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Regulation of Renal Blood Flow and Glomerular Filtration Rate

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Book cover Renal Physiology

Abstract

In the preceding chapter we learned that the process of passive filtration at the glomerulus delivers a copious volume of virtually protein-free plasma to the proximal tubule for further processing. Since major alterations in the volume of plasma filtered at the glomerulus per minute, namely, the glomerular filtration rate (GFR), would have a profound effect on the subsequent tubular processing of this filtrate, there must be some intrinsic mechanisms whereby GFR is carefully controlled. In this chapter we briefly review some of the experiments that have led to the current concept of renal autoregulation and the intrinsic control of renal blood flow (RBF), including the possible role of the juxtaglomerular apparatus. In addition to these mechanisms, the roles of the intrarenal production of renin-angiotensin and prostaglandin in autoregulation and renal regulation of volume and composition of body fluids are also discussed. Finally, we conclude with a discussion of the extrinsic control of the renal circulation.

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References

  1. Abe Y, Kishimoto T, Yamamoto K: Effect of angiotensin II antagonist infusion on autoregulation of renal blood flow. Am J Physiol 1976; 231: 1267–1271.

    PubMed  CAS  Google Scholar 

  2. Abboud FM: The sympathetic system in hypertension: State-of-the-art review. Hypertension 1982; 4 (suppl II): 208–225.

    PubMed  CAS  Google Scholar 

  3. Aiken JW, Vane JR: Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Ther 1973; 184: 678–687.

    PubMed  CAS  Google Scholar 

  4. Anderson WP, Korner PI, Selig SE: Mechanisms involved in the renal response to intravenous and renal artery infusions of noradrenaline in conscious dogs. J Physiol (Lond) 1981; 321: 21–30.

    CAS  Google Scholar 

  5. Arendshorst WJ, Finn WF, Gottschalk CW: Autoregulation of blood flow in the rat kidney. Am J Physiol 1975; 228: 127–133.

    PubMed  CAS  Google Scholar 

  6. Arundell LA, St Johns E: Effect of converting enzyme inhibition on the renal hemodynamic responses to noradrenaline infusion in rats. Br J Pharmacol 1982; 75: 553–558.

    Article  PubMed  CAS  Google Scholar 

  7. Barajas L: The ultrastructure of the juxtaglomerular apparatus as disclosed by three-dimensional reconstructions from serial sections: The anatomical relationship between the tubular and vascular components. J Ultrastruct Res 1970; 33: 116–147.

    Article  PubMed  CAS  Google Scholar 

  8. Barajas L, Powers K, Wang P: Innervation of the renal cortical tubules: A quantitative study. Am J Physiol 1984; 247: F50 - F60.

    PubMed  CAS  Google Scholar 

  9. Bayliss WM: On the local reactions of the arterial wall to changes of internal pressure. J Physiol (Lond) 1902; 28: 220–231.

    CAS  Google Scholar 

  10. Beck LH, Senesky D, Goldberg M: Sodium-independent active potassium reabsorption in proximal tubule of the dog. J Clin Invest 1973; 52: 2641–2645.

    Article  PubMed  CAS  Google Scholar 

  11. Bello-Reuss E, Trevino DL, Gottschalk GW: Effect of renal sympathetic nerve stimulation on proximal water and sodium reabsorption. J Clin Invest 1976; 57: 1104–1107.

    Article  Google Scholar 

  12. Bing J, Paulsen K: Time course of change in plasma renin after blockade of the renin system. Acta Pathol Microbiol Scand (abstract) 1975; 83: 454.

    CAS  Google Scholar 

  13. Blaustein MP: Sodium ions, calcium ions, blood pressure regulation, and hypertension: A reassessment and a hypothesis. Am J Physiol 1977; 232: C165 - C173.

    PubMed  CAS  Google Scholar 

  14. Brenner BM, Baylis C, Deen WM:. Transport of molecules across renal glomerular capillaries. Physiol Rev 1976; 56: 502–534.

