Abstract
In 1968, Dr. Gardner McMillan of the National Heart, Lung and Blood Institute called to the attention of the atherosclerosis research community that only 3% of the atherosclerosis studies supported by their Institute dealt with regression of atherosclerosis. Two years later, Armstrong and his co-workers described the regression that occurred in diet-induced coronary artery atherosclerosis of rhesus monkeys when the diet was changed from one high in cholesterol to one devoid of cholesterol.1 The recognition that atherosclerosis regression was an understudied area, the promising results of Armstrong and his co-workers and the public health importance of atherosclerosis regression together stimulated over the past decade vigorous research on regression.
Supported by SCOR in Arteriosclerosis Grant HL 14164 from the National Heart, Lung, and Blood Institute.
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References
M. L. Armstrong, E. D. Warner, and W. E. Connor, Regression of coronary atheromatosis in rhesus monkeys, Circ. Res., 27: 59 (1970).
T. B. Clarkson, T. E. Hamm, B. C. Bullock, and N. D. M. Lehner, Atherosclerosis in Old World monkeys, Prim. Med. 9: 66 (1976).
T. B. Clarkson, N. D. M. Lehner, B. G. Bullock, H. B. Lofland, and W. D. Wagner, Atherosclerosis in New World monkeys, Prim. Med, 9: 90 (1976).
M. L. Armstrong, Atherosclerosis in rhesus and cynomolgus monkeys, Prim. Med. 9: 16 (1976).
R. W. Wissler and D. Vesselinovitch, Atherosclerosis in nonhuman primates, in: “Advances in Veterinary Science and Comparative Medicine,” C. A. Brandly and C. E. Cornelius, eds., Academic Press, New York (1977).
O. W. Portman, M. Alexander, and C. A. Maruffo, Nutritional control of arterial lipid composition in squirrel monkeys: Major ester classes and types of phospholipids, J. Nutr. 91: 35 (1967).
C. A. Maruffo and O. W. Portman, Nutritional control of coronary artery atherosclerosis in the squirrel monkey, J. Athero. Res. 8: 237 (1968).
R. Pick, R. Prabhu, and G. Glick, Diet-induced atherosclerosis and experimental hypertension in stumptail macaques (Macaca arctoides). Effects of antihypertensive drugs and a non-atherogenic diet in the evolution of lesions, Atherosclerosis 29: 405 (1978).
D. A. Eggen, J. P. Strong, W. P. Newman, III, C. Catsulis, G. T. Malcom, and M. G. Kokatnur, Regression of diet-induced fatty streaks in rhesus monkeys, Lab. Invest. 31: 194 (1974).
C. F. Tucker, C. Catsulis, J. P. Strong, and D. A. Eggen, Regression of early cholesterol-induced aortic lesions in rhesus monkeys, Am. J. Pathol. 65: 493 (1971).
M. G. Kokatnur, G. T. Malcom, D. A. Eggen, and J. P. Strong, Depletion of aortic free and ester cholesterol by dietary means in rhesus monkeys with fatty streaks, Atherosclerosis 21: 195 (1975).
H. C. Stary, The origin in atherosclerotic lesions of extracellular lipid and debris and their elimination during regression, in: “State of Prevention and Therapy in Human Atherosclerosis and in Animal Models,” W. H. Hauss, R. W. Wissler, and R. Lehmann, eds., Westdeutscher Verlag, Opladen (1978).
D. Vesselinovitch, R. W. Wissler, R. Hughes, and J. Borensztajn, Reversal of advanced atherosclerosis in rhesus monkeys. Part 1. Lightmicroscopic studies, Atherosclerosis 23: 155 (1976).
R. W. Wissler and D. Vesselinovitch, Studies of regression of advanced atherosclerosis in experimental animals and man, Ann. N. Y. Acad. Sci. 275: 363 (1976).
R. G. DePalma, E. M. Bellon, S. Koletsky, and D. L. Schneider, Atherosclerotic plaque regression in rhesus monkeys induced by bile acid sequestrant, Exp. Mol. Pathol. 31: 423 (1979).
R. G. DePalma, L. Klein, E. M. Bellon, and S. Koletsky, Regression of atherosclerotic plaques in rhesus monkeys. Angiographic, morphologic, and angiochemical changes, Arch. Surg. 115: 1268 (1980).
T. B. Clarkson, M. G. Bond, B. C. Bullock, C. A. Marzetta, A study of atherosclerosis regression in Macaca mulatta. IV. Changes in coronary arteries from animals with atherosclerosis induced for 19 months and then regressed for 24 or 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl, Exp. Mol. Pathol. 34: 345 (1981).
T. B. Clarkson, M. G. Bond, B. C. Bullock, K. J. McLaughlin, and J. K. Sawyer, A study of atherosclerosis regression in Macaca mulatta. V. Changes in abdominal aorta, carotid and coronary arteries from animals with atherosclerosis induced for 38 months and then regressed for 24 or 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl. Submitted for publication.
T. B. Clarkson, N.D.M. Lehner, W. D. Wagner, R. W. St. Clair, M. G. Bond, and B. C. Bullock, A study of atherosclerosis regression in Macaca mulatta. I. Design of experiment and lesion induction, Exp. Mol. Pathol. 30: 360 (1979).
W. D. Wagner and R. W. St. Clair, A comparison of the regression of moderate and more advanced atherosclerosis in monkeys at plasma cholesterol concentrations of 200 or 300 mg/dl, Fed. Proc. 38: 1347 (1979).
W. D. Wagner, R. W. St. Clair, and T. B. Clarkson, A study in atherosclerosis regression in Macaca mulatta. II. Chemical changes in arteries from animals with atherosclerosis induced for 19 months then regressed for 24 months at plasma cholesterol concentrations of 300 or 200 mg/dl, Exp. Mol. Pathol. 32: 162 (1980).
W. D. Wagner, R. W. St. Clair, T. B. Clarkson, and J. R. Connor, A study of atherosclerosis regression in Macaca mulatta. III. Chemical changes in arteries from animals with atherosclerosis induced for 19 months and regressed for 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl, Am. J. Pathol. 100: 633 (1980).
D. J. Farrar, H. D. Green, W. D. Wagner, and M. G. Bond, Reduction in pulse wave velocity and improvement of aortic distensibility accompanying regression of atherosclerosis in the rhesus monkey, Circ. Res. 47: 425 (1980).
T. B. Clarkson, Arteriosclerosis of African green and stump-tailed macaque monkeys, in: “Atherosclerosis III,” G. Schettler and A. Weizel, eds., Springer-Verlag, New York-Heidelberg-Berlin (1974).
T. B. Clarkson, M. G. Bond, C. A. Marzetta, and B. C. Bullock, Approaches to the study of atherosclerosis regression in rhesus monkeys: Interpretation of morphometric measurements of coronary arteries, in: “Proceedings of the Fifth International Symposium on Atherosclerosis,” A. M. Gotto, Jr., L. C. Smith, and B. Allen, eds., Springer-Verlag, New York (1980).
M. G. Bond, M. R. Adams, and B. C. Bullock, Complicating factors in evaluating coronary artery atherosclerosis, Artery 9: 21 (1981).
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Clarkson, T.B. (1984). Progression and Regression of Nonhuman Primate Coronary Artery Atherosclerosis: Considerations of Experimental Design. In: Malinow, M.R., Blaton, V.H. (eds) Regression of Atherosclerotic Lesions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1773-0_4
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