Recent Developments in the Pharmacokinetic Function of Lung

  • Y. S. Bakhle
Part of the Ettore Majorana International Science Series book series (EMISS, volume 3)


Since the late 1960’s, interest in a non-respiratory function of lung, the pharmacokinetic function, has been growing with the exponential rate apparently inherent in scientific research. This function, which in spite of its name, is chiefly involved with vasoactive hormones and other endogenous substrates, is usually expressed as the change in biological activity of the substrate as it passes through the pulmonary circulation. This field of research, perhaps above all others, has emphasised the importance of cellular environment on enzymic activity by providing many examples of differences between results from broken cell preparations and those from perfused lungs either in isolation or in vivo (see Bakhle and Vane, 1974).


Angiotensin Converting Enzyme Pulmonary Circulation Perfuse Lung Oestrous Cycle Endothelial Cell Membrane 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Y. S. Bakhle
    • 1
  1. 1.Department of PharmacologyRoyal College of SurgeonsLondonEngland

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