Lecithin pp 147-153 | Cite as

Effects of Lecithin on Memory and Learning

  • Hardo Sorgatz
Part of the Advances in Behavioral Biology book series (ABBI, volume 33)


The effects of cholinergic agonists and antagonists on mnestic performance has been documented by a variety of experimental studies with animals and human beings. A summary on this topic was published by Drachman & Sahakian in 1979. These studies seem to substantiate the theory of a performance impairing effect of cholinergic antagonists, whereas a hypothesis of a memory supporting function of cholinergic agonists currently lacks empirical support and is based only on theoretical assumptions. Mainly for patients with presenile and senile dementia it could be demonstrated that mnestic impairment can be decreased by choline, physostigmine and lecithin (Etienne et al., 1979; Vroulis et al., 1981; Tweedy & Garcia, 1982; Wood & Allison, 1982; Johns et al., 1983 and Thal et al., 1983). On the other hand, Christie et al. (1979) report that lecithin had no effect on the memory performances of 12 patients with Morbus Alzheimer and only for a very few patients a tendency toward improved performance was observable.


Verbal Memory Senile Dementia Cholinergic Agonist Cholinergic Antagonist Choline Metabolism 
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  1. Bäumler, G. Lern-und Gedächtnistest LGT-3. Handanweisung. Göttingen: Hogrefe, 1974.Google Scholar
  2. Benton, A.L. A visual retention test for clinical use. Archives of Neurology and Psychiatry, 1945, 54, 212–216.PubMedCrossRefGoogle Scholar
  3. Christie, J.E., Blackburn, I.M., Glen, A.I.M., Zeisel, S., Shering, A. & Yates, CM. Effects of choline and lecithin on CSF choline and on cognitive function in patients with presenile dementia of the Alzheimer type. In: A. Barbeau, J.H. Growdon, and R.J. Wurtman (Eds.) Nutrition and the Brain. New York: Raven Press, 1979, 377–469.Google Scholar
  4. Davis, K., Mohs, R., Tinklenberg, J., Pfefferbaum, A., Hollister, L. & Kopell, B. Physostigmine: improvement of long-term memory processes in normal humans. Science, 1978, 201, 272–274.PubMedCrossRefGoogle Scholar
  5. Drachman, D. & Leavitt, J. Human memory and the cholinergic system: a relationship to aging? Archives of Neurology, 1974, 30, 113–121.PubMedCrossRefGoogle Scholar
  6. Etienne, P., Gauthier, S., Dastoor, D., Collier, B. & Ratner, J. Alzheimer’s disease: Clinical effect of lecithin treatment. In: A. Barbeau, J.H. Growdon & R.J. Wurtman (Eds.) Nutrition and the Brain. New York: Raven Press, 1979, 389–396.Google Scholar
  7. Johns, C.A., Greenwald, B.S., Mohs, R.C. & Davis, K.L. The cholinergic treatment strategy in aging and senile dementia, Psychopharmacology Bulletin, 1983, 19, 185–197.PubMedGoogle Scholar
  8. Sitaram, N., Weingartner, H. & Gillin, J. Human serial learning: Enhancement with arecholine and choline and impairment with scopolamine. Science, 1978, 201, 274–276.PubMedCrossRefGoogle Scholar
  9. Spreen, O. Der Benton-Test. Handbuch. Bern: Huber, 1974.Google Scholar
  10. Thal, L.J., Fuld, P.A., Masur, D.M., Sharpless, N.S. & Davies, P. Oral physostigmine and lecithin improve memory in Alzheimer’s disease, Psychopharmacology Bulletin, 1983, 9, 454–456.Google Scholar
  11. Tweedy, J.R. & Garcia, C.A. Lecithin treatment of cognitively impaired Parkinsons patients. European Journal of Clinical Investigation, 1982, 12, 87–90.PubMedCrossRefGoogle Scholar
  12. Vroulis, G.A., Smith, R.C., Brinkman, S., Schoolar, J. & Gordon, J. The effects of lecithin on memory in patients with senile dementia of Alzheimer’s type. Psychopharmacology Bulletin, 1981, 17, 127–128.PubMedGoogle Scholar
  13. Wood, J.L. & Allison, R.G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems, Federation Proceedings, 1982, 41, 3015–3021.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Hardo Sorgatz
    • 1
  1. 1.Institute of PsychologyTechnical University of DarmstadtFederal Republic of Germany

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