Abstract
It is well known that many enzymatic and cellular processes involve specific protein-nucleic acid associations. Examples include the interaction of a repressor with its operator DNA (see Beckwith and Zipser, 1970; Müller-Hill, 1971), of DNA polymerase with DNA (see Kornberg, 1975), of ribosomal proteins with ribosomal RNA (see Nomura et al., 1974), of aminoacyl tRNA synthetases with tRNAs (see Kisselev and Favorova, 1974; Söll and Schimmel, 1974), as well as many other systems. A prime goal is to determine the mechanism by which these interactions occur; viz., it is desirable to understand how specificity is achieved and to determine what factors are responsible for the strength of specific protein-nucleic acid associations.
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Schimmel, P.R., Budzik, G.P., Lam, S.S.M., Schoemaker, H.J.P. (1976). In Vitro Studies of Photochemically Cross-Linked Protein-Nucleic Acid Complexes. Determination of Cross-Linked Regions and Structural Relationships in Specific Complexes. In: Smith, K.C. (eds) Aging, Carcinogenesis, and Radiation Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1662-7_8
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DOI: https://doi.org/10.1007/978-1-4757-1662-7_8
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