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Pulmonary Circulation in Health and Disease pp 81–104Cite as

Active Control of the Pulmonary Circulation

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Part of the book series: Ettore Majorana International Science Series ((EMISS,volume 3))

Abstract

Chemical and nervous mechanisms influence the pulmonary circulation. Differences from the systemic circulation are related to the prime function of the lung for gas exchange and the fact that it has to transmit the whole cardiac output from right to left ventricle, For efficient gas exchange there must be matching of ventilation (V̇) and blood flow (Q̇) in individual lung units. This regulation of V̇/Q̇ ratios is achieved to some extent by changing O2 and CO2 tensions. There is, however, controversy as to the importance and efficiency of these mechanisms. Pulmonary vessels possess motor nerves which have been shown to constrict, dilate or stiffen the vessels in animal experiments. Yet in man we have no proof of any situation in which nerves function, nor any evidence of nervous tone. In the systemic circulation blood flow is switched from one organ to another according to need through nervous activity. There is no evidence for a comparable mechanism in the lung, which is uniform in function. Neither, so far as we know, is the pulmonary circulation regulated by feedback reflexes from its sensory receptors in the way that the systemic circulation is regulated by baro and chemoreceptors.

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References

  • Abraham, A. S., Gumming, C., Horsfield, K. and Prowse, K., 1970, Regional hypoxia and distribution of blood flow, Scand. J. resp. Dis., 51:33–36.

    CAS  Google Scholar 

  • Alexander, J. M., Nyby, M. D. and Jasberg, K. A., 1976, Effect of angiotensin on hypoxic pulmonary vasoconstriction in isolated dog lung, J. appl. Physiol., 41:84–88,

    PubMed  CAS  Google Scholar 

  • Austen, K F. and Orange, R. P., 1975, Bronchial asthma: Ihe possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute and chronic disease, Am. Rev. resp. Dis., 112:423–436.

    PubMed  CAS  Google Scholar 

  • Bakhle, Y. S. and Vane, J, R., 1977, Metabolic functions of the lung, in: “Lung biology in health and disease”, C. Lenfant, ed., Marcel Dekker Inc., New York and Basel.

    Google Scholar 

  • Barer, G. R., 1976, The physiology of the pulmonary circulation and methods of study, Pharmac. Ther. B., 2:247–273.

    CAS  Google Scholar 

  • Barer, G. R., Emery, C. J., Mohammed, F. H. and Mungall, I. P. F., 1978a, H and H2 histamine actions on lung vessels: their relevance to hypoxic vasoconstriction, Q. J. exp. Physiol., 63:157–1690

    PubMed  CAS  Google Scholar 

  • Barer, G. R., Howard, P. and McCurrie, J. R., 1967, The effect of carbon dioxide and changes in blood pH on pulmonary vascular resistance in cats, Clin. Sci., 32:361–376.

    PubMed  CAS  Google Scholar 

  • Barer, G. R., Howard, P., McCurrie, J. R. and Shaw, J. W., 1969, Changes in the pulmonary circulation after bronchial occlusion in anaesthetised dogs and cats, Circulation Res., 25:747–764.

    Article  PubMed  CAS  Google Scholar 

  • Barer, G. R., Howard, P. and Shaw, J. W., 1970, Stimulus-response curves of the pulmonary vascular bed to hypoxia and hyper-capnia, J. Riysiol., 211:139–155.

    CAS  Google Scholar 

  • Barer, G. R., McCurrie, J. R. and Shaw, J. W., 1971, Effect of changes in blood pH on the vascular resistance of the normal and hypoxic cat lung, Cardiovasc. Res., 5:490–497.

    Article  PubMed  CAS  Google Scholar 

  • Barer, G. R., Mohammed, F. H, and Suggett, A. J., 1977, Angiotensin, hypoxia, verapamil and pulmonary vessels, J. Riysiol., 270:43–44P.

    Google Scholar 

  • Barer, G. R., Mohammed, F., Suggett, A. J. and Twelves, C., 1978b, Hypoxic pulmonary vasoconstriction in the ferret, J. Physiol., 281:40–41 P.

    Google Scholar 

  • Barer, G. R. and Shaw, J. W., 1971, Pulmonary vasodilator and vasoconstrictor actions of carbon dioxide, J. Riysiol., 213: 633–645.

