Myelin pp 405-439 | Cite as

Immunological Responses to Myelin and Myelin Components

  • Steven W. Brostoff

Abstract

The majority of the data available on the immunology of central nervous system (CNS) myelin relate to the specificity of myelin, and in particular its basic protein component, in bringing about the clinical signs and histopathologically defined lesions characteristic of experimental allergic encephalomyelitis (EAE) via a primarily cell-mediated response. The remainder of the available data concern the detection of humoral antibody responses to myelin basic protein (MPB), cerebroside, and ganglioside. In the latter case, antibody to these components has been detected not only in experimental animals but also in normal human serum and in the serum of patients with a variety of neurological disorders.

Keywords

Myelin Basic Protein Basic Protein Central Nervous System Tissue Myelin Antigen Experimental Allergic Neuritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abramsky, O., Webb, C., Teitelbaum, D., and Arnon, R., 1975a, Cell-mediated immunity to neural antigens in idiopathic polyneuritis and myeloradiculitus, Neurology (Minneapolis) 25: 1154.Google Scholar
  2. Abramsky, O., Teitelbaum, D., Webb, C., and Arnon, R., I 975b, Neuritogenic and encephalitogenic properties of the peripheral nerve basic proteins, J. Neuropathol. Exp. Neurol. 34: 36.Google Scholar
  3. Abramsky, O., Korn-Lubetzky, I., and Teitelbaum, D., 1980, Association of autoimmune diseases and cellular immune response to the neuritogenic protein in Guillian-Barré syndrome, Ann. Neurol. 8: 117.Google Scholar
  4. Alvord, E. C., Jr., Shaw, C.-M., Hruby, S., and Kies, M. W., 1965, Encephalitogen-induced inhibition of experimental allergic encephalomyelitis: Prevention, suppression and therapy, Ann. N. Y. Acad. Sci. 122: 333.PubMedCrossRefGoogle Scholar
  5. Arnason, B. G. W., 1971, Idiopathic polyneuritis (Landry-Guillain-Barré-Strohl syndrome) and experimental allergic neuritis: A comparison, in: Immunological Disorders of the Nervous System ( L. Rowland, ed.), pp. 156–177, Williams and Wilkins, Baltimore.Google Scholar
  6. Arnason, B. G. XV., Winkler, G. F., and Hadler, N. M., 1969, Cell mediated demyelination of peripheral nerve in tissue culture, Lab Invest. 21: 1.PubMedGoogle Scholar
  7. Astrom, K. E., and Waksman, B. H., 1962, The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells, J. Pathol. Bacteriol. 83: 89.PubMedCrossRefGoogle Scholar
  8. Barbarese, E., Braun, P. E., and Carson, J. H., 1977, Identification of prelarge and presmall basic proteins in mouse myelin and their structural relationships, Proc. Natl. Acad. Sci. U.S.A. 74: 3360.PubMedCrossRefGoogle Scholar
  9. Bencina, B., Carnegie, P. R., McPherson, T. A., and Robson, G., 1969, Encephalitogenic basic protein from sciatic nerve, FEBS Lett. 4: 9.PubMedCrossRefGoogle Scholar
  10. Bergstrand, H., 1973, Localization of antigenic determinants on bovine encephalitogenic protein: Disease inducing activity of fragment 44–68 in rabbit, Neurobiology 3: 124.PubMedGoogle Scholar
  11. Bergstrand, H., and Berg, 0., 1971, Encephalitogenic activity in rabbits of the C-terminal region of bovine basic myelin protein, Eur. J. Immunol. 1: 499.PubMedCrossRefGoogle Scholar
  12. Bernard, C. C., and Lamoureux, G., 1976, Inhibition by serum of encephalitogenic activity of myelin basic protein: Nature of the serum factors responsible, Cell Irnmunol. 16: 182.CrossRefGoogle Scholar
  13. Bornstein, M. B., and Appal, S. H., 1961, The application of tissue culture to the study of experimental allergic encephalomyelitis: Patterns of demyelination, J. Neuropathol. Exp. Neurol. 20: 141.CrossRefGoogle Scholar
  14. Bornstein, M. B., and Murray, M. R., 1958, Serial observation on pattern of growth, myelination formation, maintenance and degeneration in culture of newborn rat and kitten cerebellum, J. Biophys. Biochem. Cytol. 4: 499.PubMedCrossRefGoogle Scholar
  15. Bornstein, M. B., and Raine, C. S., 1970, Experimental allergic encephalomyelitis: Antiserum inhibition of myelination in nitro, Lab. Invest. 23: 536.PubMedGoogle Scholar
  16. Braun, P. E., Frail, D. E., and Latov, N., 1982, Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy, J. Neurochem. 39: 1261.PubMedCrossRefGoogle Scholar
  17. Brockes, J. P., Raff, M. C., Nishiguchi, D. J., and Winter, J., 1980, Studies on cultured rat Schwann cells. III. Assays for peripheral myelin proteins, J. Neurocytol. 9: 67.PubMedCrossRefGoogle Scholar
  18. Brockman, J. A., Stiffey, A. V., and Tesar, W. C., 1968, An in vitro assay for encephalitogenic components of central nervous tissue, J. Immunol. 100: 1230.PubMedGoogle Scholar
  19. Brostoff, S. W., and Eylar, E. H., 1972, The proposed amino acid sequence of the Pt protein of rabbit sciatic nerve myelin, Arch. Biochem. Biophys. 153: 590.PubMedCrossRefGoogle Scholar
  20. Brostoff, S. W., and Powers, J. M., 1975, Allergic encephalomyelitis: Modificiation of the response by synthetic membrane structures containing bovine myelin basic protein and cerebroside, Brain Res. 93: 175.PubMedCrossRefGoogle Scholar
  21. Brostoff, S. W., and White, T. M., 1982, Absence of P2 protein in swine flu vaccines, J. Am. Med. Assoc. 247: 495.CrossRefGoogle Scholar
  22. Brostoff, S., Burnett, P., Lampert, P., and Eylar, E. H., 1972, Isolation and partial characterization of a protein from sciatic nerve myelin responsible for experimental allergic neuritis, Nature (London) New Biol. 235: 210.Google Scholar
  23. Brostoff, S. W., Wisniewski, H. M., Greenfield, S., Morel], P., and Eylar, E. H., 1973, Immunopathologic response in guinea pigs sensitized with peripheral nervous system myelin, Brain Res. 58: 500.PubMedCrossRefGoogle Scholar
  24. Brostoff, S. W., Reuter, W., Hichens, M., and Eylar, E. H., 1974a, Specific cleavage of the At protein from myelin with cathepsin D, J. Biol. Chem. 249: 559.PubMedGoogle Scholar
  25. Brostoff, S. W., Sacks, H., Dal Canto, M., Johnson, A. B., Raine, C. S., and Wisniewski, H. M., 1974b, The P2 protein of bovine root myelin: Isolation and some chemical and immunological properties, J. Neurochem. 23: 1037.PubMedCrossRefGoogle Scholar
  26. Brostoff, S. W., Karkhanis, Y. D., Carlo, D. J., Reuter, W., and Eylar, E. H., 1975, Isolation and partial characterization of the major proteins of rabbitt sciatic nerve myelin, Brain Res. 86: 449.CrossRefGoogle Scholar
