The Role of Prostaglandins in the Respiratory System

  • Rodolfo Paoletti
  • Andrea Poli
  • Elena Tremoli
Part of the Ettore Majorana International Science Series book series (EMISS, volume 3)

Abstract

The platelets survival time, as measured with isotopic and metabolic methods, is often shortened in patients with chronic respiratory diseases. Platelets overconsumption may be due to alterations of the intimai membranes of the pulmonary arteries, or to variations in the response of platelets themselves1,2 . This situation is likely to contribute to the pulmonary damage, by causing the continuous formation of microthrombi reducing the arterial blood supply to the lungs: it is, then, obviously responsible of the dramatic episodes of massive thrombosis of the large pulmonary arteries3,4.

Keywords

Arachidonic Acid Acetylsalicylic Acid Chronic Obstructive Lung Disease Affect Platelet Aggregation ANTIAGGREGATING Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M.D. Steele, J.H. Ellis Jr., H.S. Weily, E. Genton, Platelet survival time in patients with hypoxiemia and pulmonary hypertension, Circulation, 55, 660–662, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    E. Tremoli, L. Bertoli, F. Conti, R. Merlini, O. Mantero, Platelet antiaggregating therapy in chronic obstructive lung disease,.in press, 1979.Google Scholar
  3. 3.
    N.O. Fowler, B. Black Schaffer, R.C. Scott, M. Gueron, Idiopathic and thromboembolic pulmonary hypertension, Am. J. Med. 40, 331–333, 1966.CrossRefGoogle Scholar
  4. 4.
    C.A. Wagenvoort, D. Heath, J.E. Edwards, “The pathology of the pulmonary vasculature”, Springfield, Charles C. Thomas, Publ., 1964.Google Scholar
  5. 5.
    L.A. Harken, S.J. Slichter, Platelet and fibrinogen consumption in man, N. Engl. J. Med., 287, 999, 1972.CrossRefGoogle Scholar
  6. 6.
    J.R. Vane, Inhibitors of prostaglandin, prostacyclin and thromboxane synthesis, in “Adv. Prostaglandin and Thromboxane Research”, vol. IV, pp. 27–44, 1978, Raven Press, N.Y.Google Scholar
  7. 7.
    D. Nutgeren, E. Hazelhof, Isolation and properties of intermediates in prostaglandins biosynthesis, Biochim. Biophys. Acta 326, 448–481, 1973.CrossRefGoogle Scholar
  8. 8.
    M. Hamberg, J. Svensson and B. Samuelsson, Novel transformation of prostaglandin endoperoxides: formation of thromboxanes, in “Adv. Prostaglandins and Thromboxane Research”, vol. 1, pp. 19–27 (B. Samuelsson and R. Paoletti, eds.), Raven Press, N.Y. 1976.Google Scholar
  9. 9.
    S. Moncada, P. Needleman, S.Bunting, J.R. Vane, Prostaglandins endoperoxide and thromboxane generating systems and their selective inhibition, Prostaglandins, 12, 323–329, 1976.PubMedGoogle Scholar
  10. 10.
    J. Svensson, M. Hamberg, B. Samuelsson, Prostaglandins endoperoxides. IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets, Acta Physiol. Scand., 94, 222–228, 1975.PubMedCrossRefGoogle Scholar
  11. 11.
    P. Borgeat and B. Samuelsson, Metabolism of arachidonic acid in polimorphonuclear leukocytes. Isolation of novel hydroxy-lated compounds, 4th International Conference on Prostaglandins, Washington, D.C.,U.S.A., 1979.Google Scholar
  12. 12.
    R.J. Flower, R.J. Gryglewski, K. Herdaczynska-Cedro, J.R. Vane, Effects of antiinflammatory drugs on prostaglandins biosynthe-sis, Nature, New Biol., 238, 104–106, 1972.PubMedGoogle Scholar
  13. 13.
    R.J. Gryglewski, Steroid hormones, antiinflammatory steroids and prostaglandins, Pharmac. Res. Comm., 8, 337–347, 1976.CrossRefGoogle Scholar
  14. 14.
    R.J. Flower, G.J. Blackwell, Antiinflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation, Nature, 278, 456–459, 1979.PubMedCrossRefGoogle Scholar
  15. 15.
    S. Moncada, S. Bunting, J.R. Vane, P. Thorogood, A. Raz, P. Needleman, Imidazole, a selective potent antagonist of thromboxane synthetase, Prostaglandins, 13, 611–618, 1977.PubMedGoogle Scholar
  16. 16.
    H.A. Smythe, M.A. Ogryzlo, E.A. Murphy, The effect of sulfinpyrazone (Anturane) on platelet economy and blood coagulation in man, Can. Med. Assoc. J., 92, 818–821, 1965.PubMedGoogle Scholar
  17. 17.
    M. All, J.W.D. McDonald, Steroid hormones, antiinflammatory steroids and prostaglandins, J. Lab. Clin. Med., 89, 868–875, 1977.Google Scholar
  18. 18.
    D.C.B. Mills, J.B. Smith, The influence on platelets aggregation of drugs that affect the accumulation of 3’,5’-cyclic monophosphate in platelets, Biochem. J., 121, 185–196, 1971.PubMedGoogle Scholar
  19. 19.
    G. Masotti, L. Poggesi, G. Galanti, G.G. Neri Serneri, Stimula-tion of prostacyclin by dipyridamole, Lancet, i, 1412, 1979.CrossRefGoogle Scholar
  20. 20.
    W.F. Krol, Three large scale clinical trials of aspirin in USA, Proc. Roy. Soc. Med. 70, suppl. 7, 24–27, 1977.PubMedGoogle Scholar
  21. 21.
    Sulfinpyrazone in the prevention of cardiac death after myocardial infarction. Anturane reinfarction trial research group, N. Engl. J. Med., 298, 289–295, 1977.Google Scholar
  22. 22.
    The Canadian Cooperative Study Group, A randomized trial of aspirin and sulfinpyrazone in threatened stroke, N. Engl. J. Med., 299, 53–59, 1978.CrossRefGoogle Scholar
  23. 23.
    P. Ramwell, Washington University, personal communication.Google Scholar
  24. 24.
    E.A. Jaffe, B.B. Weksler, Recovery of endothelial cell prostacyclin production after inhibition by low doses of Aspirin, J. Clin. Invest., 63, 532–535, 1979.PubMedCrossRefGoogle Scholar
  25. 25.
    J.M. Armstrong, N. Lattimer, S. Moncada, J.R. Vane, Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prosta-glandin F1a with those of prostaglandin E2 in rats and rabbits, Brit. J. Pharmacol., 62, 125–130, 1978.CrossRefGoogle Scholar
  26. 26.
    R.S. Mitchell, G.W. Silvers, G.A. Dart, T.L. Petty, T.N. Vincent, S.F. Ryan and G.F. Filley, Clinical and morphological correlations in chronic airway obstruction, Am. Rev. Resp. Dis., 97, 54–60, 1968.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Rodolfo Paoletti
    • 1
  • Andrea Poli
    • 1
  • Elena Tremoli
    • 1
  1. 1.Institute of Pharmacology and PharmacognosyUniversity of MilanMilanItaly

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