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Plant Glycosides: Effects on Atherosclerosis Regression in Macaca Fascicularis

  • Chapter
Regression of Atherosclerotic Lesions

Abstract

The regression of atherosclerosis in various animal species has been reviewed by several investigators.1–4 The study of this phenomenon in nonhuman primates stemmed from the observations of Armstrong et al. in rhesus macaques (Macaca mulatta).5 They demonstrated that in advanced coronary atherosclerotic lesions induced by a high-cholesterol diet there is a remarkable decrease in lumen stenosis when the animals are shifted to a low-cholesterol diet. Their observations have been confirmed in the same species by Clarkson et al.,6 Stary,7 Eggen et al.,8 and Wissler,9 and have been extended to cynomolgus macaques (Macaca fascicularis) by others.10–12

This work has been carried out with the collaboration of P. McLaughlin, A. L. Livingston, G. O. Kohler, W. P. McNulty, and H. C. Stary. Publication No. 1274 of the Oregon Regional Primate Research Center, partially supported by grants RR-00163 and HL-16587 of the National Institutes of Health.

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References

  1. R. W. Wissler, Current status of regression studies, Atheroscler. Rev.3: 213 (1976).

    Google Scholar 

  2. M. R. Malinow, Regression of atherosclerosis in nonhuman primates. An overview, in: “Use of Nonhuman Primates in Cardiovascular Disease,” S. S. Kalter, ed., University of Texas Press, Austin and London (1980).

    Google Scholar 

  3. H. C. Stary, Regression of atherosclerosis in primates, Virchows Arch. [Anat. Pathol.] 383: 117 (1979).

    Google Scholar 

  4. M. L. Armstrong, Regression of atherosclerosis, Atheroscler. Rev. 1: 137 (1976).

    Google Scholar 

  5. M. L. Armstrong, E. D. Warner, and W. E. Connor, Regression of coronary atheromatosis in rhesus monkeys, Circ. Res. 27: 59 (1970).

    Article  Google Scholar 

  6. T. B. Clarkson, M. G. Bond, C. A. Marzetta, and B. C. Bullock, Approaches to the study of atherosclerosis regression in rhesus monkeys: Interpretation of morphometric measurements of coronary arteries, in: “Atherosclerosis V,” A. M. Gotto, Jr., L. C. Smith, and B. Allen, eds., Springer-Verlag, New York (1980).

    Google Scholar 

  7. H. C. Stary, The origin in atherosclerotic lesions of extracellular lipids and debris and their elimination during regression, in: “State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models,” Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, Vol. 63, W. J. Hauss, R. W. Wissler, and R. Lehman, eds., Westdeutscher Verlag, Opladen, West Germany (1978).

    Google Scholar 

  8. D. A. Eggen, J. P. Strong, W. P. Newman III, C. Catsulis, G. T. Malcolm, and M. G. Kokatnur, Regression of diet-induced fatty streaks in rhesus monkeys, Lab. Invest. 31: 294 (1974).

    Google Scholar 

  9. R. W. Wissler, Recent progress in studies of experimental primate atherosclerosis, Prog. Biochem. Pharmacol. 4: 378 (1968).

    Google Scholar 

  10. M. G. Bond, M. R. Adams, and B. C. Bullock, Complicating factors in evaluating coronary artery atherosclerosis, Artery 9: 21 (1981).

    Google Scholar 

  11. M. R. Malinow, P. McLaughlin, H. K. Naito, L. A. Lewis, and W. P. McNulty, Effect of alfalfa meal in shrinkage (regression) of atherosclerotic plaques during cholesterol feeding in monkeys, Atherosclerosis 30: 27 (1978).

    Article  Google Scholar 

  12. M. L. Armstrong and M. B. Megan, Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets, Circ. Res. 36: 256 (1975).

    Article  Google Scholar 

  13. M. R. Malinow, P. McLaughlin, L. Papworth, H. K. Naito, L. Lewis, and W. P. McNulty, A model for therapeutic intervention on established coronary atherosclerosis in a nonhuman primate, Adv. Exp. Med. Biol. 67: 3 (1976).

    Google Scholar 

  14. M. L. Roonwal and S. M. Mohnot, eds., “Primates of South Asia,” Harvard University Press, Cambridge, Massachusetts, and London, p. 89 (1977).

    Google Scholar 

  15. L. C. Fillios and G. V. Mann, The importance of sex in the variability of the cholesterolemic response of rabbits when fed cholesterol, Circ. Res. 4: 406 (1956).

    Article  Google Scholar 

  16. M. R. Malinow, Important considerations for nonhuman primate models of diet-induced atherosclerosis, in: “Primates in Nutritional Research,” K. C. Hayes, ed., Academic Press, New York and London (1979).

