Benign Diseases of the Endometrium

  • Robert J. Kurman
  • Michael T. Mazur


A wide variety of benign diseases, from rare infections to commonplace polyps, occurs in the endometrium. Furthermore, since the uterus is a target organ for hormonal stimulation; morphologic changes involving the endometrium may reflect disorders in the hypothalamic-pituitary-ovarian axis. The histologic changes are typically manifested by abnormal uterine bleeding, and an endometrial biopsy or curettage is commonly performed to control excessive bleeding or, more often, to determine its cause. The endometrial biopsy also continues to be an important and integral part of the infertility work-up. This chapter considers various benign conditions involving the uterus, with emphasis on the interpretation of endometrial biopsies and curettings. Congenital abnormalities of the uterus are also discussed.


Obstet Gynecol Endometrial Carcinoma Corpus Luteum Pelvic Inflammatory Disease Endometrial Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Aabye R (1955) Cartilage in the endometrium. Acta Obstet Gynecol Scand 34: 105PubMedCrossRefGoogle Scholar
  2. 2.
    Aksel S, Jones GS (1974) Etiology and treatment of dysfunctional uterine bleeding. Obstet Gynecol 44: 1PubMedGoogle Scholar
  3. 3.
    Altchek, A (1977) Dysfunctional uterine bleeding in adolescence. Clin Obstet Gynecol 20: 633PubMedCrossRefGoogle Scholar
  4. 4.
    Annos T, Thompson IE, Taymor ML (1980) Luteal phase deficiency and infertility: Difficulties encountered in diagnosis and treatment. Obstet Gynecol 55: 705Google Scholar
  5. 5.
    Arhelger RB, Bocian JJ (1976) Brenner tumor of the uterus. Cancer 38: 1741PubMedCrossRefGoogle Scholar
  6. 6.
    Armenia CC (1967) Sequential relationship between endometrial polyps and carcinoma of the endometrium. Ob-stet Gynecol 30: 524Google Scholar
  7. 7.
    Asherman JG (1948) Amenorrhoea traumatica (atretica). J Obstet Gynaecol Br Emp 55: 23PubMedCrossRefGoogle Scholar
  8. 8.
    Auletta FJ, Caldwell BV, Speroff L (1976) Estrogen-induced luteolysis in the rhesus monkey: Reversal with indomethacin. Prostaglandins 11: 745Google Scholar
  9. 9.
    Beer, AE (1970) Differential diagnosis and clinical analysis of dysfunctional uterine bleeding. Clin Obstet Gynecol 13: 434PubMedCrossRefGoogle Scholar
  10. 10.
    Benirschke, K (1973) Congenital anomalies of the uterus with emphasis on genetic causes. In: Norris HT, Hertig AT, Abel MR (eds) International Academy of Pathology monograph number 14, The uterus. Baltimore, Williams & Wilkins, pp 68–79Google Scholar
  11. 11.
    Berry A (1966) A cytopathological and histopathological study of bilharziasis of the female genital tract. J Pathol Bacteriol 91: 325PubMedCrossRefGoogle Scholar
  12. 12.
    Bhagavan BS, Gupta, PK (1978) Genital actinomycosis and intrauterine contraceptive devices. Hum Pathol 9: 567PubMedCrossRefGoogle Scholar
  13. 13.
    Bird CC, Willis RA (1965) The production of smooth muscle by the endometrial stroma of the adult human uterus. J Pathol Bacteriol 90: 75PubMedCrossRefGoogle Scholar
  14. 14.
    Botella-Llusia J (1967) Tuberculosis of the endometrium. In: Bertelli A, Houck JC (eds) Proceedings of the 5th World Congress on Fertility and Sterility. Stockholm 1966. Amsterdam, Excerpta Medica, International Congress Series 188, p 514Google Scholar
  15. 15.
    Brudenell JM (1955) Chronic endometritis and plasma cell infiltration of the endometrium. J Obstet Gynaecol Br Emp 62: 269PubMedCrossRefGoogle Scholar
  16. 16.
    Burke RK, Hertig AT, Miele CA (1985) Prognostic value of subacute focal inflammation of the endometrium, with special reference to pelvic adhesions as observed on laparoscopie examination. An eight-year review. J Reprod Med 30: 646Google Scholar
  17. 17.
    Cadena D, Cavanzo FJ, Leone CL, Taylor HB (1973) Chronic endometritis. A comparative clinicopathologic study. Obstet Gynecol 41: 733Google Scholar
  18. 18.
    Carmichael DE (1970) Asherman’s syndrome. Obstet Gynecol 36: 922PubMedGoogle Scholar
  19. 19.
    Cassell GH, Cole BC (1981) Mycoplasmas as agents of human disease. N Engl J Med 304: 80PubMedCrossRefGoogle Scholar
  20. 20.
