Cervical Intraepithelial Neoplasia and Condyloma

  • Alex Ferenczy
  • Barbara Winkler


The nomenclature and classification of intraepithelial squamous lesions of the cervix have a controversial history,17 now further complicated by the introduction of new terminology for the classification of cervical human papillomavirus (HPV) infection.39 The classic terminology separates noninvasive cervical lesions into two groups: dysplasia and carcinoma in situ (CIS), implying a biologic distinction between these two entities that can be reproducibly distinguished histologically.21,151 In the cytologic nomenclature using this system, dysplasia is considered a benign to possibly malignant squamous epithelial atypia, whereas CIS is designated as positive for malignant cells. In 1961, at the First International Congress on Exfoliative Cytology, the Committee on Histological Terminology for Lesions of the Uterus Cervix defined CIS as follows231: “Only those cases should be classified as CIS which, in the absence of invasion, show a surface lining epithelium in which, throughout its whole thickness, no differentiation takes place. The process may involve the lining of the cervical glands.” It is recognized that the cells of uppermost layers may show some slight flattening. The very rare case of an otherwise characteristic CIS that shows a greater degree of differentiation belongs to the exceptions for which no classification can provide. Dysplasia of the cervix was defined as 231: “... all other (than CIS) disturbances of differentiation of the squamous epithelial lining of surface and glands.... They may be characterized as of high or low degree, terms which are preferable to suspicious and non-suspicious, as the proposed terms describe the histological appearance and do not express an opinion.” The narrow and arbitrary definition of CIS and the broad, all encompassing definition of dysplasia led to diagnostic uncertainties and to a classification based solely on histology, divorced from clinical and therapeutic considerations. 21,102,173


Obstet Gynecol Cervical Intraepithelial Neoplasia Uterine Cervix Cervical Neoplasia Transformation Zone 
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  1. 1.
    Antonio DA, Fu YS, Warhol M, (1983) Multifactorial approach to the detection of cervical squamous cell dysplasia. Lab Invest 48: 4AGoogle Scholar
  2. 2.
    Arof HM, Gerbie MV, Smeltzer J (1984) Cryosurgical treatment of cervical intraepithelial neoplasia: Four-year experience. Am J Obstet Gynecol 150: 865Google Scholar
  3. 3.
    Aurelian L (1976) Sexually transmitted cancers? The case for genital herpes. J Am Vener Dis Assoc 2: 10PubMedGoogle Scholar
  4. 4.
    Baggish MS (1980) High-power density carbon dioxide laser therapy for early cervical neoplasia. Am J Obstet Gynecol 136: 117PubMedGoogle Scholar
  5. 5.
    Baggish MS (1981) Complications associated with carbon dioxide laser surgery in gynecology. Am J Obstet Gynecol 139: 568PubMedGoogle Scholar
  6. 6.
    Bamford PN, Ormerod MG, Sloane JP, Warburton MJ (1983) An immunohistochemical study of the distribution of epithelial antigens in the uterine cervix. Obstet Gynecol 61: 603PubMedGoogle Scholar
  7. 7.
    Baram A, Schacter A (1982) Cervical carcinoma: Disease of the future for Jewish women. Lancet 1: 747Google Scholar
  8. 8.
    Barron BA, Richart RM (1968) A statistical model of the natural history of cervical carcinoma based on a prospective study of 557 cases. J Natl Cancer Inst 41: 1343PubMedGoogle Scholar
  9. 9.
    Barron BA, Richart RM (1970) A statistical model of the natural history of cervical carcinoma. II. Estimates of the transition time from dysplasia to carcinoma in situ. J Natl Cancer Inst 45: 1025Google Scholar
  10. 10.
    Barron BA, Cahill MC, Richart RM (1978) A statistical model of the natural history of cervical neoplastic disease: The duration of carcinoma in situ. Gynecol Oncol 6: 196Google Scholar
  11. 11.
    Benedictis TJ, Marmar JL, Praiss DE (1977) Intraurethral condylomata acuminata management and review of the literature. J Urol 118: 767Google Scholar
  12. 12.
    Berkowitz RS, Ehrmann RL, Lavizzo-Mourey R, Knapp RC (1979) Invasive cervical carcinoma in young women. Gynecol Oncol 8: 311PubMedGoogle Scholar
  13. 13.
    Binder MA, Cates GW, Emson HE, (1985) The changing concepts of condyloma. A retrospective study of colposcopically directed cervical biopsies. Am J Obstet Gynecol 151: 213Google Scholar
  14. 14.
    Boon ME, Fox CH (1981) Simultaneous condyloma acuminatum and dysplasia of the uterine cervix. Acta Cytol 25: 393PubMedGoogle Scholar
  15. 15.
    Boyes DA, Fidler HK, Lock DR (1963) The significance of in situ carcinoma of the uterine cervix. In: Proceedings of the First International Congress of Exfoliative Cytology. Philadelphia, J. B. LippincottGoogle Scholar
  16. 16.
    Bryson SCP, Lenehan, P, Lickrish GM (1985) The treatment of grade 3 cervical intraepithelial neoplasia with cryosurgery: An 11-year experience. Am J Obstet Gynecol 151: 201PubMedGoogle Scholar
  17. 17.
    Buckley CH, Butler EB, Fox II (1982) Cervical intraepithelial neoplasia. J Clin Pathol 35: 1PubMedGoogle Scholar
  18. 18.
    Buckley CH, Butler EB, Fox H (1983) Cervical intraepithelial neoplasia. Lancet 1: 1389Google Scholar
  19. 19.
    Buckley JD, Doll R, Harris RWC, (1981) Case control study of the husbands of women with dysplasia or carcinoma of the cervix uteri. Lancet 2: 1010PubMedGoogle Scholar
  20. 20.
    Bullough WS, Laurence EB (1967) Epigenetic mitotic control. In: Tier H, Rytomaa T (eds). Control of Cellular Growth in Adult Organisms. New York, Academic Press, pp 28 - 40Google Scholar
  21. 21.
    Burghart E (1973) Early histological diagnosis of cervical cancer, 1st ed. Philadelphia, W. B. Saunders Co.Google Scholar
  22. 22.
    Burghart E, Ostor AG (1983) Site and origin of squamous cervical cancer: A histomorphologic study. Obstet Gynecol 62: 117Google Scholar
  23. 23.
    Burnett TS, Gallimore PH (1982) Personal communication, Cold Spring Harbor, N.Y.Google Scholar
  24. 24.
