Abstract
Change in the environment of arterial smooth muscle cells, and particularly in the concentration of low-density lipoprotein (LDL), is assumed to be a major factor in atherogenesis, and to be mediated through changes in the permeability of the arterial endothelium. The immediate nutrient environment of the cells in most tissues is provided by the interstitial fluid, and there is evidence that the composition of the interstitial fluid, at least in limbs, is similar to the composition of lymph obtained from the same anatomical area.1 Analyses of plasma protein concentrations in lymph from several organs and tissues have now been published, and although there is some variation in overall protein concentration, all show an inverse relationship between concentration, expressed as percentage of plasma concentration, and relative molecular mass (Mr) or molecular diameter.1–5
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Smith, E.B. (1984). Studies on Arterial Interstitial Fluid. In: Malinow, M.R., Blaton, V.H. (eds) Regression of Atherosclerotic Lesions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1773-0_14
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DOI: https://doi.org/10.1007/978-1-4757-1773-0_14
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