    PubMed  CAS  Google Scholar 

  15. Briggs J, Schubert G, Schnermann J: Evidence for an inverse relationship between macula densa NaC1 concentration and filtration rate. Pfluegers Arch 1982; 392: 372–378.

    Article  CAS  Google Scholar 

  16. Briggs JP, Wright FS: Feedback control of glomerular filtration rate: site of the effector mechanism. Am J Physiol 1979; 236: F40 - F47.

    PubMed  CAS  Google Scholar 

  17. Burg MB, Green N: Effect of ethacrynic acid on the thick ascending limb of Henle’s loop. Kidney Int 1973; 4: 301–308.

    Article  PubMed  CAS  Google Scholar 

  18. Burg MB, Stoner L, Cardinal J, Green N: Furosemide effect on isolated perfused tubules. Am J Physiol 1973; 225: 119–124.

    PubMed  CAS  Google Scholar 

  19. Campbell WB, Jackson EK, Graham RM: Saralasin induced renin release: Its blockade by prostaglandin synthesis inhibitors in the conscious rat. Hypertension 1979; 1: 637–642.

    Article  PubMed  CAS  Google Scholar 

  20. Carmines PK, Bell PD, Roman RI, et al: Prosta-glandins in the sodium excretory response to altered renal arterial pressure in dogs. Am J Physiol 1985; 248: F8 - F14.

    PubMed  CAS  Google Scholar 

  21. Christensen JA, Bohle A: The juxtaglomerular apparatus in the normal rat kidney. Virchows Arch Pathol Anat 1978; 379: 143–150.

    PubMed  CAS  Google Scholar 

  22. Cohen HJ, Marsh DJ, Kayser B: Autoregulation in vasa recta of the rat kidney. Am J Physiol 1983; 245: F32 - F40.

    PubMed  CAS  Google Scholar 

  23. Conrad KP, Brinck-Johnsen T, Gellai M, Valtin H: Renal autoregulation in chronically catheterized conscious rats. Am J Physiol 1984; 247: F229 - F233.

    PubMed  CAS  Google Scholar 

  24. Deen WM, Robertson CR, Brenner BM: Glomerular ultrafiltration. Fed Proc 1974; 33: 14–20.

    PubMed  CAS  Google Scholar 

  25. DiBona GF: The functions of the renal nerves. Rev Physiol Biochem Pharmacol 1982; 94: 75–181.

    Article  Google Scholar 

  26. Dietrich HJ: Electron microscopic studies of the innervation of the rat kidney. Z Anat Entwicki Gesch 1974; 145: 169–186.

    Article  Google Scholar 

  27. Dinerstein RI, Jones RT, Goldberg LI: Evidence for dopamine-containing renal nerves. Fed Proc 1983; 42: 3005–3008.

    PubMed  CAS  Google Scholar 

  28. DiSalvo J, Fell C: Changes in renal blood flow during renal nerve stimulation. Proc Soc Exp Biol Med 1971; 136: 150–153.

    PubMed  CAS  Google Scholar 

  29. Finke R, Gross R, Hackenthal E, et al: Threshold pressure for the pressure-dependent renin release in the autoregulating kidney of conscious dogs. Pfluegers Arch 1983; 399: 102–110.

    Article  CAS  Google Scholar 

  30. Fray JCS: Stretch receptor model for renin release with evidence from perfused rat kidney. Am J Physiol 1976; 231: 936–944.

    PubMed  CAS  Google Scholar 

  31. Galvez OG, Roberts BW, Mishkind MH, et al: Studies of the mechanism of contralateral polyuria after renal artery stenosis. J Clin Invest 1977; 59: 609–615.

    Article  PubMed  CAS  Google Scholar 

  32. Gerber JG, Nies AS, Friesinger GC, et al: The effects of PGIZ on canine renal function and hemodynamics. Prostaglandins 1978; 16: 519–528.

    Article  PubMed  CAS  Google Scholar 

  33. Gilmore JP, Cornish KG, Rogers SD, Joyner WL: Direct evidence for myogenic autoregulation of the renal microcirculation in the hamster Circ Res 1980; 47: 226–230.

