The β-Adrenergic Receptors and Their Mode of Interaction with Adenylate Cyclase

  • Alexander Levitzki
Part of the NATO ASI Series book series (NSSA, volume 72)


The classification into α- and β-receptors has been extended in recent years as a result of extensive detailed studies of structure-activity relationships; thus, β-adrenergic responses can be divided into two subclasses: βl and β2. Epinephrine and norepinephrine are approximately equipotent agonists for β1-receptors which are preferentially blocked by practolol. Epinephrine is more potent than norepinephrine in activating β2-receptors which are inhibited by butoxamine. A variety of antagonists such as propranolol, alprenolol and pindolol inhibit the catecholamine response of both βl- and β2-receptors. βl and β2 are functionally similar as both of them are coupled to and activate the enzyme adenylate cyclase as the signal system, and will therefore be discussed as a single family of β-receptors.


Adenylate Cyclase Cyclase Activation Affinity Label Catecholamine Receptor Guanyl Nucleotide 
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  1. 1.
    Levitzki, A. (1982) The mode of coupling of adrenergic receptors to adenylate cyclase, in: “Topics in Molecular Pharmacology,” A.S. V. Burgen and G.C.K. Roberts, Elsevier/North Holland Publishing Co., pp. 24 - 62.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Alexander Levitzki
    • 1
  1. 1.Department of Biological ChemistryThe Hebrew University of JerusalemJerusalemIsrael

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