    Butterworth CE, Hatch KD, Gore H, (1982) Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 35: 73PubMedGoogle Scholar
  25. 25.
    Bychkov V, Rothman M, Bardawil WA (1983) Immunocytochemical localization of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and human chorionic gonadotropin ( HCG) in cervical neoplasia. Am J Clin Pathol 79: 414Google Scholar
  26. 26.
    Campion MJ, Singer A, Clarkson PK, McCance DJ (1985) Increased risk of cervical neoplasia in consorts of men with penile condylomata acuminata. Lancet 1: 943PubMedGoogle Scholar
  27. 27.
    Cartwright RA, Sinson JD (1981) Carcinoma of penis and cervix. Lancet 1: 97Google Scholar
  28. 28.
    Casas-Cordero M, Morin C, Roy M, (1981) Origin of the koilocyte in condylomata of the human cervix. Ultra-structural study. Acta Cytol 25: 383Google Scholar
  29. 29.
    Centers for Disease Control (1983) Morbidity, Mortality Weekly Report 32: 306Google Scholar
  30. 30.
    Cevenini R, Costa S, Rumpanesi F, (1981) Cytological and histopathological abnormalities of the cervix in genital Chlamydia trachomatis infections. Br J Vener Dis 57: 334PubMedGoogle Scholar
  31. 31.
    Christopherson WM, Parker JE (1960) A study of the relative frequency of carcinoma of the cervix in the Negro. Cancer 13: 711PubMedGoogle Scholar
  32. 32.
    Clarke EA, Morgan RW, Newman AM (1982) Smoking as a risk factor in cancer of the cervix: Additional evidence from a case control study. Am J Epidemiol 115: 59Google Scholar
  33. 33.
    Clarke EA, Hatcher J, McKeowyn-Eyssen GE, Lickrish GM (1985) Cervical dysplasia: Association with sexual behavior, smoking and oral contraceptive use? Am J Obstet Gynecol 151: 612PubMedGoogle Scholar
  34. 34.
    Coppleson M (1970) The origin and nature of premalignant lesions of the cervix uteri. Int J Gynecol Obstet 8: 539Google Scholar
  35. 35.
    Coppleson M, Reid B (1967) Preclinical carcinoma of the cervix uteri, 1st ed. Oxford, Pergamon PressGoogle Scholar
  36. 36.
    Coppleson M, Pixley E, Reid B (1971) Colposcopy. A scientific and practical approach to the cervix in health and disease, 1st ed. Springfield, Ill., Charles C ThomasGoogle Scholar
  37. 37.
    Cramer DW, Cutler SJ (1974) Incidence and histopathology of malignancies of the female genital organs in the United States. Am J Obstet Gynecol 118: 443PubMedGoogle Scholar
  38. 38.
    Croissant O, Bonneaud G, Orth G (1972) Detection of the vegetative viral DNA replication in papillomavirus-induced tumors by in situ molecular hybridization. Cr Acad Sci Paris 274: 614Google Scholar
  39. 39.
    Crum CP, Levine RU (1984) Human papillomavirus infection and cervical neoplasia: New perspectives. Int J Gynecol Pathol 3: 376Google Scholar
  40. 40.
    Crum CP, Ikenberg H, Richart RM, Gissman L (1984) Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med 310: 880PubMedGoogle Scholar
  41. 41.
    Crum CP, Mitao M, Levine RU, Silverstein SJ (1985) Cervical papillomaviruses segregate within morphologically distinct precancerous lesions. J Virol 54: 675PubMedGoogle Scholar
  42. 42.
    Crum CP, Egawa K, Barron B, (1983) Human papillomavirus infection (condyloma) of the cervix and cervical intraepithelial neoplasia: A histological and statistical analysis. Gynecol Oncol 15: 88Google Scholar
  43. 43.
    Crum CP, Egawa K, Fu YS, (1983) Atypical immature metaplasia (AIM): A subset of human papillomavirus infection of the cervix. Cancer 51: 2214Google Scholar
  44. 44.
    Daling JR, Weiss ND, Klopfenstein LL, (1982) Correlates of homosexual behavior and the incidence of anal cancer. JAMA 247: 1988Google Scholar
  45. 45.
    Daniele E, Perino A, Catinella E (1985) Superficial endometrial involvement by cervical intraepithelial neoplasia detected by intrauterine cytology. Acta Cytol 29: 411PubMedGoogle Scholar
  46. 46.
    De Petrillo AD, Townsend DE, Morrow CP, (1975) Colposcopic evaluation of the abnormal Papanicolaou test in pregnancy. Am J Obstet Gynecol 121: 441Google Scholar
  47. 47.
    De Vesa SS (1984) Descriptive epidemiology of cancer of the uterine cervix. Obstet Gynecol 63: 605Google Scholar
  48. 48.
    Drescher CW, Peters WA, Roberts JA (1983) Contribution of endocervical curettage in evaluating abnormal cervical cytology. Obstet Gynecol 62: 343PubMedGoogle Scholar
  49. 49.
    Durst M, Kleinheinz MH, Gissmann L (1985) The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors. J Gen Virol: 66: 1515PubMedGoogle Scholar
  50. 50.
    Durst M, Gissman L, Ikenberg H, Zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographical regions. Proc Natl Acad Sci USA 80: 3812PubMedGoogle Scholar
  51. 51.
    Evans AS, Monaghan JM (1983) Nuclear DNA content of normal, neoplastic and wart affected cervical biopsies. Analyt Quant Cytol 5: 111Google Scholar
  52. 52.
    Fenoglio CM, Ferenczy A (1982) Etiologic factors in cervical neoplasia. Semin Oncol 9: 349PubMedGoogle Scholar
  53. 53.
    Fenoglio CM, Galloway DA, Crum CP, (1981) Herpes simplex virus and cervical neoplasia. In: Fenoglio CM, Wolff M (eds). Progress in Surgical Pathology. New York, Masson, Vol. 4, pp 45 - 82Google Scholar
  54. 54.
    Ferenczy A (1978) Steroid contraception and cervical and ovarian neoplasia. In: Sciarra JJ, Zatuchni GI, Speidel J (eds). Risks, Benefits and Controversies in Fertility Control. Hagerstown, Maryland, Harper Row, pp 194210Google Scholar
  55. 55.
    Ferenczy A (1985) Comparison of cryo-and carbon dioxide laser therapy for cervical intraepithelial neoplasia. Obstet Gynecol 66: 793PubMedGoogle Scholar
  56. 56.
