High-Density Lipoproteins and Their Role in Preventing or Retarding Atherosclerosis

  • Gerd Assmann
  • Hilko Schriewer


Among the primary risk factors of coronary heart disease (CHD), hypercholesterolemia, hypertension, and nicotine abuse take highest precedence. A total cholesterol level > 300 mg/dl signifies a high atherogenic risk for the person in question. However, hypercholesterolemia (> 300 mg/dl) is observed in only approximately 25% of all patients with CHD. The majority of CHD patients exhibit a total cholesterol level between 248 and 300 mg/dl. In correspondence with the results of the Framingham study, the distribution curve for total serum cholesterol in probands in whom CHD develops overlaps considerably with that in probands who exhibit no CHD; the average cholesterol value of probands suffering from CHD is 225 mg/dl (219 mg/dl in probands in whom CHD does not develop).1 With these results as a basis, it is not possible, in an individual case involving a total cholesterol level between 150 and 300 mg/dl, to make a statement regarding coronary risk.


Cholesteryl Ester Total Cholesterol Level Coronary Risk Framingham Study Coronary Heart Disease Patient 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Gerd Assmann
    • 1
  • Hilko Schriewer
    • 1
  1. 1.ZentrallaboratoriumUniversity of MünsterMünsterWest Germany

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