  27. Brostoff, S. W., Levit, S., and Powers, J. M., 1977, Induction of experimental allergic neuritis with a peptide from myelin P2 basic protein, Nature (London) 268: 752.CrossRefGoogle Scholar
  28. Brostoff, S. W., Powers, J. M., and Weise, M. J., 1980, Allergic encephalomyelitis induced in guinea pigs by a peptide from the NH2 terminus of bovine P2 protein, Nature (London) 285: 103.CrossRefGoogle Scholar
  29. Cambi, F., Lees, M. B., Williams, R. N., and MacKlin, W. B., 1983, Chronic relapsing experimental encephalomyelopathy produced by bovine proteolipid apoprotein: Immunological studies in rabbit, Ann. Neurol. 13: 303.PubMedCrossRefGoogle Scholar
  30. Carlo, D. J., Karkhanis, Y. D., Bailey, P. J., Wisniewski, H. M., and Brostoff, S. W., 1975, Allergic neuritis: Evidence for the involvement of the P2 and Po proteins, Brain Res. 88: 580.PubMedCrossRefGoogle Scholar
  31. Carnegie, P. R., 1971a, Amino acid sequence of the encephalitogenic basic protein front human myelin, Biochem. J. 123: 57.PubMedGoogle Scholar
  32. Carnegie, P. R., 1971b, Properties, structure and possible neuroreceptor role of the encephalitogenic protein of human brain, Nature (London) 229: 25.CrossRefGoogle Scholar
  33. Carson, J. H., 1981, High molecular weight forms of myelin basic protein in bovine brain, Trans. Am. Soc. Neurochem. 12: 102.Google Scholar
  34. Chou, C.-H. J., Chou, C.-H. F., Kowalski, T. J., Shapira, R., and Kibler, R. F., 1977, The major site of guinea-pig myelin basic protein encephalitogenic in Lewis rats, J. Neurochem. 28: 115.PubMedCrossRefGoogle Scholar
  35. Coates, A. MacKay, I. R., and Crawford, M., 1974, Immune protection against experimental autoimmune encephalomyelitis: Optimal conditions and analysis of mechanism, Cell Immunol. 12: 370.Google Scholar
  36. Cragg, B. G., and Thomas, P. K., 1964, Changes in nerve conduction in experimental allergic neuritis, J. Neurol. Neurosurg. Psychiatry 27: 106.PubMedCrossRefGoogle Scholar
  37. Cunningham, J. M., Powers, J. M., and Brostoff, S. W., 1983, Prevention of experimental allergic neuritis in the Lewis rat with bovine P2 protein, Brain Res. 258: 285.PubMedCrossRefGoogle Scholar
  38. Curtis, B. M., Forno, L. S., and Smith, M. E., 1979, Reactivation of neuritogenic activity of P2 protein, Brain Res. 175: 387.PubMedCrossRefGoogle Scholar
  39. Dal Canto, M. C., Johnson, A. B., Raine, C. S., Wisniewski, H. M., and Brostoff, S. W., 1974, Expeirmental allergic neuritis: Cells binding horseradish peroxidase conjugates of myelin basic proteins, J. Immunol. 113: 387.Google Scholar
  40. Dau, P. C., and Peterson, R. A. D., 1969, Transformation of rodent lymphoid cells with an encephalitogen of human origin, Int. Arch. Allergy Appl. Immunol. 35: 353.PubMedCrossRefGoogle Scholar
  41. David, J. R., and Paterson, P. Y., 1965, In vitro demonstration of cellular sensitivity in allergic encephalomyelitis, J. Exp. Med. 122: 1161.Google Scholar
  42. Deibler, G. E., Driscoll, B. F., and Kies, M. W., 1978, Iminunochemical and biochemical studies demonstrating the identity of a bovine spinal cord protein (SCP) and a basic protein of bovine peripheral nerve myelin (BF) J. Neurochem. 30: 401.PubMedCrossRefGoogle Scholar
  43. Driscoll, B. R., Kies, M. W., and Alvord, E. C., Jr., 1974a, Successful treatment of experimental allergic encephalomyelitis in the guinea pigs with homologous myelin basic protein, J. Immunol. 112: 392.PubMedGoogle Scholar
  44. Driscoll, B. F., Kramer, A. J., and Kies, M. W., 1974b, Myelin basic protein: Location of multiple independent antigenic regions, Science 184: 73.PubMedCrossRefGoogle Scholar
  45. Driscoll, B. F., Kies, M. W., and Alvord, E. C., Jr., 1975, Adoptive transfer of expeirmental allergic encephalomyelitis: Prevention of successful transfer by treatment with myelin basic protein, J. Immunol. 114: 291.PubMedGoogle Scholar
  46. Driscoll, B. F., Kies, M. W., and Alvord, E. C., Jr., 1979, Transfer of experimental allergic encephalomyelitis with guinea pig peritoneal exudate cells,.Science 203: 547.Google Scholar
  47. Dubois Dalcq, M., Neidieck, B., and Buyse, M., 1970, Action of anti-cerebroside sera on myelinated nervous tissue cultures, Pathol. Eur. 5: 331.PubMedGoogle Scholar
  48. Dunkley, P. R., and Carnegie, P. R., 1974, Amino acid sequence of the smaller basic protein front rat brain myelin, Biochem. J. 141: 243.PubMedGoogle Scholar
  49. Dunkley, P. R., Coates, A. S., and Carnegie, P. R., 1973, Encephalitogenic activity of peptides from the smaller basic protein of rat myelin, J. Immunol. 110: 1699.PubMedGoogle Scholar
  50. Dupouey, P., Zalc, B., Lefroit-Joly, M., and Gomes, D., 1979, Localization of galactosylceramide and sulfatide at the surface of the myelin sheath: An immunofluorescence study in liquid medium, Cell. Mol. Biol. 25: 269.Google Scholar
  51. Edgington, T. S., and Dalessio, D. J., 1970, The assessment by immunofluorescence methods of humoral anti-myelin antibodies in man, J. Immunol. 105: 248.PubMedGoogle Scholar
  52. Ellison, G. W., and Waksman, B. H., 1970, Role of the thymus in tolerance. IX. Inhibition of experimental autoallergic encephalomyelitis by intrathymic injection of encephalitogen, J. Immunol. 105: 322.PubMedGoogle Scholar
  53. Ellison, G. W., Waksman, B. H., and Rundle, N. H., 1971, Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro, Neurology 21: 778.PubMedCrossRefGoogle Scholar
  54. Ellouz, F., Adam, A., Ciorbaru, R., and Lederer, E., 1974, Minimum structural requirements for adjuvant activity of bacterial peptidoglycan derivatives, Biochem. Biophys. Res. Commun. 59: 1317.PubMedCrossRefGoogle Scholar
  55. Eylar, E. H., and Hashim, G. A., 1968, Allergic encephalomyelitis: The structure of the encephalitogenic determinant, Proc. Natl. Acad. Sci. U.S.A. 61: 644.PubMedCrossRefGoogle Scholar
  56. Eylar, E. H., Caccam, J., Jackson, J. J., Westall, F. C., and Robinson, A. B., 1970, Experimental allergic encephalomyelitis: Synthesis of disease-inducing site of the basic protein, Science 168: 1220.PubMedCrossRefGoogle Scholar
  57. Eylar, E. H., Brostoff, S., Hashim, G., Caccam, J., and Burnett, P., 1971a, Basic A1 protein of the myelin membrane: The complete amino acid sequence, J. Biol. Chem. 246: 5770.PubMedGoogle Scholar
