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The Association of Mixed Lymphocyte Reaction (MLR) Blocking Factors and Maternal Antipaternal Leukocytotoxic Antibodies with Pregnancy Outcome in Women with Recurrent Abortions Immunized with Paternal or Third Party Leukocytes

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Cellular Biology and Pharmacology of the Placenta

Part of the book series: Trophoblast Research ((TR))

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Abstract

Our recent investigations have been directed toward analyzing an immunogentic basis for recurrent idiopathic spontaneous abortions in human couples (Beer et al., 1985). We have limited our study to couples who were evaluated medically, genetically, microbiologically, and structurally as previously reported by us and were found to lack any etiology known to be associated with recurrent pregnancy losses (Beer et al., 1983). All couples had an immunogenetic work up as outline in Table 1. The materials and methods utilized in this study have been reported previously (Beer et al., 1981).

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References

  • Beard, R.W., Braude, P., Mowbray, J.F., and Underwood, J.L. (1983) Protective antibodies and spontaneous abortion. Lancet, Nov. 5, 1090.

    Google Scholar 

  • Beer, A.E., and Billingham, R.E. (1977) Histocompatibility gene polymorphism and maternal-fetal relationships. Transplant. Proc. 9, 1393–1401.

    CAS  PubMed  Google Scholar 

  • Beer, A.E., Quebbeman, J.F., Ayers, J.W.T., and Haines, R.F. (1981) Major histocompatibility complex antigens, maternal and paternal immune responses, and chornic habitual abortions in humans. Am. J. Obstet. Gynecol. 141, 987.

    CAS  PubMed  Google Scholar 

  • Beer, A.E., Quebbeman, J.F., Semprini, A.E., Smouse, P.E., and Haines, R.F. (1983) Recurrent abortion: Analysis of the roles of parental sharing of histocompatibility antigens and maternal immunological responses to paternal antigens. In: Reproductive Immunology, (eds.), S. Isojima and W.D. Billingham, Elsevier Science Publishers, Amsterdam.

    Google Scholar 

  • Beer, A.E. (1984) How did your mother not reject you? Ann. Immunol. ( Inst. Pasteur ) 135D, 315–318.

    Google Scholar 

  • Beer, A.E., Quebbeman, J.F., Hamazki, Y., and Semprini, A.E. (1985a) Pregnancy outcome in human couples with recurrent spontaneous abortions: The role(s) of HLA antigen sharing, ABO blood group antigen profiles, female serum MLR blocking factors, antisperm antibodies and immunotherapy. In: Proceedings of Second Banff Conference on Reproductive Immunology: Immunoregulation of the Maternal-Fetal Interface,(eds.), T.G. Wegmann and T.J. Gill, III, Banff, Alberta, Canada, in press.

    Google Scholar 

  • Beer, A.E., Semprini, A.E., Xiaou, Zhu., and Quebbeman, J.F. (1985b) Pregnancy outcome in human couples with recurrent spontaneous abortions: 1) HLA antigen profiles; 2) HLA antigen sharing; 3) Female serum MLR blocking factors, and 4) Paternal leukocyte immunization. Exp. Clin. Immunogene. 2 (3), 1–12.

    Google Scholar 

  • Beer, A.E., Xiaoyu, Zhu., Semprini, A.E., and Quebbeman, J.F. (1985c) Pregnancy outcome in human couples with idiopathic recurrent abortions: The role(s) of female serum mixed lymphocyte culture blocking factors, potentiating factors, and local uterine immunity before and after paternal leukocyte immunization. In: Proceedings of Fogarty International Symposium: Immunological Approaches to Contraception and Promotion of Fertility,(ed.), P. Talwar, NIH, Bethesda, Maryland, in press.

    Google Scholar 

  • Bennett, D. (1975) The T locus of the mouse cell. Cell 6, 441–454.

    Article  Google Scholar 

  • Betuel, H., Touraine, J.L., Malik, M.D., Bonnet, M.C., Carrie, J., and Traeger, J. (1982) A policy of deliberate transfusions before kidney transplantation. Transplant. Proc. 14, 151–155.

    Google Scholar 

  • Boyce, E.A., Beauchamp, G.K., and Y amakazi, K. (1983) The sensory perception of genotypic polymorphism of the major histocompatibility complex and other genes: Some physiological and phylogenetic implications. Hum. Immun. 6, 177–183.

    Article  Google Scholar 

  • Chaouat, G., Kiger, N., and Wegmann, T.G. (1983) Vaccination against spontaneous abortion in mice. J. Reprod. Immunol. 5, 389–392.

    Article  CAS  PubMed  Google Scholar 

  • Faulk, W.P., Temple, A., Lovins, R.E., and Smith, N. (1978) Antigens of human trophoblasts: A working hypothesis for their role in normal and abnormal pregnancies. Proc. Nat. Acad. Sci. USA 75, 1947–1951.