    Article  PubMed  CAS  Google Scholar 

  34. Gillies A, Morgan T: Renin content of individual juxtaglomerular apparatuses and the effect of diet, changes in nephron flow rate and in vitro acidification on the renin content. Pfluegers Arch 1978; 375: 105–110.

    Article  CAS  Google Scholar 

  35. Gocke DJ, Gerter J, Sherwood LM, Laragh JH: Physiological and pathological variations of plasma angiotensin II in man: Correlation with renin activity and sodium balance. Circ Res 1969; 24 (suppl I): 131–146.

    PubMed  CAS  Google Scholar 

  36. Goldberg LI, Glock D, Kohli JD, Barnett A: Separation of peripheral dopamine receptors by a selective DA,-antagonist. SCH 23390. Hypertension 1984; 6 (suppl I): 125–130.

    Google Scholar 

  37. Goormaghtigh N: L’appareil neuro-myoarteriol juxtaglomerulaire du rein. C R Soc Biol 1937; 124: 293–296.

    Google Scholar 

  38. Gorgas K: Structure and innervation of the juxtaglomerular apparatus of the rat. Adv Anat Embryol Cell Biol 1978; 54: 5–84.

    Google Scholar 

  39. Grantham JJ, Orloff J: Effect of prostaglandin E, on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3’, 5’-monophosphate and theophylline. J Clin Invest 1968; 47: 1154–1161.

    Article  PubMed  CAS  Google Scholar 

  40. Greger R, Schlafler E, Lang F: Evidence for electroneutral sodium chloride cotransport in the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pfluegers Arch 1983; 396: 308–314.

    Article  CAS  Google Scholar 

  41. Gutsche HU, Muller-Suur R, Schurek HJ: Ca“ antagonist prevents feedback-induced SNGFR decrease in rat kidney. Kidney Int 1975; 8: 477.

    Google Scholar 

  42. Guyton AC, Coleman TG, Fourcade JC, Navar LG: Physiologic control of arterial pressure. Bull NYAcad Med 1969; 45: 811–830.

    CAS  Google Scholar 

  43. Guyton AC, Langston JB, Navar LG: Theory for renal autoregulation by feedback of the juxtaglomerular apparatus. Circ Res 1964; 15 (suppl I): 187–197.

    PubMed  CAS  Google Scholar 

  44. Haas JA, Hammond TG, Granger JP, et al: Mechanism of natriuresis during intrarenal infusion of prostaglandin. Am J Physiol 1984; 247: F475 - F479.

    PubMed  CAS  Google Scholar 

  45. Hall JE, Coleman TG, Guyton AC, et al: Control of glomerular filtration rate by circulating angiotensin II. Am J Physiol 1981; 241: R190 - R197.

    PubMed  CAS  Google Scholar 

  46. Hermansson K, Ojteg G, Wolgast M: The cortical and medullary blood flow at different levels of renal nerve activity. Acta Physiol Scand 1984; 120: 161–169.

    Article  PubMed  CAS  Google Scholar 

  47. Hermansson K, Ojteg G, Wolgast M: The reno-renal reflex; evaluation from renal blood flow measurements. Acta Physiol Scand 1984; 120: 207–215.

    Article  PubMed  CAS  Google Scholar 

  48. Hoyer JR, Sisson SP, Vernier RL: Tamm-Horsfall glycoprotein: Ultrastructural immunoperoxidse localization in rat kidney. Lab Invest 1979; 41: 168–173.

    PubMed  CAS  Google Scholar 

  49. Ichikawa I: Direct analysis of the effector mechanism of the tubuloglomerular feedback system. Am J Physiol 1982; 243: F447 - F455.

    PubMed  CAS  Google Scholar 

  50. Insel PA, Snavely MD: Catecholamines and the kidney: Receptors and renal function. Ann Rev Physiol 1981; 43: 625–636.

    Article  CAS  Google Scholar 

  51. Jackson EK, Branch RA, Oates JA: Participation of prostaglandine in the control of renin release. in Oates JA (ed): Prostaglandins and the Cardiovascular System. New York, Raven Press, 1982, pp 255–276.

