Benign Diseases of the Cervix

  • Alex Ferenczy
  • Barbara Winkler


Cervicitis can be divided into noninfectious and infectious etiologies. Whatever the etiology, the tissue response of the cervix to injury is limited and reflects the basic mechanisms of inflammation and repair. Two types of morphologic changes, however, that are often encountered in association with a variety of inflammatory diseases deserve specific attention. These are atypia of repair and hyperkeratosis and parakeratosis.


Obstet Gynecol Cervical Intraepithelial Neoplasia Chlamydia Trachomatis Uterine Cervix Herpes Genitalis 
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  1. 1.
    Aaro LA, Jacobson LJ, Soule EH (1963) Endocervical polyps. Obstet Gynecol 21: 659PubMedGoogle Scholar
  2. 2.
    Abell MR (1971) Papillary adenofibroma of the uterine cervix. Am J Obstet Gynecol 110: 990PubMedGoogle Scholar
  3. 3.
    Abell MR, Gosling JRG (1962) Gland cell carcinoma (adenocarcinoma) of the uterine cervix. Am J Obstet Gynecol 83: 729PubMedGoogle Scholar
  4. 4.
    Adam E, Kaufman RH, Mirkovic RR, Melnick JL (1979) Persistence of virus shedding in asymptomatic women after recovery from herpes genitalis. Obst Gynecol 54: 171Google Scholar
  5. 5.
    Adam E, Kaufman RH, Melnick JL, (1973) Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. III. Am J Epidemiol 96: 427Google Scholar
  6. 6.
    Adam E, Kaufman RH, Melnick JL, (1973) Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. IV. Dysplasia and carcinoma in situ. Am J Epidemiol 98: 77Google Scholar
  7. 7.
    Adams JQ, Packer H (1955) Granuloma inguinale of the cervix. South Med J 48: 27PubMedCrossRefGoogle Scholar
  8. 8.
    Ayroud Y, Gelfand MM, Ferenczy A (1985) Florid mesonephric hyperplasia of the cervix: A report of a case with review of the literature. Int J Gynecol Pathol 4: 245Google Scholar
  9. 9.
    Berry A (1966) A cytopathological and histopathological study of bilharziasis of the female genital tract. J Pathol Bacteriol 9: 325CrossRefGoogle Scholar
  10. 10.
    Burd LI, Esterly JR (1971) Vesicular lesions of the uterine cervix. Am J Obstet Gynecol 110: 887PubMedGoogle Scholar
  11. 11.
    Burkman RT, Damewood MT (1985) Actinomyces and the intrauterine contraceptive device. In: Zatuchni, GI, Goldsmith A, Sciarra J. (eds). Intrauterine contraception. Advances and future prospects. New York, Harper Row, pp 427 - 437Google Scholar
  12. 12.
    Burnham RC, Paavonen J, Stevens CE, (1984) Mucopurulent cervicitis: The ignored counterpart of urethritis in the male. N Engl J Med 311: 1Google Scholar
  13. 13.
    Busby JG (1952) Neurofibromatosis of the cervix. Am J Obstet Gynecol 63: 674PubMedGoogle Scholar
  14. 14.
    Candy J, Abell MR (1968) Progestogen-induced adenoma-tous hyperplasia of the uterine cervix. JAMA 203: 323CrossRefGoogle Scholar
  15. 15.
    Centers for Disease Control. Morbidity and Mortality Weekly Report. (1982) Sexually transmitted diseases treatment guidelines 31: 355Google Scholar
  16. 16.
    Centers for Disease Control (1983) Morbidity Mortality Weekly Report 32: 306Google Scholar
  17. 17.
    Chang SH, Maddox WA (1971) Adenocarcinoma arising within cervical endometriosis and invading the adjacent vagina. Am J Obstet Gynecol 110: 1015PubMedGoogle Scholar
  18. 18.
    Clement PB (1985) Multinucleated stromal giant cells of the uterine cervix. Arch Pathol Lab Med 109: 200PubMedGoogle Scholar
  19. 19.
