Common Epithelial Tumors of the Ovary

  • Bernard Czernobilsky


The common epithelial tumors of the ovary constitute about two-thirds of all primary ovarian neoplasms and almost 90% of all malignant ovarian tumors.151 They are considered to be derived from the surface epithelium (coelomic epithelium or mesothelium) covering the ovary and from the underlying stroma.157a Although this histogenesis has been accepted by most authorities, the supporting evidence varies in the individual tumors from fairly conclusive to circumstantial. The histologic heterogeneity encountered in this group of tumors does not contradict their common origin. Although the ovary is not of müllerian origin, the source of these neoplasms, namely, the surface epithelium, is derived from the coelomic epithelium, which in the embryo gives rise to the müllerian ducts. The latter form the fallopian tubes, uterine body, cervix, and possibly the upper part of the vagina with their large variety of epithelia. The presence of different epithelial elements in these tumors can, therefore, be satisfactorily explained. Furthermore, admixtures of histologic elements from various epithelial ovarian tumors within a given tumor are very common and constitute further evidence of their common derivation. The cause for the great neoplastic potential of the ovarian surface epithelium, however, has not yet been elucidated.


Clear Cell Carcinoma Mucinous Tumor Ovarian Surface Epithelium Granulosa Cell Tumor Endometrioid Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Allen MS, Hertig AT (1949) Carcinoma of the ovary. Am J Obstet Gynecol 58: 640Google Scholar
  2. 2.
    Altmannsberger M, Osborn M, Schauer A, Weber K (1981) Antibodies to different intermediate filament proteins. Cell-type specific markers in paraffin-embedded tissues. Lab Invest 45: 427PubMedGoogle Scholar
  3. 3.
    Anderson C, Cameron HM, Neville AM, Simpson HW (1967) Mixed mesodermal tumors of the ovary. J Pathol Bacteriol 93: 301PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson MC, Langley FA (1970) Mesonephroid tumors of the ovary. J Clin Pathol 23: 210PubMedCrossRefGoogle Scholar
  5. 5.
    Arey LB (1961) The origin and form of the Brenner tumor. Am J Obstet Gynecol 81: 743PubMedGoogle Scholar
  6. 6.
    Arey LB (1943) Nature and significance of grooved nuclei of Brenner tumors and Watthard cell islands. Am J Obstet Gynecol 45: 614Google Scholar
  7. 7.
    August CZ, Murad TM, Newton M (1985) Multiple focal extraovarian serous carcinoma. Int J Gynecol Pathol 4: 11PubMedCrossRefGoogle Scholar
  8. 8.
    Aure JC, Hoeg K, Kalstad P (1971) Psammoma bodies in serous carcinoma of the ovary. A prognostic study. Am J Obstet Gynecol 109: 113PubMedGoogle Scholar
  9. 9.
    Aure JC, Haeg K, Kalstad P (1971) Clinical and histologic studies of ovarian carcinoma. Long-term follow-up of 990 cases. Obstet Gynecol 37: 1Google Scholar
  10. 10.
    Baak JPA, Blanco AA, Kurver PHY, Langley FA, Boon ME, Lindeman J, Overdiep SH, Nieuwlaat A, Brekelmans E (1981) Quantitation of borderline and malignant mucinous ovarian tumors. Histopathology 5: 353PubMedCrossRefGoogle Scholar
  11. 11.
    Bagley CM, Young RD, Canellos GP, DeVita VT (1972) Treatment of ovarian carcinoma: Possibilities for progress. N Engl J Med 287: 856PubMedCrossRefGoogle Scholar
  12. 12.
    Bara J, Malarewicz A, Loisillier F, Burton P (1977) Antigens common to human ovarian mucinous cyst fluid and gastric mucosa. Br J Cancer 36: 49PubMedCrossRefGoogle Scholar
  13. 13.
    Barnhill D, Heller P, Brzozowski P, Advani H, Gallup D, Park R (1985) Epithelial ovarian carcinoma of low malignant potential. Obstet Gynecol 65: 53PubMedGoogle Scholar
  14. 14.
    Bast RC, Fenny M, Lazarus H, Nadler LM, Colvin RB, Knapp RC (1981) Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68: 1351CrossRefGoogle Scholar
  15. 15.
    Bell DA, Scully RE (1985) Atypical and borderline endometrioid adenofibromas of the ovary. A report of 27 cases. Am J Surg Pathol 9: 205PubMedCrossRefGoogle Scholar
  16. 16.
    Bell DA, Scully RE (1985) Benign and borderline clear cell adenofibroma of the ovary. Cancer 56: 2922PubMedCrossRefGoogle Scholar
  17. 17.
    Berge T, Borglin NE (1967) Brenner tumors: Histogenetic and clinical studies. Cancer 20: 308PubMedCrossRefGoogle Scholar
  18. 18.
    Bettinger HF, Jacobs J (1946) A contribution to the problem of masculinization. Med J Aust 1: 10PubMedGoogle Scholar
  19. 19.