    Ferenczy A, Richart RM (1974) Female reproductive system. Dynamics of Scan and Transmission Electron Microscopy, 1st ed. New York, John Wiley SonsGoogle Scholar
  57. 57.
    Ferenczy A, Braun L, Shah KV (1981) Human papillomavirus ( HPV) in condylomatous lesions of cervix. Am J Surg Pathol 5: 661Google Scholar
  58. 58.
    Ferenczy A, Richart RM, Okagaki T (1971) Endometrial involvement by cervical carcinoma in situ. Am J Obstet Gynecol 110: 590PubMedGoogle Scholar
  59. 59.
    Ferenczy A, Mitao M, Nagai N, (1985) Latent papillomavirus and recurring genital warts. N Engl J Med 313: 784PubMedGoogle Scholar
  60. 60.
    Fidler HK, Boyes DA, Worth AJ (1968) Cervical cancer detection in British Columbia. J Obstet Gynecol Br Cornmonw 75: 392Google Scholar
  61. 61.
    Fidler HK, Boyes DA, Nichols TM, Worth AJ (1970) Cervical cytology in the control of cancer of the cervix. Mod Med Can 25: 9Google Scholar
  62. 62.
    Fletcher S (1983) Histopathology of papillomavirus infection of the cervix uteri: The history, toxonomy, nomenclature and reporting of koilocytotic dysplasias. J Clin Pathol 36: 616PubMedGoogle Scholar
  63. 63.
    Fox CH (1967) Biologic behavior of dysplasia and carcinoma in situ. Am J Obstet Gynecol 99: 960PubMedGoogle Scholar
  64. 64.
    Friedell GH, Hertig AT, Younge PA (1960) Carcinoma in Situ of the Uterine Cervix, 1st ed. Springfield, Ill. Charles C Thomas, pp 108 - 109Google Scholar
  65. 65.
    Fu YS, Reagan JW, Richart RM (1981) Definitions of precursors. Gynecol Oncol 12: S220PubMedGoogle Scholar
  66. 66.
    Fu YS, Reagan JW, Richart RM (1983) Precursors of cervical cancer. Cancer Sury 2: 359Google Scholar
  67. 67.
    Fu YS, Braun L, Shah KV, (1983) Histologic, nuclear DNA, and human papillomavirus studies of cervical condyloma. Cancer 52: 1705PubMedGoogle Scholar
  68. 68.
    Fuchs E, Green H (1980) Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell 19: 1033PubMedGoogle Scholar
  69. 69.
    Fujii T, Crum CP, Winkler B, (1984) Human papillomavirus infection and cervical intraepithelial neoplasia: Histopathology and DNA content. Obstet Gynecol 63: 99Google Scholar
  70. 70.
    Galloway DA, McDougall JK (1985) The oncogenic potential of herpes simplex viruses: Evidence for a hit-and-run mechanism. Nature 302: 21Google Scholar
  71. 71.
    Galloway DA, Fenoglio CM, Shevchuk M, McDougall JK (1979) Detection of herpes simplex RNA in human sensory ganglia. Virology 95: 265PubMedGoogle Scholar
  72. 72.
    Garrett WFH, Murphy J, O’Neil BW, Laird HM (1978) Virus-induced papillomas of the alimentary tract of cattle. Int J Cancer 22: 323Google Scholar
  73. 73.
    Gissmam L (1984) Papillomaviruses and their association with cancer in animals and in man. Cancer Sury 3: 162Google Scholar
  74. 74.
    Gissmam L, Zur Hausen H (1980) Partial characterization of viral DNA from human genital warts (condylomata acuminata). Int J Cancer 25: 605Google Scholar
  75. 75.
    Gissmam L, De Villiers EM, Zur Hausen H (1982) Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer 29: 143Google Scholar
  76. 76.
    Gissmam L, Boshart M, Durst M, (1984) Presence of human papillomavirus in genital tumors. J Invest Dermatol 83: 265Google Scholar
  77. 77.
    Gissmam L, Wolnik L, Ikenberg H, (1983) Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA 80: 560Google Scholar
  78. 78.
    Graham S (1984) Epidemiology of retinoids and cancer. J Natl Cancer Inst 73: 1423PubMedGoogle Scholar
  79. 79.
    Graham S, Priore R, Graham M, (1979) Genital cancer in wives of penile cancer patients. Cancer 44: 1870PubMedGoogle Scholar
  80. 80.
    Gross G, Ikenberg H, Gissmam L, Hagedorn M (1985) Papillomavirus infection of the anogenital region: Correlation between histology, clinical picture and virus type. Proposal of a new nomenclature. J Invest Dermatol 85: 147Google Scholar
  81. 81.
    Gross G, Pfister H, Hagedorn M, Gissmam L (1982) Correlation between human papillomavirus ( HPV) type and histology of warts. J Invest Dermatol 78: 160Google Scholar
  82. 82.
    Guijon FB, Paraskevas M, Brunham R (1985) The association of sexually transmitted diseases with cervical intraepithelial neoplasia: A case-control study. Am J Obstet Gynecol 151: 185Google Scholar
  83. 83.
    Gupta JW, Gupta PK, Shah KV, Kelly DP (1982) Distribution of human papillomavirus antigen in cervicovaginal smears and cervical tissues. Int J Gynecol Pathol 2: 160Google Scholar
  84. 84.
    Handley WS (1936) The prevention of cancer. Lancet 1: 987Google Scholar
  85. 85.
    Hare MJ, Taylor-Robinson D, Cooper P (1982) Evidence for an association between Chlamydia trachomatis and cervical intraepithelial neoplasia. Br J Obstet Gynecol 89: 489Google Scholar
  86. 86.
    Harlozinska A, Kula J, Stepinska B, (1985) Cervical carcinoma antigen, carcinoembryonic antigen (CEA) and non specific cross-reacting antigen ( NCA) in appraisal of uterine cervix smears. Am J Clin Pathol 83: 301Google Scholar
  87. 87.
    Hatch KD, Singleton HM, Orr JW, (1985) Role of endocervical curettage in colposcopy. Obstet Gynecol 65: 403PubMedGoogle Scholar
  88. 88.
    Hinselmann H, Schmitt AW (1954) In: Girardet VW (ed). Die Kolposkopie. Wuppertal-ElberfeldGoogle Scholar
  89. 89.
    Howley PM (1982) The human papillomaviruses. Arch Pathol Lab Med 106: 429PubMedGoogle Scholar
  90. 90.
    Hulka BS (1968) Cytological and histological outcome following an atypical cervical smear. Am J Obstet Gynecol 101: 190PubMedGoogle Scholar
  91. 91.
