Mutations and Mutagenesis

  • Edward A. Birge
Part of the Springer Series in Microbiology book series (SSMIC)

Abstract

The first problem facing the early bacterial geneticist was to prove that bacteria did have inherited traits. The earliest presumption was that bacteria and other microorganisms were too small to have any phenotypic traits which could be studied. That concept was disabused by the work of Beadle and Tatum, who demonstrated that biochemical reactions could be used as phenotypic traits and developed the famous “one gene-one enzyme” hypothesis. There was, however, still one remaining area of uncertainty about the existence of bacterial genetics. Many workers felt that the hypothesis of Lamarck regarding the inheritance of acquired traits was true for bacteria even though it had already been disproven for the higher eukaryotes. The first task of the fledgling science of bacterial genetics, then, was to prove that the same processes of mutation that had already been shown to occur in eukaryotes also occurred in prokaryotes.

Keywords

Mutation Rate Mutant Cell Frameshift Mutation Resistant Coloni Methyl Methane Sulfonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

General

  1. Cox, E.C. 1976. Bacterial mutator genes and the control of spontaneous mutation. Annual Review of Genetics 10:135–156.PubMedCrossRefGoogle Scholar
  2. Drake, J.W. 1970. The Molecular Basis of Mutation. San Francisco: Holden-Day.Google Scholar
  3. Marshall, B., Levy, S.B. 1980. Prevalence of amber suppressor-containing coliforms in the natural environment. Nature 286:524–525.PubMedCrossRefGoogle Scholar
  4. Roth, J.R. 1974. Frameshift mutations. Annual Review of Genetics 8: 319–346.PubMedCrossRefGoogle Scholar

Specialized

  1. Adhya, S., Gottesman, M. 1978. Control of transcription termination. Annual Review of Biochemistry 47:967–996.PubMedCrossRefGoogle Scholar
  2. Cavalli-Sforza, L.L., Lederberg, J. 1956. Isolation of pre-adaptive mutants in bacteria by sib selection. Genetics 41:367–381.PubMedGoogle Scholar
  3. Drake, J.W. 1969. Comparative rates of spontaneous mutation. Nature 221:1132.PubMedCrossRefGoogle Scholar
  4. Fitzgerald, G., Williams, L.S. 1975. Modified penicillin enrichment procedure for the selection of bacterial mutants. Journal of Bacteriology 122:345–346.PubMedGoogle Scholar
  5. Frankel, A.D., Duncan, B.K., Hartman, P.E. 1980. Nitrous acid damage to duplex DNA: distinction between deamination of cytosine residues and a novel mutational lesion. Journal of Bacteriology 142:335–338.PubMedGoogle Scholar
  6. Gorini, L. 1969. The contrasting role of strA and ram gene products in ribosomal functioning. Cold Spring Harbor Symposia on Quantitative Biology 34:101–111.PubMedCrossRefGoogle Scholar
  7. Gorini, L., Kaufman, H. 1960. Selecting bacterial mutants by the penicillin method. Science 131: 604–605.PubMedCrossRefGoogle Scholar
  8. Lederberg, J., Lederberg, E.M. 1952. Replica plating and indirect selection of bacterial mutants. Journal of Bacteriology 63:399–406.PubMedGoogle Scholar
  9. Luria, S.E., Delbrück, M. 1943. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491–511.PubMedGoogle Scholar
  10. Newcombe, H.B. 1949. Origin of bacterial variants. Nature 164:150–151.PubMedCrossRefGoogle Scholar
  11. Rossi, J.J., Berg, C.M. 1971. Differential recovery of auxotrophs after penicillin enrichment in E. coli . Journal of Bacteriology 106:297–300.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Edward A. Birge
    • 1
  1. 1.Department of Botany and MicrobiologyArizona State UniversityTempeUSA

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