    Clement PB, Scully RE (1974) Müllerian adenocarcoma of the uterus. Cancer 34: 1138PubMedCrossRefGoogle Scholar
  20. 20.
    Cohen C (1973) Three cases of amoebiasis of the cervix uteri. J Obstet Gynecol Br Commonw 80: 476CrossRefGoogle Scholar
  21. 21.
    Corey L (1984) Genital herpes. In: Holmes KK, Mardh PA, Sparling PF, Wiesner PJ (eds). Sexually transmitted diseases. New York, McGraw-Hill Book Company, pp 449474Google Scholar
  22. 22.
    Corey L, Holmes KK (1983) Genital herpes simplex virus infection: Current concepts in diagnosis, treatment and prevention. Ann Intern Med 98: 973Google Scholar
  23. 23.
    Grossen RJ (1930) A case of gumma of cervix. Am J Obstet Gynecol 19: 708Google Scholar
  24. 24.
    Crow J, McWhinney N (1979) Isolated arteritis of the cervix uteri. Br J Obstet Gynecol 86: 393CrossRefGoogle Scholar
  25. 25.
    Crum CP, Mitao M, Winkler B, (1984) Localizing chlamydial injection in cervical biopsies with the immunoperoxidase technique. Int J Gynecol Pathol 3: 191PubMedCrossRefGoogle Scholar
  26. 26.
    De Molnar AMD, Guralnick M, Ferenczy A (1978) Blue nevus of the endocervix: Report of two cases and ultrastructure. Gynecol Oncol 6: 373Google Scholar
  27. 27.
    Dougherty CM, Moore WR, Cotten N (1962) Histologic diagnosis and clinical significance of benign lesions of the nonpregnant cervix. Ann NY Acad Sci 97: 683CrossRefGoogle Scholar
  28. 28.
    Elliott GB, Elliott JDA (1973) Superficial stromal reactions of lower genital tract. Arch Pathol 95: 100PubMedGoogle Scholar
  29. 29.
    Elliott GB, Reynolds HA, Fidler HK (1967) Pseudosarcoma botryoides of cervix and vagina in pregnancy. J Obstet Gynecol Br Commonw 74: 728CrossRefGoogle Scholar
  30. 30.
    El-Mahgoub S (1972) Antispermatozoal antibodies in infertile women with cervicovaginal schistosomiasis. Am J Ob-stet Gynecol 112: 781Google Scholar
  31. 31.
    Evans CS, Goldman RL, Klein HZ, Kohout ND (1984) Necrobiotic granulomas of the uterine cervix. A probable postoperative reaction. Am J Surg Pathol 8: 841Google Scholar
  32. 32.
    Fenoglio CM, Galloway DA, Crum CO, (1981) Herpes simplex virus and cervical neoplasia. In: Fenoglio CM, Wolff M (eds). Progress in surgical pathology. New York, Masson, Vol 4, pp 45 - 82Google Scholar
  33. 33.
    Fingerland A, Sikl H (1938) Ganglioneuroma of cervix uteri. J Pathol Bacterol 47: 631CrossRefGoogle Scholar
  34. 34.
    Fluhman CF (1961) The cervix uteri and its diseases, 1st ed. Philadelphia, W. B. SaundersGoogle Scholar
  35. 35.
    Gardner HL (1966) Cervical and vaginal endometriosis. Clin Obstet Gynecol 9: 358PubMedCrossRefGoogle Scholar
  36. 36.
    Gardner HL, Fernet P (1964) Etiology of vaginitis emphysematosa. Am J Obstet Gynecol 88: 680PubMedGoogle Scholar
  37. 37.
    Giampaolo C, Murphy J, Benes S, McCormack WM (1983) How sensitive is the Papanicolaou smear in the diagnosis of infections with Chlamydia trachomatis? Am J Clin Pathol 80: 844Google Scholar
  38. 38.
    Gjonnaess H, Dalaker K, Anestad G, (1982) Pelvic inflammatory disease: Etiologic studies with emphasis on chlamydial infection. Obstet Gynecol 59: 550Google Scholar
  39. 39.