    Jariwalla RJ, Aurelian L, Ts’O PDP (1979) Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2. J Virol 30: 404PubMedGoogle Scholar
  92. 92.
    Johnson LD (1969) The histopathological approach to early cervical neoplasia. Obstet Gynecol Sury 24: 735Google Scholar
  93. 93.
    Johnson LD, Nickerson RJ, Easterday CL, (1968) Epidemiologic evidence for the spectrum of change from dysplasia through carcinoma in situ to invasive cancer. Cancer 22: 901PubMedGoogle Scholar
  94. 94.
    Jones HW, Butler RE (1980) The treatment of cervical intraepithelial neoplasia by cone biopsy. Am J Obstet Gynecol 137: 882PubMedGoogle Scholar
  95. 95.
    Kaufman RH, Irwin JF (1978) The cryosurgical therapy of cervical intraepithelial neoplasia. III. Continuing follow-up. Am J Obstet Gynecol 131: 381Google Scholar
  96. 96.
    Kaufman R, Koss LG, Kurman RJ, (1983) Caution in interpreting papillomavirus-associated lesions ( Letter ). Obstet Gynecol 62: 269Google Scholar
  97. 97.
    Kessler II (1974) Perspectives on the epidemiology of cervical cancer with special reference to the herpes virus hypothesis. Cancer Res 34: 1091PubMedGoogle Scholar
  98. 98.
    Kessler II (1977) Venereal factors in human cervical cancer: Evidence from marital clusters. Cancer 39: 1912PubMedGoogle Scholar
  99. 99.
    Kirkland JA (1963) Atypical epithelial changes in the uterine cervix. J Clin Pathol 16: 150PubMedGoogle Scholar
  100. 100.
    Kirkland JA, Stanley MA, Cellier KM (1967) Comparative study of histologic and chromosomal abnormalities in cervical neoplasia. Cancer 20: 1934PubMedGoogle Scholar
  101. 101.
    Kolstad P, Stafl A (1978) Atlas of Colposcopy, 2nd ed. Baltimore, University Park PressGoogle Scholar
  102. 102.
    Koss LG (1978) Dysplasia. A real concept or a misnomer? Obstet Gynecol 51: 374PubMedGoogle Scholar
  103. 103.
    Koss LG, Durfee GR (1956) Unusual patterns of squamous epithelium of the uterine cervix: Cytologic and pathologic study of koilocytotic atypia. Ann NY Acad Sci USA 63: 1235Google Scholar
  104. 104.
    Koss LG, Phillips A (1974) Summary and recommendations of the workshop on uterine cervical cancer. Cancer 33: 1753PubMedGoogle Scholar
  105. 105.
    Koss LG, Stewart FW, Foote FW, (1963) Some histological aspects of behavior of epidermoid carcinoma in situ and related lesions of the uterine cervix. A longterm prospective study. Cancer 16: 1160Google Scholar
  106. 106.
    Kottmeier H (1961) Evolution et traitement des épithéliomas. Rev Franç Gynécol 56: 821Google Scholar
  107. 107.
    Kreider JW, Howett MK, Wolfe SA, (1985) Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature 317: 641Google Scholar
  108. 108.
    Kurman RJ, Jenson AB, Lancaster WD (1983) Papillomavirus infection of the cervix. II. Relationship to intraepithelial neoplasia based on the presence of specific viral structural proteins. Am J Surg Pathol 7: 39Google Scholar
  109. 109.
    Kurman RJ, Jenson AB, Sinclair CF, Lancaster WD (1984) Detection of human papillomaviruses by immunocytochemistry. In: De Lellis RA (ed). Advances in Immunohistochemistry. Chicago, Year Book Medical Publishers, pp 201 - 221Google Scholar
  110. 110.
    Kurman RM, Shah KH, Lancaster WD, Jenson AB (1981) Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas. Am J Obstet Gynecol 140: 931PubMedGoogle Scholar
  111. 111.
    Kurman RL, Sanz LE, Jenson AB, (1982) Papillomavirus infection of the cervix. I. Correlation of histology with viral structural antigens and DNA sequences. Int J Gynecol Pathol 1: 17Google Scholar
  112. 112.
    Lancaster WD, Castellano C, Santos C, (1986) Human papillomavirus deoxyribonucleic acid in cervical carcinoma from primary and metastatic sites. Am J Obstet Gynecol 154: 115PubMedGoogle Scholar
  113. 113.
    La Porta RF, Taichma LB (1979) Human papillomaviral DNA replicates as a stable episome in cultured epidermal keratinocytes. Proc Natl Acad Sci USA 179: 3393Google Scholar
  114. 114.
    Lee SH, McGregor DH, Kuziez MN (1981) Malignant transformation of perianal condyloma acuminatum: A case report with review of the literature. Dis Colon Rectum 24: 462Google Scholar
  115. 115.
    Lehn H, Krieg P, Sauer G (1985) Papillomavirus genomes in human cervical tumors: Analysis of their transcriptional activity. Proc Natl Acad Sci USA 82: 5540Google Scholar
  116. 116.
    Leiman G, Harrison N, Rubin A (1980) Pregnancy following conization of the cervix: Complications related to cone size. Am J Obstet Gynecol 136: 14Google Scholar
  117. 117.
    Levine RM, Crum CP, Herman E, (1984) Cervical papillomavirus infection and intraepithelial neoplasia: A study of male sexual partners. Obstet Gynecol 64: 16Google Scholar
  118. 118.
    Loning TH, Kuhler CH, Caselitz J, Stegner HE (1983) Keratin and tissue polypeptide antigen profiles of the cervical mucosa. Int J Gynecol Pathol 2: 105PubMedGoogle Scholar
  119. 119.
    Lorincz AT, Temple GF, Patterson JA, (1986) Correlation of cellular atypia and human papillomavirus DNA sequences in exfoliated cells of the uterine cervix. Obstet Gynecol 68: 508PubMedGoogle Scholar
  120. 120.
    Lutzner MA (1983) The human papillomaviruses. Arch Dermatol 119: 631PubMedGoogle Scholar
  121. 121.
    Macgregor JE, Innes G (1980) Carcinoma of penis and cervix. Lancet 1: 1246PubMedGoogle Scholar
  122. 122.
    Makin CA, Bobrow LG, Bodmer WF (1984) Monoclonal antibody to cytokeratin for use in routine histopathology. J Clin Pathol 37: 975PubMedGoogle Scholar
  123. 123.