    Cassell GH, Younger JB, Brown MB, Blackwell RE, Davis JK, Marriott P, Stagno S (1983) Microbiologic study of infertile women at the time of diagnostic laparoscopy. N Engl J Med 308: 502PubMedCrossRefGoogle Scholar
  21. 21.
    Cavazos F, Lucas FV (1973) Ultrastructure of the endometrium. In: Norris HJ, Hertig AT, Abel MR (ed) International Academy of Pathology monograph number 14, The uterus. Baltimore, Williams & Wilkins, pp 136–174Google Scholar
  22. 22.
    Charles D (1964) Iatrogenic endometrial patterns. J Clin Pathol 17: 205PubMedCrossRefGoogle Scholar
  23. 23.
    Chen KTK, Hendricks EJ (1985) Malakoplakia of the female genital tract. Obstet Gynecol 65: 84sGoogle Scholar
  24. 24.
    Courpas AS, Morris JD, Woodruff JD (1964) Osteoid tissue in utero. Report of 3 cases. Obstet Gynecol 24: 636PubMedGoogle Scholar
  25. 25.
    Cruz-Aquino M, Shenker L, Blaustein A (1967) Pseudosarcoma of the endometrium Obstet Gynecol 29: 93Google Scholar
  26. 26.
    Cumming DC, Honore LH, Scott JZ, Williams KP (1985) The late luteal phase in infertile women: Comparison of simultaneous endometrial biopsy and progesterone levels. Fertil Steril 43: 715Google Scholar
  27. 27.
    Czernobilsky B (1978) Endometritis and infertility. Fert Steril 30: 119Google Scholar
  28. 28.
    Dallenbach-Hellweg G (1981) Histopathology of the en-dometrium, 3rd ed. New York, Heidelberg, Berlin, Springer-VerlagCrossRefGoogle Scholar
  29. 29.
    Dallenbach-Hellweg G (1984) The endometrium in infertility. Pathol Res Pract 178: 527PubMedCrossRefGoogle Scholar
  30. 30.
    Daly DC, Walters CA, Soto-Albors CE, Riddick DH (1983) Endometrial biopsy during treatment of luteal phase defects is predictive of therapeutic outcome. Fertil Steril 40: 305PubMedGoogle Scholar
  31. 31.
    Dehner LP, Askin FB (1975) Cytomegalovirus endometritis. Report of a case associated with spontaneous abortion. Obstet Gynecol 45: 211Google Scholar
  32. 32.
    Del Pozo E, Wyss H, Tolis G, Alcaniz J, Campana A, Naftolin F (1979) Prolactin and deficient luteal function. Obstet Gynecol 53: 282PubMedGoogle Scholar
  33. 33.
    Dockerty MB, Smith, RA, Symmonds RE (1950) Pseudo-malignant endometrial changes induced by administration of new synthetic progestins. Proc Mayo Clin 34: 321Google Scholar
  34. 34.
    Downs KA, Gibson M (1983) Basal body temperature graph and the luteal phase defect. Fertil Steril 40: 466PubMedGoogle Scholar
  35. 35.
    Dumoulin JG, Hughesdon PE (1951) Chronic endometritis. J Obstet Gynaecol Br Emp 58: 222PubMedCrossRefGoogle Scholar
  36. 36.
    Edwards JA, Gale RF (1972) Camptobrachydactyl: A new autosomal dominant trait with two probably homozygotes. Am J Hum Genet 24: 464Google Scholar
  37. 37.
    Eschenbach DA, Harnisch JP, Holmes KK (1977) Pathogenesis of acute pelvis inflammatory disease: Rose of contraception and other risk factors. Am J Obstet Gynecol 128 (8): 838PubMedGoogle Scholar
  38. 38.
    Farber ER, Leahy MS, Meadows TR (1968) Endometrial blastomycosis acquired by sexual contact. Obstet Gynecol 32: 195PubMedGoogle Scholar
  39. 39.
    Faulker WL, Ory HW (1976) Intrauterine devices and acute pelvic inflammatory disease. JAMA 235: 1851Google Scholar
  40. 40.
    Foix A, Bruno RO, Davison T, Lema B (1966) The pathology of postcurettage intrauterine adhesions. Am J Obstet Gynecol 96: 1027PubMedGoogle Scholar
  41. 41.
    Foss BA, Horne HW, Hertig AT (1958) The endometrium and sterility. Fertil Steril 9: 193PubMedGoogle Scholar
  42. 42.
    Friberg J, (1978) Genital mycoplasma infections. Am J Obstet Gynecol 132: 573PubMedGoogle Scholar
  43. 43.
    Friberg J (1980) Mycoplasmas and ureaplasmas in infertility and abortion. Fertil Steril 33: 351PubMedGoogle Scholar
  44. 44.
