Disorders of Abnormal Sexual Development

  • Stanley J. Robboy
  • Joseph M. Lombardo
  • William R. Welch


New insights into the biology of sexual development and advances in chromosome analysis have led to early identification and prompt treatment of the intersexual patient, which permit the person to lead a more normal life.39 Based on these recent advances, we developed a classification of abnormal sexual development that correlates the gonadal and genital anatomy with the chromosomal findings and specific genetic or metabolic defects69 (Table 2.1). This allows an integrated approach to this complex group of disorders according to the presenting signs as well as the pathophysiologic basis of the defect. The classification also groups patients who are at high risk for development of gonadal neoplasia.


Sertoli Cell Leydig Cell Seminiferous Tubule Congenital Adrenal Hyperplasia External Genitalia 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Stanley J. Robboy
  • Joseph M. Lombardo
  • William R. Welch

There are no affiliations available

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