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Dynamics of Lipids in Biomembranes

  • Chapter
Membrane Physiology

Abstract

The hypothesis underlying much of today’s research on biological membranes was formulated by Singer and Nicolson in 1972.(1) This construct, known as the fluid mosaic hypothesis, contains two essential elements. The first of these, a derivative of the Danielle model,(2) requires that the lipid component of the membrane be a bilayer in structure and contribute to the membrane its basic barrier properties. Although the lipid molecules are confined to the bilayer, they are free to exhibit a variety of motional modes such as vibration, rotation, and translation. The second element of the fluid mosaic hypothesis deals with the disposition of the protein components of the membrane. These components are immersed to varying degrees in the lipid bilayer. Some may be only superficially associated with the polar faces of the bilayer, some embedded in its hydrophobic core, and others may completely span the bilayer. The fluid nature of the bilayer permits the protein components to move in both rotational and translational modes. These diffusional motions of the individual protein components may give rise to time-dependent patterns in the compositional mosaic.

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Authors and Affiliations

  1. Department of Biochemistry, University of Virginia School of Medicine, Charlottesville, Virginia, 22901, USA

    T. E. Thompson & C. Huang

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  1. T. E. Thompson
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  2. C. Huang
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Texas Medical School at Houston, 77025, Houston, TX, USA

    Thomas E. Andreoli M.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Physiology, Yale University School of Medicine, 06510, New Haven, CT, USA

    Joseph F. Hoffman Ph.D. (Eugene Higgins Professor and Chairman) (Eugene Higgins Professor and Chairman)

  3. Division of Nephrology, University of California, San Diego, 92037, La Jolla, CA, USA

    Darrell D. Fanestil M.D. (Professor of Medicine, and Head) (Professor of Medicine, and Head)

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© 1980 Springer Science+Business Media New York

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Thompson, T.E., Huang, C. (1980). Dynamics of Lipids in Biomembranes. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D. (eds) Membrane Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1718-1_2

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  • DOI: https://doi.org/10.1007/978-1-4757-1718-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1720-4

  • Online ISBN: 978-1-4757-1718-1

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