    Ganem KJ, Parsons L, Friedell GH (1982) Endometrial ossification. Am J Obstet Gynecol 83: 1592Google Scholar
  45. 45.
    Gonzalez-Angulo A, Aznar-Ramos R (1976) Ultrastructural studies on the endometrium of women wearing TCu-200 intrauterine devices by means of transmission and scanning electron microscopy and x-ray dispersive analysis. Am J Obstet Gynecol 125: 170PubMedGoogle Scholar
  46. 46.
    Good RG, Moyer DL (1968) Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 19: 37PubMedGoogle Scholar
  47. 47.
    Gray RH (1976) Pelvic inflammatory disease and intrauterine contraceptive devices. Lancet 2: 521CrossRefGoogle Scholar
  48. 48.
    Gray SW, Skandalakis JE (1972) Embryology for surgeons: The embryological basis for the treatment of congenital defects. Philadelphia, W. B. Saunders Co., pp 633–664Google Scholar
  49. 49.
    Greenwood SM, Moran JJ (1981) Chronic endometritis: Morphologic and clinical observations. Obstet Gynecol 58: 176Google Scholar
  50. 50.
    Gump DW, Gibson M, Ashikaga T (1984) Lack of association between genital mycoplasmas and infertility. N Engl J Med 310: 937PubMedCrossRefGoogle Scholar
  51. 51.
    Gurpide E, Tseng L, Gusberg SB (1977) Estrogen metabolism in normal and neoplastic endometrium. Am J Obstet Gynecol 129: 809PubMedGoogle Scholar
  52. 52.
    Hager WD, Majmudar B (1979) Pelvic actinomycosis in women using intrauterine contraceptive devices. Am J Obstet Gynecol 133: 60PubMedGoogle Scholar
  53. 53.
    Hager, WD, Douglas B, Majmudar B, Nail) ZM, Williams OJ, Ramsey C, Thomas J (1979) Pelvic colonization with Actinomyces in women using intrauterine contraceptive devices. Am J Obstet Gynecol 135: 680PubMedGoogle Scholar
  54. 54.
    Hart WR, Prins RP, Tsai JC (1976) Isolated coccidioidomycosis of the uterus. Hum Pathol 7: 235PubMedCrossRefGoogle Scholar
  55. 55.
    Hartman CG, Geschikter GF, Speert H (1941) Effects of continuous estrogen administration in very large doses. Anat Rec [Suppl 2]79: 31Google Scholar
  56. 56.
    Hendrickson MR, Kempson RL (1980) In: Bennington JL (ed) Surgical pathology of the uterine corpus. Philadelphia, London, Toronto, W.B. Saunders Co.Google Scholar
  57. 57.
    Hilliard GD, Norris JH (1979) The pathologic effects of oral contraceptives. In: Lingeman C (ed) Recent results in cancer research. Carcinogenic steroids. New York, Springer-Verlag, Vol 66, pp 49–71Google Scholar
  58. 58.
    Ho KH (1979) Sarcoidosis of the uterus. Hum Pathol 20: 219CrossRefGoogle Scholar
  59. 59.
    Hohnman WR, Shaw ST Jr, Macaulay L, Moyer DL (1977) Vascular defects in human endometrium caused by intrauterine contraceptive devices. Contraception 16: 507CrossRefGoogle Scholar
  60. 60.
    Holmstrom EG, McLennan CE (1947) Menorrhagia associated with irregular shedding of the endometrium. Am J Obstet Gynecol 53: 727PubMedGoogle Scholar
  61. 61.
    Home HW Jr, Hertig AT, Knudsin RB (1973) Sub-clinical endometrial inflammation and T-Mycoplasma. Int J Fertil 18: 226Google Scholar
  62. 62.
    Horta JLH, Fernandez JG, Soto de Leon B, Cortes Gallegos V (1977) Direct evidence of luteal insufficiency in women with habitual abortion. Obstet Gynecol 49: 705PubMedGoogle Scholar
  63. 63.
    Hsu C (1975) Endometrial ossification. Br J Obstet Gynaecol 82: 836PubMedCrossRefGoogle Scholar
  64. 64.
    Hunt JE, Wallach EE (1974) Uterine factors in infertility; An overview. Clin Obstet Gynecol 17: 44Google Scholar
  65. 65.
    Israel R, Mishell DR Jr, Labudovich M (1970) Mechanisms of normal and dysfunctional uterine bleeding. Clin Obstet Gynecol 13: 386PubMedCrossRefGoogle Scholar
  66. 66.
    Israel SL, Roitman, HB, Clancy C (1963) Infrequency of unsuspected endometrial tuberculosis. JAMA 183: 63PubMedCrossRefGoogle Scholar
  67. 66a.
    Iwasaka T, Wada T, Kidera Y, Sugimori H (1986) Hormonal status and mycoplasma colonization in the female genital tract. Obstet Gynecol 68: 263PubMedGoogle Scholar
  68. 67.
