Gene Regulation: Selective Control of DNA Helix Openings
Gene regulation implies differential activity of DNA molecules within an individual cell. Such differential activity is observed during both gene transcription and gene replication (Frenster, 1966), and is a feature of DNA molecules within both prokaryotes (Chamberlin, 1974) and eukaryotes (Frenster and Herstein, 1973). Because gene replication appears to be secondary to gene transcription (Klevecz and Hsu, 1964; Champoux and McConaughy, 1975), the critical feature of the regulatory event appears to lie in the molecular details of selective gene transcription (Frenster, 1965d; Chamberlin, 1974). Such selectivity involves both the choice of a particular gene locus and the choice of a particular DNA strand on which to effect messenger RNA synthesis (Frenster, 1966).
KeywordsStrand Separation Acidic Macromolecule Selective Transcription Nuclear Acidic Protein Histone Displacement
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- Frenster, J.H., 1966, Control of DNA strand separations during selective transcription and asynchronous replication, Information Exchange Group Number 7, March, 1966, and in “The Cell Nucleus-Metabolism and Radiosensitivity” (H.M. Klouwen, ed.), pp. 27–46, Taylor and Francis Ltd., London.Google Scholar
- Frenster, J.H., 1973, Molecular aspects of the integration and de-repression of oncogenic viral genomes, U.S. Atomic Energy Commission, “Third Conference on Embryonic and Fetal Antigens in Cancer, ” Report CONF-731141 (Nov. 4–7, 1973 ), pp. 19–20.Google Scholar
- Fresnter, J.H., Nakatsu, S.L., and Masek, M.A., 1974, Ultrastructural probes of DNA templates within human bone marrow and lymph node cells, in “Advances in Cell and Molecular Biology,” (E. DuPraw, ed.), Vol. 3, pp. 1–19, Academic Press, New York.Google Scholar
- Nomura, S., Fischinger, P.J., Mattern, C.F.T., Gerwin, B.I., andGoogle Scholar