    CAS  Google Scholar 

  • Benumof, J. L. and Wahrenbrock, E. A, 1975, Blunted hypoxic vasoconstriction by increased lung vascular pressures, J. appl. Fhysiol., 38:846–850.

    CAS  Google Scholar 

  • Bergofsky, E. H., 1969, in: “The pulmonary circulation and interstitial space”, A. P. Fishman and H. H. Hecht, eds., University of Chicago Press, Chicago and Basel,

    Google Scholar 

  • Bergofsky, E. H. and Holtzman, S., 1967, A study of the mechanism involved in the pulmonary arterial response to hypoxia, Circulation Res., 20:506–519.

    Article  PubMed  CAS  Google Scholar 

  • Bergofsky, E. H., Lehr, D. E. and Fishman, A. P., 1962, The effect of changes in hydrogen ion concentration on the pulmonary circulation, J. clin. Invest., 41:1492–1502.

    Article  PubMed  CAS  Google Scholar 

  • Berkov, S., 1974, Hypoxic pulmonary vasoconstriction in the rat. The necessary role of angiotensin II, Cireulation Res., 35:256–261.

    Article  CAS  Google Scholar 

  • Bohr, D. R., 1977, Ine pulmonary hypoxic response — state of the field, Chest, 71 Supplement: 244–246.

    PubMed  CAS  Google Scholar 

  • Brody, J. S. and Stemmler, E. J., 1968, Differential reactivity in the pulmonary circulation, J. clin. Invest., 47:800–808.

    Article  PubMed  CAS  Google Scholar 

  • Chand, N. and Eyre, P., 1978, Spasmolytic action of histamine in airway smooth muscle, Agents and Action, 8:191–198.

    Article  CAS  Google Scholar 

  • Colebatch, H. J. H., Dawes, G. S., Goodwin, J. W. and Nadeau, R. A., 1965, The nervous control of the circulation in the fetal and newly expanded lungs of the lamb, J. Physiol., 178: 544–562.

    PubMed  CAS  Google Scholar 

  • Coleridge, J. C. G., Kidd, C. and Sharp, J. A., 1961, The distribution connections and histology of baroreceptors in the pulmonary artery with some observations on the innervation of the ductus arteriosus, J. Physiol., 156:591–602.

    PubMed  CAS  Google Scholar 

  • Daly, I. de B., and Hebb, C., 1966, “Pulmonary and bronchial vascular systems”, Arnold, London.

    Google Scholar 

  • Dawes, G. S., 1968, “Petal and neonatal physiology”, Yearbook Medical Publishers, Chicago.

    Google Scholar 

  • Dawes, G. S., 1969, in: “The pulmonary circulation and interstitial space”, A. P. Fishman and H. H. Hecht, eds., University of Chicago Press, Chicago and London.

    Google Scholar 

  • Durand, J., Ladurie, M. L. and Ranson-Bitker, B., 1970, Pulmonary circulation, in: “Progress in respiration research”, J. Widimsky and S. Daum, eds., Karger, Basel, Munchen, Paris, New York.

    Google Scholar 

  • Emery, C. J., Bee, D. and Barer, G. R., 1979, Mechanical properties and reactivity of the rat pulmonary circulation in chronic hypoxia. A possible model of human hypoxic disease. Proc. Pulmonary Circulation III, Prague, Bull. eur. Physio-path. resp. (in press).

    Google Scholar 

  • Emery, C. J., Sloan, P. J. M., Mohammed, P. H. and Barer, G. R., 1977, The action of hypercapnia during hypoxia on pulmonary vessels, Bull. eur. Fhysiopath. resp., 13:763–776.

    CAS  Google Scholar 

  • Even, P., Duroux, P., Caubarrere, I., Ruff, P., Butez, J. and Bronet, G., 1972, Respiratory effects induced by pulmonary artery occlusion, Bull. Fhysiopath. resp., 8:467–473.

    CAS  Google Scholar 

  • Fishman, A. P., 1976, Hypoxia on the pulmonary circulation. How and where it acts, Circulation Res., 38:221–231.