    Grimalt M, Argueles M, Ferenczy A (1975) Papillary cystadenofibroma of endometrium. A histochemical and ultra-structural study. Cancer 36: 137Google Scholar
  40. 40.
    Gurman ME, MacCalman J, Kern ER, (1981) The course of untreated recurrent genital herpes simplex infection in 27 women. N Engl J Med 304: 759CrossRefGoogle Scholar
  41. 41.
    Gusdon JT (1965) Hemangioma of the cervix. Am J Obstet Gynecol 91: 204PubMedGoogle Scholar
  42. 42.
    Hare MJ, Toone E, Taylor-Robinson D, (1981) Follicular cervicitis-Colposcopic appearances and association with Chlamydia trachomatis. Br J Obstet Gynecol 88: 174CrossRefGoogle Scholar
  43. 43.
    Harrison HR, Alexander ER (1984) Chlamydia trachomatis infections of the infant. In: Holmes KK, Mardh PA, Sparling PF, Weisner PJ (eds). Sexually transmitted diseases. New York, McGraw-Hill Book Co., pp 270 - 80Google Scholar
  44. 44.
    Hobson D, Karayiannis P, Byng RE, (1980) Quantitative aspects of chlamydial injection of the cervix. Br J Vener Dis 56: 56Google Scholar
  45. 45.
    Holmes KK (1984) Lower genital tract infections in women: Cystitis/urethritis, vulvovaginitis and cervicitis. In: Holmes KK, Mardh PA, Sparling PF, Weisner PJ (eds). Sexually transmitted diseases. New York, McGraw-Hill Book Co, pp 557 - 589Google Scholar
  46. 46.
    Janovski MS, Kasdon EJ (1963) Benign mesonephric papillary and polypoid tumors of the cervix in childhood. J Pediatr 63: 211PubMedCrossRefGoogle Scholar
  47. 47.
    Jones RB, Rabinovitch RA, Katz BP, (1985) Chlamydia trachomatis in the pharynx and rectum of heterosexual patients at risk for genital infection. Ann Intern Med 102: 757Google Scholar
  48. 48.
    Kaufman RH, Watts JM, Gardner HL (1969) Pemphigus vulgaris genital involvement. Obstet Gynecol 33: 264PubMedGoogle Scholar
  49. 49.
    Kaufman RH, Gardner HL, Rawls WE, (1973) Clinical features of herpes genitalis. Cancer Res 33: 1446PubMedGoogle Scholar
  50. 50.
    Kistner RW, Hertig AT (1955) Papillomas of the uterine cervix-Their malignant potentiality. Obstet Gynecol 6: 147PubMedGoogle Scholar
  51. 51.
    Kiviat NB, Paavonen JA, Brockway J, (1985) Cytologic manifestations of cervical and vaginal infections. I. Epithelial and inflammatory cellular changes. JAMA 253: 989Google Scholar
  52. 52.
    Kiviat NB, Peterson M, Kinney-Thomas E, (1985) Cytologic manifestations of cervical and vaginal infections. II. Confirmation of Chlamydia trachomatis infection by direct immunofluorescence using monoclonal antibodies. JAMA 253: 997PubMedCrossRefGoogle Scholar
  53. 53.
    Koss LG, Wolinska WH (1959) Trichomonas vaginalis cervicitis and its relationship to cervical cancer: A histocytological study. Cancer 12: 1171Google Scholar
  54. 54.
    Langley GF (1943) Primary echinococcal cyst of the uterus. Br J Surg 30: 278CrossRefGoogle Scholar
  55. 55.
    Lippert LJ, Richart RM, Ferenczy A (1974) Giant benign endocervical polyp: Report of a case. Am J Obstet Gynecol 118: 1140Google Scholar
  56. 56.
    Nahmias AJ, Roizman B (1973) Infection with herpes simplex viruses 1 and 2. N Engl J Med 289: 667, 719, 781CrossRefGoogle Scholar
  57. 57.
