Abstract
This chapter deals with the normal macroscopic, microscopic, and ultrastructural morphology of the human ovary, and its hormonal function. Since the anatomy and function of the ovary vary considerably at different stages in a woman’s life, these aspects will be considered during adulthood, childhood, and after the menopause.
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Adams EC, Hertig AT (1969) Studies on the human corpus luteum. I. Observations on the ultrastructure of development and regression of the luteal cells during the menstrual cycle. J Cell Biol 41: 696
Adams EC, Hertig AT (1969) Studies on the human corpus luteum. II. Observations on the ultrastructure of luteal cells during pregnancy. J Cell Biol 41: 716
Baca M, Zamboni L (1967) The fine structure of the human follicular oocyte. J Ultrastruct Res 19: 354
Balboni GC (1983) Structural changes: Ovulation and lu-teal phase. In: The Ovary. Serra GB (ed.) New York, Raven Press
Bassis ML (1956) Pseudodeciduosis. Am J Obstet Gynecol 72: 1029
Bersch W, Alexy E, Heuser HP, Staemmler HJ (1973) Ectopic decidua formation in the ovary (so-called deciduoma). Virchows Arch [Pathol Anat] 360: 173
Blaustein A (1984) Peritoneal mesothelium and ovarian surface epithelial cells-Shared characteristics. Int J Gynecol Pathol 3: 361
Blaustein A, Lee H (1979) Surface cells of the ovary and pelvic peritoneum: A histochemical and ultrastructural comparison. Gynecol Oncol 8: 34
Bloom W, Fawcett DW (1975) A Textbook of Histology, 10th ed. Philadelphia, Saunders
Bomsel-Helmreich O, Gougeon A, Thebault A, Saltarelli D, Milgrom E, Frydman R, Papiernik E (1979) Healthy and atretic human follicles in the preovulatory phase: Differences in evolution of follicular morphology and steroid content of follicular fluid. J Clin Endocrinol Metab 48: 686
Boss, JH, Scully RE, Wegner KH, Cohen RB (1965) Structural variations in the adult ovary-Clinical significance. Obstet Gynecol 25: 747
Bransilver BR, Ferenczy A, Richart RM (1974) Brenner tumors and Walthard cell nests. Arch Pathol Lab Med 98: 76
Centola GM (1983) Structural changes: Follicular development and hormonal requirements. In: The Ovary. Serra GB (ed). New York, Raven Press
Centola GM (1983) Structural changes: Atresia. In: The Ovary. Serra GB (ed). New York, Raven Press
Chang RJ, Judd HL (1981) The ovary after menopause. Clin Obstet Gynaecol 24: 181
Charpin C, Bhan AK, Zurawski VR Jr, Scully RE (1982) Carcinoembryonic antigen (CEA) and carbohydrate determinant 19–9 (CA 19–9) localization in 121 primary and metastatic ovarian tumors: An immunohistochemical study with the use of monoclonal antibodies. Int J Gynecol Pathol 1: 231
Cordon-Cardo C, Mattes MJ, Melamed MR, Lewis JL Jr, Old LJ, Lloyd KO (1985) Immunopathologic analysis of a panel of mouse monoclonal antibodies reacting with human ovarian carcinomas and other human tumors. Int J Gynecol Pathol 4: 121–130
Corner GW Jr (1956) The histological dating of the human corpus luteum of menstruation. Am J Anat 98: 377–401
Crisp TM, Dessouky DA, Denys FR (1970) The fine structure of the human corpus luteum of early pregnancy and during the progestational phase of the menstrual cycle. Am J Anat 127: 37–70
Croxatto, H, Ortiz M, Croxatto HB (1980) Correlation between histologic dating of human corpus luteum and the luteinizing hormone peak-biopsy interval. Am J Ob-stet Gynecol 136: 667–670
Curtis EM (1962) Normal ovarian histology in infancy and childhood. Obstet Gynecol 19: 444–454
Czernobilsky B, Moll R, Franke WW, Dallenbach-Hellweg G, Hohlweg-Majert P (1984) Intermediate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis. Pathol Res Pract 179: 31–37
