Positive Airway Pressure and Lung Edema

  • Anton Hauge
  • Gunnar Nicolaysen
Part of the Ettore Majorana International Science Series book series (EMISS, volume 3)


The litterature dealing with the events which follow after induction of positive airway pressure is vast and — sometimes, bewildering. Mead and Whittenberger1 in their chapter on “Lung inflation and hemodynamics” in Handbook of Physiology pointed out that articles on this subject commonly include the phrase “this controversial field,” in the first paragraph. Since that was written our knowledge and understanding of the effect of positive airway pressure on general hemodynamics (venous return, total O2 transport) has increased considerably. The effects on lung edema, however, still remain to be clarified.


Lung Volume Transpulmonary Pressure Pleural Pressure Lung Inflation Alveolar Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    J. Mead and J.L. Whittenberger, Lung inflation and hemodynamics, In: Handbook of Physiology. Sect. 3. Respiration. Vol. I. Washington, D.C., Amer. Physiol. Soc. (1964).Google Scholar
  2. 2.
    A.L. Barach, J. Martin, and M. Eckman, Positive pressure respiration and its application to the treatment of acute pulmonary edema, Ann. Internal Med., 12:754 (1938).CrossRefGoogle Scholar
  3. 3.
    D.G. Ashbaugh, D.L. Petty, D.B. Bigelow, and T.M. Harris, Continuous positive-pressure breathing (CPPB) in adult respiratory distress syndrome, J. Thoracic Cardiovascular Surg. 57:31 (1969).Google Scholar
  4. 4.
    E. Wagner, P.A. Rieben, K. Katsuhara, and P.F. Salisbury, Influence of airway pressure on edema in the isolated dog’s lung, Circulation Res. 9:382 (1961).PubMedCrossRefGoogle Scholar
  5. 5.
    L.G. Alexander, W.C. DeVries, and R.W. Anderson, Airway pressure and pulmonary edema formation, Surg. Forum, 24:231 (1973).PubMedGoogle Scholar
  6. 6.
    R.H. Demling, N.C. Staub, and L.H. Edmunds, Jr., Effect of end-expiratory airway pressure on accumulation of extra-vascular lung water, J. Appl. Physiol. 38:907 (1975).PubMedGoogle Scholar
  7. 7.
    D. Thornton, H. Ponhold, J. Butler, T. Morgan, and F.W. Cheney, Effects of pattern of ventilation on pulmonary metabolism and mechanics, Anesthesiology, 42:4 (1975).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Hauge, and G. Nicolaysen, Studies on transvascular fluid balance and capillary permeability in isolated lungs, Bull. Physio-Pathol. Respirat. 7:1198 (1971).Google Scholar
  9. 9.
    G. Bø, A. Hauge, and G. Nicolaysen, Alveolar pressure and lung volume as determinants of net transvascular fluid filtration, J. Appl. Physiol.: Respirat. Environ. Excercise Physiol., 42:476 (1977).Google Scholar
  10. 10.
    L.D. Iliff, Extra-alveolar vessels and edema development in excised dog lungs, Circulat. Res., 28:524 (1971).Google Scholar
  11. 11.
    B.C. Smith, V.F. Gould, F.W. Cheney, and J. Butler, Pathogenesis of hemodynamic pulmonary edema in excised dog lungs, J. Appl. Physiol. 37:904 (1974).PubMedGoogle Scholar
  12. 12.
    R.K. Albert, S. Lakshminaraayan, T.W. Huang, and J. Butler, Fluid leaks from extra-alveolar vessels in living dog lungs, J. Appl. Physiol.: Respirat. Environ. Excercise Physiol., 44:759 (1978).Google Scholar
  13. 13.
    J.B. Glazier, J.M.B. Hughes, J.E. Maloney, and J.B. West, Measurements of capillary dimensions and blood volume in rapidly frozen lungs, J. Appl. Physiol. 26:65 (1969).PubMedGoogle Scholar
  14. 14.
    G. Nicolaysen, and A. Hauge, Determinants of transvascular fluid shifts in zone I lungs, J. Appl. Physiol.: Respirat. Environ. Excercise Physiol., In press.Google Scholar
  15. 15.
    J. Gil, Influence of surface forces on pulmonary circulation, in “Pulmonary Edema,” A.P. Fishman and E.M. Renkin. eds, American Physiological Society, Bethesda (1979).Google Scholar
  16. 16.
    D.Y. Rosenzweig, J.M.B. Hughes, and J.B. Glazier, Effects of transpulmonary and vascular pressures on pulmonary blood volume in isolated lung, J. Appl. Physiol. 28:553, 1970.PubMedGoogle Scholar
  17. 17.
    S. Permutt, Mechanical influences on water accumulation in the lungs, in: “Pulmonary Edema,” A.P. Fishman and E.M. Renkin. eds., American Physiological Society, Bethesda (1979).Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Anton Hauge
    • 1
  • Gunnar Nicolaysen
    • 1
  1. 1.Institute of PhysiologyUniversity of OsloOsloNorway

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