  58. Eylar, E. H., Westall, F. C., and Brostoff, S., 1971b, Allergic encephalomyelitis: An encephalitogenic peptide derived from the basic protein of myelin, J. Biol. Chem. 246: 3418.PubMedGoogle Scholar
  59. Eylar, E. 1L, Jackson, J., Rothenberg, B., and Brostoff, S. W., 1972a, Suppression of the immune response: Reversal of the disease state with antigen in allergic encephalomyelitis, Nature (London) 236: 74.Google Scholar
  60. Eylar, E. H, Brostoff, S., Jackson, J., and Carter, H., 1972b, Allergic encephalomyelitis in monkey induced by a peptide from the At protein, Proc. Natl. Acad. Sci. U.S.A. 69: 617.PubMedCrossRefGoogle Scholar
  61. Eylar, E. H., Jackson, J. J., Bennett, C. D., Kniskern, P. J., and Brostoff, S. W., 1974, The chicken Al protein: Phylogenetic variation in the amino acid sequence of the encephalitogenic site, J. Biol. Chem. 249: 3710.PubMedGoogle Scholar
  62. Eylar, E. H., Toro-Goyco, E., Kessler, M. J., and Szymanska, I., 1982, Induction of allergic neuritis in rhesus monkeys. J. Neuroimmunol. 3: 91.PubMedCrossRefGoogle Scholar
  63. Falk, G. A., Kies, M. W., and Alvord, E. C., Jr., 1968, Delayed hypersensitivity to myelin basic protein in the passive transfer of experimental allergic encephalomyelitis, J. Immunol. 101: 638.PubMedGoogle Scholar
  64. Falk, G. A., Kies, M. W., and Alvord, E. C., Jr., 1969, Passive transfer of experimental allergic encephalomyelitis: Mechanism of suppression, J. Immunol. 103: 1248.PubMedGoogle Scholar
  65. Ferraro, A., and Cazzullo, C. I., 1948, Chronic experimental allergic encephalomyeitis in monkeys, J. Neuropathol. Exp. Neurol. 7: 235.PubMedCrossRefGoogle Scholar
  66. Ferraro, A., and Cazzullo, C. L., 1949a, Prevention of experimental allergic encephalomyelitis in the guinea pig, J. Neuropathol. Exp. Neurol. 8: 61.PubMedCrossRefGoogle Scholar
  67. Ferraro, A., and Cazzullo, C. L., 19496, Prevention of experimental allergic encephalomyelitis in the guinea pig, J. Neuropathol. Exp. Neurol. 8: 226.Google Scholar
  68. Ferraro, A., and Roizen, L., 1954, Neuropathologic variations in experimental allergic encephalomyelitis, hemorrhagic encephalomyelitis, perivenous encephalomyelitis, diffuse encephalomyelitis, patchy gliosis, J. Neuropathol. Exp. Neurol. 13: 60.Google Scholar
  69. Field, E. J., Ridley, A., and Caspary, E. A., 1963, Specificity of human brain and nerve antibody as shown by immunofluorescence microscopy, Br. J. Exp. Polio’. 44: 631.Google Scholar
  70. Field, E. J., Bel, T. M., and Carnegie, P. R., 1972, Multiple Sclerosis—Progress in Research, North-Holland, Amsterdam.Google Scholar
  71. Figlewicz, D. A., Quarles, R. H., Johnson, D., Barbarash, G. R., and Sternberger, N. H., 1981, Biochemical demonstration of the myelin-associated glycoprotein in die peripheral nervous system, J. Neurochern. 37: 749.CrossRefGoogle Scholar
  72. Franko, M. C., Koski, C. L., Gibbs, C. J., Jr., McFarlin, D. E., and Gajdusek, D. G., 1982, Monoclonal antibody specific for myelin glycoprotein P0: Derivation and characterization, Proc. Natl. Acad. Sci. U.S.A. 79: 3618.CrossRefGoogle Scholar
  73. Freund, J., Lipton, M. M., and Morrison, L. R., 1950, Demyelination in the guinea pig in chronic allergic encephalomyelitis, Arch. Pathol. 50: 108.Google Scholar
  74. Fry, J. M., Weissbarth, S., Lehrer, G. M., and Bornstein, M. B., 1971, Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue culture, Science 183: 510.Google Scholar
  75. Gasser, D. I., Palm, J., and Gonatas, N. K., 1975, Genetic control of susceptibility to experimental allergic encephalomyelitis and the A S-B locus of rats, J. Immunol. 115: 431.PubMedGoogle Scholar
  76. Gonatas, N. K., Gonatas, J. O., Stieber, A., Lisak, R., Suzuki, K., and Martenson, R. E., 1974, The significance of circulating and cell bound antibodies in experimental allergic encephalomyelitis, Am. J. Pathol. 76: 529.PubMedGoogle Scholar
  77. Greenfield, S., Brostoff, S., Eylar, E. 11., and Morell, P., 1973, Protein composition of myelin of the peripheral nervous system, J. Neurochem. 20: 1207.PubMedCrossRefGoogle Scholar
  78. Greenfield, S., Brost off, S. A1’., and Hogan, E. L., 1980, Characterization of the basic proteins from rodent PNS myelin, J. Neurochem. 34: 453.Google Scholar
  79. Greenfield, S., Weise, M. J., Gantt, G., Hogan, E. L., and Brostoff, S. W., 1982, Basic proteins of rodent peripheral nerve myelin: Immunochemical identification of the 21.5K, 18.5K, 17K, 14K and P2 proteins, J. Neurochem. 39: 1278.PubMedCrossRefGoogle Scholar
  80. Gregson, N. A., Kennedy, M., and Leibowitz, S., 1974, The specificity of antigalactocerebroside antibody and its reaction with lysolecithin-solubilized myelin, Immunology 26: 793.Google Scholar
  81. Hahn, A. F., Gilbert, J. J., and Feasby, T. E., 1980, Passive transfer of demyelination by experimental allergic neuritis serum, Acta Neuropat/rol. (Berlin) 49: 169.CrossRefGoogle Scholar
  82. Hakomori, S., 1974, Preparation and properties of antisulfatide serum, J. Imnzunol. 112: 424.Google Scholar
  83. Hall, J. I., 1967, Studies on demyelinated peripheral nerves in guinea-pigs with experimental allergic neuritis: A histological and electrophysiological study. 11. Electrophysiological observations, Brain 90: 313.PubMedCrossRefGoogle Scholar
  84. Hashim, G. A., and Schilling, F. J, 1973, Prevention of experimental allergic encephalomyelitis by non-encephalomyelitogenic basic peptides, Arch. Biochem. Biophys. 156: 287.PubMedCrossRefGoogle Scholar
  85. Hashim, G. A., and Sharpe, R. D., 1974, Experimental allergic encephalomyelitis: The structural specificty of determinants for delayed hypersensitivity, Immunochemi.stry 11: 633.CrossRefGoogle Scholar
  86. Hashim, G. A., Carvalho, E. G., and Sharpe, R. D., 1978, Definition and synthesis of the essential amino acid sequence for experimental allergic encephalomyelitis in Lewis rats, J. Inrmunol. 121: 665.Google Scholar
  87. Hashim, G. A, Wood, D. D., and Moscarello, M. A., 1980, Myelin lipophilin-induced demyelinating disease of the central nervous system, Neurochem. Res. 5: 1137.PubMedCrossRefGoogle Scholar
  88. Hinrichs, D. J., Roberts, C. M., and Waxman, F. J., 1981, Regulation of paralytic experimental allergic encephalomyelitis in rats: Susceptibility to active and passive disease reinduction, J. Imnzunol. 126: 1857.Google Scholar
  89. Hoffman, P., Gaston, D. D., and Spider, I. E., 1973, Comparison of experimental allergic encephalomyelitis induced with spinal cord, basic protein and synthetic encephalitogenic peptide, Clin. Imnzunol. Immunopathol. 1: 364.CrossRefGoogle Scholar
