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Organometallic Reagents

  • Chapter
Advanced Organic Chemistry

Part of the book series: Advanced Organic Chemistry

Abstract

The use of organometallic reagents in organic synthesis had its beginning around 1900 with the work of Victor Grignard, who discovered that alkyl and aryl halides reacted with magnesium metal to give homogeneous solutions. These “Grignard reagents” proved to be reactive carbon nucleophiles and have remained very useful synthetic reagents since that time. Organolithium reagents came into synthetic use somewhat later. In the last 20 years the number of useful synthetic reactions involving metal ions and organometallic compounds has expanded enormously. Certain of the transition metals, such as copper, palladium, and nickel, have gained important places in synthetic methodology. In addition to providing reagents for organic synthesis, the systematic study of the reaction of organic compounds with metal ions has created a large number of organometallic compounds, many with unique structures and reactivity. We shall consider here first the reagents such as the Grignard reagents and organolithium compounds. The role of transition metals in organic synthesis will then be given attention. The final section of the chapter illustrates briefly a few typical organometallic compounds.

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Authors and Affiliations

  1. University of Virginia, Charlottesville, Virginia, USA

    Francis A. Carey & Richard J. Sundberg

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  1. Francis A. Carey
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  2. Richard J. Sundberg
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© 1983 Springer Science+Business Media New York

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Carey, F.A., Sundberg, R.J. (1983). Organometallic Reagents. In: Advanced Organic Chemistry. Advanced Organic Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1821-8_6

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  • DOI: https://doi.org/10.1007/978-1-4757-1821-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1823-2

  • Online ISBN: 978-1-4757-1821-8

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