The Biochemical Function of the Pulmonary Circulation

  • D. M. Geddes
Part of the Ettore Majorana International Science Series book series (EMISS, volume 3)


The majority of studies on the biochemical properties of the pulmonary circulation have concentrated on substances with short circulating half lives. This is partly a reflection of the physiological importance of pulmonary inactivation of compounds such as catecholamines, prostaglandins and 5-hydroxytryptamine and angiotensin-I, but is also due to the technical difficulties encountered when hormones with longer circulating lives are studied. This is because the lung receives the whole cardiac output, and so only very small arterio-venous differences will occur across the lung unless considerable metabolism takes place. This section concentrates on compounds with circulating half lives much longer than those of the vasoactive amines and in particular on polypeptide hormones and drugs. It is important to emphasise that the techniques are difficult and that much of the data presented is preliminary and needs confirmation by other workers before it can be fully accepted.


Basement Membrane Free Amino Acid Pulmonary Circulation Biochemical Function Tritiated Water 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Korman M G, Hansky J, Soveny C (1973) Aust J Exp Biol Med Sci 51 679.PubMedCrossRefGoogle Scholar
  2. 2.
    Dent R I, Levine B, James B H (1973) Am J Physiol 225 1038.PubMedGoogle Scholar
  3. 3.
    Lockett M F (1972) J Physiol London 224 187PubMedGoogle Scholar
  4. 4.
    Rubenstein A H, Zwi S, Miller K (1968) Diabetologia 4 236.PubMedCrossRefGoogle Scholar
  5. 5.
    Geddes D M, Blackburn J P Muller J (1979) J Applied Physiol 46 593.Google Scholar
  6. 6.
    Brandenberger Brown E A (1974) Drug Me tab Rev 3 33CrossRefGoogle Scholar
  7. 7.
    Dollery C T, Junod A F (1976) Brit J Pharmacol 57 67.CrossRefGoogle Scholar
  8. 8.
    Geddes D M, Nesbitt K, Triall T (1979) Thorax.Google Scholar
  9. 9.
    Andersson R C G, Lewis D H, Post C (1979) Brit J Pharm 66 440P.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • D. M. Geddes
    • 1
    • 2
  1. 1.London Chest HospitalLondonUK
  2. 2.Brompton HospitalLondonUK

Personalised recommendations