Anatomic Pathology of the Kidney in Nephrotic Syndrome: Clinicopathological Abridgement

  • Anil K. Mandal


Nephrotic syndrome is a clinical condition characterized by heavy proteinuria and manifested by edema. Daily loss of protein in the urine may vary, but a 24 hr protein loss exceeding 3.5 g on more than one occasion is the most important criterion used to establish the state of nephrotic syndrome. Accompanying but less important features are hypoalbuminemia and hyperlipidemia. These clinical and laboratory findings indicate renal parenchymal disease but fail to point toward the type of renal lesion.


Nephrotic Syndrome Glomerular Basement Membrane Idiopathic Nephrotic Syndrome Renal Vein Thrombosis Congenital Nephrotic Syndrome 
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  1. Appel, G. B., William, G. S., Meltzer, J. L., and Pirani, C. L.: Renal vein thrombosis, nephrotic syndrome and systemic lupus erythematosus. Ann. Intern. Med. 85:310, 1976.Google Scholar
  2. Bhorade, M. S., Carag, H. B., Lee, H. W., Potter, E. V., and Dunea, G.: Nephropathy of secondary syphilis. J. Am. Med. Assoc. 216: 1159, 1971.CrossRefGoogle Scholar
  3. Braunstein, G. D., Lewis, E. J., Galvanek, E. G., Hamilton, A., and Bell, W. R.: The nephrotic syndrome associated with secondary syphilis. Am. J. Med. 48: 643, 1970.PubMedCrossRefGoogle Scholar
  4. Cade, R., Spooner, G., Juncos, L., Fuller, T., Tarrant, D., Raulerson, D., Mahoney, J., PickeringGoogle Scholar
  5. M., Grubb, W., and Marbury, T.: Chronic renal vein thrombosis. Am. J. Med. 63:387, 1977. Cameron, S., and Ogg, C. S.: Nephrotic syndrome in chronic lymphocytic leukemia. Br. Med. J. 4: 164, 1974.Google Scholar
  6. Churg, J., and Dachs, S.: Diabetic renal disease: Arteriosclerosis and glomerulosclerosis. In KidneyPathology Decennial, 1966–1975 (S. C. Sommers, ed.). Appleton, New York, 1975, p. 503. Churg, H., and Grishman, E.: Ultrastructure of glomerular disease: A review. Kidney Int. 7: 254, 1975.Google Scholar
  7. Eagen, J. W., and Lewis, E. J.: Glomerulopathies of neoplasia: An editorial. Kidney Int. 11: 297, 1977.PubMedCrossRefGoogle Scholar
  8. Elfenbein, B., Patchefsky, A., Schwartz, W., and Weinstein, A. G.: Pathology of the glomerulus in sickle cell anemia with and without nephrotic syndrome. Am. J. Pathol. 77: 357, 1974.PubMedGoogle Scholar
  9. Franklin, W. A., Jennings, R. B., and Earle, D. P.: Membranous glomerulonephritis: Long-term serial observations on clinical course and morphology. Kidney Int. 4: 36, 1973.PubMedCrossRefGoogle Scholar
  10. Gamble, C. N., and Reardan, J. B.: Immunopathogenesis of syphilitic glomerulonephritis. N. Engl. J. Med. 292: 449, 1975.PubMedCrossRefGoogle Scholar
  11. Gluck, M. C., Gallo, G., Lowenstein, J., and Baldwin, D. S.: Membranous glomerulonephritis. Evolution of clinical and pathological features. An. Intern. Med. 78: 1, 1973.Google Scholar
  12. Grishman, E., Churg, J., and Potash, J. G.: Glomerular morphology in nephrotic heroin addicts. Lab. Invest. 35: 415, 1976.PubMedGoogle Scholar
  13. Hallman, N., Norio, R., and Rapola, J.: Congenital nephrotic syndrome. Nephron 11:101, 1973. Hatta, I.: Electron microscopic analysis of glomerular basement membrane in membranous nephropathy. Jap. Circ. J. 36: 137, 1972.CrossRefGoogle Scholar
  14. Hartfall, S. J., Garland, H. G., and Goldie, W.: Gold treatment of arthritis. Lancet 2:838 (Oct. 9 ), 1937.Google Scholar
  15. Hayslett, J. P., Kashgarian, M., Bensch, K. G., Spargo, B. H., Freedman, L. R., and Epstein, F. H.: Clinicopathological correlations in the nephrotic syndrome due to primary renal disease. Medicine 52: 93, 1973.CrossRefGoogle Scholar
  16. Heymann, W., Hackel, D. B., and Hunter, J. L. P.: Trimethadione (tridione) nephrosis in rats. Pediatrics 25: 112, 1960.PubMedGoogle Scholar
  17. Hopper, J., Ryan, P., Lee, J. C., and Rosenau, W.: Lipoid nephrosis in 31 adult patients: Renal biopsy study by light, electron and fluorescence microscopy with experience in treatment. Medicine 49: 321, 1970.PubMedCrossRefGoogle Scholar
  18. Hyman, L. R., Burkholder, P. M., Joo, P. A., and Segar, W. E.: Malignant lymphoma and nephrotic syndrome: A clinicopathological analysis with light, immunofluorescence and electron microscopy of renal lesions. J. Pediatr. 82: 207, 1973.PubMedCrossRefGoogle Scholar
