Cyclic Decapeptides in Kidney

  • Ian R. Tebbett
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 16 A)

Abstract

The Cortinarius genus of mushrooms contains a number of species that have caused-poisonings throughout Europe. Cortinarins A and B have been isolated from these fungi and ascertained to be cyclic polypeptides; they have been shown in laboratory animals to cause nephro-toxicity characteristic of Cortinarius mushroom poisoning. HPLC systems, besides TLC, have been developed to examine methanolic extracts of kidney tissue from poisoned animals for these compounds, and for cortinarin C which is non-toxic. The toxicity of the mushrooms seems to entail a metabolic process, possibly explaining the genetic and sex-linked differences in susceptibility observed among individual humans and animals.

Keywords

Methanolic Extract Kidney Tissue Mouse Kidney Individual Human Kidney Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Ian R. Tebbett
    • 1
  1. 1.Forensic Science UnitUniversity of StrathclydeGlasgowUK

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