Electron Microscopy of Pulmonary Oedema

  • B. Cornin
Part of the Ettore Majorana International Science Series book series (EMISS, volume 3)


The major mechanisms responsible for pulmonary oedema traditionally come under two headings: hydrostatic and cytotoxic. Thus oedema of the lungs may be due to hydrostatic/oncotic forces acting on vessels of normal permeability, or to cytotoxic factors which enhance permeability irrespective of pressure gradients. Tracer substances normally retained within the blood stream are thought to distinguish between these two mechanisms by escaping when cytotoxic factors increase vascular permeability. It has been demonstrated however that permeability is affected by purely hydrostatic forces, so blurring the traditional distinction between hydrostatic and cytotoxic oedema (Pietra et al., 1968; Schneeberger and Karnovsky, 1971). Nevertheless it is convenient to consider the causes of pulmonary oedema as acting under one or other of these two mechanisms.


Pulmonary Oedema Clara Cell Cytotoxic Oedema Oedema Fluid Pinocytotic Vesicle 
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  1. Bensch, K.G., Gordon, G.B. and Miller, L., 1974, Fibrillar structures resembling leiomyofibrils in endothelial cells of mammalian pulmonary blood vessels, Z. Zellforsch., 63: 759–766.CrossRefGoogle Scholar
  2. Cottrell, T.S., Levine, O.R., Senior, R.M., Wiener, J., Spiro, D. and Fishman, A.P., 1967, Electron microscopic alterations at the alveolar level in pulmonary edema, Circul. Res., 21: 783–797.CrossRefGoogle Scholar
  3. Hurley, J.V., 1978, Current views on the mechanisms of pulmonary oedema, J. Pathol., 125: 59–79.CrossRefPubMedGoogle Scholar
  4. Kapanci, Y., Weibel, E.R., Kapla, H.P. and Robinson, F.R., 1969, Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys: Ultrastructural and morphometric studies, Lab. Invest., 20: 101–128.PubMedGoogle Scholar
  5. Lauweryns, J.M., 1971, The blood and lymphatic microcirculation of the lung, in: “Pathology Annual”, Vol. 6, S.C. Sommers, ed., Appleton-Century-Crofts, New York.Google Scholar
  6. Pietra, G.G., 1978, The basis of pulmonary edema, with emphasis on ultrastructure, in: “The lung”, W.M. Thurlbeck and M.R. Abelt, eds., Williams and Wilkins, Baltimore.Google Scholar
  7. Pietra, G.G., Szidon, J.P., Carpenter, H.A. and Fishman, A.P., 1974, Bronchial venular leakage during endotoxin shock, Am. J. Pathol., 77: 387–406.PubMedGoogle Scholar
  8. Pietra, G.G., Szidon, J.P., Leventhal, M.M. and Fishman, A.P., 1969, Hemoglobin as a tracer in hemodynamic pulmonary edema, Science, 166: 1643–1646.CrossRefPubMedGoogle Scholar
  9. Schneeberger, E.E. and Karnovsky, M.J., 1971, The influence of intravascular fluid volume on the permeability of newborn and adult mouse lungs to ultrastructural protein tracers, J. Cell Biol., 49: 319–334.CrossRefPubMedGoogle Scholar
  10. Schneeberger-Keeley, E.E. and Karnovsky, M.J., 1968, The ultra-structural basis of alveolar-capillary membrane permeability to peroxidase used as a tracer, J. Cell Biol., 37: 781–793.CrossRefPubMedGoogle Scholar
  11. Staub, N.C., 1970, The pathophysiology of pulmonary edema, Human Path., 1: 419–432.CrossRefGoogle Scholar
  12. Staub, N., 1974, Pathogenesis of pulmonary edema, Amer. Rev. Resp. Dis., 109: 358–372.PubMedGoogle Scholar
  13. Suzuki, Y., 1969, Fenestration of alveolar capillary endothelium in experimental pulmonary fibrosis and of normal bronchial capillaries, Lab. Invest., 21: 304–308.PubMedGoogle Scholar
  14. Vijeyaratnam, G.S. and Corrin, B., 1971, Fine structural alterations in the lungs of iprindole treated rats, J. Pathol. 114: 233–239.CrossRefGoogle Scholar
  15. West, J.B., Dollery, C.T. and Heard, B.E., 1965, Increased pulmonary vascular resistance in the dependent zone of the isolated dag lung caused by perivascular edema, Circulation Res., 17: 191–206.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • B. Cornin
    • 1
  1. 1.St. Thomas’s Hospital Medical SchoolUK

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