Structure, Function, and Age-Related Changes of the Human Vitreous

  • J. Sebag


During the eighteenth and nineteenth centuries four different theories of vitreous structure prevailed. Demours (1) formulated the alveolar theory. After freezing and slowly thawing the vitreous, he described a multitude of membranes oriented in all possible directions, enclosing compartments or alveoli that contained the fluid portion of the vitreous. The studies of von Haller (2) supported this concept. However, in 1780 Zinn (3) proposed that the vitreous was arranged in a concentric, lamellar configuration similar to the “layers of an onion”. The dissections and histologic preparations of von Pappenheim (4) and Brucke (5) provided evidence for the lamellar theory. Stilling (6) and Iwanoff (7) modified this theory by stating that only the peripheral third of the vitreous had a lamellar structure.


Hyaluronic Acid Basal Lamina Ciliary Body Vitreous Humour Vitreous Body 
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