    Google Scholar 

  17. H. C. Stary and M. R. Malinow, Ultrastructure of experimental coronary artery atherosclerosis in cynomolgus macaques: A comparison with the lesions of other primates, Atherosclerosis 43: 151 (1982).

    Article  Google Scholar 

  18. M. R. Malinow, A. A. Pellegrino, and E. H. Ramos, Chemical and anatomical correlations in cholesterol-fed rabbits, Acta Physiol. Latino Amer. 8: 37 (1958).

    Google Scholar 

  19. J. R. A. Mitchell and C. J. Schwartz, eds., “Arterial Disease,” F. A. Davis Co., Philadelphia (1965).

    Google Scholar 

  20. N. Anitschkow, Über die Rückbildungsvorgange be der experimentellen Atherosklerose, Verh. Dtsch. Ges. Pathol. 23: 473 (1927).

    Google Scholar 

  21. N. Anitschkow, A history of experimentation on arterial atherosclerosis in animals, in: “Cowdry’s Arteriosclerosis: A survey of the Problem,” H. T. Blumenthal, ed., Charles C. Thomas, Springfield, Illinois (1976).

    Google Scholar 

  22. M. Friedman and S. O. Byers, Observations concerning the evolution of atherosclerosis in the rabbit after cessation of cholesterol feeding, Am. J. Pathol. 43: 349 (1963).

    Google Scholar 

  23. J. T. Prior and D. D. Ziegler, Regression of experimental atherosclerosis, Arch. Pathol. 80: 50 (1965).

    Google Scholar 

  24. P. P. Gupta, H. D. Tandon, and V. Ramalingaswami, Experimental atherosclerosis in rabbits with special reference to reversal, J. Pathol. 101: 309 (1970).

    Article  Google Scholar 

  25. P. P. Gupta, H. D. Tandon, and V. Ramalingaswami, Further observations on the reversibility of experimentally induced atherosclerosis in rabbits, J. Pathol. 105: 229 (1971).

    Article  Google Scholar 

  26. D. Vesselinovitch, R. W. Wissler, K. Fischer-Dzoga, R. Hughes, and L. Dubien, Regression of atherosclerosis in rabbits. Part 1. Treatment with low fat diet, hyperoxia and hypolipidemic agents, Atherosclerosis 19: 259 (1974).

    Article  Google Scholar 

  27. M. Bevans, J. D., Davidson, and F. E. Kendall, Regression of lesions in canine arteriosclerosis, Arch. Pathol. 51: 288 (1951).

    Google Scholar 

  28. L. Horlick and L. N. Katz, Retrogression of atherosclerotic lesions on cessation of cholesterol feeding in the chick, J. Lab. Clin. Med. 34: 1427 (1949).

    Google Scholar 

  29. T. B. Clarkson, J. S. King Jr., H. B. Lofland, M. A. Feldner, and B. C. Bullock, Pathologic characteristics and composition of diet-aggrevated atherosclerotic plaques during “regression,” Exp. Mol. Pathol. 19: 267 (1973).

    Article  Google Scholar 

  30. A. S. Daoud, J. Jarmolych, J. M. Augustyn, K. E. Fritz, J. K. Singh, and K. T. Lee, Regression of advanced atherosclerosis in swine, Arch. Pathol. Lab. Med. 100: 372 (1976).

    Google Scholar 

  31. C. A. Maruffo and O. W. Portman, Nutritional control of coronary artery atherosclerosis in the squirrel monkey. J. Atheroscler. Res. 8: 237 (1968),

    Article  Google Scholar 

  32. C. F. Tucker, C. Catsulis, J. P. Strong, and D. A. Eggen, Regression of early cholesterol-induced aortic lesions in rhesus monkeys, Am. J. Pathol. 65: 493 (1971).

    Google Scholar 

  33. B. Radhakrishnamurthy, D. A. Eggen, M. Kokatnur, S. Jirge, J. P. Strong, and G. S. Berenson, Composition of connective tissue in aortas from rhesus monkeys during regression of diet induced fatty streaks, Lab. Invest. 33: 136 (1975).

    Google Scholar 

  34. J. P. Strong, D. A. Eggen, and H. C. Stary, Reversibility of fatty streaks in rhesus monkeys, Primates Med. 9: 300 (1976).

    Google Scholar 

  35. D. Vesselinovitch, R. Hughes, L. Frazier, and R. W. Wissler, Studies of the reversal of advanced atherosclerosis in the rhesus monkey, Am. J. Pathol, 70: 41a (1973) (abstract).

    Google Scholar 

  36. R. W. Wissler, D. Vesselinovitch, J. Borensztajn, and R. Hughes, Regression of severe atherosclerosis in cholestyramine-treated rhesus monkeys with or without a low-fat, low-cholesterol diet, Circulation 52(suppl. II): II-16 (1975) (abstract).