    Bhattacharaya M, Chatterjee SK, Barlow JJ, Fugi H (1982) Monoclonal antibodies recognizing tumor-associated antigen in human ovarian mucinous cystadenocarcinoma. Cancer Res 42: 1650Google Scholar
  20. 20.
    Blaustein A (1984) Peritoneal mesothelium and ovarian surface cells-Shared characteristics. Int J Gynecol Pathol 3: 361PubMedCrossRefGoogle Scholar
  21. 21.
    Bonazzi del Pogetto C, Virtanen F, Lehto V-P, Wahlström T, Saksela E (1983) Expression of intermediate filaments in ovarian and uterine tumors. Int J Gynecol Pathol 1: 359CrossRefGoogle Scholar
  22. 22.
    Bransilver BR, Ferenczy A, Richart RM (1974) Brenner tumors and Walthard cell nests. Arch Pathol 98: 76PubMedGoogle Scholar
  23. 23.
    Bransilver BR, Ferenczy A, Richart RM (1973) Female genital tract remnants: An ultrastructural comparison of hydatid of Morgagni and mesonephric ducts and tubules. Arch Pathol 96: 255PubMedGoogle Scholar
  24. 24.
    Brenner F (1907) Das oophoroma folliculare. Frankfurt Z Pathol 1: 150Google Scholar
  25. 25.
    Bruns DE, Mills SE, Savory J (1982) Amylase in fallopian tube and serous ovarian neoplasm. Immunohistochemical localization. Arch Pathol Lab Med 106: 617Google Scholar
  26. 26.
    Campbell JS, Magner D, Fournier P (1961) Adenoacanthoma of ovary and uterus occurring as coexistent or sequential primary neoplasms. Cancer 14: 817PubMedCrossRefGoogle Scholar
  27. 27.
    Cariker M, Dockerty MB (1954) Mucinous cystadenomas and mucinous cystadenocarcinomas of the ovary: A clinical pathologic study of 355 cases. Cancer 7: 302PubMedCrossRefGoogle Scholar
  28. 28.
    Charpin C, Bhan AK, Zurawski VR Jr, Scully RE (1982) Carcinoembryonic antigen (CEA) and carbohydrate determinant 19–9 (CA 19–9) localization in 121 primary and metastatic ovarian tumors: An immunohistochemical study with the use of monoclonal antibodies. Int J Gynecol Pathol 1: 231PubMedCrossRefGoogle Scholar
  29. 29.
    Clement PB, Scully RE (1978) Extrauterine mesodermal (müllerian) adenosarcoma. A clinicopathologic analysis of five cases. Am J Clin Pathol 69: 276PubMedGoogle Scholar
  30. 30.
    Colgan JY, Norris HJ (1983) Ovarian epithelial tumors of low malignant potential: A review. Int J Gynecol Pathol 1: 367PubMedCrossRefGoogle Scholar
  31. 31.
    Compton HL, Fink FM (1970) Serous adenofibroma and cystadenofibroma of the ovary. Obstet Gynecol 36: 636PubMedGoogle Scholar
  32. 32.
    Cummins PA, Fox H, Langley FA (1974) An electron microscopic study of the endometrioid adenocarcinoma of the ovary and a comparison of its fine structure with that of normal endometrium and of adenocarcinoma of the endometrium. J Pathol 113: 165PubMedCrossRefGoogle Scholar
  33. 33.
    Czernobilsky B (1977) Cystadenofibroma, adenofibroma and malignant adenofibroma of the ovary. Pathol Ann 12: 207–212Google Scholar
  34. 34.
    Czernobilsky B (1982) Endometrioid neoplasia of the ovary: A reappraisal. Int J Gynecol Pathol 1: 203PubMedCrossRefGoogle Scholar
  35. 35.
    Czernobilsky B, Moll R, Leppien G, Schweikhart G, Franke WW. Desmosomal plaque-associated vimentin filaments in human ovarian granulosa cell tumors of various histologic patterns. Am J Pathol (In press)Google Scholar
  36. 36.
    Czernobilsky B, LaBarre GC (1968) Carcinosarcoma and mixed mesodermal tumor of the ovary. A clinicopathologic analysis of 9 cases. Obstet Gynecol 31: 21PubMedCrossRefGoogle Scholar
  37. 37.
    Czernobilsky B, Borenstein R, Lancet M (1974) Cystadenofibroma of the ovary. A clinicopathologic study of 34 cases and comparison with serous cystadenoma. Cancer 34: 1971PubMedCrossRefGoogle Scholar
  38. 38.
    Czernobilsky B, Dgani R, Roth LM (1983) Ovarian mucinous cystadenocarcinoma with mural nodules of carcinomatous derivation. A light and electron microscopic study. Cancer 51: 141PubMedCrossRefGoogle Scholar
  39. 39.
    Czernobilsky B, Gillespie JT, Roth LM (1982) Adenosarcoma of the ovary. A light and electron microscopic study with a review of the literature. Diagn Gynecol Obstet 4: 25PubMedGoogle Scholar
  40. 40.
