K, et al.: Effect of metabolic regulation on renal leakiness to dextran molecules in short-term insulin-dependent diabetics. Diabetologia 17: 157–160, 1979.PubMedCrossRefGoogle Scholar
  18. 18.
    Christiansen JS: On the pathogenesis of the increased glomerular filtration rate to short-term insulin-dependent diabetes. Dan Med Bull 31: 349–361, 1984.PubMedGoogle Scholar
  19. 19.
    Mogensen CE: Early glomerular hyperfiltration in insulin-dependent diabetics and late nephropathy. Scand J Clin Lab Invest 46: 201–206, 1986.PubMedCrossRefGoogle Scholar
  20. 20.
    Mogensen CE: Glomerular filtration rate and renal plasma flow in normal and diabetic man during elevation of blood sugar levels. Scand J Clin Lab Invest 28: 177–182, 1971.PubMedCrossRefGoogle Scholar
  21. 21.
    Ek J: The influence of heavy hydration on the renal function in normal and hypertensive man Scand J Clin Lab Invest [Suppl 19] 7: 1–77, 1955.Google Scholar
  22. 22.
    Fox M, Thier S, Rosenberg L, Segal S: Impaired renal tubular function induced by sugar infusion in man. J Clin Endocrinol Metab 24: 1318–1327, 1964.PubMedCrossRefGoogle Scholar
  23. 23.
    Brochner-Mortensen J: The glomerular filtration rate during moderate hyperglycaemia in normal man. Acta Med Scand 194: 31–37, 1973.CrossRefGoogle Scholar
  24. 24.
    Christiansen JS, Frandsen M, Parving H-H: Effect of intravenous glucose infusion on renal function in normal man and in insulin-dependent diabetics. Diabetologia 21: 368–373, 1981.PubMedCrossRefGoogle Scholar
  25. 25.
    Christensen CK, Schmitz O, Pedersen EB, Alberti KGMM, Mogensen CE: Effect of 3hydroxybutyrate infusion on urinary protein excretion in healthy man. Scand J Clin Lab Invest 46: 239–243, 1986.PubMedCrossRefGoogle Scholar
  26. 26.
    Trevisan R, Nosadini R, Fioretto P, Avogaro A, Duner E, lori E, Valerio A, Doria A, Crepaldi G: Ketone bodies increase glomerular filtration rate in normal man and in patients with Type 1 (insulin dependent) diabetes. Diabetologia 30: 214–221, 1987.PubMedCrossRefGoogle Scholar
  27. 27.
    Mogensen CE, Andersen MJF: Increased kidney size and glomerular filtration rate in untreated juvenile diabetics: normalization by insulin-treatment. Diabetologia 11: 221–224, 1975.PubMedCrossRefGoogle Scholar
  28. 28.
    Kroustrup JP, Gundersen HJG, Osterby R: Glomerular size and structure in diabetes mellitus. III. Early enlargement of the capillary surface. Diabetologia 13: 207–210, 1977.PubMedCrossRefGoogle Scholar
  29. 29.
    Wiseman HJ, Saunders A, Keen H, Viberti GC: Effect of blood glucose control on increased glomerular filtration rate and kidney size in insulin-dependent diabetes. N Engl J Med 312: 617–621, 1985.PubMedCrossRefGoogle Scholar
  30. 30.
    Christensen CK, Christiansen JS, Christensen T, Hermansen K, Mogensen CE: The effect of six months continuous subcutaneous insulin infusion on kidney function and size in insulin-dependent diabetics. Diabetic Med 3: 29–32, 1986.PubMedCrossRefGoogle Scholar
  31. 31.
    Atherton A, Hill DW, Keen H, Young S, Edwards EJ: The effect of acute hyperglycaemia on the retinal circulation of the normal cat. Diabetologia 18: 233–237, 1980.PubMedCrossRefGoogle Scholar
  32. 32.
    Ditzel J, Brochner-Mortensen J, Rodbro P: A combined disturbance in renal tubular handling of phosphate leads to increased glomerular filtration rate in diabetes mellitus: a new hypothesis. Acta Endocrinol (Copenh) [Suppl 242] 97: 16–18, 1981.Google Scholar
  33. 33.
    Ditzel J, Brochner-Mortensen J, Kawahara R: Dysfunction of tubular phosphate reabsorption related to glomerular filtration and blood glucose control in diabetic children. Diabetologia 23: 406–410, 1982.PubMedCrossRefGoogle Scholar
  34. 34.
