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Immunological Responses to Myelin and Myelin Components

  • Chapter
Myelin

Abstract

The majority of the data available on the immunology of central nervous system (CNS) myelin relate to the specificity of myelin, and in particular its basic protein component, in bringing about the clinical signs and histopathologically defined lesions characteristic of experimental allergic encephalomyelitis (EAE) via a primarily cell-mediated response. The remainder of the available data concern the detection of humoral antibody responses to myelin basic protein (MPB), cerebroside, and ganglioside. In the latter case, antibody to these components has been detected not only in experimental animals but also in normal human serum and in the serum of patients with a variety of neurological disorders.

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Authors and Affiliations

  1. Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, 29425, USA

    Steven W. Brostoff

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  1. Steven W. Brostoff
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  1. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    Pierre Morell

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© 1984 Springer Science+Business Media New York

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Brostoff, S.W. (1984). Immunological Responses to Myelin and Myelin Components. In: Morell, P. (eds) Myelin. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1830-0_12

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  • DOI: https://doi.org/10.1007/978-1-4757-1830-0_12

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