    Martinez I (1969) Relationship of squamous cell carcinomaGoogle Scholar
  124. 214.
    Alex Ferenczy and Barbara Winkler of the cervix uteri to squamous cell carcinoma of the penis. Cancer 24: 777Google Scholar
  125. 124.
    Mazur MT, Cloud GA (1984) The koilocyte and cervical intraepithelial neoplasia: Time-tread analysis of a recent decade. Am J Obstet Gynecol 150: 354Google Scholar
  126. 125.
    McCance DJ, Walker PG, Dyson JL, (1983) Presence of human papillomavirus DNA sequences in cervical intraepithelial neoplasia. Br Med J 287: 784Google Scholar
  127. 126.
    McDougall JK, Galloway DA, Fenoglio CM (1980) Cervical carcinoma: Detection of herpes simplex virus RNA in cells undergoing neoplastic change. Int J Cancer 25: 1Google Scholar
  128. 127.
    McDougall JK, Nelson JA, Myerson D, (1984) HSV, CMV and HPV in human neoplasia. J Invest Dermatol 83: 725Google Scholar
  129. 128.
    Mclndoe WA, McLean MR, Jones RW, Mullins PR (1984) The invasive potential of carcinoma in situ of the cervix. Obstet Gynecol 64: 451Google Scholar
  130. 129.
    Meisels A, Fortin R, Roy M (1977) Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study. Acta Cytol 21: 379Google Scholar
  131. 130.
    Meisels A, Morin C, Casas-Cordero M (1982) Human papillomavirus infection of the uterine cervix. Int J Gynecol Pathol 1: 75PubMedGoogle Scholar
  132. 131.
    Meisels A, Morin C, Casas-Corder M (1984) Lesions of the uterine cervix associated with papillomaviruses and their clinical consequences. Adv Clin Cytol 2: 1 - 31Google Scholar
  133. 132.
    Meisels A, Roy M, Fortier M, (1981) Human papillomavirus (HPV) infections of the cervix: The atypical condyloma. Acta Cytol 25: 7Google Scholar
  134. 133.
    Meisels A, Roy M, Fortier M, Morin C (1979) Condylomatous lesions of the cervix. Morphologic and colposcopic diagnosis. Am J Diagn Gynecol Obstet 1: 109Google Scholar
  135. 134.
    Melamed MR, Flehinger BJ (1973) Early incidence rates of precancerous lesions in women using oral contraceptives. Gynecol Oncol 1: 290Google Scholar
  136. 135.
    Melnick JL, Adam E, Rawls WE (1974) The causative role of herpes virus type 2 in cervical cancer. Cancer 34: 1375PubMedGoogle Scholar
  137. 136.
    Mitao M, Reumann W, Winkler B, (1984) Chlamydial cervicitis and cervical intraepithelial neoplasia: An immunohistochemical analysis. Gynecol Oncol 19: 90Google Scholar
  138. 137.
    Mole R, Levy R, Czernobilsky B, (1983) Cytokeratins of normal epithelia and some neoplasms of the female genital tract. Lab Invest 49: 599Google Scholar
  139. 138.
    Nahmias AJ, Roizman B (1973) Infection with herpes simplex viruses 1 and 2. N Engl J Med 289: 667, 719, 781Google Scholar
  140. 139.
    Nasiell K, Nasiell M, Vaclavinkova V (1983) Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 61: 609PubMedGoogle Scholar
  141. 140.
    Navratil E, Burghardt E, Bajardi F, Nash W (1958) Simultaneous colposcopy and cytology used in screening for carcinoma of the cervix. Am J Obstet Gynecol 75: 1292PubMedGoogle Scholar
  142. 141.
    Nelson JH Jr, Hall JE (1970) Detection, diagnostic evaluation and treatment of dysplasia and early carcinoma of the cervix. Cancer J Clinicians 20: 150Google Scholar
  143. 142.
    Nelson JH, Averette HE, Richart RM (1984) Dysplasia, carcinoma in situ and early invasive carcinoma. CA 34: 306PubMedGoogle Scholar
  144. 143.
    Nikolaidis ET, Trost DC, Buchholz CL, Wilkinson EJ (1985) The relationship of histologic and clinical factors in laryngeal papillomatosis. Arch Pathol Lab Med 109: 24PubMedGoogle Scholar
  145. 144.
    Okagaki T, Clark BA, Brooker DC, Williams PP (1978) Koilocytosis in dysplastic and reactive cervical squamous epithelium: An ultrastructural study. Acta Cytol 22: 95Google Scholar
  146. 145.
    Okagaki T, Twiggs LB, Zachow KR, (1983) Identification of human papillomavirus DNA in cervical and vaginal intraepithelial neoplasia with molecularly cloned virus-specific probes. Int J Gynecol Pathol 2: 153PubMedGoogle Scholar
  147. 146.
    Olson C, Gordon DE, Robl MG, Lee KP (1969) Oncogenicity of bovine papillomavirus. Arch Environ Health 19: 827PubMedGoogle Scholar
  148. 147.
    Oriel JD (1971) Natural history of genital warts. BR J Vener Dis 47: 1PubMedGoogle Scholar
  149. 148.
    Orth G, Favre M, Breitburg F, (1980) Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer. In: Essex M, Todaro G, Zur Hausen H (eds). Viruses in Naturally Occurring Cancer. Cold Spring Harbor, N.Y., Cold Spring Harbor Laboratory Press, Vol. A, p 259Google Scholar
  150. 149.
    Paavonen J, Verterinen E, Meyer B, (1979) Genital Chlamydia trachomatis infections in patients with cervical atypia. Obstet Gynecol 54: 289PubMedGoogle Scholar
  151. 150.
    Pater MM, Pater A (1985) Human papillomavirus types 16 + 18 sequences in carcinoma cell lines of the cervix. Virology 145: 313PubMedGoogle Scholar
  152. 151.
    Patten SF Jr (1969) Diagnostic Cytology of the Uterine Cervix, 1st ed. Baltimore, Williams WilkinsGoogle Scholar
  153. 152.
    Przybora LA, Plutowa A (1959) Histological topography of carcinoma in situ of the cervix uteri. Cancer 12: 263PubMedGoogle Scholar
  154. 153.
    Purola E, Savia E (1977) Cytology of gynecologic condyloma acuminatum. Acta Cytol 21: 26PubMedGoogle Scholar
  155. 154.
    Purtilo DT (1984) Defective immune surveillance in viral carcinogenesis. Lab Invest 51: 373PubMedGoogle Scholar
  156. 155.
