Cardiology pp 141-152 | Cite as

Clinical Trials with Antiaggregating Agents in Thrombosis

  • M. Verstraete


Many agents capable of interfering with normal platelet function in vitro have been described in recent years; most are nonsteroidal anti-inflammatory agents. Not all these compounds have been shown to affect platelet aggregation and adhesiveness in experimental animals, but since animals do not develop spontaneous thrombosis, the relevance of such experiments to clinical medicine is rather tenuous. The only drugs suppressing platelet function that have been evaluated in clinical trials are aspirin, sulfinpyrazone, dipyridamole, hydroxychoroquine, Clofibrate, flurbiprofen, and lidocaine, all of which were originally used for other therapeutic purposes. Even today one still has a poor understanding of the relationship between some of their effects on platelets and a potential antithrombotic effect. It is even uncertain whether the latter property is due to their impact on platelets or to some other unknown mode of action.


Regular Aspirin AORTOCORONARY Bypass Surgery Sudden Death Rate Coronary Drug Project Research Group Affect Platelet Aggregation 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • M. Verstraete
    • 1
  1. 1.Center for Thrombosis and Vascular Research Department of Medical ResearchUniversity of LeuvenLeuvenBelgium

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