    Article  PubMed  CAS  Google Scholar 

  • Glazier, J. B. and Murray, J. P., 1971, Sites of pulmonary vasomotor activity in the dog during alveolar hypoxia and serotonin and histamine infusions, J. clin. Invest., 50: 2550–2558.

    Article  PubMed  CAS  Google Scholar 

  • Grant, B. J. B., Davies, E. E., Jones, H. A. and Hughes, J. M. B., 1976, Local regulation of pulmonary blood flow and ventilation-perfasion ratios in Coatimundi, J. appl. Physiol., 40:216–228.

    PubMed  CAS  Google Scholar 

  • Grodins, F., 1967, Some simple principles and complex realities of cardiopulmonary control during exercise, Circulation Res., Supplement 20 & 21:1.171–1.178.

    Google Scholar 

  • Gryglewski, R. J., Korbut, R. and Ocetkiewicz, A., 1978, Generation of prostacyclin by lungs in vivo and its release into the arterial circulation, Nature, 273:765–767.

    Article  PubMed  CAS  Google Scholar 

  • Harris, P. and Heath, D., 1977, “The human pulmonary circulation”, 2nd Edition, Churchill Livingstone, Edinburgh, London and New York.

    Google Scholar 

  • Hauge, A., 1968, Role of histamine in hypoxic pulmonary hypertension in the rat. I. Blockade or potentiation of endogenous amines, kinins and ATP, Circulation Res, 22:371–383.

    Article  PubMed  CAS  Google Scholar 

  • Hauge, A., 1969, Hypoxia and pulmonary vascular resistance. The relative effects of pulmonary arterial and alveolar PO2. Acta. physiol. scand., 76:121–130.

    Article  PubMed  CAS  Google Scholar 

  • Hebb, C., 1969, in: “The pulmonary circulation and interstitial space”, A. P. Fishman and H. H. Hecht, eds., University of Chicago Press, Chicago and London.

    Google Scholar 

  • Howard, P., Barer, G. R., Thompson, B., Warren, P. M., Abbot, C. J. and Mongall, I. P. F., 1975t Factors causing and reversing vasoconstriction in unventilated lung, Resp. Physiol., 24: 325–345.

    Article  CAS  Google Scholar 

  • Hughes, J. M. B., Glazier, J. B., Maloney, J. E. and West, J. B., 1968, Effects of extra-alveolar vessels on the distribution of blood flow in the dog lung, J. appl. Riysiol, 25:701–712.

    CAS  Google Scholar 

  • Hyman, A. L., Spannhake, E. W. and Kadowitz, P. J., 1977, Prosta glandins and the lung, Am. Rev. resp. Dis., 117:111–136.

    Google Scholar 

  • Ingram, R. H., Szidon, J. P. & Fishman, A. P., 1970, Response of the main pulmonary artery of dogs to neuronally released versus blood borne norepinephrine, Circulation Res., 26: 249–262.

    Article  PubMed  CAS  Google Scholar 

  • Junod, A. F., 1977, Metabolism of vasoactive agents in the lung, Am. Rev. resp. Dis., Comroe Symposium, 115:51–57.

    PubMed  CAS  Google Scholar 

  • Kadowitz, P. J., Knight, D. S., Hibbs, R. G., Ellison, J. P., Joiner, P. P., Brody, M. J. and Hyman, A. L., 1976, In fluence of 5 and 6 hydroxydopamine on adrenergic transmission and nerve terminal morphology in the canine pulmonary vascular bed, Circulation Res., 39:191–199.

    Article  PubMed  CAS  Google Scholar 

  • Kay, J. M., Waymire, J. C. and Grover, R. F., 1974, Lung mast cell hyperplasia and pulmonary histamine forming capacity in hypoxic rats, Am. J. Riysiol, 226:178–184.

    CAS  Google Scholar 

  • Lahiri, S. and Delaney, R. G., 1975, Stimulus interaction in the responses of the carotid, body chemoreceptor single afferent fibres, Resp. Riysiol., 24: 249–266.

    Article  CAS  Google Scholar 

  • Lauweryns, J. M, and Cokelaere, 1973, Hypoxia-sensitive neuroepithelial bodies. Intrapulmonary secretory neuroreceptors modulated by the C.N. S., Z. Zeilforsch. mikrosk. Anat., 145:521–540.