Deane HW, Lobel BL, Romney SL (1962) Enzymic histochemistry of normal human ovaries of the menstrual cycle, pregnancy, and the early puerperium. Am J Obstet Gynecol 83: 281–294
Dekel N, David MP, Yedwab GA, Kraicer PF (1977) Follicular development during late pregnancy. Int J Fertil 22: 24–29
Dennefors BL, Janson PO, Hamberger L, Knutsson F (1982) Hilus cells from human postmenopausal ovaries: Gonadotrophin sensitivity, steroid and cyclic AMP production. Acta Obstet Gynecol Scand 61: 413–416
Dennefors BL, Janson PO, Knutsson F, Hamberger L (1980) Steroid production and responsiveness to gonadotropin in isolated stromal tissue of human postmenopausal ovaries. Am J Obstet Gynecol 136: 997–1002
Dyer CA, Erickson GF (1985) Norepinephrine amplifies human chorionic gonadotropin-stimulated androgen biosynthesis by ovarian theca-interstitial cells. Endocrinology 116: 1645–1652
Eichner E, Bove ER (1954) In vivo studies on the lymphatic drainage of the human ovary. Obstet Gynecol 3: 287–297
Erickson GF (1978) Normal ovarian function. Clin Obstet Gynecol 21: 31–52
Feinberg R, Cohen RB (1965) A comparative histochemical study of the ovarian stromal lipid band, stromal theca cell, and normal ovarian follicular apparatus. Am J Obstet Gynecol 92: 958–969
Ferenczy A, Richart RM (1974) Female Reproductive Systems: Dynamics of Scan and Transmission Electron Microscopy. New York, Wiley
Futterweit W (1985) In: Polycystic Ovarian Disease. Clinical Perspectives in Obstetrics and Gynecology. Buchsbaum HJ (ed) New York, Springer-Verlag.
Gardner GH, Greene RR, Peckham B (1957) Tumors of the broad ligament. Am J Obstet Gynecol 73: 536–555
Gillim SW, Christensen AK, McLennan CE (1969) Fine structure of the human menstrual corpus luteum at its stage of maximum secretory activity. Am J Anat 126: 409–428
Gougeon A (1981) Frequent occurrence of multiovular follicles and multinuclear oocytes in the adult human ovary. Fertil Steril 35: 417–422
Govan ADT (1970) Ovarian follicular activity in late pregnancy. J Endocrinol 48: 235–241
Green JA, Maqueo M (1965) Ultrastructure of the human ovary. I. The luteal cell during the menstrual cycle. Am J Obstet Gynecol 92: 946–957
Green JA, Garcilazo JA, Maqueo M (1967) Ultrastructure of the human ovary. H. The luteal cell at term. Am J Obstet Gynecol 99: 855–863
Greenblatt RB, Colle ML, Mahesh VB (1976) Ovarian and adrenal steroid production in the postmenopausal woman. Obstet Gynecol 47: 383–387
Grodin JM, Siiteri PK, MacDonald PC (1973) Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab 36: 207–214
Herr JC, Heidger PM Jr, Scott Jr, Anderson JW, Curet LB, Mossman HW (1978) Decidual cells in the human ovary at term. I. Incidence, gross anatomy and ultrastructural features of merocrine secretion. Am J Anat 152: 728
Hertig AT (1964) Gestational hyperplasia of endometrium. A morphologic correlation of ova, endometrium, and corpora lutea during early pregnancy. Lab Invest 13: 1153–1191
Hertig AT (1968) The primary human oocyte: Some observations on the fine structure of Balbiani’s vitelline body and the origin of the annulate lamellae. Am J Anat 122: 107–138
Hertig AT, Adams EC (1967) Studies on the human oocyte and its follicle. I. Ultrastructural and histochemical observations on the primordial follicle stage. J Cell Biol 34: 647–675
Hidvegi D, Cibils LA, Sorensen K, Hidvegi I (1982) Ultra-structural and histochemical observations of neuroendorcine granules in nonneoplastic ovaries. Am J Obstet Gynecol 143: 590–594
Himelstein-Braw R, Byskov AG, Peters H, Faber M (1976) Follicular atresia in the infant human ovary. J Reprod Fert 46: 55–59
Honore LH, O’Hara KE (1979) Ovarian hilus cell heterotopia. Obstet Gynecol 53: 461–464
