The Therapeutic Value of Phosphatidylserine Effect in the Aging Brain
As the elucidation of the biological roles of membrane phospholipids has progressed, a new field of investigation dealing with the pharmacological effects of these compounds has become possible (Table 1). Cellular membranes in addition to their property of delimiting compartments, are endowed with surface recognition sites which, in specialized instances, yield the means of offense and defense reactions (Bruni and Toffano, 1982). The administration of phospholipid liposomes has been shown to activate blood clotting (Zwaal, 1978), complement pathways (Cunningham et al., 1979; Richards et al., 1979) and phagocytosis (Hudson et al., 1979; Wu et al., 1981). In addition, the exogenous phospholipids may enter the pathways of phospholipid metabolism yielding a number of short-lived compounds showing powerful regulation effects on biological and physiopathological phenomena. These products can be named lipid autacoid drugs since they are active drugs made in the organism itself.
KeywordsNerve Growth Factor Passive Avoidance Passive Avoidance Test Active Avoidance Test Dendritic Spine Loss
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