  19. Kaplan, B. S., Bureau, M. A., and Drummond, K. N.: The nephrotic syndrome in the first year of life: Is a pathological classification possible? J. Pediatr. 85: 615, 1974.PubMedCrossRefGoogle Scholar
  20. Kaschula, R. O. C., Uys, C. J., Kuijten, R. H., Dale, J. R. P., and Wiggelinkhuizen, J.: Nephrotic syndrome of congenital syphilis. Arch. Pathol. 97: 289, 1974.PubMedGoogle Scholar
  21. Kees, C. J., and Harrell, R. S.: Radiographic manifestations of renal vein thrombosis. J. Urol. 108:830, 1972.Google Scholar
  22. Kilcoyne, M. M., Gocke, D. J., Meltzer, J. I., Daly, J. J., Thompson, G. E., Hsu, K. C., and Tannenbaum, M.: Nephrotic syndrome in heroin addicts. Lancet 1:17, 1972.Google Scholar
  23. Kimmelstiel, P.: Diabetic nephropathy. In The Kidney. International Academy of Pathology Monograph ( F. K. Mostofi, ed.). Williams & Wilkins, Baltimore, 1966, p. 226.Google Scholar
  24. Kniker, W. T., and Sweeney, M. J.: Increased urinary basement membrane-like products in infants with congenital nephrosis and their healthy relatives. Clin. Res. 20: 115, 1972.Google Scholar
  25. Krebs, R. A., and Burvant, M. U.: Nephrotic syndrome in association with varicella. J. Am. Med. Assoc. 222: 325, 1972.CrossRefGoogle Scholar
  26. Lee, J. C., Dushkin, M., Eyring, E. J., Engleman, E. P., and Hopper, J.: Renal lesions associated with gold therapy: Light and electron microscopic studies. Arthritis Rheum. 8: 1, 1965.PubMedCrossRefGoogle Scholar
  27. Lee, J. C., Yamauchi, H., and Hopper, J.: The association of cancer and the nephrotic syndrome. Ann. Intern. Med. 64: 41, 1966.PubMedGoogle Scholar
  28. Mandai, A. K., Nordquist, J. A., Kraikitpanitch, S., and Lindeman, R. D.: An etiology of nephrotic syndrome in chronic interstitial nephritis (pyelonephritis): An electron microscopic study. Am. J. Med. Sci. 274: 317, 1977a.CrossRefGoogle Scholar
  29. Mandal, A. K., Nordquist, J. A., and Rodgers, C. L.: Glomerulopathy and arteriolopathy in congenital nephrotic syndrome: Light, electron and fluorescence microscopy studies. Human Pathol. 8: 344, 19776.Google Scholar
  30. Marcus, S. L.: The nephrotic syndrome during pregnancy. Obstet. Gynecol. Survey 18: 511, 1963. Muehrcke, R. C., Mandal, A. K., Gotoff, S. P., Isaacs, E. W., and Volini, F. I.: The clinical value of electron microscopy in renal disease. Arch. Intern. Med. 124:170, 1969.Google Scholar
  31. Plager, L., and Stutzman, L.: Acute nephrotic syndrome as a manifestation of active Hodgkin’s disease. Am. J. Med. 50: 56, 1971.PubMedCrossRefGoogle Scholar
  32. Pollak, V. E., Rosen, S., Pirani, C. L., Muehrcke, R. C., and Kark, R. M.: Natural history of lipoid nephrosis and of membranous glomerulonephritis. Ann. Intern. Med. 69: 1171, 1968.PubMedGoogle Scholar
  33. Silverberg, D. S., Kidd, E. G., Shnitka, T. K., and Ulan, R. A.: Gold nephropathy: A clinical and pathologic study. Arthritis Rheum. 13: 812, 1970.PubMedCrossRefGoogle Scholar
  34. Strom, T., Muehrcke, R. C., and Smith, R. D.: Sickle cell anemia with the nephrotic syndrome and renal vein thrombosis. Arch. Intern. Med. 129: 104, 1972.PubMedCrossRefGoogle Scholar
  35. Tornroth, T., and Skrifvars, B. O.: Gold nephropathy prototype of membranous glomerulonephritis. Am. J. Pathol. 75: 573, 1974.Google Scholar
  36. Triger, D. R., and Joeker, A. M.: Renal amyloidosis. A fourteen-year follow-up. Q. J. Med. 42: 15, 1973.PubMedGoogle Scholar
  37. Vaishnava, H., Gulati, P. D., Arora, N., Bazazmalik, G., and Gupta, D. N.: Nephrotic syndrome due to chronic pyelonephritis. J. Assoc. Physicians India 16: 435, 1968.PubMedGoogle Scholar
  38. Williams, A. O.: Nephropathy in African Children. Abstracts, XIth International Congress, 2nd World Congress of Academic and Environmental Pathology, Washington, D.C., October 17–23, 1976.Google Scholar
  39. Wing, A. J., Kibukamusoke, J. W., and Hutt, M. S. R.: Poststreptococcal glomerulonephritis and the nephrotic syndrome in Uganda. Trans. Roy. Soc. Trop. Med. Hyg. 65: 543, 1971.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Anil K. Mandal
    • 1
  1. 1.Renal Electron Microscopy Laboratory and Staff Physician, Medical Service Veterans Administration HospitalUniversity of Oklahoma College of MedicineOklahoma CityUSA

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