    Google Scholar 

  37. H. C. Stary and J. P. Strong, The fine structure of nonatherosclerotic intimai thickening, of developing, and of regressing atherosclerotic lesions at the bifurcation of the left coronary artery, Adv. Exp. Med. Biol. 67: 89 (1976).

    Google Scholar 

  38. T. B. Clarkson, N. D. M. Lehner, W. D. Wagner, R. W. St. Clair, M. G. Bond, and B. C. Bullock, Study of atherosclerosis regression in Macaca malatta. 1. Design of experiment and lesion induction, Exp. Mol. Pathol. 30: 360 (1979).

    Article  Google Scholar 

  39. T. B. Clarkson, M. G. Bond, B. C. Bullock, and C. A. Marzetta, A study of atherosclerosis regression in Macaca mulatta. 4. Changes in coronary arteries from animals with atherosclerosis induced for 19 months and then regressed for 24 or 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl, Exp. Mol. Pathol. 34: 345 (1981).

    Article  Google Scholar 

  40. R. Pick, J. Stamler, S. Rodbard, and L. N. Katz, Estrogen induced regression of coronary atherosclerosis in cholesterolfed chicks, Circulation 6: 858 (1952).

    Article  Google Scholar 

  41. M. G. Bond, B. C. Bullock, T. B. Clarkson, and N. D. M. Lehner, Effect of plasma cholesterol concentrations on regression of primate atherosclerosis, Am. J. Pathol. 83: A69 (1976)(abstract).

    Google Scholar 

  42. W. D. Wagner, R. W. St. Clair, and T. B. Clarkson, Atherosclerosis regression in rhesus monkeys at plasma cholesterol levels achievable in man, Fed. Proc. 35: 293 (1976) (abstract).

    Google Scholar 

  43. C. H. Hanson, G. O. Kohler, J. W. Dudley, E. L. Sorenson, G. R. Van Atta, K. W. Taylor, M. W. Pedersen, H. L. Carnahan, C. P. Wiltsie, W. R. Kehr, C. C. Lowe, E. H. Standford, and J. A. Yungen, Saponin content of alfalfa as related to location, cutting, variety and other variables, Crops Research ARS 33–44, United States Department of Agriculture, Agricultural Research Service (1963).

    Google Scholar 

  44. P. Griminger and H. Fisher, Dietary saponin and plasma cholesterol in the chicken, Proc. Soc. Exp. Biol. Med. 99: 424 (1958).

    Google Scholar 

  45. H. A. I. Newman, F. A. Kummerow, and H. M. Scott, Dietary saponins, a factor which may reduce liver and serum cholesterol levels, Poultry Sci. 37: 42 (1958).

    Article  Google Scholar 

  46. D. G. Oakenfull, D. E. Fenwick, R. L. Hood, D. L. Topping, R. L. Illman, and G. B. Storer, Effects of saponins on bile-acids and plasma lipids in the rat, Br. J. Nutr. 42: 209 (1979).

    Article  Google Scholar 

  47. B. Morgan, M. Heald, S. G. Brooks, J. L. Tee, and J. Green. The interactions between dietary saponin, cholesterol and related sterols in the chick, Poultry Sci. 51: 677 (1972).

    Article  Google Scholar 

  48. D. L. Topping, G. B. Storer, G. B. Calvert, R. J. Illman, D. G. Oakenfull, and R. A. Weiler, Effects of dietary saponins on fecal bile acids and neutral sterols, plasma lipids, and lipoprotein turnover in the pig, Am. J. Clin. Nutr. 33: 783 (1980).

    Google Scholar 

  49. D. L. Topping, R. P. Trimble, R. J. Illman, J. D. Potter, and D. G. Oakenfull, Prevention of dietary hypercholesterolemia in the rat by soy flour high and low in saponins, Nutr. Rep. Int. 22: 513 (1980).

    Google Scholar 

  50. D. Kritchevsky, S. A. Tepper, and J. A. Story, Isocaloric, isogravic diets in rats. 3. Effect of nonnutritive fiber (alfalfa or cellulose) on cholesterol metabolism, Nutr. Rep. Int. 9: 301 (1974).

    Google Scholar 

  51. M. R. Malinow, Triterpenoid saponins in mammals: Effects on cholesterol metabolism and atherosclerosis, in: “Biochemistry and Function of Isopentenoids in Plants,” W. D. Ness, G. Fuller, and L. S. Tsai, eds., Marcel Dekker, New York (in press).

    Google Scholar 

  52. M. R. Malinow, P. McLaughlin, C. Stafford, A. L. Livingston, and J. W. Senner, Effects of alfalfa saponins on regression of atherosclerosis in monkeys, in: “Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, Second Münster International Arteriosclerosis Symposium, band 70: Clinical Implications of Recent Research Results in Arteriosclerosis,” W. H. Hauss and R. W. Wissler, eds., Westdeutscher Verlag, Opladen, West Germany, pp. 241–254 (1983).