    Google Scholar 

  52. Jackson EK, Heidemann H, Branch RA, Gerkens JF: Low dose intrarenal infusions of PGE2, PGIZ, and 6keto-PGE, vasodilate the in vivo rat kidney. Circ Res 1982; 51: 67–72.

    Article  PubMed  CAS  Google Scholar 

  53. Johnson PC: The myogenic response, in Bohr DF, Somlyo AP, Sparks HV Jr (eds): Handbook of Phys-iology, Section II: The Cardiovascular system, vol 2. Vascular smooth muscle. Washington DC, American Physiological Society, 1980, pp 409–442.

    Google Scholar 

  54. Johnson PC: Review of previous studies and current theories of autoregulation. Circ Res 1964; 14/15 (suppl I):2–9.

    Google Scholar 

  55. Kaissling B, Kriz W: Variability of intercellular spaces between macula densa cells: A TEM study in rabbits and rats. Kidney Int 1982; 12: 9–17.

    Google Scholar 

  56. Kallskog O, Lindbom LO, Ulfendahl HR, Wolgast M: Hydrostatic pressures within the vascular structures of the rat kidney. Pfluegers Arch 1976; 363: 205–210.

    Article  CAS  Google Scholar 

  57. Katholi RE: Renal nerves in the pathogenesis of hypertension in experimental animals and humans. Am J Physiol 1983; 245: F1 - F14.

    PubMed  CAS  Google Scholar 

  58. Kon V, Ichikawa I: Effector loci for renal nerve control of cortical microcirculation. Am J Physiol 1983; 245: F545 - F553.

    PubMed  CAS  Google Scholar 

  59. Kopp U, Aurell M, Sjolander M, Ablad B: The role of prostaglandins in the a-and ß-adrenoceptor mediated renin release response to graded renal nerve stimulation. Pfluegers Arch 1981; 391: 1–8.

    Article  CAS  Google Scholar 

  60. Lush DJ, Fray JCS: Steady-state autoregulation of renal blood flow: A myogenic model. Am J Physiol 1984; 247: R89 - R99.

    PubMed  CAS  Google Scholar 

  61. Margolis BL, Stein JH: The renal circulation. in Priebe H-J (ed): International Anesthesiology Clinics: The Kidney in Anesthesia, Boston, Little Brown & Co, 1984, pp 35–63.

    Google Scholar 

  62. Moore LC: Tubuloglomerular feedback and SNGFR autoregulation in the rat. Am J Physiol 1984; 247: F267 - F276.

    PubMed  CAS  Google Scholar 

  63. Moore LC, Mason J: Perturbation analysis of tubuloglomerular feedback in hydropenic and hemorrhaged rats. Am J Physiol 1983; 245: F554 - F563.

    PubMed  CAS  Google Scholar 

  64. Morgan T: Factors controlling the release of renin. A micropuncture study in the rat. Pfluegers Arch 1977; 368: 13–18.

    Article  CAS  Google Scholar 

  65. Morgan T, Berliner RW: A study by continuous microperfusion of water and electrolyte movements in the loop of Henle and distal tubule of the rat. Nephron 1969; 6: 388–405.

    Article  PubMed  CAS  Google Scholar 

  66. Moss NG: Renal function and renal afferent and efferent nerve activity. Am J Physiol 1982; 243: F425 - F433.

    PubMed  CAS  Google Scholar 

  67. Muller-Suur R, Ulfendahl HR, Persson AEG: Evidence for tubuloglomerular feedback in juxtamedullary nephrons of young rats. Am J Physiol 1983; 244: F425 - F431.

    PubMed  CAS  Google Scholar 

  68. Ng KKF, Vane JR: Conversion of angiotensin Ito angiotensin II. Nature 1967; 216: 762–766.

    Article  PubMed  CAS  Google Scholar 

  69. Navar LG, Bell PD, White RW, et al: Evaluation of the single nephron glomerular filtration coefficient in the dog kidney. Kidney Int 1977; 12: 137–149.

