Pathogenesis of Diabetic Glomerulopathy: A Biochemical View

  • Robert G. Spiro
Part of the Topics in Renal Medicine book series (TIRM, volume 6)


Half a century has now elapsed since Kimmelstiel and Wilson described in diabetic glomeruli the distinctive periodic acid—Schiff (PAS)-reactive nodular deposits that bear their names [1]. Since that time, these initial observations have been extended and it has become evident that, although the nodular lesions are frequently not present, the diabetic glomerular disease is always characterized by basement thickening and mesangial expansion [2, 3]. Indeed it is believed that progressive accumulation of glomerular extracellular matrix is an important aspect of the defect that leads to proteinuria and ultimately to capillary occlusion with the loss of functioning filtration units.


Basement Membrane Glomerular Basement Membrane Heparan Sulfate Proteoglycan Aldose Reductase Inhibitor Lamina Densa 
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© Springer Science+Business Media Dordrecht 1988

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  • Robert G. Spiro

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