Israel SL, Rubenstone A, Meranze DR (1954) The ovary at term. I. Decidua-like reaction and surface cell proliferation. Obstet Gyncol 3: 399–407
Jacobowitz D, Wallach EE (1967) Histochemical and chemical studies of the autonomic innervation of the ovary. Endocrinology 81: 1132–1139
Janko AB, Sandberg EC (1970) Histochemical evidence for the protein nature of the Reinke crystalloid. Obstet Gynecol 35: 493–503
Joel RV, Foraker AG (1960) Fate of the corpus albicans: A morphologic approach. Am J Obstet Gynecol 80: 314–316
Jones GES, Goldberg B, Woodruff JD (1968) Histochemistry as a guide for interpretation of cell function. Am J Obstet Gynecol 100: 76–83
Judd HL, Lucas WE, Yen SSC (1974) Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial carcinoma. Am J Obstet Gynecol 118: 793–798
Judd HL, Judd GE, Lucas WE, Yen SSC (1974) Endocrine function of the postmenopausal ovary: Concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 39: 1020–1024
Kabawat SE, Bast RC Jr, Bhan AK, Welch WR, Knapp RC, Colvin RB (1983) Tissue distribution of coelomicepithelium-related antigen recognized by the monoclonal antibody 0C125. Int J Gynecol Pathol 2: 275–285
Kariminejad MH, Scully RE (1973) Female adnexal tumor of probable wolffian origin. A distinctive pathologic entity. Cancer 31: 671–677
Kraus FT, Neubecker RD (1962) Luteinization of the ovarian theca in infants and children. Am J Clin Pathol 37: 389–397
Laffargue P, Adechy-Benkoel L, Valette C (1968) Ultra-structure du stroma ovarien. Ann Anat Pathol 13: 381–401
Laffargue P, Benkoel L, Laffargue F, Casanova P, Chamlian A (1978) Ultrastructural and enzyme histochemical study of ovarian hilar cells in women and their relationships with sympathetic nerves. Hum Pathol 9: 649–659
Lamb EJ, Fucilla I, Greene RR (1960) Basement mem branes in the female genital tract. Am J Obstet Gynecol 79: 79–85
Lee PA (1983) Ovarian function from conception to puberty: Physiology and disorders. In: The Ovary. Serra GB (ed). New York, Raven Press
LeMaire WJ, Rice BF, Savard K (1968) Steroid hormone formation in the human ovary: V. Synthesis of progesterone in vitro in corpora lutea during the reproductive cycle. J Clin Endocrinol Metab 28: 1249–1256
LeMaire WJ, Conly PW, Moffett A, Spellacy WN, Cleveland WW, Savard K (1971) Function of the human corpus luteum during the puerperium: Its maintenance by exogenous human chorionic gonadotropin. Am J Obstet Gynecol 110: 612–618
Longcope C (1971) Metabolic clearance and blood production rates of estrogens in postmenopausal women. Am J Obstet Gynecol 111: 778–781
Longcope C, Hunter R, Franz C (1980) Steroid secretion by the postmenopausal ovary. Am J Obstet Gynecol 138: 564–568
Maqueo M, Goldzieher JW (1966) Hormone-induced alterations of ovarian morphology. Fertil Steril 17: 676–683
Mattingly RF, Huang WY (1969) Steroidogenesis of the menopause and postmenopausal ovary. Am J Obstet Gynecol 103: 679
McKay DG, Pinkerton JHM, Hertig AT, Danziger S (1961) The adult human ovary: A histochemical study. Obstet Gynecol 18: 13–39
McNatty KP (1978) Follicular determinants of corpus luteum function in the human ovary. In: Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology. Channing CP, Marsh JM, Sadler WA (eds). New York, Plenum Press, Vol. 112
McNatty KP (1978) Cyclic changes in antral fluid hormone concentrations in humans. Clin Endocrinol Metab 7: 577–600
McNatty KP, Makris A, DeGrazia C, Osathanondh R, Ryan KJ (1979) The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J Clin Endocrinol Metab 49: 687–699
McNatty KP, Makris A, DeGrazia C, Osathanondh R, Ryan KJ (1979) The production of progesterone, androgens, and estrogens by human granulosa cells in vitro and in vivo. J Steroid Biochem 11: 775–799
