Heterogeneity within Type II and Mody Diabetes

  • Stefan S. Fajans
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 189)


The heterogeneity within Type II diabetes (NIDDH) and within Maturity-Onset type Diabetes of Young people (MODY), a subset of NIDDM which is inherited in an autosomal dominant fashion, is discussed. Aspects of the definition and phenotypic expression of MODY are reviewed. Within NIDDM there are differences in patterns of inheritance between subgroups. HLA antigen associations are not found in most NIDDH populations but exist in three specific population groups with Type II diabetes. Within NIDDH and within MODY there are differences in the magnitude of insulin responses to glucose, differences in target tissue responsiveness to insulin in vivo, and differences in receptor and post-receptor effects of insulin. Structurally abnormal variant and biologically defective insulin molecules have been found in some Type II diabetic patients and in members of certain MODY families. The presence or absence of obesity may mark heterogeneous groups of Type II diabetic patients, in addition to the importance of obesity in uncovering an insulin secretory defect by causing insulin resistance. There is heterogeneity in susceptibility to vascular disease within NIDDM and MODY. The natural history of carbohydrate metabolism and of insulin secretory responses to glucose in early Type I diabetes and in MODY with low insulin secretory responses are illustrated and similarities and dissimilarities compared and contrasted. Failure to recognize young patients with MODY may contribute to incorrect diagnosis, management, and assignment of prognosis of this form of diabetes in the young by many practicing physicians.


Insulin Response Insulin Binding Fasting Hyperglycemia Insulin Secretory Response Human Insulin Gene 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Stefan S. Fajans
    • 1
  1. 1.The Department of Internal Medicine (Division of Edocrinology and Metabolism)The University of MichiganAnn ArborUSA

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