Cardiology pp 253-267 | Cite as

The Withdrawal of Beta Adrenergic Blocking Drugs

  • B. N. C. Prichard
  • P. Bhattacharjee
  • B. Tomlinson
  • R. J. Walden


It was found fairly soon after the introduction of beta adrenergic blocking drugs for the treatment of angina pectoris that when they were stopped abruptly an exacerbation of ischaemic symptoms sometimes occurred to above pre-beta blockade levels. The first report was in a trial of Oxprenolol in angina where seven cases of status anginosus occurred out of nineteen patient in the trial when placebo was substituted for active treatment (Wilson et. al. 1969). Two cases of severe ischaemia were reported in a trial of propranol when placebo was substituted in twenty patients with angina. One patient required hospital admission for acute coronary insufficiency and one patient died from coronary occlusion the day after the propranolol (40 mg qds) was stopped (Zoster and Beanlands, 1969). In a multidose study of propranolol in angina pectoris the patients experienced a higher incidence of chest pains during the first week of placebo compared with the second week (Prichard and Gillam, 1971). Slome (1973) reported two cases of myocardial infarction that occurred when propranolol was stopped in patients with angina pectoris. Alderman et. al. (1974) described six cases of severe ischaemia in angina patients when propranolol (80 or 160 mg/day) was stopped.


Angina Pectoris Beta Receptor Abrupt Withdrawal Withdrawal Phase Propranolol Treatment 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • B. N. C. Prichard
    • 1
  • P. Bhattacharjee
    • 1
  • B. Tomlinson
    • 1
  • R. J. Walden
    • 1
  1. 1.Department of Clinical Pharmacology School of MedicineUniversity College London The Rayne InstituteLondonUK

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