    Chapter  Google Scholar 

  53. J. O. Anderson, Effect of alfalfa saponin on the performance of chicks and laying hens, Poultry Sci. 36: 873 (1957).

    Article  Google Scholar 

  54. B. W. Heywang and H. R. Bird, The effect of alfalfa saponin on the growth, diet consumption, and efficiency of diet utilization of chicks, Poultry Sci. 33: 239 (1954).

    Article  Google Scholar 

  55. B. W. Heywang, C. R. Thompson, and A. R. Kemmerer, Effect of alfalfa saponin on laying chicks, Poultry Sci. 38: 968 (1958).

    Article  Google Scholar 

  56. I. Ishaaya, Y. Birk, A. Bondi, and Y. Tencer, Soyabean saponins, IX. Studies of their effect on birds, mammals, and cold-blooded organisms, J. Sci. Food Agric. 20: 433 (1969).

    Article  Google Scholar 

  57. G. Reshef, B. Gestetner, Y. Birk, and A. Bondi, Effect of alfalfa saponins on the growth and some aspects of lipid metabolism of mice and quails, J. Sci. Food Agric. 27: 63 (1976).

    Article  Google Scholar 

  58. E. B. Wilcox and L. S. Galloway, Serum and liver cholesterol, total lipids and lipid phosphorus levels of rats under various dietary regimes, Am. J. Clin. Nutr. 9: 236 (1961).

    Google Scholar 

  59. M. R. Malinow, W. P. McNulty, P. McLaughlin, C. Stafford, A. K. Burns, A. L. Livingston, and G. O. Kohler, The toxicity of alfalfa saponins in rats, Food Cosmet. Toxicol. 19: 443 (1981).

    Article  Google Scholar 

  60. M. R. Malinow, P. McLaughlin, W. P. McNulty, D.C. Houghton, S. Kessler, P. Stenzel, S. H. Goodnight Jr., E. J. Bardana Jr., and J. L. Palotay, Lack of toxicity of alfalfa saponins in monkeys, J. Med. Primatol. 11: 106 (1982).

    Google Scholar 

  61. M. R. Malinow, P. McLaughlin, W. P. McNulty, H. K. Naito, and L. A. Lewis, Treatment of established atherosclerosis during cholesterol feeding in monkeys, Atherosclerosis 31: 185 (1978).

    Article  Google Scholar 

  62. M. R. Malinow, W. E. Connor, P. McLaughlin, C. Stafford, D. S. Lin, A. L. Livingston, G. O. Kohler, and W. P. McNulty, Cholesterol and bile acid balance in Macaca fascicularis: Effects of alfalfa saponins, J. Clin. Invest. 67: 156 (1981).

    Article  Google Scholar 

  63. W. R. Stahl and M. R. Malinow, A survey of physiological measurements in Macaca mulatta, Folia Primatol. 7: 12 (1967).

    Article  Google Scholar 

  64. M. R. Malinow, P. McLaughlin, L. Papworth, C. Stafford, G. O. Kohler, A. L. Livingston, and P. R. Cheeke, Effect of alfalfa saponins on intestinal cholesterol absorption in rats, Am. J. Clin. Nutr. 30: 2061 (1977).

    Google Scholar 

  65. B. Gestetner, Y. Assa, Y. Henis, Y. Tencer, M. Rotman, Y. Birk, and A. Bondi, Interactions of lucerne saponins with sterols, Biochim. Biophys. Acta 270: 181 (1972).

    Article  Google Scholar 

  66. M. R. Malinow, P. McLaughlin, and C. Stafford, Prevention of hypercholesterolemia in monkeys (Macaca fascicularis) by digitonin, Am. J. Clin. Nutr. 31: 814 (1978).

    Google Scholar 

  67. D. G. Oakenfull and S. Sidhu, A physico-chemical explanation for the effects of dietary saponins on cholesterol and bile salt metabolism, Nutr. Rep. Int. 27: 1253 (1983).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cardiovascular Diseases, Oregon Regional Primate Research Center and Oregon Health Sciences University, 505 NW 185th Ave., Beaverton, OR, 97006, USA

    M. R. Malinow

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  1. Oregon Regional Primate Research Center, Beaverton, Oregon, USA

    M. Rene Malinow

  2. Department of Clinical Chemistry, A. Z. St. Jan Hospital, Brugge, Belgium

    Victor H. Blaton

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Malinow, M.R. (1984). Plant Glycosides: Effects on Atherosclerosis Regression in Macaca Fascicularis . In: Malinow, M.R., Blaton, V.H. (eds) Regression of Atherosclerotic Lesions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1773-0_6

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  • DOI: https://doi.org/10.1007/978-1-4757-1773-0_6

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