Use of Cholesteryl Ester Analogs to Study Transport of Lipoproteins in Intact Animals

  • Yechezkiel Stein
  • Yoseph Kleinman
  • Gideon Halperin
  • Olga Stein

Abstract

Deposition of lipid is one of the major events in the development of atheroma and therefore any attempt to study regression of atheroma faces the problem of quantitation of the lipids present at the various stages of regression. During the past few years we have synthesized labeled analogs of cholesteryl ester (1) and triacylglycerol (2,3) which owing to the replacement of the ester bond by an ether bond are not hydrolyzed by the esterases present in animal tissues. These compounds have been studied in several different systems in vivo and in vitro (3–9) and the data obtained indicate that they can serve as stable markers for the estimation of cholesterol ester deposited in the aortic wall.

Keywords

Cholesteryl Ester Cholesteryl Ester Transfer Protein Glyceryl Ether Hypercholesterolemic Rabbit Glycerol Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Yechezkiel Stein
    • 1
    • 2
  • Yoseph Kleinman
    • 1
    • 2
  • Gideon Halperin
    • 1
    • 2
  • Olga Stein
    • 1
    • 2
  1. 1.Lipid Research Laboratory, Department of Medicine BHadassah University HospitalJerusalemIsrael
  2. 2.Department of Experimental Medicine and Cancer ResearchHebrew University-Hadassah Medical SchoolJerusalemIsrael

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