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BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers pp 13–16Cite as

Cyclic Decapeptides in Kidney

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Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 16 A))

Abstract

The Cortinarius genus of mushrooms contains a number of species that have caused-poisonings throughout Europe. Cortinarins A and B have been isolated from these fungi and ascertained to be cyclic polypeptides; they have been shown in laboratory animals to cause nephro-toxicity characteristic of Cortinarius mushroom poisoning. HPLC systems, besides TLC, have been developed to examine methanolic extracts of kidney tissue from poisoned animals for these compounds, and for cortinarin C which is non-toxic. The toxicity of the mushrooms seems to entail a metabolic process, possibly explaining the genetic and sex-linked differences in susceptibility observed among individual humans and animals.

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References

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Author information

Authors and Affiliations

  1. Forensic Science Unit, University of Strathclyde, 204 George Steet, Glasgow, Gl 1XW, UK

    Ian R. Tebbett

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  1. Ian R. Tebbett
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, Guildford, UK

    Eric Reid

  2. ICI Pharmaceuticals Division, Alderley Park, UK

    Bryan Scales  & Ian D. Wilson  & 

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© 1986 Springer Science+Business Media New York

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Tebbett, I.R. (1986). Cyclic Decapeptides in Kidney. In: Reid, E., Scales, B., Wilson, I.D. (eds) BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers. Methodological Surveys in Biochemistry and Analysis, vol 16 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1892-8_2

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  • DOI: https://doi.org/10.1007/978-1-4757-1892-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1894-2

  • Online ISBN: 978-1-4757-1892-8

  • eBook Packages: Springer Book Archive

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