Cardiology pp 467-471 | Cite as

Neural Factors in Sudden Death

  • Peter J. Schwartz

Abstract

To understand the relationship between the nervous system and ventricular fibrillation, the leading cause of sudden death, is a key factor to comprehend the underlying pathophysiologic mechanisms, to establish rational preventive measures, and to improve the early identification of high risk patients. Considerable progress has been made during the last decade1,2,3 and some of the main points will be mentioned here, including the problem of adequate animal models for sudden death, the role of psychologic stress, of the cardiac sympathetic nerves and of the vagi, and the potential for autonomic reflexes to be used for the identification of high risk subgroups.

Keywords

Sudden Death Sudden Cardiac Death Ventricular Fibrillation Ventricular Tachyarrhythmia Exercise Stress Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. J. Schwartz, A. M. Brown, A. Malliani, and A. Zanchetti, “Neural Mechanisms in Cardiac Arrhythmias,” Raven Press, New York (1978).Google Scholar
  2. 2.
    B. Lown, Cardiovascular collapse and sudden cardiac death, in: “Heart Disease,” E. Braunwald, ed., W. B. Saunders, Philadelphia (1980).Google Scholar
  3. 3.
    P. J. Schwartz and H. L. Stone, The role of the autonomic nervous system in sudden coronary death, Ann.NY.Acad.Sci. 382:162 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    P. J. Schwartz, G. E. Billman, and H. L. Stone, Autonomic interventions in a new animal model for sudden death, Circulation Suppl.IV 64:289 (1981).Google Scholar
  5. 5.
    B. Lown, R. L. Verrier, and R. Corbalan, Psychologic stress and threshold for repetitive ventricular response, Science 182:834 (1973).PubMedCrossRefGoogle Scholar
  6. 6.
    R. L. Verrier, F. Lombardi, and B. Lown, Ef f ects of d if f erent types of behavioral stress on coronary hemodynamics, Fed. Proc. 41:1599 (1982).Google Scholar
  7. 7.
    P. J. Schwartz, The long Q-T syndrome, in: “Sudden Death,” M. E. Kulbertus and H. J. J. Wellens, eds., M. Nijhoff, The Hague (1980).Google Scholar
  8. 8.
    P. J. Schwartz, Sympathetic imbalance and cardiac arrhythmias, in: “Nervous control of Cardiovascular Function,” W. C. Randall, ed., Oxford University Press, in press (1982).Google Scholar
  9. 9.
    P. J. Schwartz and H. L. Stone, Left stellectomy in the prevention of ventricular fibrillation caused by acute myocardial ischemia in conscious dogs with anterior myocardial infarction, Circulation 62:1256 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    G. E. Billman, P. J. Schwartz, and H. L. Stone, Baroreceptor reflex control of heart rate: a predictor of sudden cardiac death, Circulation 66: in press (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Peter J. Schwartz
    • 1
  1. 1.Centro di Fisiologia Clinica e Ipertensione Ospedale MaggioreUniversity of MilanMilanItaly

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