    Article  CAS  PubMed  Google Scholar 

  • Gill, T.J. (1983) Immunogenetics of spontaneous abortions in humans. Transplant. 35, 1–6.

    Article  Google Scholar 

  • Gill, T.J. III, Siew, S., and Kunz, H.W. (1983) MHC-linked genes affecting development. J. Exp. Zool. 228, 325.

    Article  PubMed  Google Scholar 

  • Hings, I.M., and Billingham, R.E. (1981) Splenectomy and sensitization of Fischer female rats favors histoincompatibility of R2 back-cross progeny. Transplant. Proc. 13, 1253–1255.

    CAS  PubMed  Google Scholar 

  • Klatzmann, D., Gluckman, J.C., Foucault, C., Buboust, A., Bensussan, A., Assogba, J., and Berthelot, J.M. (1983) Modification of mixed lymphocyte reactivity after blood transfusions in man. Transplant. Proc. 15, 1011–1015.

    Google Scholar 

  • Lenhard, V., Maassen, G., Grosse-Wilde, H., Wernet, P., and Opelx, G. (1983) Effect on blood transfusions on immunoregulatory mononuclear cells in prospective transplant recipients. Transplant. Proc. 15, 1011–1015.

    Google Scholar 

  • McIntyre, J.A. and Faulk, W.P. (1982) Allotypic trophoblast lymphocyte crossreactive (TLX) cell surface antigens. Hum. Immunol. 4, 27.

    Article  CAS  PubMed  Google Scholar 

  • McLeod, A.M., Mason, R.J., Stewart, K.N., Power, D.A., Shewan, W.G., Edward, N., and Gatto, G.R.D. (1983) Fc-receptor blocking antibodies develop after blood transfusions and correlate with good graft outcome. Transplant. Proc. 15, 1019–1021.

    Google Scholar 

  • Michie, D., and Anderson, N.F. (1971) A strong selective effect associated with a histocompatibility gene in the rat. Ann. NY Acad Sci. 129, 88–93.

    Article  Google Scholar 

  • Mowbray, J.F., Gibbings, C., Liddell, H., Reginald, P.W., Underwood, J.L., and Beard, R.W. (1985) Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet 1, 941–943.

    Article  CAS  PubMed  Google Scholar 

  • Palm, J. (1969) Association of maternal genotype and excess heterozygosity for Ag-B histocompatibility antigens among male rats. Transplant. Proc. 1 (1), 82–84.

    CAS  PubMed  Google Scholar 

  • Palm, J. (1970) Maternal-fetal interactions and histocompatibility antigen polymorphisms. Transplant. Proc. 2, 162–173.

    CAS  PubMed  Google Scholar 

  • Persijn, G.G., Cohen, B., Lansbergen, Q., and van Rood, J.J. (1979) Retrospective and prospective studies on the effect of blood transfusions in renal transplantation in the Netherlands. Transplant. 28, 296–401.

    Google Scholar 

  • Singal, D.P., Fagnilli, L., and Joseph, S. (1983) Blood transfusions induce antiidiotypic antibodies in renal transplant patients. Transplant. Proc. 15, 1005–1008.

    Google Scholar 

  • Sucia-Foca, N., Reed, E., Rohowsky, C., Kung, P., and King, D.W. (1983) Antiidiotypic antibodies to anti-HLA receptors induced by pregnancy. Proc. Natl. Acad. Sci. Feb., 830.

    Google Scholar 

  • Thomas, M.L., Harger, J.H., Wagener, D.K., Rabin, B.S., and Gill, T.J., III (1985) Sharing and spontaneous abortion in humans. Am. J. Obstet. Gynecol. 151, 1053–1058.

    Article  CAS  PubMed  Google Scholar 

  • Voisin, G.A., and Chaouat, G. (1974) Demonstration, nature, and properties of maternal antibodies fixed on placenta, and directed against paternal antigens. J. Reprod. Fertil. 21 (Suppl.), 89.

    Google Scholar 

  • Woodruff, M.F.A. and van Rood, J.J. (1983) Possible implications of the effect of blood transfusion on allograft survival. Lancet 1, 555–556.

    Google Scholar 

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Beer, A.E., Quebbeman, J.F., Semprini, A.E., Xiaoyu, Z. (1987). The Association of Mixed Lymphocyte Reaction (MLR) Blocking Factors and Maternal Antipaternal Leukocytotoxic Antibodies with Pregnancy Outcome in Women with Recurrent Abortions Immunized with Paternal or Third Party Leukocytes. In: Miller, R.K., Thiede, H.A. (eds) Cellular Biology and Pharmacology of the Placenta. Trophoblast Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1936-9_14

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  • DOI: https://doi.org/10.1007/978-1-4757-1936-9_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1938-3

  • Online ISBN: 978-1-4757-1936-9

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