  90. Hoffman, P. M., Powers, J. M., Weise, M. J., and Brostoff, S. W., 1980, Experimental allergic neuritis. I. Rat strain differences in the response to bovine myelin antigens, Brain Res. 195: 355.PubMedCrossRefGoogle Scholar
  91. Ilolda, J. H., and Swanhorg, R. II. 1981, Regulation of experimental allergic encephalomyelitis. III. Demonstration of effector cells in tolerant rats, Fur. J. Immunol. 11: 338.Google Scholar
  92. Holda, J. H., and Swanhorg, R. Ii., 1982, Autoirmune effector cells. II. Transfer of experimental allergic encephalomyelitis with a subset of T lymphocytes, Eur. J. Imniturol. 12: 453.CrossRefGoogle Scholar
  93. Holda, J. 11., Welch, A. M., and Swanborg. R. H. 1980, Autoimmune effector cells. 1. Transfer of experimental allergic encephalomyelitis with lymphoid cells cultured with antigen, Fur. J. Immunol 10: 657.Google Scholar
  94. Hsieh, D. L., Weise, M. J., Levit, S. Powers, J. M., and Brostoff, S. W., 1981, Strucuue of bovine P., basic protein: Sequence cif a carhoxyterminal segment that is a neuritogen in rabbits, J. Neurochem. 36: 913.PubMedCrossRefGoogle Scholar
  95. Hughes, D., and Field, E. J., 1968, Inhibition of macrophage migration in r’itro by brain and encephalitogenic factor in allergic encephalomyelitis, Int. Arch. Allergy Appl. Immunol. 33: 45.PubMedCrossRefGoogle Scholar
  96. Hughes, R. A. C., Kadlubowski, M., Gray, I. A., and Leibowitz, S., 1981, Immune responses in experimental allergic neuritis, J. Neurol. Neuro.surg. Psychiatry 44: 565.CrossRefGoogle Scholar
  97. Igbal, A., Cger, J., and Aranson, B. G. W., 1981, Cell-mediated immunity in idiopathic polyneuritis, Ann. Neurol. 9 (Suppl.): 65.CrossRefGoogle Scholar
  98. Ishaque. A., Roomi, M. W., Szymanska, I., Kowalski, S., and Eylar, E. H., 1980, The PO glycoprotein of peripheral nerve myelin, Can. J. Biochem. 58: 913.Google Scholar
  99. Ishague, A., Szymanska, I., Ramwani, J., and Eylar, E. H., 1981, Allergic neuritis, phospholipid requirement for the disease inducing conformation of the protein, Brochum. Biophys. Acta 669: 28.CrossRefGoogle Scholar
  100. Ishaque, A., Hofmann, T., and Eylar, E. H., 1982, The complete amino acid sequence of the rabbit P2 protein, J. Biol. Chem. 257: 592.PubMedGoogle Scholar
  101. Jersild, L., Dupont, B., Fug, T., Platz, P. J., and Svejgaard, A., 1975, Histocompatibility determinants in multiple sclerosis, Transplant Reza. 22: 148.Google Scholar
  102. Johnson, A. B., Wisniewski, H. M., Raine, C. S., Eylar, E. H., and Terry, R. D., 1971, Specific binding of peroxidase-labeled myelin basic protein in allergic encephalomyelitis, Proc. Natl. Acad. Sci. U. S. A. 68: 2694.PubMedCrossRefGoogle Scholar
  103. Kabat, E. A., Wolf, A., and Beier, A. L., 1916, Rapid production of acute disseminated encephalomyelitis in rhesus monkey by injection of brain tissue with adjuvants,.Science 104: 362.Google Scholar
  104. Kabat, E. A., Wolf, A., and Bezel’, A. E., 1948, Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys, J. Exp. Med. 88: 417.PubMedCrossRefGoogle Scholar
  105. Kadlubowski, M., and Hughes, R. A. C., 1979, Identification of the neuritogen for experimental allergic neuritis, Nature (London) 277: 140.CrossRefGoogle Scholar
  106. Kadlubowski, M., and Hughes, R. A. C., 1980, The neuritogenicity and encephalitogenicity of P2 in the rat, guinea-pig and rabbit, J. Neurot. Sci. 48: 171.CrossRefGoogle Scholar
  107. Karkhanis, Y. D., Carlo, D. J., Brostoff, S. W., and Eylar, E. H., 1975, Allergic encephalomyelitis: Isolation of a peptide active in the monkey, J. Biol. Chem. 250: 1718.PubMedGoogle Scholar
  108. Kibler, R. F., and Barnes, A. E., 1962, Antibody studies in rabbit encephalomyelitis induced by a water soluble protein fraction of rabbit cord, J. Exp. Med. 116: 807.PubMedCrossRefGoogle Scholar
  109. Kibler, R. F., and Shapira, R., 1968, Isolation and properties of an encephalitogenic protein from bovine, rabbit and human central nervous system tissue, J. Biol. Chem. 243: 281.PubMedGoogle Scholar
  110. Kibler, R. F., Re, P. K., McKneally, S., and Shapira, R., 1972, Biological activity of an encephalitogenic fragment in the monkey, J. Biol. Chem. 247: 969.PubMedGoogle Scholar
  111. Kies, M. W., 1973, Experimental allergic encephalomyelitis, in: Biology of Brain Dysfunction, Vol. 2 (G. E. Gau11 ed.), pp. 185–224, Plenum Press, New York.Google Scholar
  112. Kies, M. W. and Alvord, E. C., Jr., 1958, Prevention of allergic encephalomyelitis by prior injection of adjuvants, Nature (London) 182: 1106.CrossRefGoogle Scholar
  113. Kies, M. W., and Alvord, E. C., Jr., 1959, Encephalitogenic activity in guinea pigs of water soluble protein fractions of nervous tissue, in: Allergic Encephalomyelitis ( M. W. Kies and E. C. Alvord, Jr., eds.), pp. 293–299, Charles C. Thomas, Springfield, Illinois.Google Scholar
  114. Kies, M. W., Driscoll, B. F., Seil, F. J., and Alvord, E. C., Jr., 1973, Myelination inhibition factor: Dissociation from induction of experimental allergic encephalomyelitis, Science 179: 689.PubMedCrossRefGoogle Scholar
  115. Kitamura, K., Suzuki, M., Suzuki, A., and Uyemura, K., 1980, The complete amino acid sequence of the P2 protein in bovine peripheral nerve myelin, FEBS Lett. 115: 27.Google Scholar
  116. Kiyota, K., and Egami, S., 1972, Electrophoretic studies of basic proteins capable of inducing experimental allergic neuritis, J. Neurochem. 19: 857.PubMedCrossRefGoogle Scholar
  117. Kornguth, S. W., Kozel, I. R., and Smithies, 0., 1972, Probable identity of tissue specific histone with encephalitogenic protein, Nature (London) New Biol. 237: 49.CrossRefGoogle Scholar
  118. Kuwert, E., and Niedieck, B., 1965, Anti-cerebroside antibodies in cerebrospinal fluid of rabbits with experimental allergic encephalomyelitis, Nature (London) 207: 991.CrossRefGoogle Scholar
  119. Laatsch, R. II., Kies, M. W., Gordon, S., and Alvord, E. C., Jr., 1962, The encephalitogenic activity of myelin isolated by ultracentrifugation, J. Exp. Med. 115: 777.PubMedCrossRefGoogle Scholar
  120. Lampert, P., 1967, Electron microscopic studies on ordinary and hyperacute experimental allergic encephalomyelitis, Acta Neuropathol. 9: 99.PubMedCrossRefGoogle Scholar