    Czernobilsky B, Silverman BB, Enterline HT (1970) Clear-cell carcinoma of the ovary. A clinicopathologic analysis of pure and mixed forms and comparison with endometrioid carcinoma. Cancer 25: 762PubMedCrossRefGoogle Scholar
  41. 41.
    Czernobilsky B, Silverman BB, Mikuta JJ (1970) Endometrioid carcinoma of the ovary. A clinicopathologic study of 75 cases. Cancer 26: 1141PubMedCrossRefGoogle Scholar
  42. 42.
    Czernobilsky B, Moll R, Franke WW, Dallenbach-Hellweg G, Hohlweg-Majert P (1984) Intermediate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis. Pathol Res Pract 179: 31PubMedCrossRefGoogle Scholar
  43. 43.
    Dallenbach F, Komitowski D (1982) Digital picture analysis of borderline papillary serous cystadenomas of the ovary. In: Dallenbach G (ed) Ovarialtumoren. New York, Springer-Verlag, pp 158–166CrossRefGoogle Scholar
  44. 44.
    Dehner LP, Norris HJ, Taylor HB (1971) Carcinosarcomas and mixed mesodermal tumors of the ovary. Cancer 27: 207PubMedCrossRefGoogle Scholar
  45. 45.
    Dictor M (1982) Ovarian malignant mixed mesodermal tumor: The occurrence of hyaline droplets containing aiantitrypsin. Hum Pathol 13: 930PubMedCrossRefGoogle Scholar
  46. 46.
    Dietel M (1985) Discrimination between benign, borderline, and malignant epithelial ovarian tumors using tumor markers: An immunohistochemical study. Cancer Detect Prevent 6: 255Google Scholar
  47. 47.
    Dockerty MB (1954) Primary and secondary ovarian adenoacanthoma. Surg Gynecol Obstet 99: 392PubMedGoogle Scholar
  48. 48.
    Ehrlich CE (1985) Clinical management of ovarian cancer. In: Roth LM, Czernobilsky B (eds) Tumors and tumorlike conditions of the ovary. New York, Churchill Livingstone, pp 247–256Google Scholar
  49. 49.
    Fathalla MF (1967) Malignant transformation in ovarian endometriosis. J Obstet Gynaecol Br Commonw 74: 85PubMedCrossRefGoogle Scholar
  50. 50.
    Fenoglio CM, Ferenczy A, Richart RM (1975) Mucinous tumors of the ovary. Ultrastructural studies of mucinous cystadenomas with histogenetic considerations. Cancer 36: 1709PubMedCrossRefGoogle Scholar
  51. 51.
    Fenoglio CM, Crum CP, Pascal RR, Richart RM (1981) Carcinoembryonic antigen in gynecologic patients. II. Immunohistological expression. Diagn Gynecol Obstet 4: 291Google Scholar
  52. 52.
    Ferenczy A, Richart RM (1974) The female reproductive system. Dynamics of scan and transmission electron microscopy. New York, John Wiley and Sons, a: p 287, b: 291, c: pp 301–303, d: 308–309Google Scholar
  53. 53.
    Fine G, Clarke HD, Horn RC (1973) Mesonephroma of the ovary. A clinical, morphological, and histogenetic appraisal. Cancer 31: 398PubMedCrossRefGoogle Scholar
  54. 54.
    Fisher ER, Krieger JS, Skirpan PJ (1955) Ovarian cystoma. Clinicopathologic observations. Cancer 8: 437PubMedCrossRefGoogle Scholar
  55. 55.
    Fox H, Kazzaz B, Langley FA (1964) Argyrophil and argentaffin cells in the female genital tract and ovarian mucinous cysts. J Pathol Bacteriol 88: 479PubMedCrossRefGoogle Scholar
  56. 56.
    Foyle A, Al-Yabi M, McCaughey WT (1981) Papillary peritoneal tumors in women. Am J Surg Pathol 5: 241PubMedCrossRefGoogle Scholar
  57. 57.
    Franke WW, Schmid E, Osborn M, Weber K (1978) Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc Natl Acad Sci USA 75: 5034PubMedCrossRefGoogle Scholar
  58. 58.
    Friedlander ML, Taylor IW, Russell P, Musgrove EA, Hedley DH, Tattersall MHN (1983) Ploidy as a prognostic factor in ovarian cancer. Int J Gynecol Pathol 2: 55PubMedCrossRefGoogle Scholar
  59. 59.
    Fu YS, Stock RJ, Reagan JW, Storaasli JP, Wentz WBC (1979) Significance of squamous components in endometrioid carcinoma of the ovary. Cancer 44: 614PubMedCrossRefGoogle Scholar
  60. 60.
    Gabbiani G, Kapanci Y, Barrazone P, Franke WW (1981) Immunochemical identification of intermediate-sized filaments in human neoplastic cells: A diagnostic aid for the surgical pathologist. Am J Pathol 104: 206PubMedGoogle Scholar
  61. 61.
    Ganjei P, Nadji M, Penneys NS, Averette HE, Morales AR (1983) Immunoreactive prekeratin in Brenner tumors of the ovary. Int J Gynaecol Pathol 1: 353CrossRefGoogle Scholar
  62. 62.