    Jewelewicz R, Khalaf S, Neuwirth RS, Vande Wide RL (1976) Obstetric complications after treatment of intrauterine synechiae ( Asherman’s syndrome ). Obstet Gynecol 47: 701Google Scholar
  69. 68.
    Jones GS (1972) Luteal phase insufficiency. Clin Obstet Gynecol 16: 255CrossRefGoogle Scholar
  70. 69.
    Jones GS (1975) Luteal phase defects. In: Behrman SJ, Kistner RW (eds) Progress in infertility, 2nd ed. Boston, Little, Brown, pp 299–324Google Scholar
  71. 70.
    Jones GS, Aksel S, Wentz AC (1974) Serum progesterone values in the luteal phase defects. Effects of chorionic gonadotropin. Obstet Gynecol 44: 26Google Scholar
  72. 71.
    Jorgensen V, Enevoldsen B (1964) The occurrence of the first menstruation after curettage. Acta Obstet Gynecol Scand 42 [Suppl 6]: 159PubMedCrossRefGoogle Scholar
  73. 72.
    Judd HL (1978) Endocrinology of polycystic ovarian disease. Clin Obstet Gynecol 21: 99PubMedCrossRefGoogle Scholar
  74. 73.
    Kahner S, Ferenczy A, Richart RM (1975) Homologous mixed müllerian tumors (carcinosarcoma) confined to endometrial polyps. Am J Obstet Gynecol 121: 278PubMedGoogle Scholar
  75. 74.
    Kaufman RH, Binder GL, Gray PN, et al. (1977) Upper genital tract changes associated with exposure in utero to diethylstilbestrol. Am J Obstet Gynecol 128: 51PubMedGoogle Scholar
  76. 75.
    Kaufman DW, Shapiro S, Rosenberg L, Monson RR, Miettnen OS, Stolley PD, Slone D (1980) Intrauterine contraceptive device use and pelvic inflammatory disease. Am J Obstet Gynecol 136: 159PubMedGoogle Scholar
  77. 76.
    Kelly HW, Miles PA, Buster JE, Scragg WH (1976) Adenocarcinoma of the endometrium in women taking sequential oral contraceptives. Obstet Gynecol 47: 200Google Scholar
  78. 77.
    Kraus FT (1973) Irradiation changes in the uterus. In: Hertig AT, Norris HJ, Abell MR (eds) International Academy of Pathology monograph number 14, The uterus. Baltimore, Williams & Wilkins, pp 457–488Google Scholar
  79. 78.
    Kurman RJ Scully RE (1976) Clear cell carcinoma of the endometrium. An analysis of 21 cases. Cancer 37: 872Google Scholar
  80. 79.
    Laatikainen T, Anderson B, Karkkainen J, et al. (1983) Progestin receptor levels in endometria with delayed or incomplete secretory changes. Obstet Gynecol 62: 592PubMedGoogle Scholar
  81. 80.
    Lackner JE, Krohn L (1932) Report of a case of teratoma of the uterus. Am J Obstet Gynecol 25: 735Google Scholar
  82. 81.
    Lamb EJ, Colliflower WW, Williams JW (1972) Endometrial histology and conception rates after clomiphene citrate. Obstet Gynecol 39: 389PubMedGoogle Scholar
  83. 82.
    Ledger WJ (1977) Infection in the female. Philadelphia, Lea & FebigerGoogle Scholar
  84. 83.
    Lyon FA, Frisch MJ (1976) Endometrial abnormalities occurring in young women on long-term sequential oral contraception. Obstet Gynecol 47: 639PubMedGoogle Scholar
  85. 84.
    Maathius JB, Horbach JGM, Hall EV (1972) A comparison of the results of hysterosalpingography and laporoscopy in the diagnosis of fallopian tube dysfunction. Fertil Steril 23: 428Google Scholar
  86. 85.
    Markee JE (1948) Morphological basis for menstrual bleeding. Bull NY Acad Med 24: 253Google Scholar
  87. 86.
    Martin E, Scholes J, Richart RM, Fenoglio CM (1979) Benign cystic teratoma of the uterus. Am J Obstet Gynecol 135: 429PubMedGoogle Scholar
  88. 87.
    Martinex-Manautou J, Maqueo M, Aznar R, Phariss BB, Zaffaroni A (1975) Endometrial morphology in women exposed to intrauterine systems releasing progesterone. Am J Obstet Gynecol 121: 175Google Scholar
  89. 88.
    Mazur MT (1981) Atypical polypoid adenomyoma of the endometrium. Am J Surg Pathol 5: 473PubMedCrossRefGoogle Scholar
  90. 89.