McNatty KP, Smith DM, Makris A, Osathanondh R, Ryan KJ (1979) The microenvironment of the human antral follicle: Interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab 49: 851–860
McNatty KP, Smith DM, Makris A, DeGrazia C, Tulchinsky D, Osathanondh R, Schiff I, Ryan KJ (1980) The intraovarian sites of androgen and estrogen formation in women with normal and hyperandrogenic ovaries as judged by in vitro experiments. J Clin Endocrinol Metab 50: 755–763
Merrill JA (1963) The morphology of the prepubertal ovary: Relationship to the polycystic ovary syndrome. South Med J 56: 225–231
Mestwardt W, Muller O, Brandau H (1978) Structural analysis of granulosa cells from human ovaries in correlation with function. In: Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology. Channing CP. Marsh JM, Sadler WA (eds). New York, Plenum Press, Vol. 112
Miettinen M, Lehto V, Virtanen I (1983) Expression of intermediate filaments in normal ovaries and ovarian epithelial, sex cord-stromal, and germinal tumors. Int J Gynecol Pathol 2: 64–71
Mikhail G, Allen WM (1967) Ovarian function in human pregnancy. Am J Obstet Gynecol 99: 308–312
Mohsin S (1979) The sympathetic innervation of the mammalian ovary. A review of pharmacological and histochemical studies. Clin Exp Pharmacol Physiol 6: 335–354
Nelson WW, Greene RR (1953) The human ovary in pregnancy. Int Abstr Surg 97: 1–23
Nelson WW, Greene RR (1958) Some observations on the histology of the human ovary during pregnancy. Am J Obstet Gynecol 76: 66–89
Nicosia SV (1983) Morphological changes of the human ovary throughout life. In: The Ovary. Serra GB (ed). New York, Raven Press
Okamura H, Virutamasen P, Wright KH, Wallach EE (1972) Ovarian smooth muscle in the human being, rabbit, and cat. Am J Obstet Gynecol 112: 183–191
Owman C, Rosengren E, Sjoberg N (1967) Adrenergic innervation of the human female reprodutive organs: A histochemical and chemical investigation. Obstet Gynecol 30: 763–773
Papadaki L, Beilby JOW (1973) The fine structure of the surface epithelium of the human ovary. J Cell Sci 8: 445–465
Pauerstein CJ, Eddy CA, Croxatto JD, Hess R, SilerKhodr TM, Croxatto HB (1978) Temporal relationships of estrogen, progesterone, and luteinizing hormone levels to ovulation in women and infrahuman primates. Am J Obstet Gynecol 130: 876–886
Pedersen PH, Larsen JF (1968) The ultrastructure of the human granulosa lutein cell of the first trimester of gestation. Acta Endocrinol 58: 481–496
Pennington GW (1974) The reproductive endocrinology of childhood and adolescence. Clin Obstet Gynaecol 1: 509–531
Peters H, Himelstein-Braw R, Faber M (1976) The normal development of the ovary in childhood. Acta Endocrinol 82: 617–630
Plentl AA, Friedman EA (1971) Lymphatic System of the female genitalia. Philadelphia, Saunders
Plotz EJ, Wiener M, Stein AA, Hahn BD (1967) Enzymatic activities related to steroidogenesis in postmenopausal ovaries of patients with and without endometrial carcinoma. Am J Obstet Gynecol 99: 182–197
Pryse-Davies J (1974) The development, structure and function of the female pelvic organs in childhood. Clin Obstet Gynaecol 1: 483–508
Rao CV (1982) Receptors for gonadotropins in human ovaries. Recent Advances in Fertility Research, Part A: Developments in Reproductive Endocrinology, pp 123–135
Reagan JW (1950) Ceroid pigment in the human ovary. Am J Obstet Gynecol 59: 433–436
Reed MJ, Beranek PA, Ghilchik MW, James VHT (1985) Conversion of estrone to estradiol and estradiol to estrone in postmenopausal women. Obstet Gynecol 66: 361–365
Reeves G (1971) Specific stroma in the cortex and medulla of the ovary. Cell types and vascular supply in relation to follicular apparatus and ovulation. Obstet Gynecol 37: 832–844