    Ray B (1977) Condyloma acuminatum of the scrotum. J Urol 117: 739PubMedGoogle Scholar
  157. 156.
    Reagan JW, Hamonic MJ (1956) The cellular pathology in carcinoma in situ; a cytohistopathological correlation. Cancer 9: 385PubMedGoogle Scholar
  158. 157.
    Reagan JW, Ng ABP, Wentz WB (1969) Concepts of genesis and development in early cervical neoplasia. Obstet Gynecol Sury 24: 860Google Scholar
  159. 158.
    Reid BL, Coppleson M (1978) The natural history of the origin of cervical cancer. In: MacDonald RR (ed). Scientific Basis of Obstetrics and Gynecology. London, Churchill Livingstone, pp 427 - 468Google Scholar
  160. 159.
    Reid R (1984) Papillomavirus and cervical neoplasia. Modern implications and future prospects. Colposcopy Gynecol Laser Surg 1: 3Google Scholar
  161. 160.
    Reid R, Fu YS, Herschmann BR (1984) Genital warts and cervical cancer. VI. The relationship between aneuploid and polyploid cervical lesions. Am J Obstet Gynecol 150: 189Google Scholar
  162. 161.
    Reid R, Herschmann BR, Crum CP, (1984) Genital warts and cervical cancer. V. The tissue basis of colposcopie change. Am J Obstet Gynecol 149: 293Google Scholar
  163. 162.
    Report of the Task Force of the Department of Health and Welfare of Canada. Cervical Cancer Screening Programs. The Walton Report (1982). Can Med Assoc J 127: 581Google Scholar
  164. 163.
    Rice RH, Pinkus GS, Warhol MJ, Antonioli DA (1984) Involucrin: Biochemistry and immunohistochemistry. In: DeLellis RA (ed). Advances in Immunohistochemistry. Chicago, Year Book Medical Publishers, pp 111 - 125Google Scholar
  165. 164.
    Richardson AC, Lyon JB (1981) The effect of condom use on squamous cell cervical intraepithelial neoplasia. Am J Obstet Gynecol 140: 909PubMedGoogle Scholar
  166. 165.
    Richart RM (1963) A radioautographic analysis of cellular proliferation in dysplasia and carcinoma in situ of the uterine cervix. Am J Obstet Gynecol 86: 925PubMedGoogle Scholar
  167. 166.
    Richart RM (1963) A clinical staining test for the in vivo delineation of dysplasia and carcinoma in situ. Am J Obstet Gynecol 86: 703PubMedGoogle Scholar
  168. 167.
    Richart RM (1964) The correlation of Schiller-positive areas on the exposed portion of the cervix with intraepithelial neoplasia. Am J Obstet Gynecol 90: 697Google Scholar
  169. 168.
    Richart RM (1964) The growth characteristics in vitro of normal epithelium, dysplasia and carcinoma in situ of the uterine cervix. Cancer Res 24: 662PubMedGoogle Scholar
  170. 169.
    Richart RM (1965) Colpomicroscopic studies of the distribution of dysplasia and carcinoma in situ on the exposed portion of the human uterine cervix. Cancer 18: 950PubMedGoogle Scholar
  171. 170.
    Richart RM (1966) Colpomicroscopic studies of cervical intraepithelial neoplasia. Cancer 19: 395Google Scholar
  172. 171.
    Richart RM (1966) The influence of diagnostic and therapeutic procedures on the distribution of cervical intraepithelial neoplasia. Cancer 19: 1635PubMedGoogle Scholar
  173. 172.
    Richart RM (1969) A theory of cervical carcinogenesis. Obstet Gynecol Sury 24: 874Google Scholar
  174. 173.
    Richart RM (1973) Cervical intraepithelial neoplasia. In: Sommers SC (ed). Pathology Annual. New York, Appleton-Century-Crofts, pp 301 - 328Google Scholar
  175. 174.
    Richart RM (1980) The patient with an abnormal Pap smear: Screening techniques and management. N Engl J Med 302: 332PubMedGoogle Scholar
  176. 175.
    Richart RM, Barron BA (1969) A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol 105: 386PubMedGoogle Scholar
  177. 176.
    Richart RM, Lerch V (1966) Time-lapse cinematographic observations of normal human cervical epithelium, dysplasia and carcinoma in situ. J Natl Cancer Inst 37: 317PubMedGoogle Scholar
  178. 177.
    Richart RM, Sciarra JJ (1968) Treatment of cervical dysplasia by out-patient electrocauterization. Am J Obstet Gynecol 101: 200PubMedGoogle Scholar
  179. 178.
    Richart RM, Vaillant HW (1965) Influence of cell collection technic upon cytologic diagnosis. Cancer 18: 1474PubMedGoogle Scholar
  180. 179.
    Richart RM_, Lerch V, Barron BA (1967) A time-lapse cinematographic study in vitro of mitosis in normal human cervical epithelium, dysplasia and carcinoma in situ. J Natl Cancer Inst 39: 571PubMedGoogle Scholar
  181. 180.
    Robboy SJ, Truslow GY, Anton J, Richart RM (1981) Role of hormones, including diethylstilbestrol in the pathogenesis of cervical and vaginal intraepithelial neoplasia. Gynecol Oncol 12: S98PubMedGoogle Scholar
  182. 181.
    Robboy SJ, Noller KL, O’Brien P, (1984) Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. JAMA 252: 2979PubMedGoogle Scholar
  183. 182.
    Robboy SJ, Szyfelbein WM, Goellner JR, (1981) Dysplasia and cytologic findings in 4,589 young women enrolled in diethylstilbesterol-adenosis ( DESAD) project. Am J Obstet Gynecol 140: 579Google Scholar
  184. 183.
    Romney SL, Palan PR, Dattagupta C, (1981) Retinoids and the prevention of cervical dysplasias. Am J Obstet Gynecol 141: 890PubMedGoogle Scholar
  185. 184.
    Rotkin ID (1973) A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res 33: 1353PubMedGoogle Scholar
  186. 185.
    Roy M, Meisels A, Fortier M, (1981) Vaginal condylomata: A human papillomavirus infection. Clin Obstet Gynecol 24: 261Google Scholar
  187. 186.
    Royston I, Aurelian L (1970) Immunofluorescent detection of herpes virus antigens in exfoliated cells from human cervical carcinoma. Proc Natl Acad Sci USA 67: 204PubMedGoogle Scholar
  188. 187.