    McCormick JF, Scorgie RDF (1977) Unilateral tubo-ovarian actinomycosis in the presence of an intrauterine device. Am J Clin Pathol 68: 622PubMedGoogle Scholar
  91. 90.
    McCracken AW, D’Agostino AN, Brucks AB, Kingsly WB (1974) Acquired cytomegalovirus infection presenting as viral endometritis. Am J Clin Pathol 61: 556PubMedGoogle Scholar
  92. 91.
    McKelvey JL (1942) Irregular shedding of the endometrium. Lancet 2: 434Google Scholar
  93. 92.
    McKusick VA, Welhalcher RC, Gragg GW (1968) Recessive inheritance of a congenital malformation syndrome. JAMA 204: 113PubMedCrossRefGoogle Scholar
  94. 93.
    McLennan CE (1952) Current concepts of prolonged or irregular endometrial shedding. Am J Obstet Gynecol 64: 988PubMedGoogle Scholar
  95. 94.
    Mead PB, Beecham JB, Van S Maeck J (1976) Incidence of infections associated with the intrauterine contraceptive device in an isolated community. Am J Obstet Gynecol 125: 79PubMedGoogle Scholar
  96. 95.
    Mears E (1965) Handbook on oral contraception. London, ChurchillGoogle Scholar
  97. 96.
    Meissner WA, Sommers SC, Sherman G (1957) Endometrial hyperplasia, endometrial carcinoma, and endometriosis produced experimentally by estrogen. Cancer 10: 500PubMedCrossRefGoogle Scholar
  98. 97.
    Mishell DR Jr, Moyer DL (1969) Association of pelvic inflammatory disease with the intrauterine device. Clin Obstet Gynecol 12: 179PubMedCrossRefGoogle Scholar
  99. 98.
    Moghissi KS (1975) Endometrium and endosalpinx of women treated with microdose progestogens. J Reprod Med 14: 217PubMedGoogle Scholar
  100. 99.
    Molnar JT, Poliak A (1983) Recurrent endometrial malakoplakia. Am J Clin Pathol 80: 762PubMedGoogle Scholar
  101. 100.
    Monif GRR (1974) Infectious diseases in obstetrics and gynecology. New York, Harper & RowGoogle Scholar
  102. 101.
    Moore DE, Spandoni LR, Foy HH, et al. (1982) Increased frequency of serum antibodies to Chlamydia trachomatis in infertility due to distal tubal disease. Lancet 1: 574CrossRefGoogle Scholar
  103. 102.
    Moszkowski E, Woodruff JD, Jones GS (1962) The inadequate luteal phase. Am J Obstet Gynecol 83: 363PubMedGoogle Scholar
  104. 103.
    Mouktar M (1966) Functional disorders due to bilharzial infection of the female genital tract. J Obstet Gynecol Br Commonw 73: 307CrossRefGoogle Scholar
  105. 104.
    Moyer DL (1975) Endometrial lesions in infertility. In: Behrman SJ, Kistner RW (eds) Progress in infertility, 2nd ed. Boston, Little, Brown, pp 91–115Google Scholar
  106. 105.
    Moyer DL, Mishell DR Jr (1971) Reactions of human endometrium to the intrauterine foreign body. II. Longterm effects on the endometrial histogy and cytology. Am J Obstet Gynecol 111: 66Google Scholar
  107. 106.
    Moyer DL, Mishell DR Jr, Bell J (1970) Reactions of human endometrium to the intrauterine device. I. Correlation of the endometrial histology with the bacterial environment of the uterus following short-term insertion of the IUD. Am J Obstet Gynecol 106: 799Google Scholar
  108. 107.
    Newton CW III, Abell MR (1973) Iatrogenic fetal implants. Obstet Gynecol 40: 686Google Scholar
  109. 108.
    Niebyl JR, Parmley TH, Spence MR, Woodruff JD (1978) Unilateral ovarian abscess associated with the intrauterine device. Obstet Gynecol 52: 165PubMedGoogle Scholar
  110. 109.
    Nicholson GW (1956) Studies of tumour formation: Polypoid teratoma of the uterus. Guy’s Hosp Rep 205: 157Google Scholar
  111. 110.
    Niven PAR, Stansfeld AG (1973) “Glioma” of the uterus: A fetal homograft. Am J Obstet Gynecol 115: 434Google Scholar
  112. 111.
    Nogales-Ortiz F, Taranco I, Nogales FF Jr (1979) The pathology of female genital tuberculosis. A 31-year study of 1436 cases. Obstet Gynecol 53: 422PubMedGoogle Scholar
  113. 112.
    Novak E (1933) Recent advances in the physiology of menstruation. Can menstruation occur without ovulation? JAMA 94: 833CrossRefGoogle Scholar
  114. 113.
    Noyes RW (1973) Normal phases of the endometrium. In: Norris HJ, Hertig AT, Abell MR (eds) The uterus. Baltimore, William & Wilkins, pp 110–135Google Scholar
  115. 114.