Rice BF, Savard K (1966) Steroid hormone formation in the human ovary: IV. Ovarian stromal compartment; formation of radioactive steroids from acetate-1–14C and action of gonadotropins. J Clin Endocrinol 26: 593–609
Rice BF, Hammerstein J, Savard K (1964) Steroid hormone formation in the human ovary: II. Action of gonadotropins in vitro in the corpus luteum. J Clin Endocrinol 24: 606–615
Scully RE (1979) Tumors of the ovary and maldeveloped gonads. In: Atlas of Tumor Pathology, Second Series, Fascicle 16. Washington, D.C., Armed Forces Institute of Pathology
Scully RE (1981) Smooth-muscle differentiation in genital tract disorders (Editorial). Arch Pathol Lab Med 105: 505–507
Scully RE, Cohen RB (1964) Oxidative-enzyme activity in normal and pathologic human ovaries. Obstet Gynecol 24: 667–681
Stangel JJ, Richart RM, Okagaki T, Cottral G (1970) Nuclear DNA content of luteinized cells of the human ovary. Am J Obstet Gynecol 108: 543–549
Starup J, Visfeldt J (1974) Ovarian morphology in early and late human pregnancy. Acta Obstet Gynecol Scand 53: 211–218
Sternberg WH (1949) The morphology, androgenic function, hyperplasia, and tumors of the human ovarian hilus cells. Am J Pathol 25: 493–521
Sternberg WH, Segaloff A, Gaskill CJ (1953) Influence of chorionic gonadotropin on human ovarian hilus cells (Leydig-like cells). J Clin Endocrinol Metab 13: 139–153
Tanabe K, Gagliano P, Channing CP, Nakamura Y, Yoshi-mura Y, Iizuka R, Fortuny A, Sulewski J, Rezai N (1983) Levels ofinhibin-F activity and steroids in human follicular fluid from normal women and women with polycystic ovarian disease. J Clin Endocrinol Metab 57: 24–31
Valdes-Dapena MA (1967) The normal ovary of childhood. Ann NY Acad Sci 142: 597–613
Vermeulen A (1976) The hormonal activity of the postmenopausal ovary. J Clin Endocrinol Metab 42: 247–253
Visfeldt J, Starup J (1974) Dating of the human corpus luteum of menstruation using histological parameters. Acta Pathol Microbiol Scand 82: 137–144
Visfeldt J, Starup J (1975) Histology of the human corpus luteum of early and late pregnancy. Acta Path Microbiol Scand 83: 669–677
Weiss G, Rifkin I (1975) Progesterone and estrogen secretion by puerperal human ovaries. Obstet Gynecol 46: 557–559
Weiss G, O’Byrne EM, Steinetz BG (1976) Relaxin: A product of the human corpus luteum of pregnancy. Science 194: 948–949
Weiss G, O’Byrne EM, Hochman JA, Goldsmith LT, Rifkin I, Steinetz BG (1977) Secretion of progesterone and relaxin by the human corpus luteum at midpregnancy and at term. Obstet Gynecol 50: 679–681
White RF, Hertig AT, Rock J, Adams E (1951) Histological and histochemical observations on the corpus luteum of human pregnancy with special reference to corpora lutea associated with early normal and abnormal ova. Contrib Embryol 34: 55–74
Wiley CA, Esterly JR (1976) Observations on the human corpus luteum: Histochemical changes during development and involution. Am J Obstet Gynecol 125: 514519
Young RH, Scully RE (1983) Ovarian tumors of probable wolffian origin. Am J Surg Pathol 7: 125–135
Yussman MA, Taymor ML (1970) Serum levels of follicle stimulating hormone and luteinizing hormone and of plasma progesterone related to ovulation by corpus luteum biopsy. J Clin Endocrinol 30: 396–399
Zhang J, Young RH, Arseneau J, Scully RE (1982) Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors)—a clinicopathological analysis of fifty cases. Int J Gynecol Pathol 1: 270–285
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Clement, P.B. (1987). Anatomy and Histology of the Ovary. In: Kurman, R.J. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1942-0_15
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