    Article  PubMed  CAS  Google Scholar 

  70. Navar LG: Renal autoregulation: Perspectives from whole kidney and single nephron studies. Am J Physiol 1978; 234: F357 - F370.

    PubMed  CAS  Google Scholar 

  71. Navar LG, Ploth DW, Bell PD: Distal tubular feedback control of renal hemodynamics and autoregulation. Ann Rev Physiol 1980; 42: 557–571.

    Article  CAS  Google Scholar 

  72. Pricam C, Humbert F, Perrelet A, Orci L: Gap junctions in mesangial and lacis cells. J Cell Biol 1974; 63: 349–354.

    Article  PubMed  CAS  Google Scholar 

  73. Riggs DS: Control Theory and Physiological Feedback Mechanisms. Baltimore, Williams & Wilkins Co, 1970.

    Google Scholar 

  74. Robertson CR, Deen WM, Troy JL, Brenner BM: Dynamics of glomerular ultrafiltration in the rat. III. Hemodynamics and autoregulation. Am J Physiol 1972; 223: 1191–1200.

    PubMed  CAS  Google Scholar 

  75. Rogenes PR: Single-unit and multiunit analyses of renorenal reflexes elicited by stimulation of renal chemoreceptors in the rat. J Auton New Sys 1982; 6: 143–156.

    Article  CAS  Google Scholar 

  76. Roman RJ, Kauker ML: Renal effect of prostaglandin synthetase inhibition in rats: Micropuncture studies. Am J Physiol 1978; 235: F111 - F118.

    PubMed  CAS  Google Scholar 

  77. Sadowski J, Wocial B: Renin release and autoregulation of blood flow in a new model of non-filtering and non-transporting kidney. J Physiol (Load) 1977; 266: 219–233.

    CAS  Google Scholar 

  78. Schnabel E, Kriz W: Morphometric studies of the extraglomerular mesangial cell field in volume expanded and volume depleted rats. Anat Embryol 1984; 170: 217–222.

    Article  PubMed  CAS  Google Scholar 

  79. Schnermann J, Briggs J: Function of the juxtaglomerular apparatus: Local control of glomerular hemodynamics. in Seldin DW, Giebisch G (eds): The Kidney: Physiology and Pathophysiology. New York, Raven Press, 1985, vol 1, pp 669–697.

    Google Scholar 

  80. Schnermann J, Briggs JP, Kriz W, Moore LC, Wright FS: Control of glomerular vascular resistance by the tubuloglomerular feedback mechanism. in Keaf A, Giebisch G, Bolis L, Gorini S (eds): Renal Pathophysiology, Recent Advances. New York, Raven Press, 1980, pp 165–182.

    Google Scholar 

  81. Schnermann J, Briggs J, Weber PC: Tubuloglomerular feedback, prostaglandins and angiotensin in the autoregulation of glomerular filtration rate. Kidney Int 1984; 25: 53–64.

    Article  PubMed  CAS  Google Scholar 

  82. Schnermann J, Ploth DW, Hermle M: Activation of tubulo-glomrular feedback by chloride transport. Pfluegers Arch 1976; 362: 229–240.

    Article  CAS  Google Scholar 

  83. Schnermann J, Persson AEG, Agerup B: Tubuloglomerular feedback. Non-linear relationship between glomerular hydrostatic pressure and loop of Henle perfusion rate. J Clin Invest 1973; 52: 862–869.

    Article  PubMed  CAS  Google Scholar 

  84. Schnermann J, Wright FS, Davis JM, et al: Regulation of superficial nephron filtration rate by tubuloglomerular feedback. Pfluegers Arch 1970; 318: 147–175.

    Article  CAS  Google Scholar 

  85. Schrier RW: Effects of the adrenergic nervous system and catecholamines on systemic and renal hemodynamics, sodium and water excretion and renin secretion. Kidney Int 1974; 6: 291–306.

    Article  PubMed  CAS  Google Scholar 

  86. Seymour AA, Davis JO, Freeman RH, et al: Renin release from filtering and nonfiltering kidneys stimulated by PGI2 and PGD2. Am J Physiol 1979; 237: F285 - F290.