    Garcia-Bunnel R, Morris B (1964) Histochemical observation on mucin in human ovarian neoplasms. Cancer 17: 1108CrossRefGoogle Scholar
  63. 63.
    Goldman RL (1970) A Brenner tumor of the testis. Cancer 26: 853PubMedCrossRefGoogle Scholar
  64. 64.
    Gondos B (1971) Electron microscopic study of papillary serous tumors of the ovary. Cancer 27: 1455PubMedCrossRefGoogle Scholar
  65. 65.
    Gray LA, Barnes ML (1967) Endometrioid carcinoma of the ovary. Obstet Gynecol 29: 694PubMedGoogle Scholar
  66. 66.
    Green CL (1957) Identification of alpha-amylase as a secretion of the human fallopian tube and “tube-like” epithelium of müllerian and mesonephric duct origin. Am J Obstet Gynecol 73: 402PubMedGoogle Scholar
  67. 67.
    Greene RR (1952) The diverse origins of Brenner tumors. Am J Obstet Gynecol 64: 878PubMedGoogle Scholar
  68. 68.
    Griffiths CT (1974) Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma. In: Symposium on ovarian carcinoma. Natl Cancer Inst Monogr 42: 101Google Scholar
  69. 69.
    Gooneratne S, Sassone M, Blaustein A, Talerman A (1982) Serous surface papillary carcinoma of the ovary. A clinicopathologic study of 16 cases. Int J Gynecol Pathol 1: 258PubMedCrossRefGoogle Scholar
  70. 70.
    Hallgrimson J, Scully RE (1972) Borderline and malignant Brenner tumors of the ovary. A report of 15 cases. Acta Pathol Microbiol Scand A [Suppl 80] 233: 56Google Scholar
  71. 71.
    Hart WR, Norris HJ (1973) Borderline and malignant mucinous tumors of the ovary. Histologic criteria and clinical behaviour. Cancer 31: 1031PubMedCrossRefGoogle Scholar
  72. 72.
    Hayes D (1972) Mesonephroid tumors of the ovary. J Obstet Gynaecol Br Commonw 79: 728PubMedCrossRefGoogle Scholar
  73. 73.
    Hertig AT, Gore H (1961) Atlas of tumor pathology, Section IX, Vol 33. Tumors of the female sex organs. Part 3: Tumors of the ovary and fallopian tube. Washington, DC, Armed Forces Institute of Pathology, pp 106–109Google Scholar
  74. 74.
    Hughesdon PE (1958) Thecal and allied reactions in epithelial ovarian tumors. J Obstet Gynaecol Br Commonw 65: 702CrossRefGoogle Scholar
  75. 75.
    Hull MGR, Campbell CR (1973) The malignant Brenner tumor. Obstet Gynecol 42: 527PubMedCrossRefGoogle Scholar
  76. 76.
    Idelson MG (1963) Malignancy in Brenner tumors of the ovary, with comments on histogenesis and possible estrogen production. Obstet Gynecol Sury 18: 246CrossRefGoogle Scholar
  77. 77.
    Janovski NA, Paramanandhan TL (1973) Ovarian tumors. Tumors and tumor-like conditions of the ovaries, fallopian tubes and ligaments of the uterus. Stuttgart, Georg Thieme, a: p 32, b: pp 119–123Google Scholar
  78. 78.
    Jensen RD, Norris HJ (1972) Epithelial tumors of the ovary. Occurrence in children and adolescents less than 20 of age. Arch Pathol 94: 29PubMedGoogle Scholar
  79. 79.
    Jondahl WH, Dockerty MD, Randall CM (1950) Brenner tumors of the ovary: A clinicopathologic study of 31 cases. Am J Obstet Gynecol 60: 160PubMedGoogle Scholar
  80. 80.
    Joshi VV (1968) Primary Krukenberg tumor of the ovary. Review of literature and case report. Cancer 22: 1199PubMedCrossRefGoogle Scholar
  81. 81.
    Kabawat SE, Bast RC, Welch WR, Knapp RC, Colvin RB (1983) Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous endometrioid and clear cell types. Am J Clin Pathol 79: 98PubMedGoogle Scholar
  82. 82.
    Kabawat SE, Bast RC, Bhan AK, Welch WR, Knapp RC, Colvin RB (1983) Tissue distribution of a coelomicepithelium-related antigen recognized by the monoclonal antibody OC 125. Int J Gynecol Pathol 2: 275PubMedCrossRefGoogle Scholar
  83. 83.
    Kannerstein M, Churg J, McCaughey WTE, Hill DP (1977) Papillary tumors of the peritoneum in women: Mesothelioma or papillary carcinoma. Am J Obstet Gynecol 127: 306PubMedGoogle Scholar
  84. 84.
    Kao GF, Norris HJ (1979) Unusual cystadenofibromas: Endometrioid, mucinous, and clear cell types. Obstet Gynecol 54: 729PubMedGoogle Scholar
  85. 85.
    Kao GF, Norris HJ (1978) Cystadenofibromas of the ovary with epithelial atypia. Am J Surg Pathol 2: 357PubMedCrossRefGoogle Scholar
  86. 86.