    Newton WL, Reardon LV, DeLeva AM (1960) A comparative study of the subcutaneous inoculation of germ-free and conventional guinea pigs with two strains Trichomonas vaginalis. Am J Trop Med Hyg 9: 56PubMedGoogle Scholar
  58. 58.
    Nicolas TM, Fidler HK (1971) Microglandular hyperplasia in cervical cone biopsies taken for suspicious and positive cytology. Am J Clin Pathol 56: 424Google Scholar
  59. 59.
    Norris HJ, Taylor HB (1966) Polyps of the vagina: A benign lesion resembling sarcoma botryoides. Cancer 19: 226Google Scholar
  60. 60.
    Paavonen JA, Vesterinen E, Meyer B, Saksela E (1982) Colposcopic and histological findings in cervical chlamydial infection. Obstetrics 59: 712Google Scholar
  61. 61.
    Paavonen JA, Brunham R, Kiviatt N, (1982) Cervicitis-Etiologic, clinical and histopathologic findings. In: Mardh PA, Holmes KK, Oriel JD, (eds). Chlamydial infections. New York, Elsevier, pp 141 - 146Google Scholar
  62. 62.
    Paavonen JA, Kiviat N, Brunham RC, (1985) Prevalence and manifestations of endometritis among women with cervicitis. Am J Obstet Gynecol 152: 280PubMedGoogle Scholar
  63. 63.
    Patel DS, Bhagavan BS (1985) Blue nevus of the uterine cervix. Hum Pathol 16: 79PubMedCrossRefGoogle Scholar
  64. 64.
    Purola E, Paavonen JA (1982) Routine cytology as a diagnostic aid in chlamydial cervicitis. Scand J Infect Dis B345: 55Google Scholar
  65. 65.
    Richart RM (1973) Cervical intraepithelial neoplasia. In: Sommers SC (ed). Pathology annual. New York, AppletonCentury-Crofts, pp 301 - 328Google Scholar
  66. 66.
    Richter GA, Pratt JH, Nicolas DR, Coulam CV (1972) Actinomycosis of the female genital organs. Minn Med 55: 1003PubMedGoogle Scholar
  67. 67.
    Ridley JH (1968) The histogenesis of endometriosis. A review of facts and fancies. Obstet Gynecol Sury 23: 1CrossRefGoogle Scholar
  68. 68.
    Rilke F, Cantaboni A (1964) Lipomas of the uterus. Presentation of 2 cases and review of the recent literature. Ann Obstet Gynecol 86: 645Google Scholar
  69. 69.
    Robboy SJ, Welch WR (1977) Microglandular hyperplasia in vaginal adenosis associated with oral contraceptives and prenatal diethylstilbestrol exposure. Obstet Gynecol 49: 430PubMedGoogle Scholar
  70. 70.
    Roth E, Taylor HB (1966) Heterotopic cartilage in the uterus. Obstet Gynecol 27: 838PubMedGoogle Scholar
  71. 71.
    Schacter J (1978) Chlamydial infections. N Engl J Med 298: 428, 490, 540CrossRefGoogle Scholar
  72. 72.
    Schacter J (1984) Biology of Chlamydia trachomatis. In: Holmes KK, Mandh PA, Sparling PF, Weisner PJ (eds). Sexually transmitted diseases. New York, McGraw-Hill Book Co., pp 243 - 257Google Scholar
  73. 73.
    Schacter J, Stoner E, Moncada J (1983) Screening for chlamydial infections in women attending family planning clinics. West J Med 138: 375Google Scholar
  74. 74.
    Schaefer C (1970) Tuberculosis of female genital tract. Clin Obstet Gynecol 13: 965PubMedCrossRefGoogle Scholar
  75. 75.
    Scherrick JC, Vega JG (1962) Congenital intramural cysts of the uterus. Obstet Gynecol 19: 486Google Scholar
  76. 76.
    Schwartz DA (1984) Carcinoma of the uterine cervix and schistosomiasis in West Africa (Review of the literature). Gynecol Oncol 19: 365PubMedCrossRefGoogle Scholar
  77. 77.
