Principles of Water and Nonelectrolyte Transport across Membranes

  • Thomas E. Andreoli
  • James A. Schafer

Abstract

Classical deductions concerning the manner in which water and nonelectrolytes traverse biological membranes have their origin in the observations of Overton(1) and Collander and Bärlund.(2) Overton formulated the generalization that the rate of penetration of nonelectrolytes into plant cells was proportional to their oil-water partition coefficient. Collander and Bärlund(2) confirmed these observations but noted that, in certain instances, the cellular permeability of solutes was related primarily to molecular size rather than lipid solubility. These two dissimilar phenomena led to the hypothesis that natural membranes were mosaic structures containing lipids and pores, or molecular sieves. The degree to which molecular size, rather than lipid solubility, regulated the penetration of solutes into cells was dependent on the fractional membrane area occupied by pores and the characteristics of the individual pores.(3) Current theories concerning membrane pores depend, in the main, on this hypothesis.

Keywords

Water Diffusion Lipid Bilayer Membrane Solvent Flow Unstirred Layer Toad Urinary Bladder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Thomas E. Andreoli
    • 1
  • James A. Schafer
    • 1
  1. 1.Division of Nephrology, Department of Medicine, and Department of Physiology and BiophysicsUniversity of Alabama School of MedicineBirminghamUSA

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