    Kao GF, Norris HJ (1978) Benign and low grade variants of mixed mesodermal tumor (adenosarcoma) of the ovary and adnexal region. Cancer 42: 1314PubMedCrossRefGoogle Scholar
  87. 87.
    Katzenstein A-LA, Mazur MT, Morgan TE, Kao MS (1978) Proliferative serous tumors of the ovary. Histologic features and prognosis. Am J Surg Pathol 2: 339PubMedCrossRefGoogle Scholar
  88. 88.
    Kent SW, McKay DG (1960) Primary cancer of the ovary. Am J Obstet Gynecol 80: 430PubMedGoogle Scholar
  89. 89.
    Kerner H, Gaton E, Czernobilsky B (1981) Unusual ovarian, tubal and pelvic mesothelial inclusions in patients with endometriosis. Histopathology 5: 277PubMedCrossRefGoogle Scholar
  90. 90.
    Klemi PJ, Meurman L, Grönroos M, Talerman A (1982) Clear cell (mesonephroid) tumors of the ovary with characteristics resembling endodermal sinus tumor. Int J Gynecol Pathol 1: 95PubMedCrossRefGoogle Scholar
  91. 91.
    Kottmeier HL (1952) The classification and treatment of ovarian tumors. Acta Obstet Gynecol Scand 31: 313PubMedCrossRefGoogle Scholar
  92. 92.
    Kottmeier HL (1968) Surgical management-Conservative surgery. Indications according to the type of the tumor. In: Gentil F, Junqueira AC (eds) Ovarian cancer. UICC Monograph Series, New York, Springer-Verlag, Vol 11, pp 157–164Google Scholar
  93. 93.
    Kottmeier HL (1965) The diagnosis and treatment of ovarian malignancies. Arch Pathol 37: 51Google Scholar
  94. 94.
    Kraus FT (1967) Gynecologic pathology. St. Louis, CV Mosby, p 333Google Scholar
  95. 95.
    Kurman RJ, Craig JM (1972) Endometrioid and clear cell carcinoma of the ovary. Cancer 29: 1653PubMedCrossRefGoogle Scholar
  96. 96.
    Kurman RJ, Norris HJ (1982) Endometrial neoplasia: Hyperplasia and carcinoma. In: Blaustein A (ed) Pathology of the female genital tract, 2nd ed. New York, Springer-Verlag, pp 331–333Google Scholar
  97. 97.
    Kurman RJ, Ganjei P, Nadji M (1984) Contributions of immunocytochemistry to the diagnosis and study of ovarian neoplasms. Int J Gynecol Pathol 3: 3PubMedCrossRefGoogle Scholar
  98. 98.
    Langley FA, Cummins PA, Fox H (1972) An ultrastructural study of mucin-secreting epithelia in ovarian neoplasms. Acta Pathol Microbiol Scand [Suppl 80] 233: 76Google Scholar
  99. 99.
    Lauchlan SL (1966) Histogenesis and histogenetic relationship of Brenner tumors. Cancer 19: 1628PubMedCrossRefGoogle Scholar
  100. 100.
    Limber GK, King RE, Silverberg SG (1973) Pseudomyxorna peritonaei. A report of ten cases. Ann Surg. 178: 587PubMedCrossRefGoogle Scholar
  101. 101.
    Long ME, Taylor HC (1964) Endometrioid carcinoma of the ovary. Am J Obstet Gynecol 90: 936PubMedGoogle Scholar
  102. 102.
    Long RT, Spratt JS, Dowling E (1969) Pseudomyxoma peritonaei: New concepts in management with a report of 17 patients. Am J Surg 117: 160Google Scholar
  103. 103.
    Malloy JJ, Dockerty MB, Welch JS, Hunt AB (1965) Papillary ovarian tumors. I. Benign tumors and serous and mucinous cystadenocarcinomas. Am J Obstet Gynecol 93: 867PubMedGoogle Scholar
  104. 104.
    McGee CT, Cromer DW, Greene RR (1962) Mesonephric carcinoma of the cervix-Differentiation from endocervical adenocarcinoma. Am J Obstet Gynecol 84: 358Google Scholar
  105. 105.
    Meyer R (1932) Über verschiedene Erscheinungsformen der als typus Brenner bekannten Eierstockgeschwulst, ihre Absonderung von den Granulosa-Zell Tumoren and Zuordnung unter andere Ovarialgeschwülste. Arch Gynaek 148: 541CrossRefGoogle Scholar
  106. 106.
    Miettinen M, Lehto V-P, Virtanen I (1983) Expression of intermediate filaments in normal ovaries and ovarian epithelial, sex cord-stromal, and germinal tumors. Int J Gynecol Pathol 2: 64PubMedCrossRefGoogle Scholar
  107. 107.
    Miles PA, Norris HJ (1972) Proliferative and malignant Brenner tumors of the ovary. Cancer 30: 174PubMedCrossRefGoogle Scholar
  108. 108.