    Article  CAS  Google Scholar 

  • Ledsome, J. R., 1977, Reflex role of pulmonary arterial barorecep-tors, Am. Rev. resp. Dis., Comroe Symposium, 115:245–250.

    PubMed  CAS  Google Scholar 

  • Lloyd, T. C. and Schneider, A. J. L., 1970, Reflex pulmonary vascular responses to distension of the lungs and left heart, J. appl. Physiol., 29:318–322.

    PubMed  Google Scholar 

  • Lockhart, A., Zeller, M., Mensch-Dechene, J., Antezano, G., Paz-Zamora, M., Vargas, E. and Courdet, J., 1976, Pressure-flow-volume relationships in pulmonary circulation of normal Highlanders, J. appl. Physiol., 41:449–456.

    PubMed  CAS  Google Scholar 

  • McMurtry, I. F., Hiser, W. W., Reeves, J. T. and Grover, R. F., 1975, Dissociation of hypoxia and angiotensin II-induced pulmonary vasoconstriction by saralasin, Fed. Proc., 34: 438.

    Google Scholar 

  • McMurtry, I. F., Davidson, I. B., Reeves, J. T. and Grover, R. F., 1976, Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs, Circulation Res., 38:99–104.

    Article  PubMed  CAS  Google Scholar 

  • McMurtry, I. F., Petrun, M. D. and Reeves, J. T., 1978, Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia, Am. J. Physiol., H105–H109.

    Google Scholar 

  • Malik, A. B., 1977, Pulmonary vascular response to increase in intracranial pressure:role of sympathetic mechanisms, J. appl Physiol. Respirat. Environ. Exercise Physiol., 42:335–343.

    CAS  Google Scholar 

  • Mentzner, R. M., Rubio, R. and Berne, R. M., 1975, Release of adenosine by hypoxic canine lung tissue and its possible role in the pulmonary circulation, Am. J. Physiol, 229:1625–1631.

    Google Scholar 

  • Mills, E. and Jobsis, F. F., 1972, Mitochondrial respiratory chain and chemoreceptor response to changes in oxygen tension, J. Neurophysiol., 35:405–428.

    PubMed  CAS  Google Scholar 

  • Mungall, I. P. F., 1976, Hypoxia and lung mast cells: influence of disodium cromoglycate, Thorax, 31:94–100.

    Article  PubMed  CAS  Google Scholar 

  • Naeye, R. L., 1961, Arterial changes during the neonatal period, Archs. Path., 71:121–128.

    CAS  Google Scholar 

  • Nison, K. H. and Hauge, A., 1968, Effects of temperature changes on the pressor response to acute hypoxia in isolated rat lungs, Acta. physiol. scand., 73: 111–120.

    Article  Google Scholar 

  • Piene, H., 1976a, The influence of pulmonary blood flow rate on vascular input impedance and hydraulic power in the sympathetically and noradrenaline stimulated cat lung, Acta physiol. scand., 98:44–53.

    Article  PubMed  CAS  Google Scholar 

  • Piene, H., 1976b, Improved left ventricular performance by the transmission of pulse waves through the pulmonary vascular bed, Acta. physiol. scand. 98:450–456.

    Article  PubMed  CAS  Google Scholar 

  • Piene, H. and Hauge, A., 1976a, Reduction of pulsatile hydraulic power in the pulmonary circulation caused by moderate vasoconstriction, Cardiovasc. Res., 10:503–516.

    Article  PubMed  CAS  Google Scholar 

  • Piene, H, and Hauge, A., 1976b, Influence of moderate vasoconstriction on the wave reflection properties of the pulmonary arterial bed, Acta, physiol. scand., 98:37–43.

    Article  CAS  Google Scholar 

  • Reuben, S. R., Gersch, B. J., Swadling, J. P. and Lee, G. de J., 1970, Measurement of pulmonary arterial distensibility in the dog. Cardiovasc. Res., 4:473–481.

    Article  PubMed  CAS  Google Scholar 

  • Reuben, S. R., Swadling, J. P., Gersch, B. J. and Lee, G. de J., 1971, Impedance and transmission properties of the pulmonary arterial system, Cardiovasc. Res., 5:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Severinghaus, J. W., Swenson, E. W., Finley, T. N., Lategola, M. and Williams, J., 1961, Unilateral hypoventilation produced in dogs by occluding one pulmonary artery, J. appl. Riysiol., 16:53–60.

