Steroid Hormone Receptors in Endocrine-Related Tumors

  • Paolo Marchetti
  • Giovanni Scambia
  • Gigliola Sica
  • Vittoria Natoli
  • Stefano Iacobelli
Part of the NATO ASI Series book series (NSSA, volume 72)

Abstract

One of the main objectives in the fight against cancer is the identification of precise tumor markers which can aid in selecting the most appropriate treatment for each individual patient. This is particularly relevant with regard to tumors arising in hormone target tissues, such as breast, endometrium, ovary and prostate carcinoma or leukemia and lymphoma, which often retain the hormone sensitivity of their parent cells. Endocrine manipulations designed to modify endogenous hormone influences on some of these tumors preceeded any rational understanding of the mechanism of hormone action. The concept of steroid receptors was introduced into the scientific world for the first time about twenty years ago (Folca et al., 1961; Jensen and Jacobson, 1962). A great deal of work has been done in recent years on the mechanism of action of steroid hormones and relationships between the presence of receptors in endocrine-related tumors and both the responsiveness to therapy and the prognosis. However, it is now generally accepted that the mere presence of receptors in target cells is not sufficient to guarantee hormone responsiveness (Yamamoto and Alberts, 1976; Gehering, 1980; Lippman and Nawata, 1982).

Keywords

Breast Cancer Estrogen Receptor Endometrial Cancer Glucocorticoid Receptor Endometrial Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Paolo Marchetti
    • 1
  • Giovanni Scambia
    • 1
  • Gigliola Sica
    • 1
  • Vittoria Natoli
    • 1
  • Stefano Iacobelli
    • 1
  1. 1.Laboratory of Molecular Endocrinology and Department of HistologyCatholic University of the Sacred HeartRomeItaly

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