Chemically-Induced DNA-Protein Cross-Links

  • John O. Thomas


Naturally occurring nucleic acids are found in intimate association with proteins. Viral DNA or RNA is folded within a protein capsid; the bacterial chromosome is associated with polyamines, proteins, and membrane components (Worcel and Burgi, 1975); and the DNA of eukaryotes is associated with histones and non-histone proteins. Cross-links between nucleic acids and the surrounding proteins have been generated by UV radiation both in vitro and in vivo (Smith, This Volume). They have been employed in studies of nucleic acid-protein interactions (Schimmel et al, This Volume), and may lead to viral inactivation (Gordon, This Volume), cell death (Smith, This Volume; Todd and Han, This Volume), and perhaps carcinogenesis.


Sulfur Mustard Nitrogen Mustard Cesium Chloride Polycyclic Hydrocarbon Ehrlich Cell 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • John O. Thomas
    • 1
  1. 1.Department of BiochemistryStanford University Medical SchoolStanfordUSA

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