Human Tumor Cells in Vitro pp 487-515 | Cite as
The Strategy of a Search for Viral Involvement in Human Cancer
Abstract
The first suggestions that viruses could be concerned in the causation of neoplasia in birds were made over 60 years ago (Ellermann and Bang, 1908; Rous, 1911), to be followed, 20–30 years later, by compelling evidence (Bittner, 1942; Shope and Hurst, 1933; Gross, 1951) that viruses could similarly cause tumors in mammals. However, it is only recently that serious consideration has been given to the possibility that such a situation could also obtain in man. In principle, this has been because morphological, immunological, and biochemical, as well as biological, studies of animal model systems have established an association between viruses and neoplasms, particularly leukemias and sarcomas, in a whole range of mammalian species, extending from mice to primates (Dameshek and Dutcher, 1970), but similar studies have not so far led to the isolation and characterization of an authentic human cancer virus. This chapter represents an attempt to discover why this should be so, to decide what kind of evidence might be needed in the future to indicate viral involvement in the genesis of any one human tumor, and to see how current studies measure up to the criteria adopted.
Keywords
Herpes Simplex Virus Type Herpes Virus Rous Sarcoma Virus Feline Leukemia Virus Tissue Culture SupernatantPreview
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References
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