    Rubio CA, Lagerlof B (1974) Studies on the histogenesis of experimentally induced cervical carcinoma. Acta Pathol Microbiol Scand 82: 153Google Scholar
  189. 188.
    Sadeghi SB, Hsieh EW, Gunn SW (1984) Prevalence of cervical intraepithelial neoplasia in sexually active teenagers and young adults. Am J Obstet Gynecol 148: 726PubMedGoogle Scholar
  190. 189.
    Sebastian JA, Leeb BO, See R (1978) Cancer of the cervix-A sexually transmitted disease. Cytologic screening in a prostitute population. Am J Obstet Gynecol 131: 620Google Scholar
  191. 190.
    Schachter J, Hill EC, King EB (1975) Chlamydial infection in women with cervical dysplasia. Am J Obstet Gynecol 123: 753PubMedGoogle Scholar
  192. 191.
    Schneider PS, Krumholz BA, Topp WC, (1984) Molecular heterogeneity of female genital wart (condylomata acuminata) papillomaviruses. Int J Gynecol Pathol 2: 329PubMedGoogle Scholar
  193. 191a.
    Shah K, Kashima H, Polk BF, et al (1986) Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis. Obstet Gynecol 68: 795PubMedGoogle Scholar
  194. 192.
    Shevchuk MM, Richart RM (1982) DNA content of condyloma acuminatum. Cancer 49: 489PubMedGoogle Scholar
  195. 193.
    Shingleton HM, Richart RM, Wiener J, Spiro D (1968) Human cervical intraepithelial neoplasia. Fine structure of dysplasia and carcinoma in situ. Cancer Res 28: 695Google Scholar
  196. 194.
    Shorkri-Tobibzadeh S, Koss LG, Molnar J, Romney S (1981) Association of human papillomavirus with neoplastic processes in the genital tract of four women with impaired immunity. Gynecol Oncol 12: S129Google Scholar
  197. 195.
    Sillman F, Stanek A, Sedlis A, (1984) The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women. Am J Obstet Gynecol 150: 300PubMedGoogle Scholar
  198. 196.
    Silverberg E (1983) Cancer statistics, 1983. CA 33: 9PubMedGoogle Scholar
  199. 197.
    Singer A, Reid BD, Coppleson M (1976) A hypothesis: The role of a high risk male in the etiology of cervical carcinoma. A correlation of epidemiology and molecular biology. Am J Obstet Gynecol 126: 111Google Scholar
  200. 198.
    Smith JW, Townsend DE, Sparks RS (1971) Genetic variants of glucose-6-phosphate dehydrogenase in the study of carcinoma of the cervix. Cancer 28: 529PubMedGoogle Scholar
  201. 199.
    Smith PG, Kinlen LJ, White GC, (1980) Mortality of wives of men dying with cancer of the penis. Br J Cancer 41: 422PubMedGoogle Scholar
  202. 200.
    Sprang ML, Isaacs JH, Boraca CT (1977) Management of carcinoma-in-situ of the cervix. Am J Obstet Gynecol 129: 47PubMedGoogle Scholar
  203. 201.
    Spriggs AI, Bowey CE, Cowdell RH (1971) Chromosomes of precancerous lesions of the cervix uteri. Cancer 27: 1239PubMedGoogle Scholar
  204. 202.
    Staff A, Mattingly RF (1975) Angiogenesis of cervical neoplasia. Am J Obstet Gynecol 121: 845Google Scholar
  205. 203.
    Staff A, Mattingly RF (1973) Colposcopic diagnosis of cervical neoplasia. Obstet Gynecol 41: 168Google Scholar
  206. 204.
    Staff A, Wilkinson EJ, Mattingly RF (1977) Laser treatment of cervical and vaginal neoplasia. Am J Obstet Gynecol 128: 14Google Scholar
  207. 205.
    Stein DS (1980) Transmissible venereal neoplasia. Am J Obstet Gynecol 137: 864PubMedGoogle Scholar
  208. 206.
    Stern E (1969) Epidemiology of dysplasia. Obstet Gynecol Sury 24: 711Google Scholar
  209. 207.
    Stern E, Neely PM (1963) Carcinoma and dysplasia of the cervix: A comparison of rates for new and returning populations. Acta Cytol 7: 357Google Scholar
  210. 208.
    Sugimori H, Matsuyama T, Kashimura M, (1979) Histological study of microinvasive carcinoma of the uterine cervix. Gynecol Oncol 7: 153PubMedGoogle Scholar
  211. 209.
    Suprun HZ, Schwartz J, Spira H (1985) Cervical intraepithelial neoplasia and associated condylomatous lesions. A preliminary report on 4,764 women from northern Israel. Acta Cytol 29: 334PubMedGoogle Scholar
  212. 210.
    Swan SH, Brown WL (1981) Oral contraceptive use, sexual activity and cervical carcinoma. Am J Obstet Gynecol 139: 52PubMedGoogle Scholar
  213. 211.
    Syrjanen KJ, Heinonen UM, Kauraniemi T (1981) Cytologic evidence of the association of condylomatous lesions with dysplastic and neoplastic changes in the uterine cervix. Acta Cytol 25: 17PubMedGoogle Scholar
  214. 212.
    Syrjanen KJ, Yayrynen M, Saarikoski S, (1985) Natural history of cervical human papillomavirus ( HPV) infections based on prospective follow-up. Br J Obstet Gynaecol 92: 1086Google Scholar
  215. 213.
    Taichman LB, Breitbind F, Croissant O, Orth G (1984) The search for a culture system for papillomaviruses. J Invest Dermatol 83: 25Google Scholar
  216. 214.
    Takeuchi A, McKay DB (1960) The area of the cervix involved by carcinoma in situ and anaplasia (atypical hyperplasia). Obstet Gynecol 15: 134PubMedGoogle Scholar
  217. 215.
    Terris M, Wilson F, Nelson JH Jr (1973) Relation of circumcision to cancer of the cervix. Am J Obstet Gynecol 117: 1056PubMedGoogle Scholar
  218. 216.
    Townsend DE, Richart RM (1983) Cryotherapy and carbon dioxide laser management of cervical intraepithelial neoplasia. A controlled comparison. Obstet Gynecol 61: 75Google Scholar
  219. 217.
    Trevathan E, Layde P, Webster LA, (1983) Cigarette smoking and dysplasia and carcinoma in situ of the uterine cervix. JAMA 250: 499PubMedGoogle Scholar
  220. 218.