    Ming SC, Goldman H (1962) Hormonal activity of Brenner tumors in postmenopausal women. Am J Obstet Gynecol 83: 666PubMedGoogle Scholar
  109. 109.
    Minkowitz S, Cohen HM (1966) Adenocarcinoma within serous cystadenofibroma of the ovary. NY State J Med 66: 529Google Scholar
  110. 110.
    Moll R, Franke WW, Schiller DL, Geiger B, Krepler R (1982) The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31: 11PubMedCrossRefGoogle Scholar
  111. 111.
    Moll R, Levy R, Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G, Franke WW (1983) Cytokeratins of normal epithelia and some neoplasms of the female genital tract. Lab Invest 49: 599PubMedGoogle Scholar
  112. 112.
    Moore JG, Schifrin BS, Erez S (1965) Ovarian tumors in infancy, childhood and adolescence. Am J Obstet Gynecol 93: 850Google Scholar
  113. 113.
    Mori T, Inaji H, Nakajo Y, Ikenaka T, Kosaki G (1979) Immunochemical studies of intestinal mucus antigen (IMA) and CEA-related antigens (NCA-2, NCA) in normal intestinal mucosa. Proc VII Intern Soc Oncodevelopmental Biology 179Google Scholar
  114. 114.
    Morris JM, Scully RE (1958) Endocrine pathology of the ovary. St. Louis, CV Mosby, pp 131–139Google Scholar
  115. 115.
    Nagle RB, Clark VA, McDaniel KM, Davis JR (1983) Immunohistochemical demonstration of keratins in human ovarian neoplasms. A comparison of methods. J Histochem Cytochem 31: 1010PubMedCrossRefGoogle Scholar
  116. 116.
    Ng ABP (1968) Mixed carcinoma of the endometrium. Am J Obstet Gynecol 102: 506PubMedGoogle Scholar
  117. 117.
    Norris HJ, Taylor HB (1966) Mesenchymal tumors of the uterus. III. A clinical and pathologic study of 31 carcinosarcomas. Cancer 19: 1459PubMedCrossRefGoogle Scholar
  118. 118.
    Norris HJ, Roth E, Taylor HB (1966) Mesenchymal tumors of the uterus. II. A clinical and pathologic study of 31 mixed mesodermal tumors. Obstet Gynecol 28: 57PubMedGoogle Scholar
  119. 119.
    Novak E, Woodruff JD, Novak ER (1954) Probable mesonephric origin of certain female genital tumors. Am J Obstet Gynecol 68: 1222PubMedGoogle Scholar
  120. 120.
    Novak ER, Woodruff JD (1959) Mesonephroma of the ovary-Thirty-five cases from the ovarian tumor registry of the American Gynecological Society. Am J Obstet Gynecol 77: 632PubMedGoogle Scholar
  121. 121.
    Novak ER, Woodruff JD (1979) Novak’s gynecologic and obstetric pathology with clinical and endocrine relations. Philadelphia, WB Saunders, pp 394–395Google Scholar
  122. 122.
    Osborn M, Weber K (1983) Tumor diagnosis by intermediate filament typing: A novel tool for surgical pathology. Lab Invest 48: 372PubMedGoogle Scholar
  123. 123.
    Pfleiderer A, Teufel G (1968) Incidence and histochemical investigation of enzymatically active cells in stroma of ovarian tumors. Am J Obstet Gynecol 102: 997PubMedGoogle Scholar
  124. 124.
    Prat J, Scully RE (1979) Sarcomas in ovarian mucinous tumors. A report of two cases. Cancer 44: 1327PubMedCrossRefGoogle Scholar
  125. 125.
    Prat J, Scully RE (1979) Ovarian mucinous tumors with sarcoma-like mural nodules. A report of seven cases. Cancer 44: 1332PubMedCrossRefGoogle Scholar
  126. 126.
    Prat J, Young RH, Scully RE (1982) Ovarian mucinous tumors with foci of anaplastic carcinoma. Cancer 50: 3007Google Scholar
  127. 127.
    Pratt-Thomas HR, Kreutner A, Underwood PB, Dowdeswell H (1976) Proliferative and malignant Brenner tumors of ovary. Report of two cases, one with Meigs’ syndrome, review of literature and ultrastructural comparisons. Gy-necol Oncol 4: 176CrossRefGoogle Scholar
  128. 128.
    Reagan JW (1949) Histopathology of ovarian pseudomucinous cystadenoma. Am J Pathol 25: 689PubMedGoogle Scholar
  129. 129.
    Roth LM (1974) The Brenner tumor and the Walthard cell nest. An electron microscopic study. Lab Invest 31: 15PubMedGoogle Scholar
  130. 130.
    Roth LM (1971) Fine structure of the Brenner tumor. Cancer 27: 1482PubMedCrossRefGoogle Scholar
  131. 131.
    Roth LM, Czernobilsky B (1985) Ovarian Brenner tumors. II. Malignant. Cancer 56: 592CrossRefGoogle Scholar
  132. 132.
    Roth LM, Sternberg WH (1971) Proliferating Brenner tumors. Cancer 27: 687PubMedCrossRefGoogle Scholar
  133. 133.