    Noyes RW, Haman JO (1954) Accuracy of endometrial dating. Fertil Steril 4: 504Google Scholar
  116. 115.
    Ober WB (1966) Synthetic progesten-oestrogen preparations and endometrial morphology. J Clin Pathol 19: 138PubMedCrossRefGoogle Scholar
  117. 116.
    Ober WB (1977) Effects of oral and intrauterine administration of contraceptives on the uterus. Hum Pathol 8: 513PubMedCrossRefGoogle Scholar
  118. 117.
    Ober WB, Bronstein SB (1967) Endometrial morphology following oral administration of quinestrol. Int J Fertil 23: 210Google Scholar
  119. 118.
    Ober WB, Sobrero AJ, Kurman R, Gold S (1968) Endometrial morphology and polyethylene intrauterine devices. A study of 200 endometrial biopsies. Obstet Gynecol 32: 782PubMedGoogle Scholar
  120. 119.
    Ory HW (1978) A review of the association between intrauterine devices and acute pelvic inflammatory disease. J Reprod Med 20: 200PubMedGoogle Scholar
  121. 120.
    Osborne JL, Bennett MJ (1978) Removal of intraabdominal intrauterine contraceptive devices. Br J Obstet Gynecol 85: 868CrossRefGoogle Scholar
  122. 121.
    Osborne NG (1977) The significance of mycoplasma in pelvic infection. J Reprod Med 19: 39PubMedGoogle Scholar
  123. 122.
    Oster G, Salgo MP (1975) The copper intrauterine device and its mode of action. N Engl J Med 293: 432PubMedCrossRefGoogle Scholar
  124. 123.
    Paavonen J, Aine R, Teisala K, et al. (1985) Comparison of endometrial biopsy and peritoneal fluid cytologic testing with laporoscopy in the diagnosis of acute pelvic inflammatory disease. Am J Obstet Gynecol 151: 645PubMedGoogle Scholar
  125. 124.
    Paavonen J, Aime K, Teisala K, et al. (1985) Chlamydial endometritis. J Clin Pathol 38: 726PubMedCrossRefGoogle Scholar
  126. 125.
    Paavonen J, Kiviat N, Brunham RC et al. (1985) Prevalence and manifestations of endometritis among women with cervicitis. Am J Obstet Gynecol 152: 280PubMedGoogle Scholar
  127. 126.
    Payan H, Daino J, Kish M (1964) Lymphoid follicles in endometrium. Obstet Gynecol 23: 570Google Scholar
  128. 127.
    Perkins MB (1960) Pneumopolycystic endometritis. Am J Obstet Gynecol 80: 332PubMedGoogle Scholar
  129. 128.
    Peterson WF, Novak ER (1956) Endometrial polyps. Ob-stet Gynecol 8: 40Google Scholar
  130. 129.
    Plant A (1950) Human infection with Cryptococcus glabre-tus. Report of case involving uterus and fallopian tube. Am J Clin Pathol 20: 377Google Scholar
  131. 130.
    Povey WG (1970) Abnormal uterine bleeding at puberty and climacteric. Clin Obstet Gynecol 13: 474PubMedCrossRefGoogle Scholar
  132. 131.
    Rao NB (1969) Malacoplakia of broad ligament, inguinal region and endometrium. Arch Pathol 88: 85PubMedGoogle Scholar
  133. 132.
    Remington JS (1973) Toxoplasmosis. In: Charles D, Finland M (eds) Obstetric and perinatal infections. Philadelphia, Lea & Febiger, pp 27–74Google Scholar
  134. 132a.
    Robb JA, Benirschke K, Barmeyer R (1986) Intrauterine latent herpes simplex virus infection: I. Spontaneous abortion. Hum Pathol 17: 1196Google Scholar
  135. 133.
    Roca AN, Guajardo M, Estrada WJ (1980) Glial polyp of the cervix and endometrium. Report of a case and review of the literature. Am J Clin Pathol 73: 718Google Scholar
  136. 134.
    Rock J, Garcia CR, Menkin, MF (1959) A theory of menstruation. Ann NY Acad Sci 75: 831PubMedCrossRefGoogle Scholar
  137. 135.
    Rodriguez M, Okagaki T, Richart RM (1972) Mycotic en dometritis due to Candida. A case report. Obstet Gynecol 39: 292Google Scholar
  138. 136.
    Rosenfeld DL, Chudow S, Bronson RA (1980) Diagnosis of luteal phase inadequacy. Obstet Gynecol 56: 193PubMedGoogle Scholar
  139. 137.
    Roth E, Taylor HB (1966) Heterotopic cartilage in uterus. Obstet Gynecol 27: 838PubMedGoogle Scholar
  140. 138.
