Myelin pp 405-439 | Cite as

Immunological Responses to Myelin and Myelin Components

  • Steven W. Brostoff


The majority of the data available on the immunology of central nervous system (CNS) myelin relate to the specificity of myelin, and in particular its basic protein component, in bringing about the clinical signs and histopathologically defined lesions characteristic of experimental allergic encephalomyelitis (EAE) via a primarily cell-mediated response. The remainder of the available data concern the detection of humoral antibody responses to myelin basic protein (MPB), cerebroside, and ganglioside. In the latter case, antibody to these components has been detected not only in experimental animals but also in normal human serum and in the serum of patients with a variety of neurological disorders.


Myelin Basic Protein Basic Protein Central Nervous System Tissue Myelin Antigen Experimental Allergic Neuritis 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Steven W. Brostoff
    • 1
  1. 1.Department of NeurologyMedical University of South CarolinaCharlestonUSA

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