Plasma Lipoprotein Changes Induced by Diets. Effect on Progression and Regression of Arterial Lesions in Nonhuman Primates

  • Victor H. Blaton
  • B. Declerq


Owing to their close phylogenetic relationship to man, nonhuman primates are important models for research on human atherosclerosis. Development of an understanding of lipoprotein metabolism in these animals may lead to a more complete understanding of the relationship between atherosclerosis and circulating lipoproteins in human beings. The purpose of this presentation is to compare available information on the distribution and structural and metabolic aspects of plasma lipoproteins in nonhuman and human primates.


Nonhuman Primate Rhesus Macaque Cholesterol Ester Plasma Lipoprotein Atherogenic Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    L. L. Rudel and H. B. Lofland, Circulating lipoproteins in nonhuman primates, in “Primates in Medicine,” E. I. Goldsmith and J. Moor-Jankowski, eds., S. Karger, Basel (1976).Google Scholar
  2. 2.
    L. L. Rudel, Plasma lipoproteins in atherogenesis in nonhuman primates: an overview, in “The Use of Nonhuman Primates in Cardiovascular Diseases,” S. S. Kalter, ed., University of Texas Press, Austin and London (1980).Google Scholar
  3. 3.
    H. B. Lofland, R. W. St. Clair, J. MacNintch, and R. W. Prichard, Atherosclerosis in New World primates, Arch. Path. 83: 211 (1967).Google Scholar
  4. 4.
    V. Blaton and H. Peeters, The nonhuman primates as models for studying human atherosclerosis: studies on the chimpanzee, the baboon, and the rhesus macaque, in “Atherosclerosis Drug Discovery,” C. E. Day, ed., Plenum, New York (1976).Google Scholar
  5. 5.
    V. Blaton, R. Vercaemst, M. Y. Rosseneu, J. Mortelmans, R. L. Jackson, A. M. Gotto, and H. Peeters, Characterisation of baboon plasma high-density lipoproteins and of their major apoproteins, Biochemistry 2: 157 (1977).Google Scholar
  6. 6.
    V. Blaton, R. Vercaemst, N. Vandecasteele, H. Caster, and H. Peeters, Isolation and partial characterisation of chimpanzee plasma high-density lipoproteins and their apoproteins. Biochemistry 13: 1127 (1974).CrossRefGoogle Scholar
  7. 7.
    V. Blaton, D. Vandamme, M. Vastesager, J. Mortelmans, and H. Peeters, Dietary induced hyperbetalipoproteinemia in chimpanzees: comparison to the human hyperlipoproteinemia, Exp. Molec. Pathol. 20: 132 (1974).CrossRefGoogle Scholar
  8. 8.
    V. Blaton, M. De Buyzere, B. Declerq, A. Pracetyo, G. Vanderkelen, J. Delanghe, and J. Spincemaille, Effects of polyunsaturated isocaloric fat diets on the plasma lipids, apoproteins and fatty acids, Atherosclerosis (in press).Google Scholar
  9. 9.
    M. Rosseneu, B. Declercq, D. Vandamme, R. Vercaemst, F. Soetewey, H. Peeters, and V. Blaton, Influence of oral polyunsaturated and saturated phospholipid treatment on the lipid composition and fatty acid profile of chimpanzee lipoproteins, Atherosclerosis 32: 41 (1979).CrossRefGoogle Scholar
  10. 10.
    M. Shinitsky and Y. Barenholz, Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing diacethyl-phosphate, J. Biol. Chem. 249: 26 (1974).Google Scholar
  11. 11.
    D. Vesselinovitch, R. W. Wissler, J. Borensztajn, and T. Schaffner, The effect of diets with or without cholestyramine on the lesion components of atherosclerotic plaques, Fed. Proc. 37: 835 (1978)Google Scholar
  12. 12.
    W. D. Wagner, R.W., St. Clair, T. B. Clarkson, and J. R. Connor, A study of atherosclerosis regression in Macaca mulatta, Am. J. Pathol. 100: 633 (1980.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Victor H. Blaton
    • 1
  • B. Declerq
    • 1
  1. 1.Department of Clinical ChemistryAlgemeen Ziekenhuis Sint-JanBruggeBelgium

Personalised recommendations