Cardiology pp 509-515 | Cite as

Manifestations of Coronary Disease Predisposing to Stroke: The Framingham Study

  • W. B. Kannel
  • P. A. Wolf
  • J. Verter

Abstract

The relation of coronary heart disease to development of strokes in general and brain infarction in particular has been examined prospectively over 24 years of follow-up in the Framingham Study cohort. In the course of 24 years of biennial surveillance, there were 169 strokes in men and 175 in women aged 45–84; brain infarctions occurred in 100 men and 107 women, comprising 60% of strokes. Routine ECG’s chest X-rays coronary heart disease and cardiac failure status were ascertained biennially on regular examinations and risk of strokes determined in relation to these. Age and other stroke risk factors (including blood pressure, diabetes cigarettes and lipids were also routinely measured and were taken into account in multivariate analysis of the net and joint effects of CHD manifestations as precursors of strokes. The incidence of stroke was lower and stroke occurred later in life than coronary heart disease. Stroke incidence in men lagged that of myocardial infarction by more than 10 years. In women, the incidence of brain and myocardial infarction was similar. In men the average annual incidence of myocardial infarction (8.5/1000) was three times that for brain infarction (2.7/1000).1

Keywords

Coronary Heart Disease Brain Infarction Framingham Study Coronary Circulation Chronic Atrial Fibrillation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. A. Wolf, and W. B. Kannel, Controllable risk factors for stroke: Preventive implications of trends in stroke mortality, in: “Diagnosis and Management of Stroke and TIA’s,” J. S. Meyer and T. Shaw, eds., Addison-Wesley Publishing Company, p.26–61 (1981).Google Scholar
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    P. A. Wolf, W. B. Kannel, P. Sorlie, and P. McNamara, Asymptomatic carotid bruit and risk of stroke, JAMA 245:1442–1445 (1981).PubMedCrossRefGoogle Scholar
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    W. B. Kannel, T. Gordon, and W. P. Castelli, Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease, The Framingham Study, Ann.Intern.Med. 72: 813 (1970).PubMedCrossRefGoogle Scholar
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    P. A. Wolf, T. R. Dawber, H. E. Thomas Jr. , and W. B. Kannel, Epidemiological assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study, Neurology 28:973–977 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • W. B. Kannel
    • 1
  • P. A. Wolf
    • 1
  • J. Verter
    • 1
  1. 1.Chief Section of Preventative Medicine and EpidemiologyBoston University School of MedicineUSA

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