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Gene Regulation: Selective Control of DNA Helix Openings

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Aging, Carcinogenesis, and Radiation Biology

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Abstract

Gene regulation implies differential activity of DNA molecules within an individual cell. Such differential activity is observed during both gene transcription and gene replication (Frenster, 1966), and is a feature of DNA molecules within both prokaryotes (Chamberlin, 1974) and eukaryotes (Frenster and Herstein, 1973). Because gene replication appears to be secondary to gene transcription (Klevecz and Hsu, 1964; Champoux and McConaughy, 1975), the critical feature of the regulatory event appears to lie in the molecular details of selective gene transcription (Frenster, 1965d; Chamberlin, 1974). Such selectivity involves both the choice of a particular gene locus and the choice of a particular DNA strand on which to effect messenger RNA synthesis (Frenster, 1966).

Supported in part by Research Grants CA-10174 and CA-13524 from the National Cancer Institute, by Research Grant IC-45 from the American Cancer Society, and by a Research Scholar Award from the Leukemia Society.

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Authors and Affiliations

  1. Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305, USA

    John H. Frenster

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  1. John H. Frenster
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  1. Stanford University School of Medicine, Stanford, California, USA

    Kendric C. Smith

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Frenster, J.H. (1976). Gene Regulation: Selective Control of DNA Helix Openings. In: Smith, K.C. (eds) Aging, Carcinogenesis, and Radiation Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1662-7_4

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  • DOI: https://doi.org/10.1007/978-1-4757-1662-7_4

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