    Leyssac PP: The renin angiotensin system and kidney function: a review of contributions to a new theory. Acta Physiol Scand [Suppl] 442: 1–52, 1976.Google Scholar
  35. 35.
    Jensen PK, Christensen O, Steven K: A mathematical model of fluid transport in the kidney. Acta Physiol Scand 112: 373–385, 1981.PubMedCrossRefGoogle Scholar
  36. 36.
    Brochner-Mortensen J, Stockel M, Sorensen PJ, Nielsen AH, Ditzel J: Proximal glomerulo-tubular balance in patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 27: 189–192, 1984.PubMedGoogle Scholar
  37. 37.
    Parving H-H, Noer I, Kehlet H, Mogensen CE, Svendsen PAA, Heding LG: The effect of short-term glucagon infusion on kidney function in normal man, Diabetologia 13: 323–325, 1977.PubMedCrossRefGoogle Scholar
  38. 38.
    Parving H-H, Christiansen JS, Noer I, Tronier B, Mogensen CE: The effect of glucagon infusion on kidney function in short-term insulin dependent juvenile diabetics. Diabetologia 19: 350–354, 1980.PubMedCrossRefGoogle Scholar
  39. 39.
    Parving H-H, Noer I, Mogensen CE, Svendsen PAA: Kidney function in normal man during short-term growth hormone infusion. Acta Endocrinol (Copenh) 89: 796–800, 1978.Google Scholar
  40. 40.
    Corvilain J, Abramow M: Some effects of human growth hormone on renal hemodynamics and on tubular phosphate transport in man. J Clin Invest 41: 1230–1235, 1962.PubMedCrossRefGoogle Scholar
  41. 41.
    Christiansen JS, Gammelgaard J, Orskov H, Andersen AR, Telmer S, Parving H-H: Kidney function and size in normal subjects before and during growth hormone administration for one week. Eur J Clin Invest 11: 487–490, 1981.PubMedCrossRefGoogle Scholar
  42. 42.
    Christiansen JS, Gammelgaard J, Frandsen M, Orskov H, Parving H-H: Kidney function and size in type 1 diabetic patients before and during growth hormone administration for one week. Diabetologia 22: 333–337, 1982.PubMedCrossRefGoogle Scholar
  43. 43.
    Hostetter TH, Rennke HG, Brenner BM: The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72: 375–380, 1982.PubMedCrossRefGoogle Scholar
  44. 44.
    Christiansen JS, Feldt-Rasmussen B, Parving H-H: Short-term inhibition of prostaglandin synthesis has no effect on the elevated glomerular filtration rate in early insulin-dependent diabetes. Diabetic Med 2: 17–20, 1985.PubMedCrossRefGoogle Scholar
  45. 45.
    Esmatjes E, Fernandez MR, Halperin I, Camps J, Gaya J, Arroyo V, Rivera F, Figuerola D: Renal hemodynamic abnormalities in patients with short term insulin-dependent diabetes mellitus: role of renal prostaglandins. J Clin Endocrinol Metab 60: 1231–1235, 1985.PubMedCrossRefGoogle Scholar
  46. 46.
    Burden AC, Thurston H: Plasma renin activity in diabetes mellitus. Clin Sci 56: 255–259, 1979.PubMedGoogle Scholar
  47. 47.
    Christlieb AR: Renin—angiotensin—aldesterone system in diabetes mellitus. Diabetes [Suppl 2] 25: 820–825, 1976.Google Scholar
  48. 48.
    DeChatel R, Weidmann P, Flammer J, Ziegler WH, Beretta-Piccoli C, Vetter W, Reubi FC: Sodium, renin, aldosterone, catecholamines and blood pressure in diabetes mellitus. Kidney [nt 12: 412–421, 1977.CrossRefGoogle Scholar
  49. 49.
    Hostetter TH, Rennke HG, Brenner BM: The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72: 375–380, 1982.PubMedCrossRefGoogle Scholar
  50. 50.
    Wiseman MJ, Drury PL, Viberti GC, Keen H: Plasma renin activity in insulin-dependent diabetics with raised glomerular filtration rate. Clin Endocrinol 21: 409–414, 1984.CrossRefGoogle Scholar
  51. 51.
    Christiansen JS, Giese J, Damkjaer M, Parving H-H: The renin—angiotensin system and kidney function during initial insulin treatment in diabetic man. (In press, 1987).Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1988

Authors and Affiliations

  • Jens Sandahl Christiansen

There are no affiliations available

Personalised recommendations