Tubular Reabsorption and Secretion: Classification Based on Overall Clearance Measurements

  • Esmail Koushanpour
  • Wilhelm Kriz


In the preceding chapter we analyzed the sequential processing of the filtrate and the mechanisms of tubular transport of major electrolytes and water along the various segments of the nephron. That analysis was largely based on successful application of in-vivo micropuncture, in-vitro microperfusion, and electrophysiological techniques at the level of a single nephron. However, such techniques have been used to delineate the sequential processing of only a limited number of substances. To ascertain the renal handling of those solutes (mostly nonelectrolytes) for which micropuncture data are scarce or as yet not available, we must resort to the standard overall clearance technique. Therefore, in this chapter, we expand on the materials presented in Chapter 7 and consider in more detail the overall (as opposed to sequential) processing of the major nonelectroyte constituents of the filtrate, using the standard clearance measurements. From such information we can determine the net tubular transport of a substance by the kidney as well as classify the type of cellular transport process involved.


Uric Acid Glomerular Filtration Rate Proximal Tubule Titration Curve Plasma Glucose Concentration 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Esmail Koushanpour
    • 1
  • Wilhelm Kriz
    • 2
  1. 1.Northwestern University Medical SchoolChicagoUSA
  2. 2.University of HeidelbergHeidelbergFederal Republic of Germany

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