Ionizing Radiation-Induced DNA-Protein Cross-Linking

  • Osamu Yamamoto


Ionizing radiation-induced damage in DNA includes deamination and ring scission of the purine and pyrimidine bases, base elimination by scission of the glycoside bond, and strand breaks produced by scission of the ester bond between sugar and phosphate groups or by scission of the sugar moiety. In addition, cross-linking between DNA and other substances and also intra- or inter-molecular cross-linking of DNA are produced by ionizing radiation.


Aromatic Amino Acid Covalent Binding Nucleic Acid Basis Pyrimidine Base Amino Acid Radical 
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© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Osamu Yamamoto
    • 1
  1. 1.Research Institute for Nuclear Medicine and BiologyHiroshima UniversityHiroshimaJapan

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