Structural and Biophysical Basis of Tubular Transport

  • Esmail Koushanpour
  • Wilhelm Kriz
Chapter

Abstract

The ultrafiltrate as it traverses the various nephron segments undergoes considerable modifications both in volume and in composition. The small volume of excreted urine is largely due to reabsorption of nearly all the ultrafiltrate, both solutes and water, along with the addition of some important solutes by tubular secretion.

Keywords

Tight Junction Tubular Transport Substrate Flux Junctional Strand Basal Infoldings 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bodansky O: Diagnostic applications of enzymes in medicine. Am J Med 1959; 27: 861 - 874.PubMedCrossRefGoogle Scholar
  2. 2.
    Britton HG: Permeability of the human red cell to labelled glucose. J Physiol 1964; 170: 1 - 20.PubMedGoogle Scholar
  3. 3.
    Christensen HN: Biological Transport, ed 2. Reading, Mass, Addison-Wesley Publishing Co, 1975.Google Scholar
  4. 4.
    DiBona DR, Mills JW: Distribution of Na’-pump sites in transporting epithelia. Fed Proc 1979; 38: 134 - 143.PubMedGoogle Scholar
  5. 5.
    Drenckhahn D, Groschel-Stewart U: Localization of myosin, actin, and tropomyosin in rat intestinal epithelium: Immunohistochemical studies at the light and electron microscope levels. J Cell Biol 1980; 86: 475 - 482.PubMedCrossRefGoogle Scholar
  6. 6.
    Erlij D, Martinez-Palomo A: Role of tight junctions in epithelial function, in Giebisch G, Tosteson DC, Ussing HH (eds): Membrane Transport in Biology. vol 3. Berlin, Springer-Verlag, 1978, pp 27 - 53.Google Scholar
  7. 7.
    Frieden C: Treatment of enzyme kinetic data. J Biol Chem 1964; 239 (19): 3522 - 3531.PubMedGoogle Scholar
  8. 8.
    Ganote CE, Grantham JJ, Moses HL, et al: Ultra-structural studies of vasopressin effect on isolated per-fused renal collecting tubules of the rabbit. J Cell Biol 1968; 36: 355 - 367.PubMedCrossRefGoogle Scholar
  9. 9.
    Kaissling B: Structural aspects of adaptive changes in renal electrolyte excretion. Am J Physiol 1982; 243: F211 - F226.PubMedGoogle Scholar
  10. 10.
    Katz A: Renal Na-K-ATPase: its role in tubular sodium and potassium transport. Am J Physiol 1982; 242: F207 - F219.PubMedGoogle Scholar
  11. 11.
    Koushanpour E: Renal Physiology: Principles and Functions, ed 1. Philadelphia, WB Saunders Co, 1976.Google Scholar
  12. 12.
    Kriz W: Der Bau transportierender Epithelien. Verh Anat Ges 1984; 78: 25 - 40.Google Scholar
  13. 13.
    Kriz W, Schiller A, Taugner R: Freeze-fracture studies on the thin limbs of Henle’s loop in Psammomys obesus. Am J Anat 1981; 162: 23 - 34.PubMedCrossRefGoogle Scholar
  14. 14.
    Pfaller W: Structure function correlation on rat kidney. Adv Anat Embryo! Cell Biol 1981; 70: 1 - 100.CrossRefGoogle Scholar
  15. 15.
    Pinto da Silva P, Kachar B: On tight junction structure. Cell 1982; 28: 441 - 450.PubMedCrossRefGoogle Scholar
  16. 16.
    Rosenberg T, Wilbrandt W: Carrier transport uphill. I. General. J Theoret Biol 1963; 5: 288 - 305.CrossRefGoogle Scholar
  17. 17.
    Schiller A, Taugner R: Freeze-fracturing and deep-etching with the volatile cryoprotectant ethanol reveals true membrane surfaces of kidney structures. Cell Tissue Res 1980; 210: 57 - 69.PubMedCrossRefGoogle Scholar
  18. 18.
    Singer SJ, Nicolson GL: The fluid mosaic model of the structure of cell membranes. Science 1972; 175: 720 - 731.PubMedCrossRefGoogle Scholar
  19. 19.
    Spring KR, Hope A: Dimensions of cells and lateral intercellular spaces in living Necturus gallbladder. Fed Proc 1979; 38: 128 - 133.PubMedGoogle Scholar
  20. 20.
    Sutherland EW, Robison CA, Butcher RW: Some aspects of biological role of adenosine 3’,5’-monophosphate (cyclic AMP). Circulation 1968; 37: 279 - 306.CrossRefGoogle Scholar
  21. 21.
    Tisher CC, Kokko JP: Relationship between peritubular oncotic pressure gradients and morphology in isolated proximal tubules. Kidney Int 1974; 6: 146 - 156.PubMedCrossRefGoogle Scholar
  22. 22.
    Van Deurs B, Luft JH: Effects of glutaraldehyde fixation on the structure of tight junctions. A quantitative freeze-fracture analysis. J Ultrastruct Res 1979; 68: 160 - 172.PubMedCrossRefGoogle Scholar
  23. 23.
    Wade JB, O’Neil RG, Pryor JL, et al: Modulation of cell membrane area in renal collecting tubules by corticosteroid hormones. J Cell Biol 1979; 81: 439 - 445.PubMedCrossRefGoogle Scholar
  24. 24.
    Wilbrandt W, Rosenberg T: The concept of carrier transport and its corollaries in pharmacology. Pharmacol Rev 1961; 13: 109 - 183.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Esmail Koushanpour
    • 1
  • Wilhelm Kriz
    • 2
  1. 1.Northwestern University Medical SchoolChicagoUSA
  2. 2.University of HeidelbergHeidelbergFederal Republic of Germany

Personalised recommendations