Applicability of HPLC Chiral Stationary Phases to Pharmacokinetic and Disposition Studies on Enantiomeric Drugs

  • Irving W. Wainer
Chapter
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 16 A)

Abstract

The scope of this article is evident from the section headings.

  • Resolution of enantiomeric drugs on HPLC chiral stationary phases (CSP’s). # Resolution of enantiomers as diastereoisomers. # Resolution of enantiomers on CSP’s.

  • Commercially available CSP’s. # Type I CSP’s. # Type II CSP’s. # Type III CSP’s. # Type IV CSP’s.

  • Type I CSP’s in pharmacological studies. # An overview. # Studies of the stereoselectivity of propranolol disposition and clearance. # Stereochemical aspects of the metabolism of ibuprofen. # Glutethv-mide metabolism in glutethimide-intoxicated patients. # Pharmacological studies of the stereoselective metabolism of polycyclic aromatic hydrocarbons.

  • Pharmacokinetic applications using other CSP’s. # An overview. # Determination of (R)- and (S)-disopyramide in human plasma.

  • A look toward the future.

Keywords

Chiral HPLC Enantiomeric Composition Chiral Resolution Methyl Amide Cellulose Carbamate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Irving W. Wainer
    • 1
  1. 1.Division of Drug ChemistryU.S. Food and Drug AdministrationUSA

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