Regulation of Renal Blood Flow and Glomerular Filtration Rate

  • Esmail Koushanpour
  • Wilhelm Kriz


In the preceding chapter we learned that the process of passive filtration at the glomerulus delivers a copious volume of virtually protein-free plasma to the proximal tubule for further processing. Since major alterations in the volume of plasma filtered at the glomerulus per minute, namely, the glomerular filtration rate (GFR), would have a profound effect on the subsequent tubular processing of this filtrate, there must be some intrinsic mechanisms whereby GFR is carefully controlled. In this chapter we briefly review some of the experiments that have led to the current concept of renal autoregulation and the intrinsic control of renal blood flow (RBF), including the possible role of the juxtaglomerular apparatus. In addition to these mechanisms, the roles of the intrarenal production of renin-angiotensin and prostaglandin in autoregulation and renal regulation of volume and composition of body fluids are also discussed. Finally, we conclude with a discussion of the extrinsic control of the renal circulation.


Renal Blood Flow Renin Release Afferent Arteriole Thick Ascend Limb Efferent Arteriole 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Esmail Koushanpour
    • 1
  • Wilhelm Kriz
    • 2
  1. 1.Northwestern University Medical SchoolChicagoUSA
  2. 2.University of HeidelbergHeidelbergFederal Republic of Germany

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