    CAS  Google Scholar 

  • Shaw, J. W., 1971, Pulmonary vasodilator and vasoconstrictor actions of histamine, J. Riysiol, 215:34–35p.

    Google Scholar 

  • Spencer, H. and Leof, D., 1964, The innervation of the human lung. J. Anat., 98:599–609.

    PubMed  CAS  Google Scholar 

  • Stern, S. and Braun, K., 1966, Effect of chemoreceptor stimulation on pulmonary veins, Am. J. Riysiol., 210:535–539.

    CAS  Google Scholar 

  • Sylvester, J. T. and McGowan, C., 1978, The effect of agents that bind to cytochrome P-450 on hypoxic pulmonary vasoconstriction, Circulation Res., 43:429–437.

    Article  PubMed  CAS  Google Scholar 

  • Szidon, J. P. and Fishman, A. P., 1969, in: “The pulmonary circulation and interstitial space”, A. P. Fishman and H. H. Hecht, eds., University of Chicago Press, Chicago and London.

    Google Scholar 

  • Szidon, J. P. and Flint, J. F., 1977, Significance of sympathetic innervation of pulmonary vessels in response to acute hypoxia, J. appl. Physiol. Respirat. Environ. Exercise Riysiol., 43:65–71.

    CAS  Google Scholar 

  • Thompson, B., Barer, G. R. and Shaw, J. W., 1976, The action of histamine on the pulmonary vessels of cats and rats, Clin. & exp. Riarmac. & Physiol., 3:399–414.

    Article  CAS  Google Scholar 

  • Tyler, T. L., Leffler, C. W. and Cassin, S., 1977, Effects of prostaglandin precursors, prostaglandins and prostaglandin metabolites on pulmonary circulation of perinatal goats. Chest, 71 Supplement:271–273.

    PubMed  CAS  Google Scholar 

  • Vane, J. R., 1969, The release and fate of vasoactive hormones in the circulation, B. J. Pharmac., 35:209–242.

    Article  CAS  Google Scholar 

  • Viles, P. H. and Shepherd, J. T., 1968, Evidence for a dilator action of carbon dioxide on the pulmonary vessels of the cat, Circulation Res., 22:325–332.

    Article  PubMed  CAS  Google Scholar 

  • Wagner, P. D., Dantzker, D. R., Dueck, R., Clausen, J. L. and West, J. B., 19771 Ventilation-perfusion inequality in chronic obstructive pulmonary disease, J. clin. Invest., 59:203–216.

    Article  PubMed  CAS  Google Scholar 

  • Weir, E. K., McMurtry, I. F., Tucker, A., Reeves, J. T. and Grover, R. F., 1976, Prostaglandin synthetase inhibitors do not decrease hypoxic pulmonary vasoconstriction, J. appl, Riysiol., 41:714–718.

    CAS  Google Scholar 

  • West, J. B., 1969, in: “The pulmonary circulation and interstitial space”, p 302, A. P. Fishman and H. H. Hecht, eds., University of Chicago Press, Chicago and London.

    Google Scholar 

  • West, J. B., 1977, State of the art. Ventilation-perfusion relationships, Am. Rev. resp. Dis., 116:919–943.

    PubMed  CAS  Google Scholar 

  • Widdicomhe, J. G., 1974, in: “Recent advances in physiology”, p.p. 239–278, R. J. Linden, ed., Churchill Livingstone, Edinburgh and London.

    Google Scholar 

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  1. epartment of Medicine, University of Sheffield, England

    Gwenda R. Barer

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  1. Gwenda R. Barer
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Editors and Affiliations

  1. The Midhurst Medical Research Institute, Midhurst, Sussex, UK

    G. Cumming

  2. University of Palermo, Palermo, Italy

    G. Bonsignore

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Barer, G.R. (1980). Active Control of the Pulmonary Circulation. In: Cumming, G., Bonsignore, G. (eds) Pulmonary Circulation in Health and Disease. Ettore Majorana International Science Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1721-1_6

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  • DOI: https://doi.org/10.1007/978-1-4757-1721-1_6

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