Diabetic Neuropathy

  • Peter James Dyck
  • Anthony Windebank
  • Hitoshi Yasuda
  • F. John Service
  • Robert Rizza
  • Bruce Zimmerman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 189)


The incidence and prevalence of diabetic neuropathies in Insulin Dependent (IDDM) and Non-Insulin Dependent (NIDDM) Diabetes Mellitus is not known because in previous studies the heterogeneity of diabetes and of the neuropathies was not taken into account, criteria for diagnosis and surveillance for neuropathy were variable, and studies were not prospective or population based. We have begun such prospective epidemiologic studies using a uniform algorithm for the classification of the diabetic disorders and uniform and validated approaches for the assessment of symptoms, neurologic deficits and various quantitative end-points of neural dysfunction. As regards cause, a key question which we are trying to answer is whether hyperglycemia and associated metabolic alterations affect neural tissue directly or whether there is an intervening tissue alteration between metabolic derangement and tissue change. Improved control of hyperglycemia does not appear to be associated with rapid neurologic improvement, possibly arguing for an intervening tissue alteration. The recently observed decrease in nerve oxygen tension and blood flow in streptozotocin diabetes suggests that an alteration of the nerve microenvironment may relate importantly to the cause of diabetic neuropathy.


Nerve Conduction Diabetic Neuropathy Nerve Conduction Velocity Motor Nerve Conduction Velocity Motor Conduction Velocity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Peter James Dyck
    • 1
  • Anthony Windebank
    • 1
  • Hitoshi Yasuda
    • 1
  • F. John Service
    • 1
  • Robert Rizza
    • 1
  • Bruce Zimmerman
    • 1
  1. 1.Peripheral Nerve Laboratory Department of NeurologyMayo ClinicRochesterUSA

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