    PubMed  CAS  Google Scholar 

  87. Sikri KL, Foster CL, MacHugh N, Marshall RD: Localization of Tamm-Horsfall glycoprotein in the human kidney using immunofluorescene and immuno-electron microscopical techniques. J Anat 1981; 132: 597–605.

    PubMed  CAS  Google Scholar 

  88. Shipley RE, Study RS: Changes in renal blood flow, extraction of inulin, GFR, tissue pressure and urine flow with acute alterations of renal artery blood pressure. Am J Physiol 1951; 167: 675–688.

    Google Scholar 

  89. Sjoquist M, Goransson A, Kallskog O, Ulfendahl HR: The influence of tubulo-glomerular feedback on the autoregulation of filtration rate in superficial and deep glomeruli. Acta Physiol Scand 1984; 122: 235–242.

    Article  PubMed  CAS  Google Scholar 

  90. Slick GL, Aguilera AJ, Zambraski EJ, et al: Renal neuroadrenergic transmission. Am J Physiol 1975; 229: 60–65.

    PubMed  CAS  Google Scholar 

  91. Steiner RW, Tucker BJ, Blantz RC: Glomerular hemodynamics in rats with chronic sodium depletion: Effect of saralasin. J Clin Invest 1979; 64: 503–512.

    Article  PubMed  CAS  Google Scholar 

  92. Stoner LC, Burg MB, Orloff J: Ion transport in cortical collecting tubule: effect of amiloride. Am J Physiol 1974; 227: 453–459.

    PubMed  CAS  Google Scholar 

  93. Tannenbaum J, Splawinski JA, Oates JA, Nies AS: Enhanced renal prostaglandin production in the dog. I. Effect on renal function. Circ Res 1975; 36: 197–203.

    Article  PubMed  CAS  Google Scholar 

  94. Taugner C, Poulsen K, Hackenthal E, Taugner R: Immunocytochemical localization of renin in mouse kidney. Histochemistry 1979; 62: 19–27.

    Article  PubMed  CAS  Google Scholar 

  95. Taugner R, Schiller A, Kaissling B, Kriz W: Gap junctional coupling between the JGA and the glomerular tuft. Cell Tissue Res 1978; 186: 279–285.

    Article  PubMed  CAS  Google Scholar 

  96. Thurau K: Renal hemodynamics. Am J Med 1964; 36: 698–719.

    Article  PubMed  CAS  Google Scholar 

  97. Thurau K, Dahlheim H, Gruner A, et al: Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa. Circ Res 1972; 31 (suppl II): 182–186.

    PubMed  Google Scholar 

  98. Thurau K, Mason J: The intrarenal function of the juxtaglomerular apparatus, in Thurau K (ed): MTP Int. Rev. Sci. Kidney and Urinary Tract Physiology. Baltimore, University Park Press, 1974, Ser I, vol 6, pp 357–390.

    Google Scholar 

  99. Tobian L, Tomboulian A, Janecek J: Effect of high perfusion pressures on the granulation of juxtglomerular cells in an isolated kidney. J Clin Invest 1959; 38: 605–610.

    Article  PubMed  CAS  Google Scholar 

  100. Work J, Baehler RW, Kotchen TA, et al: Effect of prostaglandin inhibition on sodium chloride reabsorption in the diluting segment of the conscious dog. Kidney Int 1980; 17: 24–30.

    Article  PubMed  CAS  Google Scholar 

  101. Wright FS, Briggs JP: Feedback control of glomerular blood flow, pressure, and filtration rate. Physiol Rev 1979; 59: 958–1006.

    PubMed  CAS  Google Scholar 

  102. Young DK, Marsh DJ: Pulse wave propagation in rat renal tubules: Implications for GFR autoregulation. Am J Physiol 1981; 240: F446 - F458.

    PubMed  CAS  Google Scholar 

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Koushanpour, E., Kriz, W. (1986). Regulation of Renal Blood Flow and Glomerular Filtration Rate. In: Renal Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1912-3_6

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  • DOI: https://doi.org/10.1007/978-1-4757-1912-3_6

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