    Twiggs LB, Clark BA, Okagaki T (1981) Basal cell pseudopodia in cervical intraepithelial neoplasia; progressive reduction of number with severity: A morphometric quantification. Am J Obstet Gynecol 139: 640Google Scholar
  221. 219.
    Valkova B, Ormerod MG, Moncrieff D, Colemen DV (1984) Epithelial membrane antigen in cells from the uterine cervix: Immunocytochemical staining of cervical smears. J Clin Pathol 37: 984Google Scholar
  222. 220.
    VanNiekerk WA (1962) Cervical cells in megaloblastic anemia of puerperium. Lancet 1: 1277PubMedGoogle Scholar
  223. 221.
    Vessey MP (1984) Exogenous hormones in the aetiology of cancer in women. J Roy Soc Med 77: 542PubMedGoogle Scholar
  224. 222.
    Vessey MP, McPherson K, Lawless M, Yeates D (1983) Neoplasia of the cervix and contraception: A possible adverse effect of the pill. Lancet 2: 930Google Scholar
  225. 223.
    Vonka V, Kanka J, Hirsch I, (1984) Prospective study on the relationship between cervical neoplasia and herpes simplex type 2 virus. II. Herpes simplex type 2 antibody presence in sera taken at enrolment. Int J Cancer 33: 61PubMedGoogle Scholar
  226. 224.
    Vonka V, Kanka J, Jelinek I, (1984) Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. 1. Epidemiological characteristics. Int J Cancer 33: 49Google Scholar
  227. 225.
    Wagner D, Ikenberg H, Boehm N, Gissmam L (1984) Identification of human papillomavirus in cervical swabs by deoxyribonucleic acid in situ hybridization. Obstet Gynecol 64: 767PubMedGoogle Scholar
  228. 226.
    Warhol MJ, Antonioli DA, Pinkus GS, (1982) Immunoperoxidase staining for involucrin: A potential diagnostic aid in cervicovaginal pathology. Hum Pathol 13: 1095Google Scholar
  229. 227.
    Warhol MJ, Pinkus GS, Rice RH, (1984) Papillomavirus infection of the cervix. III. Relationship of the presence of viral structural proteins to the expression of involucrin. Int J Gynecol Pathol 3: 71Google Scholar
  230. 228.
    Wassertheil-Smoller S, Romney SL, Wylie-Rosset J, (1981) Dietary vitamin C and uterine cervical dysplasia. Am J Epidemiol 114: 714PubMedGoogle Scholar
  231. 229.
    Watts SL, Phelps WC, Ostrow RS, (1984) Cellular transformation by human papillomavirus DNA in vitro. Science 225: 634PubMedGoogle Scholar
  232. 230.
    Weed JC, Curry SL, Duncan ID, (1978) Fertility after cryosurgery of the cervix. Obstet Gynecol 52: 245PubMedGoogle Scholar
  233. 231.
    Weid GL (1961) Proceedings of the First International Congress on Exfoliative Cytology, 1st ed. Philadelphia, J. B. LippincottGoogle Scholar
  234. 232.
    Whitehead N, Reyner F, Lindenbaum J (1973) Megaloblastic changes in the cervical epithelium: Association of oral contraceptive therapy and reversal with folic acid. JAMA 266: 1421Google Scholar
  235. 233.
    WHO Scientific Group: Neoplasia of the uterine cervix. (1978) In: WHO Scientific Group: Steroid Contraception and the Risk of Neoplasia. (Technical Report Series 619). World Health Organization, Geneva, Switzerland, pp. 26 - 33Google Scholar
  236. 234.
    WHO collaborative study of neoplasia and steroid contraceptives (1985) Invasive cervical cancer and combined oral contraceptives. Br Med J 290: 961Google Scholar
  237. 235.
    Wilbanks GD, Carter B (1970) Fluorescence of cervical intraepithelial neoplasia induced by tetracycline and acridine orange. Am J Obstet Gynecol 106: 726PubMedGoogle Scholar
  238. 236.
    Wilbanks GD, Richart RM (1967) The peurperal cervix, injuries and healing: A colposcopic study. Am J Obstet Gynecol 97: 1105Google Scholar
  239. 237.
    Wilbanks GD, Terner JY, Richart RM (1967) The DNA content of cervical intraepithelial neoplasia studies by two-wave length Feulgen cytophotometry. Am J Obstet Gynecol 98: 792PubMedGoogle Scholar
  240. 238.
    William DC (1977) Venereally transmitted anal warts: Medical aspects. Human Sexuality 11: 77Google Scholar
  241. 239.
    Winkler B, Richart RM (1985) The histology of CIN, VIN, and VAIN. In: Baggish MS (ed). Basic and Advanced Laser Surgery in Gynecology. Norwalk, Conn, AppletonCentury-Crofts, pp 131 - 159Google Scholar
  242. 240.
    Winkler B, Norris HJ, Fenoglio CM (1982) The female genital tract. In: Ridell RH (ed). Pathology of Drug-induced and Toxic Diseases. New York, Churchill LivingstoneGoogle Scholar
  243. 241.
    Winkler B, Crum CP, Fujii T, (1984) Koilocytotic lesions of the cervix: The relationship of mitotic abnormalities to the presence of papillomavirus antigens and nuclear DNA content. Cancer 53: 1081Google Scholar
  244. 242.
    Wolfendale MR, King S, Usherwood M (1983) Abnormal cervical smears: Are we in for an epidemic? Br Med J 287: 525Google Scholar
  245. 243.
    Wright NH, Vessey MP, Kenward B, (1975) Neoplasia and dysplasia of the cervix uteri and contraception: A possible protective effect of the diaphragm. Br J Cancer 38: 2783Google Scholar
  246. 244.
    Yee C, Krishnan-Hewlett I, Baker CC, (1985) Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am J Pathol 119: 361PubMedGoogle Scholar
  247. 245.
    Zur Hausen H (1977) Human papillomaviruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol 78: 1PubMedGoogle Scholar
  248. 246.
    Zur Hausen H (1982) Human genital cancer: Synergism between two virus infection or synergism between a virus infection and initiating events? Lancet 2: 1370PubMedGoogle Scholar
  249. 247.
    Zur Hausen H, de Villiers EM, Gissmam L (1981) Papillomaviruses and human genital cancer. Gynecol Oncol 12: 124Google Scholar
  250. 248.
    Zur Hausen H, Gissman L, Boshart M, (1984) Presence of human papillomavirus in genital tumors. J Invest Dermatol 83: 26SGoogle Scholar

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© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Alex Ferenczy
  • Barbara Winkler

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