    Rotterdam H (1978) Chronic endometritis: A clinicopathologic study, Pathol Annu 13: 209PubMedGoogle Scholar
  141. 139.
    Salm R (1972) The incidence and significance of early carcinomas in endometrial polyps. J Pathol 108: 47PubMedCrossRefGoogle Scholar
  142. 140.
    Saw, EC, Smale LE, Einstein H, Huntington RW (1975) Female genital coccidioidomycosis. Obstet Gynecol 45: 199PubMedGoogle Scholar
  143. 141.
    Schenken JR, Tamisiea J (1956) Enterobius vermicularis (pinworm) infection of the endometrium. Am J Obstet Gynecol 72: 913Google Scholar
  144. 142.
    Schneider V, Behm FG, Mumaw VR (1982) Ascending herpetic endometritis. Obstet Gynecol 59: 259PubMedGoogle Scholar
  145. 143.
    Scommegna A, Dmowski WP (1973) Dysfunctional uterine bleeding. Clin Obstet Gynecol 16: 221PubMedCrossRefGoogle Scholar
  146. 144.
    Shaw ST, Maucaulay LK, Hohman WR (1979) Vessel density in endometrium of women with and without intrauterine contraceptive devices. A morphometric evaluation. Am J Obstet Gynecol 135: 101Google Scholar
  147. 145.
    Silverberg SG, Makowski EL (1975) Endometrial carcinoma in young women taking oral contraceptive agents. Obstet Gynecol 46: 503PubMedGoogle Scholar
  148. 146.
    Silverberg SG, Makowski EL, Roche WD (1977) Endometrial carcinoma in women under 40 years of age: Comparison of cases in oral contraceptive users and nonusers. Cancer 39: 592Google Scholar
  149. 147.
    Sinykin MB, Goodlin RC, Barr MM (1956) Irregular shedding of the endometrium. Am J Obstet Gynecol 71: 990PubMedGoogle Scholar
  150. 148.
    Sobrino LG, Kase N (1970) Endocrinologie aspects of dysfunctional uterine bleeding. Clin Obstet Gynecol 13: 400CrossRefGoogle Scholar
  151. 149.
    Smiles MR, Wiebe RH, Aksel S, Hammond CB (1977) The diagnosis and therapy ofluteal phase deficiency. Fertil Steril 28: 1033Google Scholar
  152. 150.
    Southam AL, Richart RM (1966) The prognosis for adolescents with menstrual abnormalities. Am J Obstet Gynecol 94: 637PubMedGoogle Scholar
  153. 151.
    Speroff L, Glass RH, Kase NG (1983) Clinical gynecologic endocrinology and infertility, 3rd ed. Baltimore, Williams & Wilkins, pp 467–492Google Scholar
  154. 152.
    Spirtos NJ, Yurewicz EC, Moghisii KS, et al. (1985) Pseudocorpus luteum insufficiency: A study of cytosol progesterone receptors in human endometrium. Obstet Gynecol 65: 535Google Scholar
  155. 153.
    Stray-Pedersen B, Lorentzen-Styr A-M (1977) Uterine toxoplasma infections and repeated abortions. Am J Obstet Gynecol 128: 716PubMedGoogle Scholar
  156. 154.
    Stray-Pedersen B, Bruu A-L, Molne K (1982) Infertility and uterine colonization with Ureaplasma urealyticum. Acta Obstet Gynecol Scand 61: 21PubMedCrossRefGoogle Scholar
  157. 155.
    Stray-Pedersen B, Eng J, Reikvam TM (1978) Uterine T-mycoplasma colonization in reproductive failure. Am J Obstet Gynecol 130: 307PubMedGoogle Scholar
  158. 156.
    Sutherland AM (1958) Tuberculosis of endometrium: A report of 250 cases with results of drug treatment. Obstet Gynecol 11: 527PubMedGoogle Scholar
  159. 157.
    Tam MR, Stamm WE, Handsfield HH, et al. (1984) Culture-independent diagnosis of Chlamydia trachomatis using monoclonal antibodies. N Engl J Med 310: 1146PubMedCrossRefGoogle Scholar
  160. 158.
    Targum SD, Wright NH (1974) Association of th6 intrauterine device and pelvic inflammatory disease: A retrospective pilot study. Am J Epidemiol 100: 262Google Scholar
  161. 159.
    Taylor AB (1960) Sarcoidosis of the uterus. J Obstet Gynecol Br Emp 67: 32CrossRefGoogle Scholar
  162. 160.
    Taylor RN, Welch KL, Sklar DM, et al. (1984) Heterotopic skin in the uterus. A report of an unusual case. J Reprod Med 29: 837Google Scholar
  163. 161.
    Taylor-Robinson D, McCormack WM (1980) The genital mycoplasmas. Part 1. N Engl J Med 302: 1003Google Scholar
  164. 162.