  121. Lassmann, H., and Wisniewski, H. M., 1979, Chronic relapsing experimental allergic encephalomyelitis, Arch. Neurol. 36: 490.PubMedCrossRefGoogle Scholar
  122. Latov, N., Braun, P. E., Gross, R. B., Sherman, W. H., Penn, A. S., and Chess, L., 1981a, Plasma cell dyscrasia and peripheral neuropa thy: Identification of the myelin antigens that react with human paraproteins, Proc. Natl. Acad. Sci. U.S. A. 78: 139.CrossRefGoogle Scholar
  123. Latov, N., Gross, R. B., Kastelman, J., Flanagan, T., Lamme, S., Alkaitis, D. A., Olarte, M. R., Sherman, W. H., Chess, I., and Penn, A. S., 1981b, Complement-fixing antiperipheral nerve myelin antibodies in patients with inflammatory polyneuritis and with polyneuropathy and paraproteinemia, Neurology 31: 1530.PubMedCrossRefGoogle Scholar
  124. Leibowitz, S., 1966, Immunological reactions in the central nervous system, J. R. Coll. Physicians London 1: 85.Google Scholar
  125. Lennon, V. A., and Carnegie, P. R., 1974, Immunological responses of guinea pigs to a synthetic autoantigen of brain, Fur. J. Immunol. 4: 60.Google Scholar
  126. Lennon, V. A., Whittingham, S., Carnegie, P. R., McPherson, T. A., and McKay, I. R., 1971, Detection of antibodies to the basic protein of human myelin by radioimmunoassay and immunofluorescence, J. Immunol. 107: 56.PubMedGoogle Scholar
  127. Lerner, R. A., and Dixon, F. J., 1966, Transfer of bovine experimental allergic glomerulonephritis (EAG) with serum, J. Exp. Med. 124: 431.PubMedCrossRefGoogle Scholar
  128. Levine, S., 1971, Relationship of experimental allergic encephalomyelitis to human disease, in: Immunological Disorders of the Nervous System (I. P. Rowland, ed.), pp. 33–49, Williams and Wilkins, Baltimore.Google Scholar
  129. Levine, S., and Sowinski, R., 1971, Allergic encephalomyelitis: New form featuring polymorphonuclear leucocytes, Science 171: 498.PubMedCrossRefGoogle Scholar
  130. Levine, S., and Sowinski, R., 1975, Allergic encephalomyelitis in the reputedly resistant strain of rats, J. Immunol. 114: 597.PubMedGoogle Scholar
  131. Levine, S., and Wenk, E. J., 1965a, Induction of experimental allergic encephalomyelitis in rats without the use of adjuvants,, lnn. N. 1’. Acad. Sci. 122: 209.CrossRefGoogle Scholar
  132. Levine. S., and \V’enk, E. J., 1965h, Allergic encephalomyelitis: A hyperacute form,,Science 146: 1681.Google Scholar
  133. Levine, S., 11’enk, E. J. and Hoenig, E. VI., 1967, Passive transfer of allergic encephalomyelitis bc’t lVet’n inbred rat strains: Correlation with transplantation antigens. Transplantation 5: 534.PubMedCrossRefGoogle Scholar
  134. Levine, S., Sowinski, R., Gruc’newald, R., and Kies, M. W., 1972, Experimental allergic (ncephal)myelitis: Production by myelin basic protein adsorbed on particulate adjuvants, Immunology 23: 609.PubMedGoogle Scholar
  135. I.evit, S., Powers, J. M., Milek, D., and Brostoff, S. W., 1980, Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs, Neurochem. Res. 5: 37.CrossRefGoogle Scholar
  136. I.in, J. T., Rowe, P., Brostoff, S. AV., and Abdon. N. 1., 1982, Lymphocyte studies in a patient with chronic polyradiculoneuropathy, Neurology (NY) 32: 1127.CrossRefGoogle Scholar
  137. Lipton, M. M., and Freund, J., 1953, The transfer of experimental allergic encephalomyelitis in the rat by means of parabiosi.s, J. Iranrnmol. 71: 380.Google Scholar
  138. Lisak, R. P., Heinze, R. G., Kies, M. W., arid Alvord, E. C., Jr., 1969, Antibodies to encephalitogenic basic protein iu (petitncnt !1 allergic encephalomyelitis, Pror. Soc. F. p. Biol. A1ed. 130: 814.Google Scholar
  139. Lisak, R. P., Falk, G. A., Heusze, R. G., Kies, M. W., and Alvord, E. C., Jr., 1970, Dissociation of antibody production from disease suppression in the iii hibinon of aI lei gte encephalomyelitis by myelin basic protein, J. Imntunol. 104: 1935.Google Scholar
  140. Lisak, R. P., Daida,’1’., Kennedy, P. C;. E., Saida, K., Silberberg, H., and Leibowiu, S., 1980, EAE, EAN and gal acto(rebroside sera bind to o!igodendtocytes and Schscaun cells, J. Neurol. Sci. 48: 287.PubMedCrossRefGoogle Scholar
  141. London, Y., 1971, Ox peripheral nerve myelin membrane: Purification and partial characterization of two basic proteins. Biochirn. Biophys. Arta 249: 188.CrossRefGoogle Scholar
  142. Lublin, F. I)., Maurer, P. H., Berry, R. G., and Tippet!, D., 1981, Delayed, relapsing experimental allergic encephalomyelitis in mice, J. Inrnurnol. 126: 819.Google Scholar
  143. MacKay, 1. R., Carnegie, P. R., and Coates, A. S., 1973, immunopathologiea1 comparisons between experimental autoimmune encephalonyelit is and multiple sclerosis, Clin. Exp. Immuno!. 15: 471.Google Scholar
  144. Macklin, W. B., Schwarting, G. A., Lees, M. B., and Cohen, S. R., 1981, Production and purification of antibody to bovine white matter proteolipid apoprotcin, J. Neu nor Item. 36: 101.Google Scholar
  145. Macklin, W. B., Braun, P. E., and Lacs, M. B., 1982. Electroblot analysis of the myelin proteolipid protein, J. Neu rosci. Res. 7: 1.CrossRefGoogle Scholar
  146. Mansson, J. E., Holmgrcn, J., I. t. Y. T., Wa nor, M. T., and Sv’nncrholm, L., 1974, Chemical anti immunological characterization of the major glucosamine-containing ganglioside of human tissues. Med. Biol. 52: 240.Google Scholar
  147. Martenson, R. E., 1981, Predicted structure of the myelin P2 protein, Trans. Am. Soc. Neurochem. 12: 121.Google Scholar
  148. Martenson, R. E., Deibler, G. E., and Kics, M. W., 1971, Comparison of amino acid sequence of hypothalmic peptide, brain specific histone and myelin basic protein, Nature (London) New Biol. 234: 87.Google Scholar
  149. Martenson, R. E., Deibler, G. E. Kies, M. W., McKneally, S. S., Shapira, R., and Kibler, R. F., 1972, Differences between the two myelin basic proteins of the rat central nervous system, Biochim. Biophys. Arta 263: 193.Google Scholar
  150. Martenson. R. E., Levine, S., and Sowinski, R., 1975, The location of regions in guin pig and bovine myelin basic proteins which induce experimental allergic encephalomyelitis elitis in Lewis rats, J. 1 ntnzuutol. 114: 592.Google Scholar
  151. McDermott, J. A., and Keith, B., 1980. Antigen-induced suppression of experimental allergic neuritis in the guinea pig, J. Nerzroi. Sci. 46: 137.CrossRefGoogle Scholar
  152. McFarlin. D. E., Blank, S. E., Kibler, R. E., McKneally, S., and Shapira, R., 1973, Experimental allergic encephalomyelitis in the rat: Response to encephalitogenic proteins and peptides, Science 179: 478.CrossRefGoogle Scholar
