Lecithin pp 155-166 | Cite as

Dissemination and Activity of AL 721 after Oral Administration

  • Meir Shinitzky
  • Rachel Haimovitz
Part of the Advances in Behavioral Biology book series (ABBI, volume 33)


Absorption of phospholipids in the small intestine is, in general, associated with hydrolysis by pancreatic lipases to water soluble products that eventualy reintegrate in the mucosa cells. An alternative route of phospholipid absorption is by endocytosis of small and tight assemblies like liposomes without hydrolysis. It might be therefore expected that shortly after absorption of phospholipids through one of these routes their composition in the blood stream is largely preserved. Along this rationale AL 721, a lipid mixture designated to reduce excess cholesterol from peripheral membranes, can be administered per os for in vivo application. A series of animal and human studies, where AL 721 was administered per os, lend support to this conclusion.


High Density Lipoprotein Pancreatic Lipase Membrane Cholesterol Cell Plasma Membrane Mitogenic Stimulation 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Meir Shinitzky
    • 1
  • Rachel Haimovitz
    • 1
  1. 1.Department of Membrane ResearchThe Weizmann Institute of ScienceRehovotIsrael

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