Applicability of HPLC Chiral Stationary Phases to Pharmacokinetic and Disposition Studies on Enantiomeric Drugs
Abstract
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Resolution of enantiomeric drugs on HPLC chiral stationary phases (CSP’s). # Resolution of enantiomers as diastereoisomers. # Resolution of enantiomers on CSP’s.
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Commercially available CSP’s. # Type I CSP’s. # Type II CSP’s. # Type III CSP’s. # Type IV CSP’s.
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Type I CSP’s in pharmacological studies. # An overview. # Studies of the stereoselectivity of propranolol disposition and clearance. # Stereochemical aspects of the metabolism of ibuprofen. # Glutethv-mide metabolism in glutethimide-intoxicated patients. # Pharmacological studies of the stereoselective metabolism of polycyclic aromatic hydrocarbons.
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Pharmacokinetic applications using other CSP’s. # An overview. # Determination of (R)- and (S)-disopyramide in human plasma.
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A look toward the future.
Keywords
Chiral HPLC Enantiomeric Composition Chiral Resolution Methyl Amide Cellulose CarbamatePreview
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