  153. McPherson, T. A., Marchalonis, J. J., and Lennon, V., 1970, Binding of encephalitogenic basic protein by serum globulins, Immrnrology 19: 929.Google Scholar
  154. Mehta, P. D., Lassmann, H., and Wisniewski, H. M., 1981, Immunologic studies of chronic relapsing EAE in guinea pigs: Similarities to multiple sclerosis, J. Imntunol. 127: 334.Google Scholar
  155. Milek, D. J. Sarvas, H. O., Greenfield, S., Weise, M. J., and Brostoff, S. W., 1981, An immunological characterization of the basic proteins of rodent sciatic nerve myelin, Brain Re.c. 208: 387.Google Scholar
  156. Milek, D. Powers, J. Cunningham, J., and Brostoff, S. W., 1983, Experimental allergic neuritis Humoral and cellular immune responses to the cyanogen bromide peptides of the Pzprotein, J. Neuroimmunol. 4: 105–117.Google Scholar
  157. Mitlwn, F. A. Agrrwal. H. C., Friar, E. II., Fishman, M. A., Blank, W., and Bunge, R. P., 1982a, Studies with antiseria against peripheral nervous system myelin and myelin basic proteins. 1. Effects of antiserum upon living cultures of nervous tissue, Brain Res. 250: 321.CrossRefGoogle Scholar
  158. Mithen, F. A., Agrawal, H. C., Fishman, M. A., Eylar, E. II., and Bunge, R. P., 1982b, Studies with antiseria against peripheral nervous system myelin and myelin basic proteins II. Immuhistochemical studies in cultures of rat dorsal root ganglion neurons and Schwann cells, Brain Res. 250: 333.PubMedCrossRefGoogle Scholar
  159. Morgan, I. M., 1946, Allergic encephalomyelitis in monkeys in response to injection of normal monkey cord, J. Bacterial. 51: 614.Google Scholar
  160. Nagai, Y., Akiyanta, K., Suzuki, K., Kartni, D., Watanabe, Y., Shimono, ‘T., Shiba, “r., Kusumoto, S., Ikuta, F., and Takeda, S., 197ßa, Minimum structural requirernents for encephaIilogen and for adjuvant in the induction of experimental allergic neuritis, Cell. Inzm lino l. 35: 158.Google Scholar
  161. Nagai, Y., Uchida, T., Takeda, S., and Ikuta, F., 19786, Restoration of activity for induction of experimental allergic pen plierai neuritis by combination of myelin basic protein P., and gangliosides from peripheral nerve, Neuro.sci. Lett. 8: 247.Google Scholar
  162. Nagai, M., Marcus, D. M., and Ledeen, R., 1974, Properties of antisera to ganglioside Gsrr and asialo GM!, J. Inzmunol. 113: 84.Google Scholar
  163. Nakanmra, R. M., and Weigle, W. O., 1969, Transfer of experimental autoimrnune thyroiditis by serum from thyroidectomized donors, J. Exp. fled. 130: 393.Google Scholar
  164. Namikawa, T., Richert, J. R., Driscoll, B. F., Kies, M. W., and Alvord, E. C., Jr., 1982, Transfer of allergic encephalomyelitis with spleen cells from donorssensitized with myelin basic protein in incomplete Freund’s adjuvant, J. Lmniono. 128: 932.Google Scholar
  165. Oldstone, M. B. A., and Dixon, F. J., 1968, Immunohistochemical studies of allergic encephalomyelitis, Ant. J. Pat/in!. 52: 251.Google Scholar
  166. Pan itch, H. S., 1980, Adoptive transfer of experimental allergic encephalomyelitis with activated spleen cells comparison Olin nitro activation by cotuanavalin Aand myelin basic protein, Cell. Immunal. 56: 163.CrossRefGoogle Scholar
  167. Panitch, H. S., and Ciccone, C., 1981, Adoptive transfer of experimental allergic encephalomyelitis: Requirement for macrophages in activation of spleen cells itt nitro by cotuanavalin A or myelin basic protein. Cell. linnumol. 60: 24.Google Scholar
  168. Pan itch, 11. S., and McFarlin, D. E., 1977, Fxperintentl allergic encephalornyelitis: Enhancement of cell-mediated transfer by cotuanavalin A, J. Inzmunol. 119: 1134.Google Scholar
  169. Paterson, P. Y., I960,’1’ransfer of allergic ens ephalonryelitis in rats by means of lymph node cells, J. Exp. Bled. 111: 119.Google Scholar
  170. Paterson, P. Y., 1973, Multiple sclerosis: An imnntnological reassessment, J. Cltrotzw Dis. 26: 119.CrossRefGoogle Scholar
  171. Peters, B. A.,;tod Ilinri(hs, D. J., 1982, Passive uansferofexperimental allergic encephalomyelitisin the Lewis rat with activated spleen cells Differential activation with mitogens, Cell. Immunol. 69: 175.Google Scholar
  172. Pettinelli, C. B.,;rnd Mt Fatlin, I). E., 1981, Adoptive transferal experimental allergic encephalomyelitis in SJI. J mice af ter iii nitro acu vat ion of lymph node cells by myelin basic protein: Requirement for I.yt 1+2-T lymphocytes, J. Immunol. 127: 1420.Google Scholar
  173. Prineas, J., Raine, C. S., and Wisniewski, H., 1969, An ultastructural study of dcrnyelination and remyelination. III. Chronic experimental allergic encephalomyelitis in the central nervous system. Lab. Inzesst. 21: 472.Google Scholar
  174. Quarles, R. I., 1980, Glycoproteins from central and peripheral myelin, in: Myelin: Chemistry and Biology (;. Raskin, ecl.), p. 55, Alan R. I,iss, New York.Google Scholar
  175. Rai ne, C. S., and Stone, S. H., 1977. Animal model for multiple sclerosis: Chronic experimental allergic encephalomyelitis in inbred guinea pigs, N. Y.State J. Med. 77: 1693.PubMedGoogle Scholar
  176. Raine, C. S., “Fraugott, I1., Nussenblatt, R. B., and Stone, S. H., 1980, Optic neuritis and chronic relapsing experimental allergic encephalomyelitis: Relationship to clinical course and comparison with multiple sclerosis, Lab. Invest. 42: 327.Google Scholar
  177. Raine, C. S., Johnson, A. B., Marcus, D, M., Suzuki, A., anti Bornstein, M. B., 1981, Demyelination in nitro: Absorption studies demonstrate that galactocerebroside is a major target, J. Neural. Sri. 52: 117.Google Scholar
  178. Rapport, M. M., 1970, 1.ipicl haptens, in: Handbook of Neu rocltentistr’, Vol. 3 (A. Lajtha, ed.), p. 509, Plenum Press, New York.Google Scholar
  179. Richert, J. R., Driscoll, B. F., Kies, M. W., and Alvord, Jr., E. C., 1979, Adoptive transfer of experimental allergic encephalomyelitis: Incubation of rat spleen cells with specific antigen, J. Ii nuno1. 122: 494.Google Scholar
  180. Richert, J. R., Kies, M. W., and Alvord, E. C., Jr., 1981, Enhanced transfer of experimental allergic encephalomyelitis with Lewis rat lymph node cells, J. Neorointnnntol. 1: 195.Google Scholar
  181. Rivers, T. M., and Schwentker, F. F., 1935, Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys, J. Exp. 1fed. 61: 689.CrossRefGoogle Scholar
