The Ultrastructure of Diabetic Nephropathy in Type 1 (Insulin-Dependent) Diabetes: Structural and Functional Relationships and Determinants of Prognosis

  • Rudolf W. Bilous
  • Michael W. Steffes
  • S. Michael Mauer
Part of the Topics in Renal Medicine book series (TIRM, volume 6)


There have been many descriptive reports of the ultrastructural appearances of the kidney in diabetic patients [1–5], but quantification of the observed changes had to await the development of accurate stereologic methods for the measurement of glomerular components [6, 7]. Using these techniques, it is possible to measure the thickness, surface areas, and volume fractions of those structures most affected by diabetes.


Diabetic Nephropathy Glomerular Basement Membrane Urinary Albumin Excretion Filtration Surface Tubular Basement Membrane 
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Copyright information

© Springer Science+Business Media Dordrecht 1988

Authors and Affiliations

  • Rudolf W. Bilous
  • Michael W. Steffes
  • S. Michael Mauer

There are no affiliations available

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