The β-Adrenergic Receptors and Their Mode of Interaction with Adenylate Cyclase

  • Alexander Levitzki
Part of the NATO ASI Series book series (NSSA, volume 72)

Abstract

The classification into α- and β-receptors has been extended in recent years as a result of extensive detailed studies of structure-activity relationships; thus, β-adrenergic responses can be divided into two subclasses: βl and β2. Epinephrine and norepinephrine are approximately equipotent agonists for β1-receptors which are preferentially blocked by practolol. Epinephrine is more potent than norepinephrine in activating β2-receptors which are inhibited by butoxamine. A variety of antagonists such as propranolol, alprenolol and pindolol inhibit the catecholamine response of both βl- and β2-receptors. βl and β2 are functionally similar as both of them are coupled to and activate the enzyme adenylate cyclase as the signal system, and will therefore be discussed as a single family of β-receptors.

Keywords

Adenylate Cyclase Cyclase Activation Affinity Label Catecholamine Receptor Guanyl Nucleotide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Levitzki, A. (1982) The mode of coupling of adrenergic receptors to adenylate cyclase, in: “Topics in Molecular Pharmacology,” A.S. V. Burgen and G.C.K. Roberts, Elsevier/North Holland Publishing Co., pp. 24 - 62.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Alexander Levitzki
    • 1
  1. 1.Department of Biological ChemistryThe Hebrew University of JerusalemJerusalemIsrael

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