    Roth LM, Czernobilsky B, Langley FA (1981) Endometrioid adenofibromatous and cystadenofibromatous tumors. Benign, proliferating and malignant. Cancer 48: 1838PubMedCrossRefGoogle Scholar
  134. 134.
    Roth LM, Dallenbach-Hellweg G, Czernobilsky B (1985) Ovarian Brenner tumors. I. Metaplastic, proliferating and of low malignant potential. Cancer 56: 582PubMedCrossRefGoogle Scholar
  135. 135.
    Roth LM, Liban E, Czernobilsky B (1982) Ovarian endometrioid tumors mimicking Sertoli and Sertoli-Leydig cell tumors (sertoliform variant of endometrioid carcinoma). Cancer 50: 1322PubMedCrossRefGoogle Scholar
  136. 136.
    Roth LM, Langley FA, Fox H, Wheeler JE, Czernobilsky B (1984) Ovarian clear cell adenofibromatous tumors: Benign, of low malignant potential, and associated with invasive clear cell carcinoma. Cancer 53: 1156PubMedCrossRefGoogle Scholar
  137. 137.
    Rothman D, Blumenthal HT (1959) Serous adenofibroma and cystadenofibroma of the ovary. Report of five cases with malignant change in one. Obstet Gynecol 14: 389PubMedGoogle Scholar
  138. 138.
    Russell P (1979) The pathological assessment of ovarian neoplasms. I. Introduction to the common “epithelial” tumors and analysis of benign “epithelial” tumors. Pathology 11: 5PubMedCrossRefGoogle Scholar
  139. 139.
    Russell P (1979) The pathological assessment of ovarian neoplasms. II. The proliferating “epithelial” tumors. Pathology 11: 251PubMedCrossRefGoogle Scholar
  140. 140.
    Salazar H, Merkow LP, Walter WS, Pardo M (1974) Human ovarian neoplasms: Light and electron microscopic correlations. II. The clear cell tumor. Obstet Gynecol 44: 551PubMedGoogle Scholar
  141. 141.
    Sampson JA (1925) Endometrial carcinoma of the ovary arising in endometrial tissue in that organ. Arch Surg 10: 1CrossRefGoogle Scholar
  142. 142.
    Santesson L (1961) Suggested classification of ovarian tumors. Meeting of the Cancer Committee of the International Federation of Gynecologists and Obstetricians. Stockholm, Sweden, August 24–26Google Scholar
  143. 143.
    Santesson L, Kottmeier HL (1968) General classification of ovarian tumors. In: Gentils F, Junqueira AC (eds) Ovarian cancer, UICC Monograph Series, New York, Springer-Verlag, Vol II, pp 1–8Google Scholar
  144. 144.
    Saunders P, Price AB (1970) Mixed mesodermal tumor of the ovary arising in pelvic endometriosis. Proc R Soc Med 63: 1050PubMedGoogle Scholar
  145. 145.
    Schiller W (1939) Mesonephroma ovarii. Am J Cancer 35: 1Google Scholar
  146. 146.
    Schiller W (1943) Parvilocular tumors of the ovary. Arch Pathol 35: 391Google Scholar
  147. 147.
    Schiller W (1934) Zur histogenese der Brennerschen ovarial Tumoren. Arch Gynaekol 157: 65CrossRefGoogle Scholar
  148. 148.
    Schlegel R, Banks-Schlegel S, Pinkus GS (1980) Immunohistochemical localization of keratin in normal human tissues. Lab Invest 42: 91PubMedGoogle Scholar
  149. 149.
    Schlegel R, Banks-Schlegel S, McLeod JA, Pinkus GS (1980) Immunoperoxidase localization of keratin in human neoplasms. A preliminary survey. Am J Pathol 101: 41PubMedGoogle Scholar
  150. 150.
    Schuller EF, Kirol PM (1966) Prognosis in endometrioid carcinoma of the ovary. Obstet Gynecol 27: 850Google Scholar
  151. 151.
    Scully RE (1970) Recent progress in ovarian cancer. Hum Pathol 1: 73PubMedCrossRefGoogle Scholar
  152. 152.
    Scully RE (1979) Atlas of tumor pathology. Second series. Fascicle 16. Tumors of the ovary and maldeveloped gonads. Washington, DC, Armed Forces Institute of Pathology, a: p 55, b: p 75, c: p 102, d: p 127, e: pp 132–135, f: pp 63–64Google Scholar
  153. 153.
    Scully RE (1970) Germ cell tumors of the ovary. In: Sturgis SH, Taymor ML (eds) Progress in gynecology. New York, Grune & Stratton, Vol V, p 343Google Scholar
  154. 154.
    Scully RE, Barlow JF (1967) “Mesonephroma” of ovary. Tumor of müllerian nature related to the endometrioid carcinoma. Cancer 20: 1405Google Scholar
  155. 155.
    Scully RE, Cohen RB (1964) Oxidative-enzyme activities in normal and pathologic human ovaries. Obstet Gynecol 24: 667PubMedGoogle Scholar
  156. 156.