    Taylor-Robinson D, McCormack WM (1980) The genital mycoplasmas. Part 2. N Engl J Med 302: 1063Google Scholar
  165. 163.
    Thiery M (1955) Irregular shedding of the endometrium. Gynaecologia (Basel) 139: 1Google Scholar
  166. 164.
    Thomas W Jr, Sadeghieh B, Fresco R, Rubenstone AI, Stepto RC, Carasso B (1978) Malacoplakia of the endometrium, a probable cause of postmenopausal bleeding. Am J Clin Pathol 69: 637PubMedGoogle Scholar
  167. 165.
    Toaff R, Ballas S (1978) Traumatic hypomenorrhea-amenorrhea ( Asherman’s syndrome ). Fertil Steril 30: 379Google Scholar
  168. 165a.
    Venkataseshan VS, Woo TH (1985) Diffuse viral papillomatosis (condyloma) of the uterine cavity. Int J Gynecol Pathol 4: 370PubMedCrossRefGoogle Scholar
  169. 166.
    Wallach EE (1972) The uterine factor in infertility. Fertil Steril 23: 138PubMedGoogle Scholar
  170. 167.
    Weicker ML, Kaneb GD, Goodale RH (1940) Primary echinococcal cyst of the uterus. N Engl J Med 223: 574CrossRefGoogle Scholar
  171. 168.
    Weiss NS, Sayvetz TA (1980) Incidence of endometrial cancer in relation to the use of oral contraceptives. N Engl J Med 302: 551PubMedCrossRefGoogle Scholar
  172. 169.
    Wenckelbach GFC, Curry B (1976) Cytomegalovirus infection of the female genital tract. Histologic findings in three cases and review of the literature. Arch Pathol Lab Med 100: 1609Google Scholar
  173. 170.
    Wentz AC (1980) Endometrial biopsy in the evaluation of infertility. Fertil Steril 33: 121PubMedGoogle Scholar
  174. 171.
    Wentz AC (1982) Diagnosing luteal phase inadequacy. Fertil Steril 37: 334PubMedGoogle Scholar
  175. 172.
    Wentz AC, Herbert CM, Maxson WS, Garner CH (1984) Outcome of progesterone treatment of luteal phase inadequacy. Fertil Steril 41: 856PubMedGoogle Scholar
  176. 173.
    Westrom L, Bentsson LP, Mordh PA (1976) The risk of pelvic inflammatory disease in women using intrauterine contraceptive devices as compared to nonusers. Lancet 2: 221PubMedCrossRefGoogle Scholar
  177. 174.
    Williams AO (1967) Pathology of schistosomiasis of the uterine cervix due to S. haematobium. Am J Obstet Gynecol 98: 784PubMedGoogle Scholar
  178. 175.
    Winkler B, Reumann W, Mitao M (1984) Chlamydial endometritis. A histological and immunohistochemical analysis. Am J Surg Pathol 8: 771Google Scholar
  179. 176.
    Winter JD, Faiman C, Reyes FI (1978) Normal and abnormal pubertal development. Clin Obstet Gynecol 21: 67PubMedCrossRefGoogle Scholar
  180. 177.
    Winter JD, Kohn G, Mellinin WJ, et al. (1968) A familial syndrome of renal, genital, and middle ear anomalies. J Pediatr 72: 88PubMedCrossRefGoogle Scholar
  181. 178.
    Wolfe SA, Mackles A (1960) Malignant lesions arising from benign endometrial polyps. Obstet Gynecol 20: 542Google Scholar
  182. 179.
    Woodruff JD, Pauerstein CJ (1969) The fallopian tube structure: Function, pathology and management. Baltimore, Williams & WilkinsGoogle Scholar
  183. 180.
    Wynn RM (1967) Intrauterine devices: Effects on ultra-structure of human endometrium. Science 156: 1508PubMedCrossRefGoogle Scholar
  184. 181.
    Wynn RM (1968) Fine structural effects of intrauterine contraceptives on the human endometrium. Fertil Steril 19: 867Google Scholar
  185. 182.
    Yaffe H, Ron M, Polishuk WZ (1978) Amenorrhea, hypomenorrhea, and uterine fibrosis. Am J Obstet Gynecol 130: 599PubMedGoogle Scholar
  186. 183.
    Young RH, Kleinman GM, Scully RE (1981) Glioma of the uterus. Am J Surg Pathol 5: 695PubMedCrossRefGoogle Scholar
  187. 184.
    Young RH, Treger T, Scully RE (1986) Atypical polypoid adenomyoma of the uterus. A report of 27 cases. Am J Clin Pathol 86: 139PubMedGoogle Scholar
  188. 185.
    Zettergren L (1973) Glial tissue in the uterus. Am J Pathol 171: 419Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Robert J. Kurman
  • Michael T. Mazur

There are no affiliations available

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