    Selzer F, Nelson HM (1962) Benign papilloma (polypoid tumor of the cervix uteri in children: Report of two cases. Am J Obstet Gynecol 84: 165Google Scholar
  78. 78.
    Shafer MA, Chen KL, Kromhout LK, (1985) Chlamydial endocervical infections and cytologic findings in sexually active female adolescents. Am J Obstet Gynecol 151: 767Google Scholar
  79. 79.
    Slavutin L (1979) Uterine gliosis and ossification. Am J Diagn Gynecol Obstet 1: 351Google Scholar
  80. 80.
    Stamm WE, Holmes KK (1984) Chlamydia trachomatis infections of the adult. In: Holmes KK, Mandh PA, Sparling PF, Weisner PJ (eds). Sexually transmitted diseases. New York, McGraw-Hill Book Co., pp 258 - 269Google Scholar
  81. 81.
    Stein BJ, Siciliano A (1966) Necrotizing herpes simplex viral infection of the cervix during pregnancy: Mimic of squamous cell carcinoma. Am J Obstet Gynecol 94: 249Google Scholar
  82. 82.
    Stout AP (1943) Hemangioendothelioma: A tumor of blood vessels featuring vascular endothelial cells. Ann Surg 118: 445PubMedCrossRefGoogle Scholar
  83. 83.
    Taylor HB, Irey NS, Norris HJ (1967) Atypical endocervical hyperplasia in women taking oral contraceptives. JAMA 202: 637PubMedCrossRefGoogle Scholar
  84. 84.
    Tchertkoff V, Ober WB (1966) Primary chancre of the cervix uteri. NY State J Med 66: 1921Google Scholar
  85. 85.
    Tsukada Y, Piver MS, Barlow JT (1977) Microglandular hyperplasia of the endocervix following long-term estrogen treatment. Am J Obstet Gynecol 127: 888PubMedGoogle Scholar
  86. 86.
    Vellios F, Ng ABP, Reagan JW (1973) Papillary adenofibroma of the uterus. A benign mesodermal mixed tumor of müllerian origin. Am J Clin Pathol 60: 543Google Scholar
  87. 87.
    Wagner ED (1974) The replication of herpesvirus. Am Sci 62: 584Google Scholar
  88. 88.
    Westrom L, Mardh PA (1972) Genital chlamydial infections in the female. In: Mardh PA, Holmes KK, Oriel JD, (eds). Chlamydial infections. New York, Elsevier, pp 121 - 141Google Scholar
  89. 89.
    Westrom L, Mardh PA (1984) Salpingitis. In: Holmes KK, Mardh PA, Sparling PF, Weisner PJ (eds). Sexually transmitted diseases. New York, McGraw-Hill Book Co., pp 615 - 632Google Scholar
  90. 90.
    Wilbanks GD, Carter B (1963) Vaginitis emphysematosa. Obst Gynecol 22: 301Google Scholar
  91. 91.
    Wilkinson E, Dufour DR (1976) Pathogenesis of microglandular hyperplasia of the cervix uteri. Obstet Gynecol 47: 189PubMedGoogle Scholar
  92. 92.
    Willis RA (1962) The borderland of embryology and pathology, 2nd ed. Washington D.C., ButterworthGoogle Scholar
  93. 93.
    Winkler B, Crum CP (1986) Chlamydia trachomatis infection of the female genital tract: Pathogenetic and clinicopathologic considerations. In: Sommers SC, Fechner RE, Rosen PP (eds). Pathology annual. E. Norwalk, CT, Appleton-Century-CroftsGoogle Scholar
  94. 94.
    Winkler B, Richart RN (1985) CervicaUuterine pathologic considerations in pelvic infection. In: Zatuchni GI, Goldsmith A, Sciarra JJ (eds). Intrauterine contraception: Advances and future prospects. New York, Harper Row, pp 438 - 449Google Scholar
  95. 95.
    Young RH, Harris NL, Scully RE (1985) Lymphoma-like lesions of the lower female genital tract: A report of 16 cases. Int J Gynecol Pathol 4: 289PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1987

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  • Alex Ferenczy
  • Barbara Winkler

There are no affiliations available

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