    Scully RE, Richardson GS, Barlow JF (1966) The development of malignancy in endometriosis. Clin Obstet Gynecol 9: 384PubMedCrossRefGoogle Scholar
  157. 157.
    Serov SF, Scully RE, Sobin LH (1973) International histological classification of tumours, No. 9. Histological typing of ovarian tumours. Geneva, World Health Organization, a: p 37, b: pp 17–18Google Scholar
  158. 158.
    Shanks HGI (1961) Pseudomyxoma peritonei. J Obstet Gynaecol Br Commonw 68: 212CrossRefGoogle Scholar
  159. 159.
    Sharman A, Sutherland AM (1947) A case of serous adenofibroma of the ovary. J Obstet Gynaecol Br Emp 54: 382PubMedCrossRefGoogle Scholar
  160. 160.
    Shevchuk MM, Fenoglio CM, Richart RM (1980) Histogenesis of Brenner tumors. II. Histochemistry and CEA. Cancer 46: 2617PubMedCrossRefGoogle Scholar
  161. 161.
    Silverberg SC (1973) Ultrastructure and histogenesis of clear cell carcinoma of the ovary. Am J Obstet Gynecol 115: 394PubMedGoogle Scholar
  162. 162.
    Silverberg SC (1971) Brenner tumor of the ovary. A clinicopathologic study of 60 tumors in 54 women. Cancer 28: 588PubMedCrossRefGoogle Scholar
  163. 163.
    Sternberg W (1963) Nonfunctioning ovarian neoplasms. In: Grady HC, Smith DE (eds) The ovary. International academy of pathology monograph. Baltimore, Williams & Wilkins, pp 209–254Google Scholar
  164. 164.
    Tarridge J, Kingsley WB (1968) “Mesonephroma” of the ovary. A report of five cases. Cancer 22: 1208Google Scholar
  165. 165.
    Taylor HC (1929) Malignant and semimalignant tumors of the ovary. Surg Gynecol Obstet 48: 702Google Scholar
  166. 166.
    Teilum G (1969) Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extra embryonic (yolk sac-allantoic) structures of the rat’s placenta. Cancer 12: 1092CrossRefGoogle Scholar
  167. 167.
    Timonen S, Purola E (1967) Adenofibroma and cystadenofibroma of the ovary. Ann Chir Gynaecol Fenn [Suppl. 56] 154: 5Google Scholar
  168. 168.
    Towers RP (1956) A note on the origin of the pseudomucinous cystadenoma of the ovary. J Obstet Gynaecol Br Emp 63: 253PubMedCrossRefGoogle Scholar
  169. 169.
    Tweeddale DN, Early LS, Goodsitt ES (1964) Endometrial adenoacanthoma. A clinical and pathologic analysis of 82 cases with observations on histogenesis. Obstet Gynecol 23: 611Google Scholar
  170. 170.
    Ueda G, Tanaka Y, Hiramatsu K, Inoue Y, Yamasaki M, Inoue M, Kurachi K, Mori T (1982) Immunohistochemical study of mucous antigens in gynecologic tumors with special reference to argyrophil cells. Int J Gynecol Pathol 1: 41PubMedCrossRefGoogle Scholar
  171. 171.
    Ulbright TM, Roth LM, Stehman FB (1984) Secondary ovarian neoplasia. A clinicopathologic study of 35 cases. Cancer 53: 1164PubMedCrossRefGoogle Scholar
  172. 172.
    Van Kley H, Cramer SF, Bruns De (1981) Serous ovarian neoplastic amylase (SONA): A potentially useful marker for serous ovarian tumors. Cancer 48: 1444PubMedCrossRefGoogle Scholar
  173. 173.
    Winter S, Yarrasch ED, Schmid E, Franke WW, Denk H (1980) Differences in polypeptide composition of cytokeratin filaments, including filaments from different epithelial tissues and cells. Eur J Cell Biol 22: 371Google Scholar
  174. 174.
    Woodruff JD, Acosta AA (1962) Variations in the Brenner tumors. Am J Obstet Gynecol 83: 657PubMedGoogle Scholar
  175. 175.
    Woodruff JD, Novak ER (1954) Papillary serous tumors of the ovary. Am J Obstet Gynecol 67: 1112PubMedGoogle Scholar
  176. 176.
    Woodruff JD, Bie LS, Sherman RJ (1960) Mucinous tumors of the ovary. Obstet Gynecol 16: 699PubMedGoogle Scholar
  177. 177.
    Woodruff JD, Williams TJ, Goldberg B (1963) Hormone activity of the common ovarian neoplasm. Am J Obstet Gynecol 87: 679PubMedGoogle Scholar
  178. 178.
    Young RH, Scully RE (1982) Ovarian sex cord—stromal tumors. Recent progress. Int J Gynecol Pathol 1: 101PubMedCrossRefGoogle Scholar
  179. 179.
    Young RH, Prat J, Scully RE (1982) Ovarian endometrioid carcinomas resembling sex cord—stromal tumors. A clinicopathological analysis of 13 cases. Am J Surg Pathol 6: 513PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1987

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  • Bernard Czernobilsky

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