Cyclic Decapeptides in Kidney

  • Ian R. Tebbett
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 16 A)


The Cortinarius genus of mushrooms contains a number of species that have caused-poisonings throughout Europe. Cortinarins A and B have been isolated from these fungi and ascertained to be cyclic polypeptides; they have been shown in laboratory animals to cause nephro-toxicity characteristic of Cortinarius mushroom poisoning. HPLC systems, besides TLC, have been developed to examine methanolic extracts of kidney tissue from poisoned animals for these compounds, and for cortinarin C which is non-toxic. The toxicity of the mushrooms seems to entail a metabolic process, possibly explaining the genetic and sex-linked differences in susceptibility observed among individual humans and animals.


Methanolic Extract Kidney Tissue Mouse Kidney Individual Human Kidney Toxicity 
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  1. 1.
    Short, A.I.K., Watling, R., MacDonald, M.K. & Robson, J.S. (1980) Lancet ii, 942–943.CrossRefGoogle Scholar
  2. 2.
    Grzymala, S. (1957) Z. Pilzk.23, 139–142.Google Scholar
  3. 3.
    Colon, S., Deteix, P., Bervard, M., Gerault, A., Finaz, A., Zech, P. & Traeger, J. (1982) Kidney International21, 121.CrossRefGoogle Scholar
  4. 4.
    Tebbett, I.R. & Caddy, B. (1984) Experientia40, 441–446.CrossRefGoogle Scholar
  5. 5.
    Tebbett, I.R. & Caddy, B. (1984) J. Chromatog.283, 417–420.CrossRefGoogle Scholar
  6. 6.
    Hulmi, S.P., Siddonen, P., Forström, J. & Vilska, J. (1974) Duodecim. 90, 1044–1055.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Ian R. Tebbett
    • 1
  1. 1.Forensic Science UnitUniversity of StrathclydeGlasgowUK

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