  182. Rivers, T. M., Sprunt, D. H., and Berry, G. P., 1933, Observation on attempts to produce acute disseminated encephalomyelitis in monkeys, J. Exp. 1ed. 58:39.Google Scholar
  183. Rohoz-Ein stein, E., and Henderson, N., 1959, Preparation and properties of water soluble proteins hom bovine cord with ‘al lergic“encephalomyelitis actiivity, in: Aller;gir Enrephalomyeliti.s (v1. C. Kies and E. C. Alvord, Jr., eds.), pp. 281–292, Charles C Thomas, Springfield, Illinois.Google Scholar
  184. Saida, K., Saida, T., Brown, M. J., Silberbetgg, D. H., arid Asbtirv, A. K., 1978. Antiserum-mediatecl demyelimiation in c li n: A sequential study using intraneural injection of experimental allergic neuritis serum, Lab. Incest. 39: 449.Google Scholar
  185. Saida, K., Saida, T., Brown, M. J., and Silberberg, D. II., 1979, In z’ino dem ‘eIiisation inducecl by intraneural injection of antigalactocerebroside scrum: A morphologic study, Ani. J. Patltol. 95: 99.Google Scholar
  186. Saida. T., Silberberg, D. H., Fry, J. M., and Manning, M. C., 1977, Demvclinating antigalacto cerebroside antibodies in LAN and EAE, J. Netcropathol. Exp. Neurol. 36:627.Google Scholar
  187. Saida, I,., Saida, K., Silberberg, D. I-I., and Brown, M. J., 1978, Transfer of demyelination 6v inuaneural injection of experimental allergic neuritis serum, Nature (London) 272: 639.CrossRefGoogle Scholar
  188. Saida, T., Saida, K., Brown, M. J., and Silberherg, D. 1-I., I979a, Peripheral nerve clentyelination jml tic eci by intraneural injection of experimental allergic encephalomyelitis Serum, J. Neuropathol. E.vp. Neurol. 38: 498.Google Scholar
  189. Saida, T., Saida, K., Dorfrnan, S. H., SiIherberg, D. f I., Sumner, A. J., Manning, M. C., I.isak, R. P., and Brown, M. J., 1979b, Experimental allergic neuritis induced by sensitization with galactocerebroside, Science 204: 1103.PubMedCrossRefGoogle Scholar
  190. Saida, T., Saida, K., and Silberberg, D. H., 1979e, Demyelination produced by experimental alletggic neuritis serum and antigalactocerebroside antiserum in CNS cultures: An ultrastructural study, Acta Neuropathol. (Berlin) 48: 19.CrossRefGoogle Scholar
  191. Saida, T., Saida, K., Silberberg, D. H., and Brown, M. J., 1981, Experimental allergic neuritis induced by galactocerebroside Ann. Neural. 9(Suppl.):87.Google Scholar
  192. Saida, T., Saida, K., Lisak, R. P., Brown, M. J., Silberberg, D. H., and Asbury, A. K., 1982, In ciao demyelinating activity of sera from patients with Guillain-Barré syndrome, Ann. Neural. 11: 69.Google Scholar
  193. Sarvis, H. O., Milek, D. J., Weise, M. J., Carnow, T. B., Fudenberg, H. H., and Brostoff, S. W., 1980, Radioimmunoassay for the P_ protein of bovine peripheral nerve myelin, J. Immunol. 124: 557.Google Scholar
  194. Schwartz, M., Sela, B. A., and Eshhar, N., 1982, Antibodies to gangliosides and myelin autoantigens are produced in mice following sciatic nerve injury, J. Neurochem. 38: 1192.PubMedCrossRefGoogle Scholar
  195. Seil, F. J., Falk, G. A., Kies, M. W., and Alvord, E. C., Jr., 1968, The in nitro demyelinating activity of sera from guinea pigs sensitized with whole CNS and with purified encephalitogen, Exp. Neural. 22: 545.CrossRefGoogle Scholar
  196. Seil, F. J., Kies, M. W., and Bacon, M. S., 1981, A comparison of demyelinating and myelinatiomi inhibiting factor induction by whole peripheral nerve tissue and P2 protein, Brain Res. 210: 441.PubMedCrossRefGoogle Scholar
  197. Shapira, R., Chou, F. L.-H., McKneally, S., Urban, E., and Kibler, R. F., 1971, Biological activity and synthesis of an encephalitogenic deteminant, Science 173: 736.PubMedCrossRefGoogle Scholar
  198. Shaw, C. M., Alvord, E. C., Jr., Kaku, J., and Kies, M. W., 1965, Correlation of experimental allergic encephalomyelitis with delayed type skin sensitivity to specific homologous encephalitogen, Ann. N. Y. Acad. Sei. 122: 318.CrossRefGoogle Scholar
  199. Sheffield, W. D., Gonatas, N. K., and Kim, S. U., 1977, Kinetics of the in nitro lymphocyte response to myelin basic protein in the Lewis amid Brown Norway strains of rat, J. Imnnenol. 119: 1762.Google Scholar
  200. Sheremata, W. A., Cosgrove, J. B. R., and Eylar, E. H., 1974, Cellular hypersensitivity to basic rnyelin (A i) protein and clinical multiple sclerosis, N. Engl. J. Med. 291: 14.PubMedCrossRefGoogle Scholar
  201. Sheremata, W., Colby, S., Karkhanis, Y., and Eylar, E. H., 1975, Cellular hypersensitivity to basic myelin (P2) protein in the Guillain-Barré synclronte, Can. J. Neural. Sri. 2: 87.Google Scholar
  202. Sheremata, W., Eylar, E. H., Syzmanska, I., and Sazant, A., 1981, Peripheral nerve myelin P_ protein in influenza vaccine, Ann. Neuol. 10: 91.Google Scholar
  203. Sherwin, A. L., 1966, Chronic allergic neuropathy in the rabbit, Arch. Neural. 15:289Google Scholar
  204. Shiraki, H., and Otani, S., 1959, Clinical and pathological features of rabies post-saccinal encephalo myelitis in man, in: Allergic Encephalomyelitis (M. W. Kies and E. C. Alvord, Jr., eels.), pp. 58–129, Charles C Thomas, Springfield, Illinois.Google Scholar
  205. Spitler, L. E., Von Muller, C. M., Fudenberg, H. H., and Eylar, E. H., 1972, Experimental allergic encephalomyelitis: Dissociation of cellualr immunity to brain protein and disease production, J. Exp. Med. 136: 156.PubMedCrossRefGoogle Scholar
  206. Sriram, S., Solomon, D., Rouse, R. V., and Steinman, I., 1982, Identification of T cell subsets and Blymphocytes in mouse brain experimental allergic encephalitis lesions, J. Immunol. 129: 1649.PubMedGoogle Scholar
  207. Steinman, L., Cohen, I., and Teitelbaum, D., 1980, Natural occurrence of thymocytes that react with myelin basic protein, Neurology 30: 755.PubMedCrossRefGoogle Scholar
  208. Sternberger, N. H., Quarles, R. H., Itoyama, Y., and Webster, H. de F., 1979, Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat, Proc. Natl. Acad. Sci. U.S.A. 76: 1510.PubMedCrossRefGoogle Scholar
  209. Stone, S. H., 1961, Transfer of allergic encephalomyelitis by lymph node cells in inbred guinea pigs, Science 134: 619.PubMedCrossRefGoogle Scholar
  210. Stone, S. H., and Lerner, E. V., 1965, Chronic disseminated allergic encephalomyelitis in guinea pigs, Science 122: 226.Google Scholar
  211. Sumner, A. J., Saida, K., Saida, T., Silberberg, D. H., and Asbury, A. K., 1982, Acute conduction block associated with experimental antiserum-mediated demyelination of peripheral nerve, Arm. Neural. 11: 469.CrossRefGoogle Scholar
  212. Suzuki, M., Kitamura, K., Uyemura, K., Ogawa, Y., Ishihara, Y., and Matsuyama, H., 1980, Neuritogenic activity of peripheral nerve myelin proteins in Lewis rats, Neuro.sci. Lett. 19: 353.CrossRefGoogle Scholar
  213. Swanborg, R. H., 1972. Antigen induced inhibition of experimental allergic encephalomyelitis. 1. Inhibition in guinea pigs injected with nonencephalitogenic modified myelin basic protein, J. Immunol. 109: 540.PubMedGoogle Scholar
  214. Swierkosz, J. E., and Swanborg, R. H., 1977, Immunoregulation of experimental allergic encephalomyelitis: Conditions for induction of suppressor cells and analysis of mechanism, J. Immunol. 119: 1501.PubMedGoogle Scholar
  215. Teitelbaum, D., Meshorer, A., Hirshfield, T., Amnon, R., and Sela, M., 1971, Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide, Eur. J. Immunol. 1: 242.PubMedCrossRefGoogle Scholar
  216. Trapp, B. D., McIntyre, L. J., Quarles, R. H., Sternberger, N. H., and Webster, H. de F., 1979, Imrnunocytochemical localization of rat peripheral nervous system myelin proteins: P2 protein is not a component of all peripheral nervous system myelin sheaths, Proc. Natl. Acad. Sci. U.S.A. 76: 3552.PubMedCrossRefGoogle Scholar
  217. Trapp, B. D., Itoyama, Y., Macintosh, and Quarles, R. H., 1983, P., protein in oligodendrocytes and myelin of the rabbit central nervous system, J. Neurochem. 40: 47.Google Scholar
  218. Traugott, U., Shevach, E., Chiba, J., Stone, J. H., and Raine, C. S., 1981, Autoimmune encephalo- myelitis: Simultaneous identification of T and B cells in the target organ, Science 214: 1251.PubMedCrossRefGoogle Scholar
  219. Uemura, K., Yuzawa-Watanabe, M., Kitazawa, N., and Taketomi, T., 1980, Immunochemical studies of lipids. VI. Reactions of anti-sulfatide antibodies with sulfatide in liposomal and myelin membranes, J. Biochem. 87: 1221.PubMedGoogle Scholar
  220. Uyemura, K., Tobari, C., Hirano, S., and Tsukada, Y., 1972, Comparative studies on the myelin proteins of bovine peripheral nerve and spinal cord, J. Neurochem. 19: 2607.PubMedCrossRefGoogle Scholar
  221. Uyemura, K., Suzuki, M., Kitamura, K., Horie, K., Ogawa, Y., Matsuyama, H., Nozaki, S., and Muramatsu, I., 1982, Neruitogenic determinant of bovine P2 protein in peripheral nerve myelin. I. Neurochem. 39: 895.CrossRefGoogle Scholar
  222. Waksman, B. H., 1963, Experimental immunologic disease of the peripheral nervous system, in: Mechanisms of Demyelination ( A. S. Rose and C. M. Pearson, eds.), p. 170, McGraw-Hill, New York.Google Scholar
  223. Waksman, B. H., and Adams, R. D., 1955, Allergic neuritis, an experimental disease of rabbits induced by injection of peripheral nervous tissue and adjuvants, J. Exp. Med. 102: 213.CrossRefGoogle Scholar
  224. Waksman, B. H., and Adams, R. D., 1956, A comparative study of experimental allergic neuritis in the rabbit, guinea pig and mouse, J. Neuropathol. Exp. Neurol. 15: 293.PubMedCrossRefGoogle Scholar
  225. Waksman, B. H., and Adams, R. D., 1962, A histological study of the early lesion in experimental allergic encephalomyelitis in the guinea pig and rabbit, Am. J. Pathol. 41: 135.PubMedGoogle Scholar
  226. Weise, M. J., and Brostoff, S. W., 1982, Conformation of bovine nerve root P2 protein: Characteristics of the molecule from circular dichroism spectra, J. Neurochem. 38: 1600.PubMedCrossRefGoogle Scholar
  227. Weise, M. J., Hsieh, D. L., Hoffman, P. M., Powers, J. M., and Brostoff, S. W., 1980a, Bovine peripheral nervous system myelin P2 protein: Chemical and immunological characterization of the cyanogen bromide peptides, J. Neurochem. 35: 393.PubMedCrossRefGoogle Scholar
  228. Weise, M. J., Hsieh, D. L., Levit, S., and Brostoff, S. W., 1980b, Bovine P2 protein: Sequence at the NFL-terminal of the protein, J. Neurochem. 35: 388.PubMedCrossRefGoogle Scholar
  229. Welch, A. M., Holda, J. H., and Swanborg, R. H., 1980, Regulation of experimental allergic encephalomyelitis. II. Appearance of suppressor cells during the remission phase of the disease, J. Immunol. 125: 186.PubMedGoogle Scholar
  230. Wenk, E. J., Levine, S., and Warren, B., 1967, Passive transfer of allergic encephalomyelitis with blood leucocytes, Nature (London) 214: 803.CrossRefGoogle Scholar
  231. Westall, F. C., Robinson, A. B., Caccam, J., Jackson, J., and Eylar, E. H., 1971, Essential chemical requirements for induction of allergic encephalomyelitis, Nature (London) 229: 22.CrossRefGoogle Scholar
  232. Whittingham, S., Bencina, B., Carnegie, P. R., and McPherson, T. A., 1972, Properties of antibodies produced in rabbits to human myelin and myelin basic protein, Int. Arch. Allergy Appl. Irnmunot. 47: 250.CrossRefGoogle Scholar
  233. Willenborg, D. O., 1979, Experimental allergic encephalomyelitis in the Lewis rat: Studies on the mechanism of recovery from disease and acquired resistance to reinduction, J. Immunot. 123: 1145.Google Scholar
  234. Williams, R. M., Lees, M. B., Cambi, F., and Macklin, W. B., 1982, Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter protelipid apoprotein, J. Neuropathol. Exp. Nets roi. 41: 508.CrossRefGoogle Scholar
  235. Wisniewski, H. M., Brostoff, S. W., Carter, H., and Eylar, E. H., 1974, Recurrent experimental allergic polyganglioradiculoneuritis, Arch. Neural. 30: 347.CrossRefGoogle Scholar
  236. Yokoyama, M., ‘I’rams, E. G., and Brady, R. O., 1962, Sphingolipid antibodies in sera of animals and patients with central nervous system lesions, Proc. Soc. Exp. Biot. Med. 111: 350.Google Scholar
  237. Yonezawa, T. Ishihara, Y., and Matsuyama, H., 1968, Studies on experimental allergic peripheral neuritis. I. Demyelinating patterns studies in vitro, J. Neuropathot. Exp. Neurot. 27: 453.Google Scholar
  238. Zweiman, B., Moskovitz, A. R., Rostami, A., Lisak, R. P., Pleasure, D. E., and Brown, M. J., 1982, Antibodies to P and Pi myelin antigens in experimental allergic neuritis and allergic encephalomyelitis, J. Neuroimmunol. 2: 331.PubMedCrossRefGoogle Scholar
  239. Zweiman, B., Rostami, A., I.isak, R. P., Moskovitz, A. R., and Pleasure, D. E., 1983, Immune reactions to P., protein in human inflammatory demyelinative neuropathies, Neurology (NY) 33: 234.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Steven W. Brostoff
    • 1
  1. 1.Department of NeurologyMedical University of South CarolinaCharlestonUSA

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